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IHO Week 4 > Non-Hodgkin Lymphoma > Flashcards

Non-Hodgkin Lymphoma Flashcards

1
Q

Causes of lymphadenopathy

A

Most common cause overall: benign reaction to infection
Most common malignant cause: metastatic carcinoma
Lymphoma far down on the list

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2
Q

follicular hyperplasia things you must know

A 
Large, irregular follicles
Mixture of cells in germinal centers
Tingible body macrophages
B-cell response to some immune stimulus
Benign
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3
Q

Interfollicular hyperplasia things you must know

A

Expanded area between follicles
Mixture of cells
Partial effacement
T-cell response to some immune stimulus

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4
Q

total effacement

A

can’t see anything/follicles - worry about malignancy

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5
Q

Non-hodgkin lymphoma things you must know

A

Malignant proliferation of lymphoid cells (blasts or mature cells) in lymph nodes
Skips around
Many subtypes
Most are B cell

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6
Q

sxs of NHL

A

Painless, firm lymphadenopathy
Extranodal manifestations
“B” symptoms: weight loss, night sweats, fever

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7
Q

Low grade NHL

A

Older patients
Indolent (incurable!)
Small, mature cells
Non-destructive

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8
Q

high grade NHL

A

Children, sometimes
Aggressive (curable?)
Big, ugly cells
Destructive

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9
Q

Types of NHL: Low Grade

A

Small lymphocytic lymphoma
Malt lymphoma
Follicular lymphoma
Mycosis fungoides

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10
Q

Types of NHL: High Grade

A

Large cell lymphoma
Lymphoblastic lymphoma
Burkitt lymphoma

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11
Q

Small Lymphocytic Lymphoma, things you must know

A

Small mature lymphocytes
Same thing as CLL
B-cell lesion, but CD5+ (weird!)
Long course; death from infection

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12
Q

Richter’s transformation

A

Low grade –> high grade, more aggressive

bad prognosis

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13
Q

Marginal Zone lymphoma things you must know

A

Actually a bunch of lymphomas
Marginal zone pattern
Malt lymphoma
Helicobacter pylori

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14
Q

Malt lymphoma is a

A

marginal zone lymphoma

mucosa-associated lymphoid tissue

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15
Q

Mantle Cell Lymphoma things you must know

A

Mantle zone pattern
Small angulated lymphocytes
t(11;14) – cyclin D1 and IgH
More aggressive

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16
Q

mantle cell cytogenetics

A

t(11;14)

cyclin D1 and IgH - cyclin D1 over expressed –> cell divides more often than should

17
Q

follicular lymphoma things you must know

A

Follicular pattern (later diffuse)
Small cleaved cell, mixed or large cell
Grade 1, 2, or3
t(14;18) - IgH and bcl-2

18
Q

cytogenetics follicular lymphoma

A

t(14;18) - IgH and bcl-2

Tells cells not to undergo apoptosis

19
Q

follicular lymphoma grading

A

1 - small cell
2 - mixed
3 - large cell
prognosis is dependent on grading

20
Q

morphology follicular lymphoma

A

butt cells

21
Q

markers follicular lymphoma

A

CD20

22
Q

staging and prognosis Follicular Lymphoma

A 
1 - single node
2 - two or more on same side of diaphragm
3 - two or more on both sides diaphragm
4 - diffuse extranodal involvement
A- no additional symptoms
B- weight loss, night sweats, fever
23
Q

Mycosis fungoides/Sezary syndrome things you must know

A

Skin lesions/Blood involvement
Cerebriform lymphocytes
T-cell immunophenotype

24
Q

Pautrier microabsesses

A

tumor cells of MF/SS

25
Q

morphology MF/SS

A

cerebriform lymphocytes

26
Q

Diffuse large-cell lymphoma things you must know

A 
Large B cells
Extranodal involvement
Grows rapidly	
Bad prognosis
total effacement
27
Q

Lymphoblastic Lymphoma things you must know

A

Two types: B and T
Lymphoblasts in diffuse pattern
Same as ALL
T-lymphoblastic lymphoma often in teenage male with mediastinal mass

28
Q

Lymphoblastic lymphoma same as

A

ALL

29
Q

T cell Lymphoblastic lymphoma common presenation

A

teenage male w/ mediastinal mass

30
Q

Burkitt lymphoma things you must know

A

Child with fast-growing, extranodal mass
Starry-sky pattern
t(8;14) = c-myc and IgH
Occasionally involves blood

31
Q

morphology burkitt lymphoma

A

starry-sky pattern (sky = tumor cells, stars are TBM contradiction but tumor needs them to eat up quickly turning over cells)

32
Q

cytogenetics burkitt lymphoma

A

t(8;14) = c-myc and IgH

33
Q

adult T-cell leukemia/lymphoma things you must know

A

Japan/Caribbean basin
HTLV-1
Skin lesions, hypercalcemia
Very aggressive

34
Q

morphology adult t-cell leukemia/lymphoma

A

weird flowery cells

IHO Week 4 (15 decks)

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