CLL

Question 1

Chronic lymphoproliferative Disorders Things you must know

Answer 1

Malignant proliferation of lymphocytes in blood, bone marrow
Several disorders; CLL most important
Occur only in adults
Long course; indolent but incurable

Question 2

chronic lymphocytic leukemia things you must know

Answer 2

Small, mature lymphocytes
= small lymphocytic lymphoma
B-cell, but CD5+ (weird!)
Long but inexorable course

Question 3

CLL same as

Answer 3

SLL

Question 4

immunophenotype markers for CLL

Answer 4

Positive for:
B-cell antigens (CD20)
A T-cell antigen (CD5)!

Negative for:
TdT

Question 5

Clinical findings CLL

Answer 5

Older (>40)
Asymptomatic at first
Later, organ infiltration
Infection may occur due to hypogammaglobulinemia

Question 6

tx cLL

Answer 6

Conservative

Reduce organomegaly, infections

Question 7

prognosis CLL

Answer 7

Counts, adenopathy, BM pattern
Mean survival: 9 years
Death usually from infection

Question 8

Hairy Cell leukemia things you must know

Answer 8

Hairy cells
Splenomegaly without lymphadenopathy
Pancytopenia
TRAP +

Question 9

Clinical findings HCL

Answer 9

Older (>40)
M:F = 5:1
Big spleen but no lymphadenopathy!
Pancytopenia (usually) and monocytopenia (always)

Question 10

why pancytyopenia in HCL

Answer 10

release something that causes fibrosis - hard for normal cells to get out

Question 11

cytochemistry in HCL

Answer 11

TRAP+

Question 12

immunophenotype for HCL

Answer 12

Positive for B cell antigens

negative for CD5

Question 13

tx HCL

Answer 13

chemotherapy

Question 14

prognosis HCL

Answer 14

Good - usually 10+ years