Heart Failure

Question 1

Phosphodiesterase 3 inhibitors

Answer 1

Inamrinone

Milrinone

Question 2

Decrease cAMP breakdown

Answer 2

Inamrinone

Milrinone

Question 3

Inamrinone and milrinone effects

Answer 3

Vasodilation
Dec peripheral vascular resistance
INCREASE CARDIAC CONTRACTILITY

Question 4

Applications of Inamrinone and Milrinone

Answer 4

Acute DECOMPENSATED heart failure

Increase mortality in chronic failure

Question 5

Inamrinone and Milrinone ROA and duration

Answer 5

Only IV

3-6 hrs

Question 6

Main toxicity of Bypiridines

Answer 6

ARRYTHMIAS

Question 7

Nesiritide class

Answer 7

Natriuretic Peptides

Question 8

If Inamrinone and Milrinone dec cAMP breakdown, Nesiritide?

Answer 8

Directly increases cGMP by activating BNP receptors

Question 9

Nesiritide effects other than Vasodilation?

Answer 9

Diuresis

Question 10

Drugs that are used without reducing mortality

Answer 10

Nesiritide

Digoxin

Question 11

Nesiritide ROA and duration

Answer 11

IV only

18 MINUTES

Question 12

Nesiritide toxicity

Answer 12

RENAL DAMAGE

Question 13

Spirinolactone targets Aldosterone receptors in the?

Answer 13

Collecting Ducts

Question 14

Effects of enhancing salt and water excretion of Spirinolactone in the heart?

Answer 14

Dec remodelling

Dec mortality

Question 15

Drugs that shown to reduce mortality in CHRONIC HEART FAILURE?

Answer 15

Spirinolactone
Captopril
Carvedilol

Question 16

Spirinolactone ROA and duration that shows SLOW onset and offset?

Answer 16

Oral

24-72 hrs

Question 17

Hyperkalemia with antiandrogenic actions are toxicities of?

Answer 17

Spirinolactone

Question 18

ACE inhibitor used in Heart Failure

Answer 18

Captopril

Question 19

Captopril effects

Answer 19

Microvessels dilatation
Dec remodeling
Dec aldosterone secretion

Question 20

Extra-cardiac applications of Captopril

Answer 20

Diabetic Renal Disease

Question 21

Captopril ROA, Duration and Half life

Answer 21

Oral
Half-life 2-4hrs
Duration 12-24 hrs

Question 22

More selective, no antiandrogen effect and reduces HF mortality than SPIRINOLACTONE

Answer 22

Eplerenone

Question 23

Toxicity: Hyperkalemia, Angioneurotic edema and cough

Answer 23

CAPTOPRIL

Question 24

Other ACE inhibitors and ARBs used in HF

Answer 24

Enalapril; Candesartan

Question 25

Losartan has the same effects as Captopril which are?

Answer 25

Microvessels dilatation Dec Remodeling Dec aldosterone secretion

Question 26

Losartan ROA and duration

Answer 26

Oral | 6-8 hrs

Question 27

Losartan = Captopril in toxicity except

Answer 27

COUGH, ARBs ang gamitin

Question 28

B Blockers that reduce HF mortality

Answer 28

Carvedilol Metoprolol Bisoprolol Nebivolol

Question 29

Drugs for Chronic heart failure

Answer 29

Captopril Carvedilol Digoxin

Question 30

Drugs for acute decompensated HF

Answer 30

``` Inamrinone and Milrinone Nesiritide Nitropusside Dobutamine Dopamine ```

Question 31

Carvedilol ROA and Duration

Answer 31

Oral | 10-12 hrs

Question 32

Common toxicity of Carvedilol

Answer 32

Bronchospasm AV Block ACUTE CARDIAC DECOMPENSATION

Question 33

Digoxin MOA

Answer 33

Inhibition of Na/K ATPase pump, reduce Ca expulsion thereby increasing Ca storage in the sarcopladmic reticulum

Question 34

Contradicting effects of INCREASE CONTRACTILITY and PARASYMPATHOMIMETIC is observed in what drug?

Answer 34

Digoxin

Question 35

Digoxin distinct Clinical Application

Answer 35

Rapid ventricular rate in atrial fibrillation

Question 36

Digoxin ROA and duration

Answer 36

Oral and Parenteral | 36-40 hrs

Question 37

Digoxin toxicity

Answer 37

Cardiac Arrythmias Nausea and Vomiting DIARRHEA

Question 38

Drug used for HF that has VENODILATION

Answer 38

Isosorbide dinitrate

Question 39

Aside from VENODILATION, ISD does

Answer 39

Reduction of ventricular stretch and preload

Question 40

Drug that is used for ANGINA, ACUTE AND CHRONIC HF

Answer 40

ISD

Question 41

ISD ROA and duration

Answer 41

Oral | 4-6 hrs

Question 42

Drugs under Bypiridines

Answer 42

Inamrinone | Milrinone

Question 43

ISD is synergistic with?

Answer 43

PDE5 inhibitors

Question 44

Dilatory targets of Hydralazine

Answer 44

Arterioles

Question 45

Reduces BP and AFTERLOAD thereby increase CO

Answer 45

Hydralazine

Question 46

Hydralazine + Nitrates

Answer 46

Reduce HF mortality

Question 47

Hydralazine ROA and duration

Answer 47

8-12 hrs | Oral

Question 48

Famous Arteriole and Vein dilator

Answer 48

Nitropusside

Question 49

Since Nitropusside affects arterioles and veins in dilation, they also reduces?

Answer 49

Afterload and Preload

Question 50

Nitropusside ROA and duration

Answer 50

IV | 1-2 minutes

Question 51

CYANIDE POISONING

Answer 51

Nitropusside

Question 52

It is a beta selective agonist that increase cAMP synthesis

Answer 52

Dobutamine

Question 53

Dobutamine effects

Answer 53

Increase CO and contractility

Question 54

Intermittent Therapy in Chronic Heart Failure

Answer 54

Dobutamine

Question 55

Similarity of Dobutamine and Dopamine?

Answer 55

For ACUTE DECOMPENSATED HEART FAILURE and Toxicity (Arrhythmia)

Question 56

How can you activate both a and b receptor using dopamine?

Answer 56

Give large doses Sus basic

Question 57

Dopamine application aside from ADHF?

Answer 57

Shock