Combined Deck: 24.1, 23.2, 23.1, 22.2, 22.1, 21.1, 21.2, 20.1, 20.2 Flashcards

Question

22.2 A four-year-old boy is in refractory ventricular fibrillation. The recommended dose of amiodarone is a) 40mg b) 80mg c) 120mg d) 160mg

Answer 1

80mg Age + 4 x 2-> 4 + 4 x 2 =16kg 5 x 16mg =80mg | 16kg x 5mg/kg = 80mg

Answer 2

a) 1:670 (or 1:700)

Answer 3

b) 1 or more RF

Answer 4

d. asepsis Asepsis: the prevention of microbial contamination of living tissues or sterile materials. Disinfection: the inactivation of non-sporing organisms using either thermal or chemical means. Sterilisation: complete destruction of all micro-organisms, including spores. https://www.anzca.edu.au/getattachment/e4e601e6-d344-42ce-9849-7ae9bfa19f15/PG28(A)-Guideline-on-infection-control-in-anaesthesia

Answer 5

History of eczema APRICOT study

Answer 6

b. grimacing conjugate gaze facial grimace eye opening purposeful movement tidal volume greater than 5 ml/kg Source: SPANZA 2019 article

Answer 7

4 | GCS 7-12

Answer 8

B. Initially decreases then normalises Oral glucose tolerance test — The most specific dynamic test for establishing the diagnosis of acromegaly is an OGTT. When performing the test, we measure serum GH before and two hours after glucose administration; the criterion for the diagnosis of acromegaly is a GH concentration greater than 1 ng/mL. In normal subjects, serum GH concentrations fall to 1 ng/mL or less within two hours after ingestion of 75 g glucose. In contrast, the post-glucose values are greater than 2 ng/mL in over 85 percent of patients with acromegaly. Following oral glucose administration in humans, a transient suppression of plasma GH levels for 2–3 h is observed followed by a delayed rise occurring at 3–5 h post glucose ingestion. This initial suppression seems to be related to a glucose-mediated increase in hypothalamic somatostatin release. Evidence supporting this hypothesis emerges from the findings that in healthy individuals, GH secretion in response to GHRH or GH secretagogue is diminished after an oral glucose load. Furthermore, the inhibitory effect of glucose is reversed with the acetylcholinesterase inhibitor pyridostigmine, a substance thought to suppress somatostatin release from the hypothalamus. These findings support the hypothesis that oral glucose load is associated with a somatostatin release into the hypophyseal portal blood suppressing GH levels. The delayed GH rise would result from a decrease in somatostatinergic tone and hence an increase in GHRH. Subsequently, the available pituitary stores of GH are released leading to a rebound rise in GH.

Answer 9

50 4th consensus guidelines for management of PONV

Answer 10

D 90 A-a = PAO2 - PaO2 Alveolar air equation gives PAO2 PAO2 = PiO2 - PaCO2 / R PAO2 = 0.4 x (760 - 47) - 48 / 0.8 so, as PaO2 given as 135 A-a = 228 - 135 = 93

Answer 11

c) DOO The pacing mode will be DOO when the programmed pacing mode is a dual chamber mode or an MVP mode (AAIR<=>DDDR, AAI<=>DDD), VOO when the programmed pacing mode is a single chamber ventricular mode, and AOO when the programmed pacing mode is a single chamber atrial mode.

Answer 12

1 hour ASRA: 1 hour Although the occurrence of a bloody or difficult neuraxial needle placement may increase risk, there are no data to support mandatory cancellation of a case. Direct communication with the surgeon and a specific risk-benefit decision about proceeding in each case are warranted. Currently, insufficient data and experience are available to determine if the risk of neuraxial haematoma is increased when combining neuraxial techniques with the full anticoagulation of cardiac surgery. We suggest postoperative monitoring of neurologic function and selection of neuraxial solutions that minimise sensory and motor block to facilitate detection of new/progressive neurodeficits. NYSORA: Administration of intravenous heparin intraoperatively should be delayed for at least 1 hour after epidural placement; a delay before administration of subcutaneous heparin is not required. In cases of full heparinization for CPB, additional precautions include delaying surgery for 24 hours in the event of a traumatic tap, tightly controlling the heparin effect and reversal, and removing catheters when normal coagulation is restored.

Answer 13

200mg Hydrocortisone or 25mg Prednisolone Conversion Prednisone 1mg = Hydrocortisone 4mg = Dexamethasone 0.15mg = Triamcinolone 0.8mg = Methylprednisolone 0.8mg = Betamethasone 0.15mg = (https://litfl.com/corticosteroids-overview/)

Answer 14

A Massive bronchopleural fistula. Nick Chrimes 2022 - Journal of Anaesthesia ‘Preventing unrecognised oesophageal intubation: a consensus guideline from the Project for Universal Management of Airways and international airway societies’ Causes of exhaled carbon dioxide detection despite oesophageal intubation No alveolar ventilation occurring -Prior ingestion of carbonated beverages or antacids -Gastric insufflation of CO2 for upper gastrointestinal endoscopy -Prolonged ventilation with facemask or poorly positioned supraglottic airway before attempting tracheal intubation -Bystander rescue breaths Some alveolar ventilation potentially occurring -Tracheo-oesophageal fistula with tube tip proximal to fistula -Proximal oesophageal intubation with uncuffed tube in a paediatric patient

Answer 15

c) Allow the eye to proptose Orbital Compartment Syndrome The orbital compartment is a fixed space with limited capacity for expansion. If something like blood fills part of that space the pressure increases and may result in ischaemia of the optic nerve or the retina. A lateral canthotomy is a way of releasing this pressure. You have up to approximately 2 hours before irreversible visual loss occurs. It may occur in less than 2 hours however, so speed is of the essence. use local anesthetic but warn the patient that they may feel pain Perform the canthotomy: place the scissors across the lateral canthus and incise the canthus full thickness Perform cantholysis: Grasp the lateral lower eyelid with toothed forcepsPull the lower eyelid anteriorlyPoint the scissors toward the patient’s nose, place the blades either side of the lateral canthal tendon, and cut. By cutting the canthal tendon,the counter pressure of the eyelid on the is relieved and the eye is allowed to proptose and pressure is relieved.

Answer 16

b) anterior communicating artery https://case.edu/med/neurology/NR/SubarachnoidHemorrhageAComm3.htm https://www.thieme-connect.com/products/ejournals/pdf/10.1055/s-0039-1681979.pdf https://case.edu/med/neurology/NR/NRHome.htm (scroll down to subarachnoid imaging area)

Answer 17

RLL 1.Superior (apical bronchus 6) -> most common site for foreign body or secretions to collect if patient laying flat in bed

Answer 18

c) Embolic Blue Book 2017 Perioperative Stroke Epidemiology A perioperative stroke is defined as one that occurs either intra-operatively or in the post-operative period within 30 days70. Perioperative strokes are associated with an increased length of stay and a six-fold increased mortality. Any combination of surgery and anaesthesia is associated with an increased risk of stroke irrespective of the type of surgery. This may relate to coagulation changes The most common type of perioperative stroke is ischaemic stroke of embolic origin (heart or aorta). Hypotension is rarely the cause of perioperative stroke. Haemorrhagic stroke is uncommon which probably reflects the fact that severe hypertension during anaesthesia is a rare event, and anticoagulants have typically been withheld. The risk of perioperative stroke varies depending on the type of the surgery and patients’ risk factors. Procedural risk Urgent surgery is associated with an increased risk of stroke when compared to elective surger. Cardiac, vascular and brain surgeries are defined as “high-risk” as these have an increased risk of stroke when compared to other types of surgery. Valvular and aortic repair surgeries have a stroke risk as high as 8 to 10 per cent. Perioperative strokes in non-high-risk surgery are relatively rare and are estimated to have an incidence of about 1/1000 cases80. Patients’ risk factors >Age >history of previous stroke or transient ischaemic attack >renal failure >atrial fibrillation >history of cardiovascular diseases are identified risk factors for perioperative stroke. Atrial fibrillation is associated with a two-fold increase in the risk of death and stroke after carotid endarterectomy.

