Coagulopathies Flashcards
(18 cards)
Differential for platelet / bleeding disorders (PVC Pipes0
PVC Pipes
Platelets
VWD
Clotting factors
Pipes
Platelet Probs
Not enough (<50,000) from decreased production or increased destruction / sequestration
Not working due to aspirin, NSAIDs, Uremia, Genetic
vWD
Type I most common
Decreased platelet adhesion and lack of stabilized factor VIII
Clotting Factors
Most common - VIII and IX
Vitamin K deficiency (for VII, IX, X, II, I)
Liver disease
Presence of factor inhibitors
Pipes
Vasculitis Scurvy Ehlers Danlos Steroids Sepsis Drugs
Assesses extrinsic pathway
PT / INR
Assesses intrinsic pathway
PTT
Most common congenital coagulopathy
Von Willebrand Disease
Bleeding in nasal, sinus vagina, GI mucous membranes. Common cause of menorrhagia. Can have increased PTT. Abnormal PFA
vWD
Second most common coagulopathy after vWD. The most severe bleeding disorder
Hemophilia A
X-Linked Recessive
Severe - epistaxis, intracranial bleeding, soft tissue and gingiva bleeding, Hematemesis, Melena, etc.
Less severe may have excessive bleeding following surgery
Hemophilia A (VIII Deficiency)
Coag tests in Hem A (VIII Deficiency)
Normal PT, Increased PTT
Most common acquired coagulopathy
Vitamin K deficiency
Typical patient of this disorder is postoperative, not eating well, receiving broad spectrum antibiotics
Vitamin K deficiency
Vitamin K factors
VII, IX, X, II, I
Virchow’s Triad
Hypercoagulable State
Vascular Injury
Stasis
Acquired hyper coagulable states
Malignancy (Trousseau's) Pregnancy Nephrotic Syndrome Estrogen meds Immobilization Myeloproliferative Diseases
Genetic causes for hyper coag states
Factor V Leiden (activated protein C resistance)
Protein C deficiency
Protein S deficiency
