Coagulation and UA Flashcards Preview

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Flashcards in Coagulation and UA Deck (25):
1

Factor V (leiden) mutation

most common hereditary blood coagulation disorder in US

2

Prothrombin time (PT) and INR is used to evaluate

-extrinsic coagulation system
-used to guide warfarin/coumadin therapy

3

therapeutic INR value for DVT/PE/TIA
mechanical heart valves

2-3
5-6

4

Heparin works on the ( ) pathway and is tested via

intrinsic, partial thromboplastin time (PTT)

5

test to measure conversion of fibrinogen to fibrin

-thrombin time

6

Decreased levels of fibrinogen indicate

-DIC (disseminated intravascular clotting) bc excess thrombin cleaves fibrinogen, which ultimately leaves behind multiple fibrin clots in the circulation

7

most notable subtype of fibrin split products is and is produced how?

D-dimer (DVT, PE, MI)
-produced by action of plasmin on deposited fibrin
-used to evaluate evidence of fibrin formation

8

Direct Coomb's test function and postive result?

-use pts RBCs to test for presence of antibody on pts cells, also used to screen for AI hemolytic anemia/hemolytic transfusion rxn
-indicates immune mechanism is attacking patient's own RBCs

9

Indirect Coombs test function

-Used to check cross-match prior to blood transfusion
-used in pre-natal testing to asses RH and ABO incompatibility

10

alkaline pH can indicate

-bacteria/UTI

11

acidic pH can indicate

-high protein diet
-COPD
-acidosis

12

specific gravity roughly correlates with ( ) and increased/decreased levels indicate what?

osmolality
increased-volume depletion
decreased-over hydration, pyelonephritis

13

best indicator of renal disease?

24 hour urine study if persistent proteinuria present

14

glucose level of ( ) will begin to be seen in urine?

180

15

Leukocyte esterase test is used to detect....

-lysed WBC
-when combined with nitrite test, suspect UTI

16

Positive nitrite test indicates?

-infection
-bacteeria converts nitrates to nitrite

17

Hematuria can indicate....

-stones
-tumor
-infection

18

positive billirubin indicates

-obstructive jaundice
-hepatitis

19

Casts are used to identify

certain kidney diseases and overall disease states

20

hyaline casts are seen in...

-HTN
-nephrotic syndrome
-after exercise

21

RBC casts are seen in...

-acute glomerulonephritis
-lupus nephritis

22

WBC casts are seen in...

-Pyelonephritis
-acute interstitial nephritis

23

Positive myogloblin indicates

-skeletal muscle injury
-CO poisoning
-delirium tremors

24

Bence-Jones protein is used to detect....

multiple myeloma

25

24 hr urine increased results can indicate....

VMA and metanephrines (byproducts of epi) which indicates pheochromocytoma, neuroblastoma