Answer 19

Lean Body Weight For infusion: Adjusted body weight NDMB: Lean Body weight Sux: Total body weight Source: SOBA UK

Answer 20

B do blood patch at lumbar level with no further investigation

Answer 21

b. Suprascapular nerve Suprascapula nerve (C5,6) - innervates supra and infraspinatus - comes off superior trunk of the brachial plexus, and is usually anaesthetised by an interscalene block - sensory innervation to 70% posterior-superior shoulders and portion of the anterior axilla and the ACJ Supraclavicular nerve (C3,4) - provides sensory to the 'cape' of the shoulder - component of the cervical plexus block - lies outside the brachial plexus - commonly missed during supraclavicular brachial plexus blocks Subscapular nerve: - subscapularis - medial rotation shoulder Dorsal scapular nerve: - branch of the brachial plexus - supplies rhomboid major muscle, rhomboid minor muscle, and levator scapulae muscle - causes the scapula to be moved medially towards the vertebral column - Dorsal scapular nerve syndrome can cause a winged scapula, with pain and limited motion Thoracodorsal nerve: - thoracodorsal nerve also branches from the posterior division of the brachial plexus - this nerve innervates the latissimus dorsi muscle. ## Footnote https://resources.wfsahq.org/atotw/the-shoulder-block/

Answer 22

c) Alprostadil (PGE1) From Paediatric BASIC on CHD: - Resuscitation of an infant or newborn in shock should follow a standard approach regardless of the aetiology. - Any patient with a duct dependent lesion either for pulmonary blood flow, or systemic output, will require PGE1. The problem is that whether or not a duct dependent lesion is present is unclear in most cases. If CHD has been diagnosed antenatally, PGE1 should be started. - The cyanosed neonate presenting with severe cyanosis (O2 <75) and/or in extremis should be started on PGE1; the assumption being that the duct has closed and needs to be reopened.

Answer 23

d) Respiratory Acidosis with incomplete compensation Uncertain of this answer, not enough info to calculate anion gap pH 7.2 = acidaemia pCO2 84 = respiratory acidosis HCO3 43 = metabolic alkalosis as compensation BE 16 = metabolic alkalosis Boston rules: Chronic fully compensated Respiratory acidosis Expected compensation is 3-4 mmol/L rise for every 10mmHg rise in PCO2. Expected metabolic compensation therefore is HCO3 = 24 + 4 x ((84-40)/10) = 24 + 4x (44/10) = 24 + 4 x (4.4) = 24 + 17.6 = 41.6 Metabolic acidosis PaCO2 should be 1.5 x HCO3 + 8 = 72.5 Rules (from K.Brandis Acid-base rules anaesthesia mcq): - 1 for 10 (acute resp acidosis), 4 for 10 (chronic resp acidosis) - 2 for 10 (acute resp alkalosis), 5 for 10 (chronic resp alkalosis) - 1.5xHCO + 8 = expected pCO2 in a metabolic acidosis - 0.7xHCO3 + 22 = expected pCO2 in a metabolic alkalosis https://www.anaesthesiamcq.com/AcidBaseBook/ab9_3.php

Answer 24

less bradycardia

Answer 25

d) Arrhythmia - caution if conduction disease however Contraindications are current coagulopathy (or anticoagulated), recent myocardial infarction, pathologic bradycardia, and glaucoma. Source Radiopaedia Contralateral stellate ganglion/phrenic nerve block/neuropathy

Answer 26

SS /GCS Repeat APMSE

Answer 27

a. 2/7/9/10 Hypovitaminosis of Vitamin K (Bile required for absorption) Source: BMC Article https://bmcpregnancychildbirth.biomedcentral.com/articles/10.1186/s12884-022-04875-w

Answer 28

Not actually remembered answers B undergoing manual inline stabilisation (posterior column problem, all others are anterior column issues) https://www.anzca.edu.au/getattachment/9ef4cd97-2f02-47fe-a63a-9f74fa7c68ac/PS56BP-Guideline-on-equipment-to-manage-difficult-airways-Background-Paper Straight laryngoscope blades: These may be considered for patients with anterior column problems including: - prominent maxillary incisors - retrognathia - large tongue and - large floppy epiglottis The Miller straight blade with its low profile produces a higher pressure on the submandibular tissues with the same force (pressure = force/area), and can be used to lift the epiglottis directly 75 to facilitate intubation. There is evidence to support better success rates with straight blades as a rescue device when the Macintosh blade has failed. However, comparative studies of straight blades and videolaryngoscopy are lacking. As the paraglossal technique for straight laryngoscope blades is different from Macintosh blades, training and ongoing volume of practice is recommended for optimal use. It should be recognised that while straight blades provide better laryngoscopic views, the incidence of difficult intubation due to the narrower field of vision is increased . McCoy (CLM) laryngoscope blades When “McCoy” laryngoscope blades are in their flexed position, they apply pressure at the base of the tongue lifting the epiglottis anteriorly and are therefore, suitable for posterior column problems (e.g. manual inline stabilisation of head and neck) where the mandible and submandibular tissues are normal. However, the effect of this levering action of McCoy blades has not been shown to consistently improve laryngeal view. When compared to Glidescope TM videolaryngoscopes, McCoy laryngoscope blades resulted in longer tracheal intubation times in bariatric patients. Recommendations concerning Straight and McCoy laryngoscope blades: Page 15 PG56(A)BP Difficult airway equipment BP 2021 Advanced equipment, such as videolaryngoscopy and the common availability of flexible bronchoscopes and intubation guides/bougies, may prove to be better alternatives to difficult airway management. While evidence is currently lacking, it is recommended that Straight and McCoy laryngoscope blades are not required in DATs unless operators have been trained in their use and have ongoing volume of practice (Weak recommendation for, level of evidence moderate quality)

Answer 29

a. 35 Major updates (2022) to 1991 National Institutes of Health guidelines for bariatric surgery Metabolic and bariatric surgery (MBS) is recommended for individuals with a body mass index (BMI) 35 kg/m2 , regardless of presence, absence, or severity of co-morbidities. MBS should be considered for individuals with metabolic disease and BMI of 30-34.9 kg/m2 BMI thresholds should be adjusted in the Asian population such that a BMI 25 kg/m2 suggests clinical obesity, and individuals with BMI 27.5 kg/m2 should be offered MBS. Long-term results of MBS consistently demonstrate safety and efficacy. Appropriately selected children and adolescents should be considered for MBS. https://www.soard.org/article/S1550-7289(22)00641-4/fulltext#:~:text=The%201991%20NIH%20Consensus%20Statement,surgery%20that%20is%20applied%20universally Contraindications: - Inflammatory disease of GI tract (ulcers, oesophagitis, Crohn's) - Upper GI bleeding - Portal Htn - Liver Cirrhosis - Chronic Pancreatitis - Laparascopic surgery may be technically difficult in patients weighing >180kg and may be considered a relative contraindication

Answer 30

a) Stopping caffeine Eat a well-balanced diet that's low in salt Limit alcohol Enjoy regular physical activity Manage stress Maintain a healthy weight Quit smoking Foods that are rich in potassium are important in managing high blood pressure (HBP or hypertension) because potassium lessens the effects of sodium. The more potassium you eat, the more sodium you lose through urine. Potassium also helps to ease tension in your blood vessel walls, which helps further lower blood pressure. Source AHA

Answer 31

e. Hypotension https://www.safetyandquality.gov.au/sites/default/files/2022-06/sepsis_clinical_care_standard_2022.pdf

Answer 32

28 days Aprepitant PI: "Alternative or "back-up" measures of contraception should be used during treatment with this medicine and for one month following the last dose of this medicine." Pharmacokinetics: - aprepitant is a CYP3A4 inhibitor - caution is also advised with warfarin and phenytoin use

Answer 33

pain score

Answer 34

b. adrenaline 1mg boluses The risk of administering adrenaline in conventional doses is with profound hypertension, bleeding, or tearing of vessel anastomoses on return of spontaneous circulation (ROSC), which can precipitate catastrophic harm or further cardiac arrest. Adrenaline remains a useful drug in peri-arrest situations in smaller doses.

