Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Pharma 3 > Coagulation > Flashcards

Coagulation Flashcards

1
Q

Enzyme less specific for fibrin

A

Reteplase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

More fibrin specific and longer half life

A

Temacteplase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Urine enzyme that directly activates plasminogen

A

Urokinase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

A preformed complex of streptokinase and plasminogen

A

Anistreplase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Combines with plasminogen to form an active complex that converts plasminogen to plasmin

A

Streptokinase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Antidote of excess thrombolytic activity

A

Aminocaproic acid

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Lysine analog that blocks plasmin binding

A

Aminocaproic acid

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Used in women with previa

A

Tranecamic acid

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

ADR of Tranexamic acid

A

THROMBOSIS

GUT bleeding

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Most common cause of DIC

A

Sepsis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Aprotinin MOA

A

Serpin that inhibits FREE plasmin fibrinolysis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Most commonly used anti platelet agent

A

Aspirin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Irreversibly inhibited by aspirin

A

TXA2

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Most common disease associated with anti platelet usage of children

A

Reye’s

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Sulfonylureas with aspirin

A

Increase hypoglycemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Drug that will be inhibited by aspirin when taken simultaneously

A

Probenecid- aspirin will inhibit it’s URICOSURIA effect

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Aspirin overdose management

A

Forced alkaline diuresis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Drugs for prosthetic valves

A

Dipyridamole
Warfarin
Aspirin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Dipyridamole MOA

A

Lowers platelet calcium

Increase cAMP formation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Bradycardia effects when taken with Dipyridamole

A

Beta Blockers

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

Prevents thrombotic stroke

A

Ticlipidine

22
Q

Why use Ticlipidine?

A

Some patients can’t tolerate aspirin

23
Q

Ticlipidine MOA

A

Inhibits ADP induced expression of platelet glycoprotein receptors

24
Q

Management of toxicity effects of Ticlipidine

A

CBC

25
Q

A natural anti coagulant

A

Heparin

26
Q

A patient came in your office at 2:30 pm complaining of Chest pain happened 2 hours prior to consult. Knowing the Golden Hour pf heparin admin. What time will you administer the anti coagulant?

A

6:30 pm

27
Q

Increases the activity of anti thrombin 3

A

Heparin

28
Q

Heparin ROA and onset

A

IV or SC never IM

30-60 minutes

29
Q

Risk of bleeding in Heparin can be manifested with patients simultaneously taking what group of drugs?

A

Salicylates

30
Q

Heparin overdose

A

Protamine sulfate

31
Q

Pentasaccharide of active heparin residues

A

Fondaparinux

32
Q

Hirudin analog

A

Lepirudin

Bivalirudin

33
Q

No antidote for this drugs

A

Lepirudin

Drotrecogin alfa

34
Q

An L arginine analog, reversible anti coagulant effects

A

Agatroban

35
Q

Px with renal insufficiency

A

Agatroban - hepatically metabolized

36
Q

Px with hepatic insufficiency

A

Lepirudin- renally excreted

37
Q

Recombinant activated protein c

A

Drotrecogin alfa

38
Q

Factors inhibited by drotrecogin alfa

A

Va and VIIIa

39
Q

Dicumarol and Warfarin are?

A

Coumarins

40
Q

Rat poison

A

Dicumarol

41
Q

Most widely used coumarin

A

Warfarin

42
Q

Coumarin ROA and onset

A

Oral

8-12 hour DELAY

43
Q

Heparin on pregnant px with DVT

A

Warfarin is teratogenic

44
Q

DOC for atherosclerosis

A

Clopidogrel or Prasugrel

45
Q

Increase factor VIII activity

A

Desmopressin acetate

46
Q

Percutaneous transluminal coronary angioplasty DOC

A

Abciximab

47
Q

Abciximab MOA

A

Binds to platelet glycoprotein IIb and IIIa receptors

48
Q

Percutaneous transluminal coronary angioplasty WITH ASPIRIN AND HEPARIN

A

Eptifibatide and Tirofiban

49
Q

Antidote for coumarin overdose

A

Vit K

50
Q

Major drawback of thrombolytics

A

Mahal

Pharma 3 (3 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions