Coagulation

Question 1

Enzyme less specific for fibrin

Answer 1

Reteplase

Question 2

More fibrin specific and longer half life

Answer 2

Temacteplase

Question 3

Urine enzyme that directly activates plasminogen

Answer 3

Urokinase

Question 4

A preformed complex of streptokinase and plasminogen

Answer 4

Anistreplase

Question 5

Combines with plasminogen to form an active complex that converts plasminogen to plasmin

Answer 5

Streptokinase

Question 6

Antidote of excess thrombolytic activity

Answer 6

Aminocaproic acid

Question 7

Lysine analog that blocks plasmin binding

Answer 7

Aminocaproic acid

Question 8

Used in women with previa

Answer 8

Tranecamic acid

Question 9

ADR of Tranexamic acid

Answer 9

THROMBOSIS

GUT bleeding

Question 10

Most common cause of DIC

Answer 10

Sepsis

Question 11

Aprotinin MOA

Answer 11

Serpin that inhibits FREE plasmin fibrinolysis

Question 12

Most commonly used anti platelet agent

Answer 12

Aspirin

Question 13

Irreversibly inhibited by aspirin

Answer 13

TXA2

Question 14

Most common disease associated with anti platelet usage of children

Answer 14

Reye’s

Question 15

Sulfonylureas with aspirin

Answer 15

Increase hypoglycemia

Question 16

Drug that will be inhibited by aspirin when taken simultaneously

Answer 16

Probenecid- aspirin will inhibit it’s URICOSURIA effect

Question 17

Aspirin overdose management

Answer 17

Forced alkaline diuresis

Question 18

Drugs for prosthetic valves

Answer 18

Dipyridamole
Warfarin
Aspirin

Question 19

Dipyridamole MOA

Answer 19

Lowers platelet calcium

Increase cAMP formation

Question 20

Bradycardia effects when taken with Dipyridamole

Answer 20

Beta Blockers

Question 21

Prevents thrombotic stroke

Answer 21

Ticlipidine

Question 22

Why use Ticlipidine?

Answer 22

Some patients can’t tolerate aspirin

Question 23

Ticlipidine MOA

Answer 23

Inhibits ADP induced expression of platelet glycoprotein receptors

Question 24

Management of toxicity effects of Ticlipidine

Answer 24

CBC

Question 25

A natural anti coagulant

Answer 25

Heparin

Question 26

A patient came in your office at 2:30 pm complaining of Chest pain happened 2 hours prior to consult. Knowing the Golden Hour pf heparin admin. What time will you administer the anti coagulant?

Answer 26

6:30 pm

Question 27

Increases the activity of anti thrombin 3

Answer 27

Heparin

Question 28

Heparin ROA and onset

Answer 28

IV or SC never IM | 30-60 minutes

Question 29

Risk of bleeding in Heparin can be manifested with patients simultaneously taking what group of drugs?

Answer 29

Salicylates

Question 30

Heparin overdose

Answer 30

Protamine sulfate

Question 31

Pentasaccharide of active heparin residues

Answer 31

Fondaparinux

Question 32

Hirudin analog

Answer 32

Lepirudin | Bivalirudin

Question 33

No antidote for this drugs

Answer 33

Lepirudin | Drotrecogin alfa

Question 34

An L arginine analog, reversible anti coagulant effects

Answer 34

Agatroban

Question 35

Px with renal insufficiency

Answer 35

Agatroban - hepatically metabolized

Question 36

Px with hepatic insufficiency

Answer 36

Lepirudin- renally excreted

Question 37

Recombinant activated protein c

Answer 37

Drotrecogin alfa

Question 38

Factors inhibited by drotrecogin alfa

Answer 38

Va and VIIIa

Question 39

Dicumarol and Warfarin are?

Answer 39

Coumarins

Question 40

Rat poison

Answer 40

Dicumarol

Question 41

Most widely used coumarin

Answer 41

Warfarin

Question 42

Coumarin ROA and onset

Answer 42

Oral | 8-12 hour DELAY

Question 43

Heparin on pregnant px with DVT

Answer 43

Warfarin is teratogenic

Question 44

DOC for atherosclerosis

Answer 44

Clopidogrel or Prasugrel

Question 45

Increase factor VIII activity

Answer 45

Desmopressin acetate

Question 46

Percutaneous transluminal coronary angioplasty DOC

Answer 46

Abciximab

Question 47

Abciximab MOA

Answer 47

Binds to platelet glycoprotein IIb and IIIa receptors

Question 48

Percutaneous transluminal coronary angioplasty WITH ASPIRIN AND HEPARIN

Answer 48

Eptifibatide and Tirofiban

Question 49

Antidote for coumarin overdose

Answer 49

Vit K

Question 50

Major drawback of thrombolytics

Answer 50

Mahal