Answer 35

d. PCA https://case.edu/med/neurology/NR/SubarachnoidHemorrhag3%20Pcom3.htm

Answer 36

a. Electromyography of internal laryngeal muscles

Answer 37

c. Decreased amplitude, increased latency

Answer 38

Intracranial haemorrhage AHA https://www.ahajournals.org/doi/epub/10.1161/HYPERTENSIONAHA.118.11513

Answer 39

Mast cell degranulation - anaphylactoid reaction

Answer 40

e) 2 vertebral bodies inferior to carina

Answer 41

C. Opioids A. Non-depolarising muscle relaxants - false - NMBDs abolish MEPs B. Nitrous oxide - false - N2O can completely abolish MEPs D. Propofol - false - PPF has less of an effect than volatiles, but still affects MEPs E. Volatiles - false - volatiles are the most likely NMBDs > volatiles > N2O > PPF > opioids https://www.uptodate.com/contents/anesthesia-for-elective-spine-surgery-in-adults While neurologic injury can cause changes in recorded potentials, other factors can interfere with interpretation. Confounding factors that can occur during surgery include inhalational anesthetics, hypothermia, hypotension, hypoxia, anemia, and preexisting neurologic lesions. Inhaled anesthetics such as isoflurane, sevoflurane, and nitrous oxide can reduce the amplitude and prolong the latency of SSEP and can completely abolish MEP. Neuromuscular blocking agents (NMBAs) also abolish motor evoked potentials and cannot be used when monitoring. Intravenous anesthetics such as propofol, barbiturates, and opioids have less of an effect on monitoring, though very deep anesthesia, even with propofol, can affect waveforms. https://www.uptodate.com/contents/neuromonitoring-in-surgery-and-anesthesia Evoked potentials — Evoked potential monitoring is used to assess the integrity of the tested neural pathway. Somatosensory, visual, and brainstem auditory evoked potentials monitor neurologic structures between peripheral sites where specific stimulations are applied, and responses are recorded from central locations. Motor evoked potentials monitor such structures by stimulating the motor cortex and recording from the epidural space (D-wave) or, more commonly, from distal muscles. Changes in evoked responses can result from technical, positional, pharmacologic, physiologic, or surgical causes. For spine surgery, both MEPs and SSEPs are used to monitor spinal cord function to increase sensitivity. Motor and sensory tracts are anatomically distinct and have different vascular supply in areas of the cortex, brainstem, and spinal cord. Motor evoked potentials (MEPs) – MEP responses are affected by even very low concentrations of volatile anesthetic agents. In general, total intravenous anesthesia (TIVA) facilitates MEP monitoring. However, inhalation agents at 0.5 MAC or less can be used in many patients, especially during intracranial surgery Opioids – IV opioids cause small, dose-dependent depression of SSEP and MEP responses, though even at very high doses of opioids, evoked potentials can be recorded [76-78]. Infusions of remifentanil, fentanyl, or sufentanil are commonly used as part of TIVA during neuromonitoring. Opioids tend to produce high-amplitude slow waves in the EEG. Balanced anesthetic approach — When SSEPs and MEPs are monitored, a balanced anesthetic using both a low-dose inhalation anesthetic (up to 0.5-MAC isoflurane, sevoflurane, or desflurane) and low- to medium-dose propofol (eg, propofol, 40 to 75 mcg/kg/min IV) with a relatively high-dose opioid (eg, remifentanil 0.1 to 0.4 mcg/kg/min) offers several advantages: ●Movement with motor stimulation is reduced, which is particularly important during intracranial aneurysm surgery. ●The addition of a 0.3 to 0.5 MAC inhalation agent may reduce the chance of awareness under anesthesia. ●Compared with TIVA, the addition of a 0.5 MAC inhalation agent allows reduction of the dose of propofol infusion, facilitating more rapid wakeup and earlier neurologic examination. ●Compared with TIVA, the chance of accidental interruption of the anesthetic for mechanical reasons (ie, kinked or infiltrated IV catheter or tubing such that IV agents no longer infuse) is reduced.

Answer 42

D. Weakness in abductor pollicis brevis Muscles weak in C8-T1 radiculopathy but intact in ulnar neuropathy 1. flexor pollicis brevis 2. abductor pollicis brevis 3. opponens pollicis 4. lateral lumbricals AbOF the Law may be useful—the abductor (Ab) and flexor (F) pollicis brevis, opponens pollicis (O), and lateral lumbricals (Law) are “above the law” that intrinsic hand muscles are ulnar-innervated

Answer 43

a. Obesity Obesity and pulmonary function testing https://www.jacionline.org/article/S0091-6749(05)00164-8/fulltext - Full pulmonary function tests are often necessary to better characterize the spirometric abnormalities seen in the obese patient - The most sensitive indicator of obesity is a low expiratory reserve volume (ERV) and functional residual capacity - Restriction is seen in more severe obesity, with reductions in TLC and FVC. - However, residual volume is often preserved because of the relative high closing volume in relation to ERV.

Answer 44

a. 3 (snoring, BMI, Htn) Snoring loudly Tiredness during day time Observed Apnoea Pressure: Htn BMI > 35 Age > 50 Neck circumference >40cm (43cms male) Gender: Male

Answer 45

B. Cardiac hernation https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.109.896829

Answer 46

High C-Spine injury

Answer 47

d) aortic dilation Osteoarthritis nerve compression syndrome due to bony overgrowth, and carpal tunnel syndrome Hypertension Diabetes mellitus Cardiomyopathy/HF Colorectal cancer Sleep Apnea Thyroid nodules and thyroid cancer Hypogonadism Compression of the optic chiasm Source: BJA

Answer 48

Fuck this question e. Decreased CPSP pain at 12 months or it could be updated with an option that says makes no difference most likely they will just remove the question and this is a big waste of time https://pubs.asahq.org/anesthesiology/article/135/6/1091/117748/Preoperative-Paravertebral-Block-and-Chronic-Pain --->This says it makes no difference in 2021 https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD007105.pub4/full ----> this says weak evidence but it helps prevent persistent post surgical pain at 3-12months in 2018 ----> ANZCA pain book references this article ANZCA pain book https://www.bjaed.org/article/S2058-5349(18)30101-X/fulltext A recent review showed that, whilst there was little effect on intra- and postoperative opioid consumption and PONV, patients receiving either both single-shot injections or placement of paravertebral catheters had less acute pain in the first 72 h after surgery. There is also a suggestion that the use of TPVB for acute postsurgical pain may protect against the development of chronic postsurgical pain after breast surgery at 6 months. For breast cancer surgery any form of regional anaesthesia (18 RCTs, n=1,297) reduces CPSP 3 to 12 months after surgery compared with systemic analgesia (OR 0.43; 95%CI 0.28 to 0.68) (NNT 7); specifically paravertebral block (PVB) (6 RCTs, n=419) is effective (OR 0.61; 95%CI 0.39 to 0.97) (NNT 11). In our study population, regional anaesthesia-analgesia (paravertebral block and propofol) did not reduce breast cancer recurrence after potentially curative surgery compared with volatile anaesthesia (sevoflurane) and opioids. The frequency and severity of persistent incisional breast pain was unaffected by anaesthetic technique. Clinicians can use regional or general anaesthesia with respect to breast cancer recurrence and persistent incisional pain. https://www.thelancet.com/pdfs/journals/lancet/PIIS0140-6736(19)32313-X.

Answer 49

a) Pupillary constriction and reaction to light Stellate ganglion block causes ipsilateral Horner's Syndrome: Ptosis (eyelid droop) Miosis (constricted pupils) Anhydrosis (loss of sweating) Enophthalmos (sinking of eyeball into the bony cavity that protects the eye) *Pupillary constriction in response to light is controlled by the Edinger-Westphal nucleus of CN3, which will remain intact.

Answer 50

a. Barrier protection for a week In the case of non-oral hormonal contraceptives, the patient must use an additional non hormonal contraceptive method for the next 7 days

Answer 51

C. Foetal neuroprotection https://www.kemh.health.wa.gov.au/~/media/HSPs/NMHS/Hospitals/WNHS/Documents/Clinical-guidelines/Obs-Gyn-Guidelines/Preterm-Labour-Magnesium-Sulphate-for-Neuroprotection-of-the-Fetus.pdf?thn=0#:~:text=MgSO4%20is%20only%20given%20to,4%20hours%20prior%20to%20delivery.

