coagulation Flashcards Preview

Z MD1 Cardiac physiology > coagulation > Flashcards

Flashcards in coagulation Deck (20)
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1
Q

types of tests used in haematology

A

to predict bleeding to predict clotting to monitor drugs used to manipulate the haemostatic system

2
Q

initiation phase of the coagulation cascade involves what?

A

injury of vessel wall leads to contact between blood and subendothelial cells TF exposed and starts off the system

3
Q

What is the “starter motor” for coagulation cascade?

A

tissue factor

3
Q

specific assays for bleeding

A

factor assays VWF AG Collagen binding assays fibrinogen

4
Q

what does secondary haemostasis involve?

A

activation of coagulation factors formation of fibrin (bulk of clot that covers hole)

5
Q

Virchow’s triad

A

three things that are involved in blood clotting - vessel wall - blood flow - blood composition any of these three things can cause abnormal blood blotting

6
Q

key principles of most coagulation tests

A
  • sample integrity crucial - standard curve developed (for interpretation) - control samples - duplicate testing - multiple consistent tests before labelling a patient
7
Q

What is special about the endothelium around your body?

A

it acts differently in arteries and veins, and in every specific site within your body

8
Q

coagulation system involves

A

a complex series of proteins in plasma that interact with platelets and blood vessel walls

9
Q

What is the main action of thrombin?

A

converts fibrinogen to fibrin –> clot formation

9
Q

3 types of factor assays

A

functional clot based assays chromogenic assays immunological assays

11
Q

what does fibrinolysis inolve?

A

activation of fibrinolysis lysis of the clot

11
Q

What is the key enzyme in the coagulation cascade?

A

thrombin

13
Q

3 main phases of the coagulation cascade

A

initiation phase amplification phase propagation phase

14
Q

which factors does walfarin inhibit?

A

2, 7, 9, 10

16
Q

if abnormal APTT, which factors abnormal?

A

12, 11, 10, 9

17
Q

global function tests for bleeding

A

ACT APTT INR/PT thrombin generation

18
Q

amplification phase of the coagulation cascade involves what?

A

thrombin burst!!

19
Q

propagation phase of coagulation cascade involves what?

A

precipitates the making of stable fibrin clot

20
Q

what does primary haemostasis involve?

A

vasoconstriction (limiting amount of blood to site) platelet adhesion platelet aggregation