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Hematology 2 > Coagulation Disorders > Flashcards

Coagulation Disorders Flashcards

(52 cards)

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1
Q

is a generalized activation of hemostasis
secondary to systemic disease

A

Disseminated Intravascular Coagulation

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2
Q

It will cause Fibrin formation and
coagulation factors and platelets will then
be consumed.

A

Disseminated Intravascular Coagulation

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3
Q

In DIC Fibrinolysis will also be Active and Result
to increased

A

FDPs such as D-Dimer

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4
Q

trigger which increases clotting would lead to

A
  • Consumption of Platelets
    -Increased Consumption of Clotting factors
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5
Q

Consumption of Platelets and Increased Consumption of Clotting factors leads to

A

Thrombus formation at the site of injury + in Microcirculation

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6
Q

Thrombus formation at the site of injury + in Microcirculation leads to

A

Hemorragic syndrome (DIC)

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7
Q

Clinical Conditions Triggering DIC

A
  • Sepsis or severe infection
  • Trauma
  • Organ destruction
  • Malignancy
  • Obstetrical calamities
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8
Q

Has AD inheritance

A

Dysfibrinogenemia, VWD

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9
Q

Has X linked inheritance

A

Hemophilia A, Hemophilia B/Christmas Disease

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10
Q

Has no bleeding tendency (AR INHERITANCE)

A

FXII Def, Fletcher Trait,
Fitzgerald Trait

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11
Q

Acute Disseminated intravascular coagulation is characterized by

A

Hypofibrinoginemia

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12
Q

Disseminated Intravascular Coagulation is prolonged in

A

Both PT and APTT

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13
Q

Von willebrand Disease

A

PT Normal, APTT Prolonged

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14
Q

Which test result would be normal in patient with dysfribrinoginemia?

A

Immunological Fibrinogen Level

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15
Q

Which of the following laboratory Findings is associated with Factor XIII deficiency?

A

Clot solubility in 5 M urea solution

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16
Q

No bleeding is observed in deficiency of which of the following factors?

A

XII

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17
Q

Which laboratory test is affected by heparin therapy?

A

Thrombin time

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18
Q

Hemophilia B is:

A

X-Linked

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19
Q

10-16 sec is the Normal range for:

A

Prothrombin Time

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20
Q

Which of the following factor will be decreased in cases of Vitamin K deficiency?
I. Christmas Factor. II. Proconvertin
III. Stuart Factor IV. Hageman Factor

A

I, II and III

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21
Q

Which of the following is a characteristic of Classic Hemophilia?

Study These Flashcards
A

Mild to severe Bleeding

22
Q

Prolonged APTT, Prothrombin Time, and Bleeding Time is a result for which condition?

23
Q

PT: Normal, APTT: Prolonged, Bleeding Time: Increased. What is the possible condition

24
Q

Glanzmann Thrombasthenia:

Study These Flashcards
A

PT and PT Normal

25
The most frequent bleeding disorder of childhood, which can lead to life-threatening bleeding:
Vitamin K deficiency
26
Rosenthal Syndrome
PT Normal, APTT Prolonged
27
APTT is used to?
Heparin Therapy Common Pathway
28
Which of the following will be abnormal in Von Willebrand disease?
APTT
29
Christmas Disease:
PT Normal, APTT Prolonged
30
Fletcher factor Deficiency may be associated with:
Thrombosis
31
The test that is commonly used to monitor warfarin therapy:
INR ( international normalized ratio)
32
Citrated plasma for APTT and PT testing should be centrifuged at 2500 x g for:
15 min
33
Thrombocytopenia
Both PT and APTT Prolonged
34
The most common subtype of Classic Von willebrand disease:
1
35
Which results are associated with Hemophilia A?
Prolonged APTT, Normal PT
36
The prothrombin Time requires that the patient’s citrated plasma be combined with:
CCa++ and Thromboplastin
37
Thrombophilia is associated with which of the following disorders:
Hyperfibrinogenemia
38
Hypofibrinogenemia:
Both PT and APTT Prolonged
39
A stabilized clot is insoluble to what reagent?
5 m urea
40
Rosenthal Syndrome will result to a prolonged result in:
APTT
41
Which of the following complications may occur as a result of decreased tissue factor inhibitor?
Increased Thrombosis Risk
42
All of the following are Activators except?
Metagross
43
Ehler-Danlos Syndrome:
PT and PT Normal
44
Factor XIII Deficiency
PT and PT Normal
45
The most suitable product for the treatment of Hemophilia A
Factor VIII concentrate
46
Fibrin Monomers are increased in which of the following conditions:
DIC
47
Therapeutic Modality for Plasma
FF Plasma
48
Parahemophilia:
Both PT and APTT Prolonged
49
Which characteristic describes Antithrombin? Synthesized by Megakaryocytes Activated by Protein C Both Neither
neither
50
Intrinsic Factors (PPT)
12,11, 9,8
51
Extrinsic clotting factors (PT)
(3), 7
52
Common clotting factor (PT & APTT)
10, 5, 2,1

Hematology 2 (8 decks)

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