Answer 52

b. 24 hours ASA guidelines -If creatinine clearance >/=30 ml.min-1 (Cockcroft-Gault), proceed with surgery after two half lives (24 h) since the last dose, under general anaesthesia (or spinal anaesthesia if indicated) - If creatinine clearance < 30 ml.min-1, proceed with surgery after four half lives (48 h) since the last dose, under general anaesthesia (or spinal anaesthesia if indicated)

Answer 53

d. 7500 100ml/kg blood volume in term parturient 7.5L (Average increase around 48%) BJAed

Answer 54

b. 100ml Paediatric weight estimation: Luscombe: Weight (kg) = (age x 3) + 7 RCH: Weight (kg) = (age + 4) x 2 Formula for calculating transfusion volume (mL) Children <20 kg: PRBC (mL) = wt (kg) x Hb (g/L) rise (desired Hb – actual Hb) x 0.5 (transfusion factor) Children >20 kg: 1 unit PRBC Example: 6 + 4 x 2 = 20kg 20kg x 10g/l x 0.5 = 100ml

Answer 55

b) Thumb abduction (flexor pollicis brevis) D. Paraesthesia/sensory loss over medial forearm (medial antebrachial cutaneous) Severing Ulnar nerve alone results in numbness of the 4th (ring) and 5th (little) fingers alone C8 and T1 supply the medial antebrachial cutaneous nerve Muscles weak in C8-T1 radiculopathy but intact in ulnar neuropathy 1. flexor pollicis brevis 2. abductor pollicis brevis 3. opponens pollicis 4. lateral lumbricals AbOF the Law may be useful—the abductor (Ab) and flexor (F) pollicis brevis, opponens pollicis (O), and lateral lumbricals (Law) are “AbOF the Law” that intrinsic hand muscles are ulnar-innervated

Answer 56

d) Reduced RR BJA: HFNP oxygen therapy https://www.bjanaesthesia.org/article/S0007-0912(17)53999-9/fulltext - reduced RR - increased minute volume - reduced WOB, reduced Vd, reduced AWR - provides CPAP 3-7 cmH20 (mouth closed)

Answer 57

a) Cold Saline Irrigation

Answer 58

HOCM if these remembered options are correct Alternative is Aortic Stenosis which is more common than HOCM in this age group

Answer 59

Nitrous oxide Nitrous oxide boiling point -88.6C, critical temperature +36C -> so is below critical temp at room temp, therefore exists as a vapour in equilibrium with its liquid phase and is dependent upon pressure applied to it. Pressure gauge not informative – will always read ~52 bar (the pressure at which N2O liquefies at 20C). As vapour is drawn off, N2O moves from liquid to vapour phase, maintaining the equilibrium and same vapour pressure within the cylinder. To determine contents: cylinder must be weighed and weight of empty cylinder subtracted, then number of moles of N2O in cylinder calculated using Avogadro’s number.

Answer 60

Absolute most = Insulin, but probably not an option. Sulphonylureas most likely

Answer 61

Answer: c) MS CEACCP 2012 Neuromuscular disorders and anaesthesia. Part 2: specific neuromuscular disorders Multiple sclerosis This is the most frequently occurring demyelinating neuromuscular disorder. It is a chronic relapsing condition characterized by the formation of plaques within the brain and spinal cord. These plaques cause demyelination around the axons, resulting in weakness and spasticity as well as sensory dysfunction. Anaesthetic considerations. Local anaesthetics may exacerbate symptoms due to the increased sensitivity of demyelinated axons to local anaesthetic toxicity. Non-depolarizing neuromuscular blocking agents may be used in normal doses. Caution should be exercised when using depolar- izing neuromuscular blocking agents if the patient is debilitated. Temperature maintenance is important as symptoms can deteriorate with an increase in temperature, as demyelinated axons are also more sensitive to heat. BJA: Perioperative management of myasthenia gravis (2021 - written after this MCQ): Several factors, many associated with surgery and anaesthesia, may exacerbate myasthenia or lead to a myasthenic crisis, a life-threatening condition in which severe respiratory muscle insufficiency leads to respiratory failure. Crises are most commonly precipitated by infection. Other precipitants include surgery, residual neuromuscular block, pain, many drugs, hypo- and hyperthermia, reduction or withdrawal of treatment, pregnancy, stress and sleep deprivation.

Answer 62

a) Critical appraisal PICO is a mnemonic used to describe the four elements of a good clinical foreground question: P = Population/Patient/Problem - How would I describe the problem or a group of patients similar to mine? I = Intervention - What main intervention, prognostic factor or exposure am I considering? C = Comparison - Is there an alternative to compare with the intervention? O = Outcome - What do I hope to accomplish, measure, improve or affect?

Answer 63

d) loss of pain and temperature Brown sequard. Loss of pain and temp on contralateral side. Paralysis and loss of proprioreception on ipsilateral side

Answer 64

30ml/kg https://journals.lww.com/ccmjournal/Fulltext/2021/11000/Executive_Summary__Surviving_Sepsis_Campaign_.14.aspx

Answer 65

d. Urine osmolarity <100 DIAGNOSTIC CRITERIA >hypotonic hyponatraemia >urine osmolality > plasma osmolality (<275mOsm/kg) (i.e. concentrated urine despite hypotonic blood) >urinary Na+ > 20mmol/L >normal renal, hepatic, cardiac, pituitary, adrenal and thyroid function >euvolaemia (absence of hypotension, hypovolaemia, and oedema) correction by water restriction CAUSES (MAD CHOP) Major Surgery >abdominal >thoracic >transsphenoidal pituitary surgery (6-7 days post op) ADH production by tumours (Ectopic) >small cell bronchogenic carcinoma >adenocarcinoma of pancreas/duodenum >leukaemia >lymphoma >thymoma Drugs >antidepressants (e.g. SSRI, TCAs, MAOIs) >psychotropics (e.g. haloperidol, chlorpromazine), carbamazepine, Na+ valproate) >anaesthetic drugs (barbiturates, inhalational agents, oxytocin, opioids) >ADH analogues (vasopressin, DDAVP) >chemotherapy (e.g.Vinca alkaloids, Melphalan, Methotrexate and cyclophosphamide) >others (e.g. NSAIDs, amiodarone, ciprofloxacin, morphine, MDMA, proton pump inhibitors) CNS Disorders >cerebral trauma >brain tumour (primary or metastases) >meningitis/encephalitis >brain abscess >SAH >acute intermittent porphyria >SLE Hormone deficiency >hypothyroidism >adrenal insufficiency Others >Guillain-Barre Syndrome >HIV infection (early symptomatic or AIDS) >hereditary SIADH >giant cell arteritis >idiopathic (occult small cell or olfactory neuroblastoma) Pulmonary Disorders >pneumonia (viral, fungal, bacterial) >TB >lung abscess MANAGEMENT 1. see hyponatraemia 2. fluid restrict 3. incremental increase in Na+ if indicated to avoid central pontine myelinolysis 4. medications to decrease ADH secretion >Demeclocycline >Tolvaptan / Conivaptan

Answer 66

e Na 140 Mg 1.5 K 5.0 acetate 27 lactate 0

Answer 67

a) Anaemia No effect - Fetal haemoglobin (HbF) - SulphHb - Bilirubin (absorption peaks are 460, 560 and 600 nm) - dark skin Falsely low reading 1. Methaemoglobin (MetHb). The presence of MetHb will prevent the oximeter from working accurately and the readings will tend towards 85%, regardless of the true saturation. 2. Methylene blue. When methylene blue is used in surgery (e.g. parathyroidectomy or to treat methaemoglobinaemia), a short-lived reduction in saturation estimations is seen. Readings may fall by 65% at a concentration of 2-5 mg/kg for between 10 and 60 minutes. 3. Indocyanine green. Use of this dye (e.g. in cardiac output studies) may cause a transient reduction in recorded saturations. 4. A reduction in peripheral pulsatile blood flow produced by peripheral vasoconstriction results in an inadequate signal for analysis. 5. Venous congestion, which may be caused by tricuspid regurgitation, high airway pressures and the Valsalva manoeuvre, may produce venous pulsations which can produce low readings. 6. Venous congestion of the limb may affect readings, as can a badly positioned probe. 7. External fluorescent light in the operating theatre may cause the oximeter to be inaccurate, and the signal may be interrupted by surgical diathermy. Shivering may cause difficulties in picking up an adequate signal. 8. Nail varnish may cause falsely low readings. Falsely high reading 1. Carboxyhaemoglobin (CoHb). CoHb (haemoglobin combined with carbon monoxide) is registered as 90% oxygenated haemoglobin and 10% desaturated haemoglobin - therefore the oximeter will overestimate the saturation. Calibration - Oximeters are calibrated during manufacture and automatically check their internal circuits when they are turned on. - They are accurate in the range of oxygen saturations of 70% to 100% (+/-2%), but are less accurate under 70%. Below the saturation of 70%, readings are extrapolated. - The data for calibration came from human volunteer studies, hence it was unethical to allow the saturations to fall below 70%. Due to the shape of the oxyhaemoglobin curve, the saturation starts to fall rapidly at 90%. Limitations - The oximeter averages its readings every 10-20 seconds. Hence, they cannot detect acute desaturation. The finger probe has a response time of approximately 60 seconds, whereas the ear probe has a response time of 10-15 seconds. - The site of application should be checked at regular intervals, as pressure sores and burns have been reported. - The pulse oximeter only provides information about oxygenation. It does not give any indication of the patient’s carbon dioxide elimination.

Answer 68

Decreased SVR Hyperthyroidism: increases HR increases cardiac contractility. increases LVEF increases diastolic relaxation increases CO SVR decreases >T3 induces systemic vasodilation.

