Coagulopathies Flashcards Preview

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Flashcards in Coagulopathies Deck (18)
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1

Differential for platelet / bleeding disorders (PVC Pipes0

PVC Pipes

Platelets
VWD
Clotting factors
Pipes

2

Platelet Probs

Not enough (<50,000) from decreased production or increased destruction / sequestration

Not working due to aspirin, NSAIDs, Uremia, Genetic

3

vWD

Type I most common

Decreased platelet adhesion and lack of stabilized factor VIII

4

Clotting Factors

Most common - VIII and IX

Vitamin K deficiency (for VII, IX, X, II, I)

Liver disease

Presence of factor inhibitors

5

Pipes

Vasculitis
Scurvy
Ehlers Danlos
Steroids
Sepsis
Drugs

6

Assesses extrinsic pathway

PT / INR

7

Assesses intrinsic pathway

PTT

8

Most common congenital coagulopathy

Von Willebrand Disease

9

Bleeding in nasal, sinus vagina, GI mucous membranes. Common cause of menorrhagia. Can have increased PTT. Abnormal PFA

vWD

10

Second most common coagulopathy after vWD. The most severe bleeding disorder

Hemophilia A

X-Linked Recessive

11

Severe - epistaxis, intracranial bleeding, soft tissue and gingiva bleeding, Hematemesis, Melena, etc.

Less severe may have excessive bleeding following surgery

Hemophilia A (VIII Deficiency)

12

Coag tests in Hem A (VIII Deficiency)

Normal PT, Increased PTT

13

Most common acquired coagulopathy

Vitamin K deficiency

14

Typical patient of this disorder is postoperative, not eating well, receiving broad spectrum antibiotics

Vitamin K deficiency

15

Vitamin K factors

VII, IX, X, II, I

16

Virchow's Triad

Hypercoagulable State
Vascular Injury
Stasis

17

Acquired hyper coagulable states

Malignancy (Trousseau's)
Pregnancy
Nephrotic Syndrome
Estrogen meds
Immobilization
Myeloproliferative Diseases

18

Genetic causes for hyper coag states

Factor V Leiden (activated protein C resistance)

Protein C deficiency

Protein S deficiency