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Y3 GI Conditions > Coeliac disease > Flashcards

Coeliac disease Flashcards

1
Q

Type of inflammatory disease in coeliac disease

A

T-cell mediated autoimmune

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2
Q

Repeated exposure to trigger and reaction leads to two things in coeliac disease

A
  • villus atrophy

- crypt hypertrophy

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3
Q

Protein trigger in coeliac

A

Gluten (gliadin)

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4
Q

Coeliac leads to what type of bowel dysfunction

A

Malabsorption

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5
Q

Affected area of bowel in coeliac

A

Jejunum

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6
Q

Autoantibodies in coeliac

A
  • anti-TTG
  • anti-EMA
  • anti-DGPs
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7
Q

All new cases of what endocrine disease are tested for coeliac due to their close association

A

T1DM

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8
Q

3 autoimmune diseases associated with coeliac

A
  • dermatitis herpetiformis
  • graves
  • autoimmune hepatitis
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9
Q

Age distribution in coeliac

A

Bimodal

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10
Q

Two alleles linked to coeliac in families where the disease runs

A
  • HLA-DQ2

- HLA-DQ8

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11
Q

Is coeliac more common in males or females

A

Female

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12
Q

Coeliac symptoms

A
  • abdominal pain
  • diarrhoea
  • N/V
  • abdo distension
  • fatigue
  • weight loss
  • failure to thrive
  • mouth ulcers
  • neurological symptoms
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13
Q

what two things are found in endoscopy

A
  • villus atrophy

- crypt hypertrophy

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14
Q

Stool is analysed in coeliac to

A

Exclude infections

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15
Q

FBC in coeliac shows

A

Anaemia

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16
Q

Antibodies tested for in coeliac

A
  • Anti-TTG IgA
  • total IgA
  • anti-EMA
17
Q

Mx

A

Gluten free

18
Q

Symptoms of the complication of patchy-associated T cell lymphoma

A
  • weight loss
  • diarrhoea
  • abdo pain
19
Q

Explain the microcytic and macrocytic anaemia in coeliac (& large RWD)

A

Lack of absorption of iron, B12, folate

20
Q

Explain the bleeding in coeliac

A

Reduced vitK absorption

21
Q

when should patients with coeliac take gluten

A

before diagnostic procedure

Y3 GI Conditions (23 decks)

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