Answer 69

d. XIII But Fibrinogen (I) is the most significant factor that

Answer 70

d) 10 minutes - best answer; one of those shit questions that depends on your source. Morgan & Mikhail's (chapter 36: anaesthesia for ophthalmic surgery): " Succinylcholine increases IOP by 5-10mmHg for 5-10 minutes". - due to prolonged contracture of the EOM BARASH: Succinylcholine increases IOP 7 to 10 mmHg reaching a peak pressure 1 to 2 minutes after IV administration and returns to the baseline in 5 to 7 minutes. This increase may be attenuated by pretreatment with anesthetics, although none completely eliminates the increase in IOP. In the presence of a lacerated globe, this increase in IOP may increase the extrusion of intraocular contents although greater increases in IOP may occur during crying and coughing. Yao & Artusio's: - also quotes same information: increases IOP 7 to 10mmHg, returning to baseline in 5 - 7 minutes. Stoelting's: Intraoccular pressure peaks at 2-4 minutes after administration and returns to normal by 6 minutes

Answer 71

Ischaemic optic neuropathy (anterior) https://www.researchgate.net/figure/Top-Funduscopic-examination-revealed-pale-and-swollen-discs-with-small-hemorrhages-on_fig2_6759964 At the onset of PION, the optic disc often appears normal, pallor is only seen after 6–8 weeks. The absence of optic disc edema is a key feature distinguishing PION from AION. Perioperative PION patients may have profound bilateral vision loss (70% of cases), and worse visual outcomes. Prexisting factors that have been related to Perioperative PION include: male sex, obesity, obstructive sleep apnea and amiodarone or PDE-5 inhibitor use.[4]

Answer 72

CMAC video stylet see image for alternative equipment images

Answer 73

b. Cold saline irrigation of brain Seizures, either focal or generalized, are most likely to occur during cortical mapping. They are treated by irrigating the brain tissue with ice-cold saline. They usually cease with this treatment alone, but occasionally benzodiazepines, anti-epileptic drugs, or re-sedation with airway control are required. An emergency plan for airway control has to be in place at all times and this can be challenging as the patient's head is fixed in head pins and often away from the ventilator. The options include the insertion of an LMA which may be easier than oro-tracheal intubation. Awake craniotomy is generally a well-tolerated procedure with a low rate of conversion to general anaesthesia and a low rate of complications. One of the most frequent complications is patient intolerance of the procedure, often because of the urinary catheter or prolonged positioning and intra-operative seizures.

Answer 74

Hunsaker Mon-jet ventilation tube for microlarnygeal surgery Description: -Laser-safe -fluoroplastic -self-centring catheter Uses: -subglottic ventilation during microlaryngeal surgery Components: - proximal end for attaching to jet insufflation system -proximal end allows passage of stylet to aid insertion -Side port at proximal end for monitopring airway pressure and ETCO2 -Outer diameter 4.3mm for maintaining good surgical access -Green basket to keep the centre port at its tip away from tracheal mucosa and avoiding potential damage from jet ventilation

Answer 75

a. Splenomegaly Associated with high doses >4mg/kg/hr and prolonged use (>48hrs) Safe doses of propofol infusion for sedation in ICU are considered to be 1-4mg/kg/hr -> fatal Cases pf PRIS have been reported after infusion doses as low as 1.9-2.6mg/kg/hr Risk factors: i. Young age ii. Critical illness iii. High fat and low Carbohydrate intake iv. Inborn errors of mitochondrial fatty acid oxidation v. Catecholamine infusion/ High catecholamine and glucocorticoid levels vi. Steroid therapy vii. Severe head injuries Characteristics: i. Bradycardia ii. Severe metabolic acidosis iii. Cardiovascular collapse iv. Rhabdomyolysis v. Hyperlipidaemia vi. Renal failure vii. Hepatomegaly Management: - Routine monitoring of CK and triglycerides should be performed for the at risk population ○ Daily CK and triglyceridees after 48hrs of propofol infusion ○ Increasing CK in the absence of other pathology triggers suspiscion of PRIS - Propofol immediately stopped and alternative (midazolam and alfentanil) are used - PRIS is difficult to treat once it occurs - CVS support provided as needed - Renal replacement therapy may be required to treat lactic acidosis, clear propofol and its metabolites from the patient rapidly - Catecholamine resistant shock has been reported - Pacing has been used with limited success ECMO has been reported and successfully used in the CVS support of PRIS

Answer 76

c) 1:8000 Awareness rates GA with no muscle relaxant = 1:136,000 GA with muscle relaxation = 1/8,000 CTS 1/8,600 E-LSCS = 1/670 Overall 1:19,000

Answer 77

3. Median Nerve

Answer 78

D. Amitriptyline Amitriptyline (used in low doses for 90 days from onset of the herpes zoster rash) reduces the incidence of postherpetic neuralgia N.B Antiviral agents started within 72 hours of onset of the herpes zoster rash accelerate the resolution of acute pain (U) (Level I) but **do not reduce** the incidence, severity and duration of postherpetic neuralgia UTD Both Gabapentinoids and TCAs are effective at TREATING postherpetic neuralgia. The former have lower risk of discontinuation due to adverse side effects. For moderate or severe pain, use gabapentinoids.

Answer 79

c. 5 min Circulatory determination of death in the context of organ donation 12 Circulatory determination of death in the context of organ donation requires the absence of spontaneous movement, breathing and circulation. Absence of circulation is evidenced by absent arterial pulsatility for 5 minutes, using intra-arterial pressure monitoring and confirmed by clinical examination (absent heart sounds and/or absent central pulse). In cases without an arterial line, electrical asystole should be observed for 5 minutes on the electrocardiogram and confirmed by clinical examination. 13 For the purposes of organ donation, circulatory determination of death should be documented using a specific form (see Appendix E) to demonstrate explicitly that all criteria set out in this Statement are met. The same criteria should be listed in local hospital forms

Answer 80

A. Reduced RR BJA HFNOT It has been demonstrated that patients with acute hypoxaemic respiratory failure experience improved comfort and tolerance with HFNOT compared with humidified oxygen via a facemask, and traditional non-invasive ventilation masks. Subjective feelings of dyspnoea AND RESPRIATORY RATES are REDUCED as is airway dryness.

Answer 81

A. High frequency

Answer 82

Remembered answers don’t help differentiate. [A. Paraethesia of the 5th digit - can be ulnar only B. Paraesthesia over index finger - will be median only C. Flexor carpi ulnaris function - can be ulnar only D. Paraesthesia/sensory loss over medial forearm - can be ulnar only E. Adductor pollicis function - can be ulnar only C8-T1 radiculopathy Will cause: Loss of Thumb and finger abduction (flexor pollicis brevis - suppled by both ulnar deep branch (C8-T1) and median nerve lateral terminal branch C6-T1) Severing Ulnar nerve alone results in numbness of the 4th (ring) and 5th (little) fingers alone, and potentially medial forearm sensation (C8 and T1 supply the medial antebrachial cutaneous nerve), although loss of forearm sensation is more common in C6 radiculopathies. All intrinsic muscles of the hand are innervated by the ulnar nerve, except for 4 muscles supplied by the median nerve. These muscles may be weak in C8-T1 radiculopathy but intact in ulnar neuropathy. 1. flexor pollicis brevis 2. abductor pollicis brevis, in part. 3. opponens pollicis 4. lateral lumbricals AbOF the Law may be useful—the abductor (Ab) and flexor (F) pollicis brevis, opponens pollicis (O), and lateral lumbricals (Law) are “above the law” Or LOAF

