Clinical Pharmacology Flashcards
(47 cards)
What do we require of drug therapy in all patients where possible?
Effective treatment or prophylaxis
Safe
Easily administered by owner/veterinarian
Good value for money
What do we need to understand before medicating pets?
What disease/clinical sign we are treating
Which drug/drugs would be effective and why
What are the potential side effects
What patient conditions might affect drug dose
How is the drug administered to maximum effect
What does a drug need to do to be therapeutically effective?
Be absorbed into the blood stream (unless local tx)
Be transported to the site of the body where action is required
Have its action terminated once an effect has been achieved
Be eliminated from the body safely
What are pharmacokinetics?
What the body does to the drug
What are pharmacodynamics?
What the drug does to the body
What does pharmacokinetics encompass?
Absorption
Distribution
Metabolism
Elimination
When do drugs not need to be absorbed into the bloodstream?
Oral administration of drugs that act within the intestinal lumen
Drugs used topically for local effect on the skin or mucous membranes
What influences drug absorption into the bloodstream?
Ability to cross membranes
Route of administration
Chemical formulation of the drug (particle size/rate of dissolution of a tablet)
Volume of injection
What are the advantages and disadvantages of oral drug administration?
Convenient
Many drugs are absorbed effectively
Some drugs are destroyed or altered by gastric acid/intestinal flora but can use coated drugs
Where are oral drugs absorbed?
Mainly from the small intestine as there is a large surface area (rate of gastric emptying important)
Why is the oral bio availability of a drug <1?
Incomplete absorption
Metabolism in gut/gut wall
First pass metabolism in the liver
Enterohepatic recycling and incomplete resorption after excretion into bile
What is the first pass effect?
Drugs given orally must pass through the liver before reaching the systemic circulation
They may be metabolised by the liver which will affect how much drug reaches the circulation
How do you tell how large the first pass metabolism of a drug is?
If there is a big difference between the dose given IV and the dose given orally = significant first pass metabolism
What effect does pathology have on first pass metabolism?
If there is significant hepatic dysfunction then first pass metabolism will be reduced increasing bio availability
Increased risk of toxicity for drugs with narrow therapeutic index and prolonged duration of effect of drug
How is the volume of distribution of a drug calculated?
Total amount of drug/plasma concentration
What are the different body compartments?
Total body water (plasma, intracellular, extracellular)
Fat
Bone
How is volume of distribution interpreted?
Very low (0.05-01 L/kg) confined to plasma
Low (0.2 L/kg) confined to plasma and interstitial space
Intermediate (0.6 L/kg) enters total body water
High (>1 L/kg) sequestered in tissue
What are some important factors affecting distribution?
Blood flow
Protein binding
Membrane permeation
Tissue solubility (water, bone, fat)
What factors can alter blood flow?
Shock Dehydration Cardiac failure Age Drugs (propanolol)
What proteins can drugs bind to?
Albumin
Several other serum proteins
Where do drugs bind to on the proteins?
Inert or non-receptor binding sites
What factors can influence drug binding?
Decreased serum protein levels may result in increased free drug concentration
Very young and geriatric patients have lower plasma protien
How does protein binding affect distribution and elimination?
Limits passage from blood into interstitial fluid, milk, placenta and glomerular ultrafiltrate
Why does protein binding matter?
Toxicity associated with displacement is unusual
Displaced drug is instantly available for distribution, metabolism and excretion
New equilibrium is rapidly attained
