Flashcards in Coagulation and UA Deck (25):
Factor V (leiden) mutation
most common hereditary blood coagulation disorder in US
Prothrombin time (PT) and INR is used to evaluate
-extrinsic coagulation system
-used to guide warfarin/coumadin therapy
therapeutic INR value for DVT/PE/TIA
mechanical heart valves
Heparin works on the ( ) pathway and is tested via
intrinsic, partial thromboplastin time (PTT)
test to measure conversion of fibrinogen to fibrin
Decreased levels of fibrinogen indicate
-DIC (disseminated intravascular clotting) bc excess thrombin cleaves fibrinogen, which ultimately leaves behind multiple fibrin clots in the circulation
most notable subtype of fibrin split products is and is produced how?
D-dimer (DVT, PE, MI)
-produced by action of plasmin on deposited fibrin
-used to evaluate evidence of fibrin formation
Direct Coomb's test function and postive result?
-use pts RBCs to test for presence of antibody on pts cells, also used to screen for AI hemolytic anemia/hemolytic transfusion rxn
-indicates immune mechanism is attacking patient's own RBCs
Indirect Coombs test function
-Used to check cross-match prior to blood transfusion
-used in pre-natal testing to asses RH and ABO incompatibility
alkaline pH can indicate
acidic pH can indicate
-high protein diet
specific gravity roughly correlates with ( ) and increased/decreased levels indicate what?
decreased-over hydration, pyelonephritis
best indicator of renal disease?
24 hour urine study if persistent proteinuria present
glucose level of ( ) will begin to be seen in urine?
Leukocyte esterase test is used to detect....
-when combined with nitrite test, suspect UTI
Positive nitrite test indicates?
-bacteeria converts nitrates to nitrite
Hematuria can indicate....
positive billirubin indicates
Casts are used to identify
certain kidney diseases and overall disease states
hyaline casts are seen in...
RBC casts are seen in...
WBC casts are seen in...
-acute interstitial nephritis
Positive myogloblin indicates
-skeletal muscle injury
Bence-Jones protein is used to detect....