Answer 83

e) VVI with intermittent failure to sense

Answer 84

a. Bullying Bullying is unreasonable behaviour that creates a risk to health and safety. It is behaviour that is repeated over time or occurs as part of a pattern of behaviour. “Unreasonable behaviour” is behaviour that a reasonable person, having regard to all the circumstances, would expect to victimise, humiliate, undermine or threaten the person to whom the behaviour is directed. 1. Direct bullying – behaviour that is overt and usually involves conduct directed at a person to belittle or demean them. Examples include: > Aggressive and intimidating behaviour. > Belittling, degrading or humiliating comments. > Spreading misinformation or malicious rumours. > Interfering with a person’s property or work equipment. > Displaying offensive material (for example pornography). 2. Indirect bullying – behaviour that excludes or removes benefits from a person. Examples include: > Assigning meaningless tasks unrelated to the job. > Setting tasks that are unreasonably below or beyond a person’s skill level. > Deliberately changing work rosters to inconvenience particular employees. > Deliberately withholding information that is vital for effective work performance. Harassment is any type of unwanted behaviour that offends, humiliates or intimidates a person, and targets them on the basis of a characteristic covered by anti-discrimination law, for example gender, race, ethnicity or disability, etc. In general, harassment is any behaviour that is: Unwelcome, not asked for and not returned. Likely to humiliate (put someone down), seriously embarrass, offend or intimidate (threaten or scare) someone. Based on a personal characteristic (or family or friend’s characteristic) protected by law. Discrimination means treating a person with an identified attribute or personal characteristic as set out in legislation less favourably than a person who does not have the attribute or personal characteristic. > Gender. > Transgender, gender history and trans-sexual status. > Pregnancy and potential pregnancy. > Childbirth or breastfeeding. > Marital status. > Sexual orientation. > Lawful sexual activity. > Disability or impairment. > Race (including colour, nationality, descent and origin). > Physical features. > Age. > Carer status and family responsibilities. > Religious belief or activity. > Political belief or activity. > Trade union membership and industrial activity. > Associated with a person who is identified by reference to any of these attributes Sexual Harassment Sexual harassment is against the law. Sexual harassment is unwelcome sexual behaviour, which could be expected to make a person feel offended, humiliated or intimidated. It can be physical, verbal or written. Victimisation Victimisation is unlawful. Victimisation occurs when a person is treated unfairly due to that person having made a complaint of sexual harassment. Victimisation is behaviour that makes a person suffer a detriment including feeling uncomfortable, isolated, insecure or intimidated. https://www.anzca.edu.au/resources/corporate-documents/anzca-policy-on-bullying-discrimination-and-harass.pdf

Answer 85

c) 4 weeks ANZCA PS

Answer 86

A: Sartorius

Answer 87

E)Wait for it to wear off > Neostigmine inhibits plasma cholinesterases (that could slow mivacurium metabolism), but effects are less than the inhibition of acetylcholinesterases, resulting in a “net” reversal of nondepolarizing block. Dose in stem inappropriate though. > Administration of whole blood or FFP is not recommended unless there is another primary indication for the transfusion. > In patients with homozygous pseudocholinesterase deficiency, will result in prolonged NMB; monitor and await.

Answer 88

Sartorius repeat

Answer 89

b) 2,5 Air: 1, 5 Oxygen: 2, 5 N2O: 3,5 CO2: 2, 6 He: 2, 4 Cyclopropane 3, 6 Entonox 7

Answer 90

a. HR increases

Answer 91

a) dulaglutide The primary mechanism of action of dulaglutide, as an incretin mimetic hormone or an analogue of human glucagon-like peptide-1, is to increase insulin secretion when glucose levels are elevated, decrease glucagon secretion, and **delay gastric emptying** in an effort to lower postprandial glucose level. Acarbose: Acarbose is a complex oligosaccharide that acts as a competitive, reversible inhibitor of pancreatic alpha-amylase and membrane-bound intestinal alpha-glucoside hydrolase. Pancreatic alpha-amylase hydrolyzes complex carbohydrates to oligosaccharides in the small intestine By delaying the digestion of carbohydrates, acarbose slows glucose absorption, resulting in a reduction of postprandial glucose blood concentrations. -> causes delayed gastric emptying but is not necessarily a part of its therapeutic effect

Answer 92

a) 3% saline 100ml 100ml bolus of 3% saline (should raise serum Na by 2-3 meq/L). If no improvement in neurological symptoms, can repeat bolus 1-2 more times at 10 minute intervals. Frusemide only recommended if APO

Answer 93

e. Increased risk of non fatal cardiac arrest POISE II * clonidine 200mcg per day - did not reduce the rate of composite outcome of death or nonfatal MI - but it increased the risk of clinically important hypotension and nonfatal cardiac arrest * aspirin initiation or continuation – no significant effect on rate of composite of death or non fatal MI but increased risk of major bleeding

Answer 94

a. increased bleeding and normal aptt and inr Bleeding because cold = we know this Haemtology analyzer in labs warms blood to 37.2 degrees (fixes hypothermia on sample)

Answer 95

f. perindopril Hypotensive transfusion reactions, which account for almost 3% of all transfusion reactions, are associated with patients treated with angiotensin-converting enzyme inhibitors. The current hypothesis suggests that they are caused by bradykinin-induced vasodilation in the absence of allergic, hemolytic, or septic mechanisms. The hypotension observed frequently is unresponsive to conventional therapy with catecholamines. The suggested intraoperative management includes cessation of transfusion and washing red blood cells before blood replacement. Hypotensive reactions to transfusion may not always be recognized. To prevent these reactions, clinicians have several options: they may discontinue the ACE inhibitor (elective transfusion), not use a leukoreduction filter (if the patient has no absolute requirement for leukoreduced blood components), use washed cellular components, or use components that have undergone leukoreduction at the collection facility or the hospital blood bank before transfusion (since bradykinin is degraded during storage).

Answer 96

Picture in Q shows medial winging of right shoulder Answer = b Can be caused by injury to long thoracic nerve (serratus ant’) or serratus itself a. Accessory nerve (Trapezius paralysis, causing lateral winging) b. Long thoracic N- (Serratus anterior paralysis, causing medial winging) c. Dorsal scapular N (Rhomboids paralysis, causing lateral winging) d. Suprascapular nerve (Infra and supraspinatus – doesn’t affect scapula) In addition, here is an example of lateral winging

Answer 97

Decreased SVR - increased CO, increased SBP and decreased DBP with widened PP Up to Date Cardiovascular - Patients with hyperthyroidism have an increase in cardiac output, due both to increased peripheral oxygen needs and increased cardiac contractility. Heart rate is increased, pulse pressure is widened, and peripheral vascular resistance is decreased

Answer 98

d) Esmolol Management of Arrhythmias After Heart Transplant https://www.ahajournals.org/doi/10.1161/CIRCEP.120.007954 In asymptomatic patients, additional cardiac monitoring such as 24-Holter or an event monitor can be useful to assess the SVT burden, and a trial of atrioventricular nodal blockers (β-blockers preferably) can be attempted with caution in view of potential risk of bradycardia. Calcium channel blockers such as diltiazem and verapamil are contraindicated in patients taking immunosuppression such as tacrolimus and cyclosporine as it can impair the metabolism CYP3A, which increases the levels of these drugs potentially causing renal toxicity. The use of adenosine in the management of SVT has remained a subject of controversy for over a quarter century. In the past, adenosine was contraindicated in patients post-OHT due to its supersensitivity and presumed risk of prolonged atrioventricular block. Thus, based on the aforementioned data, in patients with OHT, adenosine is feasible and safe at reduced doses (starting at 1.5 mg for patients ≥60 kg) as long as patients are closely monitored, with dose escalation as needed. Furthermore, the 2010 American Heart Association guidelines on advanced cardiovascular life support also recommended lowering the initial dose of adenosine to 3 mg for the acute management of SVT in patients with OHT.

Answer 99

low resistance MAPLESON E - Derived from the Ayre T-piece used in Mapleson D circuit and functions on the same principle as Mapleson D - The primary difference is in the length of the tubing that is increased to be greater than the patient’s tidal volume - For spontaneous ventilation, the expiratory limb is open to the atmosphere - It has no valves so there is no resistance to airflow nor points for possible mechanical failure - Rebreathing is dependent on the fresh gas flow, patients minute volume and capacity of the expiratory limb - Its main use is in paediatric patients

Answer 100

c) comparisons of means between three groups in normally distributed data ANOVA (analysis of variance): comparisons of means between more than two groups or between several measurements in the same group is called analysis of variance and is frequently cited by the acronym ANOVA

Answer 101

RCA or LCx https://litfl.com/mi-localization-ecg-library/

Answer 102

d) Trigger for initiating CICO Rescue is SpO2 <90% - According to the Vortex Approach the trigger for initiating CICO Rescue is the inability to confirm adequate alveolar oxygen delivery following best efforts at all three upper airway lifelines. Trigger for Initiating CICO Rescue VORTEX APPROACH The trigger for initiating CICO Rescue is the inability to confirm adequate alveolar oxygen delivery following best efforts at all three upper airway lifelines. Note that this trigger is independent of the oxygen saturations since, even in the unusual situation where the oxygen saturations remain high following best efforts at all three lifelines, the inability to confirm alveolar oxygen delivery means that eventual desaturation is inevitable. Rather than being a deterrent to its performance, recognition of the need for CICO Rescue while the oxygen saturations remain high should be viewed as advantageous – providing increased time to perform this confronting procedure in a more controlled manner, thereby increasing the chance of success. Conversely, a critically low oxygen saturation is not in itself a trigger to initiate CICO Rescue if best efforts at all three lifelines have not yet been completed. While legitimate opportunities to enter the Green Zone in a timely fashion via the familiar upper airway lifelines remain, these should be given priority, as they are more likely to be successful than resorting to an unfamiliar and more traumatic technique. Oxygen saturations are therefore not a relevant consideration in deciding the trigger for CICO Rescue – this is always “the inability to confirm adequate alveolar oxygen delivery following best efforts at all three upper airway lifelines”. They are, however, a relevant consideration in making the context dependent decision of what constitutes a best effort at each lifeline in a particular situation. This is because the oxygen saturations impact on how much time it is reasonable to invest in optimising each of the upper airway lifelines before declaring a best effort. When the oxygen saturations are critically low it might be reasonable to have only one attempt at each lifeline before declaring a best effort, even though this means leaving some potential optimisation interventions untried. This is because the incremental benefit of repeated attempts to optimise a lifeline that has already failed is typically low relative to untried alternative lifelines. Thus the time expended on such low yield interventions cannot be justified when the patient is already critically hypoxaemic and alternatives (including CICO Rescue) with a substantially higher likelihood of success remain.

Answer 103

a. 1% i.e. what is the positive predictive value (PPV) for this test PPV= TP/ TP +FP Negative Predictive Value = TN / TN + FN Prevalence of 1/1000 Sensitivity of 100% Specificity of 90% Of patients that are disease positive in population of 1000 TP = 1 FN = 0 -> 100% sensitivity Of patients that are disease negative in population of 1000 FP = 99 TN = 900 -> 90% Specificity PPV= 1/ 1 + 99 = 1/100 =1% NPV= 900/ 900 + 0 = 1/1 = 100%

Answer 104

a) delayed gastric emptying

Answer 105

B. 7.32 https://emj.bmj.com/content/18/5/340 The values of pH on arterial and venous samples were highly correlated (r=0.92) with an average difference between the samples of −0.4 units. There was also a high level of agreement between the methods with the 95% limits of agreement being −0.11 to +0.04 units. https://litfl.com/vbg-versus-abg/ pH - Good correlation - pooled mean difference: +0.035 pH units

Answer 106

laryngectomy tube Rusch Larygoflex Reinforced Laryngectomy tube -

Answer 107

b. low frequency high amplitude Changes in the electroencephalogram during anaesthesia and their physiological basis https://academic.oup.com/bja/article/115/suppl_1/i27/234261 Figure 1 shows raw EEG waveforms during isoflurane anaesthesia. During light anaesthesia: -amplitude is shallow and frequency is high. When a higher concentration is administered: -amplitude deepens and EEG frequency slows. During deep anaesthesia: - a ‘burst and suppression’ pattern becomes apparent, characterized by extreme activity, represented by high-frequency, large-amplitude waves (bursts), alternating with flat traces (suppression). - This pattern, excluding brain ischaemia or other factors, indicates that anaesthesia is too deep. Beyond this, flat traces become dominant and, eventually waveforms are no longer apparent. During isoflurane, sevoflurane or propofol anaesthesia, this sequence of changes in pattern is almost identical. The major difference in EEG between the volatile agents (isoflurane or sevoflurane) and propofol is apparent in power in the theta range. During propofol anaesthesia, theta power remains low regardless of concentration, but during isoflurane or sevoflurane anaesthesia, it increases at surgical concentrations of anaesthesia.

Answer 108

e. Sotalol Drugs that INCREASE defibrillation threshold: + Amiodarone (Chronic) + Atropine + lignocaine + Diltiazem + Flecainide + Verapamil + Venlafaxine + Anaesthetic agents. Drugs that DECREASE defibrillation threshold: - Sotalol - Amiodarone (acute) - Nifekalant Drugs with No Change in DFT = B- blocker = Disopyramide = Procainamide = Propafenone https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304797/

Answer 109

c. Superior sagittal Risk factors for venous air embolism include sitting craniotomy, posterior fossa surgery and procedures near the superior sagittal sinus. In these situations, the surgical site is often above the level of the right atrium and hence venous air entrainment is facilitated, or there is a large risk of venous exposure through which air may be entrained. Depending on the volume of air entrained, reduced end-tidal carbon dioxide, arrhythmias or right heart failure and cardiovascular collapse are all possible. However, changes in clinical parameters often occur late and are nonspecific for small volumes of entrainment. Specific monitoring for detection of venous air embolism includes non-invasive means such as end-tidal nitrogen, precordial Doppler or stethoscope and transcranial Doppler. Invasive methods include transoesophageal echocardiography, oesophageal stethoscope, pulmonary artery catheter and central venous pressure monitoring. https://resources.wfsahq.org/atotw/anaesthesia-for-craniotomy-and-brain-tumour-resection/

Answer 110

8. Suprascapular nerve

Answer 111

a) PEA I couldn't find a great article on this anywhere. BJAED hasn't got much either

Answer 112

e) Standards of quality improvement Quality Improvement (Standards for QUality Imporvement and Reporting Excellence) CONSORT: randomised trials PRISMA: systematic reviews and meta-analysis (Preferred Reporting Items for Systematic reviews and meta-analysis). STROBE: observational studies

Answer 113

B. Nasocilliary Nerve a branch of Ophthalmic division of trigeminal

Answer 114

A Apnea is defined as the cessation of airflow for ten or more seconds. Hypopnea is defined as a recognizable, transient reduction, but not a complete cessation of, breathing for ten or more seconds. Hypopnea requires a 4% fall in SpO2 https://www.ncbi.nlm.nih.gov/books/NBK441909/#:~:text=Obstructive%20Sleep%20Apnea%20(OSA)%2C,for%20ten%20or%20more%20seconds.

Answer 115

d) less motor block to quads APMSE 5th edition: Other regional and local analgesic techniques "Adductor canal block results in similar postoperative pain outcomes following total knee arthroplasty versus femoral nerve block with less quadriceps weakness, earlier mobilisation and better functional recovery

Answer 116

a) electrical alternans Physical findings in Tamponade: - A number of findings may be present on physical examination, depending upon the type and severity of cardiac tamponade - None of the findings alone are highly sensitive or specific for the diagnosis. Beck's triad 1. Low arterial blood pressure 2. Dilated neck veins 3. Muffled heart sounds - Are present in only a minority of cases of acute cardiac tamponade. Diagnosis: Clinical diagnosis is usually suspected based on the history and physical examination findings, which may include: ●Chest pain ●Syncope or presyncope ●Dyspnea and tachypnea ●Hypotension ●Tachycardia ●Peripheral edema ●Elevated jugular venous pressure ●Pulsus paradoxus

Answer 117

b. Plasmin Plasminogen activation results in increased conversion of plasminogen to plasmin, the latter an enzyme that breakdowns the fibrinogen in blood clots. Tranexamic acid is a synthetic derivative of lysine that exerts antifibrinolytic effects by blocking lysine binding sites on plasminogen molecules, inhibiting the interaction of plasminogen with formed plasmin and fibrin. As a result, inhibition of plasminogen activation results in stabilization of the preformed fibrin meshwork produced by secondary hemostasis.

Answer 118

b IV fluids and KCL UTD Stricture post Lap Sleeve Gastrectomy management Although sleeve strictures have been reported in 0.26 to 4 percent of LSG operations, <1 percent result in symptoms that require endoscopic or surgical intervention A stricture can manifest acutely, early after surgery, or more chronically. Although strictures can occur anywhere along the long staple line, they are most often located at the level of the incisura angularis for anatomic reasons. The etiologies of post-LSG strictures are either mechanical or functional. Mechanical strictures usually derive from the use of small bougies, stapling too close to the bougie (especially at the incisura angularis), twisting of the staple line creating a "spiral" sleeve, or aggressive imbrication of the staple line. Functional stenoses derive from edema or hematomas at the staple line. As a result, functional stenoses are transient, which present immediately following LSG and resolve spontaneously with expectant treatment. Patients who present with obstructive symptoms during the early postoperative period should be resuscitated with hydration and antiemetic medications and studied with an upper gastrointestinal (UGI) series. Stable patients with a stricture can be observed to allow postsurgical mucosal edema to resolve, typically in 24 to 48 hours. Patients who cannot handle their own secretions require nasogastric tube decompression, preferably placed under fluoroscopic guidance. Patients with an acute stricture who do not respond to conservative management require early surgical reintervention. Laparoscopy could demonstrate kinking of the gastric tube, a tight suture, or a compressing hematoma. ●Endoscopy is a good initial treatment for short-segment strictures, most of which can be dilated with balloons. Multiple treatments in four- to six-week intervals are sometimes needed to treat the stricture and improve patient symptoms. Stents have also been tried but are not effective for post-LSG strictures. ●Laparoscopic seromyotomy is a treatment option for long-segment strictures . In a small retrospective study, patients treated with laparoscopic seromyotomy had good symptomatic relief. ●Conversion to an RYGB is the last option for patients with a refractory stricture who have failed all other treatments.

Answer 119

c) Early repair Coil within 24 hours Early repair - the outcome in terms of survival free of disability at 1 year is significantly better with endovascular coiling. Preferably within 24 hours

Answer 120

reduce onset time c) faster onset of anaesthetic https://pubmed.ncbi.nlm.nih.gov/28708665/ agrees with faster onset but for non obstetric surgery UTD hyperbaric bupivacaine because of its rapid onset and the option to modify the spinal level by changing the position of the operating table. Plain bupivacaine (ie, slightly hypobaric, prepared in saline) may also be used for spinal anesthesia for CD. The literature comparing safety and efficacy of hyperbaric with isobaric bupivacaine for CD is inconclusive

Answer 121

b) Reduced mean valve gradient TAVI decreased: - AKI - AF - Transfusion - Mean prosthetic valve gradient TAVI increased: - Major vascular complications - Permanent pacemaker implantation - Paravalvular regurgitation - Need for re-intervention

Answer 122

c) 0, 1, 4, 24 Serum tryptase levels are recommended to be collected as soon as possible after the onset of symptoms and then at 1 hour, 4 hours and after 24 hours. https://www.anzca.edu.au/resources/professional-documents/endorsed-guidelines/anaphylaxis-guideline-2022.pdf

Answer 123

e) Interquartile Range https://statisticsbyjim.com/basics/skewed-distribution/ https://statisticsbyjim.com/basics/variability-range-interquartile-variance-standard-deviation/ A measure of variability is a summary statistic that represents the amount of dispersion in a dataset. How spread out are the values? While a measure of central tendency describes the typical value, measures of variability define how far away the data points tend to fall from the center. In statistics, variability, dispersion, and spread are synonyms that denote the width of the distribution. Just as there are multiple measures of central tendency, there are several measures of variability. When a distribution has lower variability, the values in a dataset are more consistent. However, when the variability is higher, the data points are more dissimilar and extreme values become more likely. Consequently, understanding variability helps you grasp the likelihood of unusual events. > Range is easy to understand, it is based on only the two most extreme values in the dataset, which makes it very susceptible to outliers. If one of those numbers is unusually high or low, it affects the entire range even if it is atypical. >The interquartile range is the middle half of the data. To visualize it, think about the median value that splits the dataset in half. The interquartile range is the middle half of the data that is in between the upper and lower quartiles. In other words, the interquartile range includes the 50% of data points that fall between Q1 and Q3 > The interquartile range is a robust measure of variability in a similar manner that the median is a robust measure of central tendency. Neither measure is influenced dramatically by outliers because they don’t depend on every value. Additionally, the interquartile range is excellent for skewed distributions, just like the median. > when you have a normal distribution, the standard deviation tells you the percentage of observations that fall specific distances from the mean. However, this doesn’t work for skewed distributions, and the IQR is a great alternative. > Variance is the average squared difference of the values from the mean. Unlike the previous measures of variability, the variance includes all values in the calculation by comparing each value to the mean. To calculate this statistic, you calculate a set of squared differences between the data points and the mean, sum them, and then divide by the number of observations. Hence, it’s the average squared difference. >While higher values of the variance indicate greater variability, there is no intuitive interpretation for specific values. Despite this limitation, various statistical tests use the variance in their calculations. For an example, read my post about the F-test and ANOVA. While it is difficult to interpret the variance itself, the standard deviation resolves this problem! > The standard deviation is the standard or typical difference between each data point and the mean. When the values in a dataset are grouped closer together, you have a smaller standard deviation. On the other hand, when the values are spread out more, the standard deviation is larger because the standard distance is greater > The standard deviation is just the square root of the variance. Recall that the variance is in squared units. Hence, the square root returns the value to the natural units. The symbol for the standard deviation as a population parameter is σ while s represents it as a sample estimate. To calculate the standard deviation, calculate the variance as shown above, and then take the square root of it. Voila! You have the standard deviation! > People often confuse the standard deviation with the standard error of the mean. Both measures assess variability, but they have extremely different purposes. > When you have normally distributed data, or approximately so, the standard deviation becomes particularly valuable. You can use it to determine the proportion of the values that fall within a specified number of standard deviations from the mean. For example, in a normal distribution, 68% of the values will fall within +/- 1 standard deviation from the mean. This property is part of the Empirical Rule. This rule describes the percentage of the data that fall within specific numbers of standard deviations from the mean for bell-shaped curves.

Answer 124

b) Subclinical Hyperthyoirdism Subclinical hyperthyroidism: low TSH, normal T3 + T4 Clinical hyperthyroidism: low TSH, high T3, high/normal T4 Subclinical hypothyroidism: high TSH, normal T3 + T4 Clinical hypothyroidism: high TSH, low/normal T3, i T4 Amiodarone: high/normal TSH, low T3 (2o to inhibition of pituitary T4 to T3 conversion) Sick euthyroid: low TSH, low T3 Hypophysectomy (central hypothyroidism): low/normal TSH/T3/T4 Compliant on thyroxine: normal TSH, high/normal T3, low T4 Non-compliant w thyroxine (pt taking several tabs prior to Dr’s appointment): high TSH, normal T4

Answer 125

e. Obturator

Answer 126

Control seizures first a) Midazolam if an option or c) propofol or treat seizures 1st followedLAST - ABCD - Intralipid 1.5mL/kg

Answer 127

c. Lupus anticoagulant (normal PT, raised APTT) Lupus anticoagulant (more likely to be associated with thrombosis than bleeding) ## Footnote https://www.uptodate.com/contents/image?imageKey=HEME%2F79969

Answer 128

doing an epidural on a patient who is labouring with normal pregnancy and no comorbidities 1. Avoid routinely performing preoperative blood investigations, chest X-ray or spirometry prior to surgery, but instead order in response to patient factors, symptoms and signs, disease, or planned surgery. 2. Avoid ordering cardiac stress testing for asymptomatic patients prior to undergoing low to intermediate risk non-cardiac surgery. 3. Avoid administering packed red blood cells (blood transfusion) to a young healthy patient with a haemoglobin of ≥70g/L who does not have on-going blood loss, unless the patient is symptomatic or haemodynamically unstable. 4. Avoid initiating anaesthesia for patients with limited life expectancy, at high risk of death or severely impaired functional recovery, without discussing expected outcomes and goals of care. 5. Avoid initiating anaesthesia for patients with significant co-morbidities without adequate, timely preoperative assessment and postoperative facilities to meet their needs. 6. Avoid routine prescription of slow-release opioids in the management of acute pain unless there is a demonstrated need, close monitoring is available and a cessation plan is in place

Answer 129

c) Discharge from recovery Aldrete score, which includes five elements (activity, respiration, circulation, consciousness, oxygen saturation) [16]. The original scoring system was developed before the invention of pulse oximetry and used the patient's colouration as a surrogate marker of their oxygenation status. A modified Aldrete scoring system was described in 1995 which replaces the assessment of skin colouration with the use of pulse oximetry to measure SpO2. The Modified Aldrete system includes five additional elements that are particularly useful during the Phase II recovery period prior to discharge to home (dressing, pain, ambulation, feeding, urine output)

Answer 130

c) Dabigatran Idarucizumab (Praxbind) is a monoclonal antibody to dabigatran Dabigatran bleeding may be treated with: - idarucizumab - haemodialysis - TXA will decrease fibrinolysis and has some effect - FFP also has some effect Humanized monoclonal antibody fragment (Fab) indicated in patients treated with dabigatran (Pradaxa) when reversal of the anticoagulant effects are needed for emergency surgery or urgent procedures, or in the event of life-threatening or uncontrolled bleeding - 5 g IV, provided as 2 separate vials each containing 2.5 g/50 mL (see Administration) - Limited data support administration of an additional 5 g Dosage Modifications Renal impairment: Renal impairment did not impact the reversal effect of idarucizumab; no dosage adjustment required Hepatic impairment: Not studied Dosing Considerations This indication is approved under accelerated approval based on a reduction in unbound dabigatran and normalization of coagulation parameters in healthy volunteers; continued approval for this indication may be contingent upon the results of an ongoing cohort case series study

Answer 131

c) 770mg Product info: Fresenius-Kabi When prolonged epidural blocks are used, either by continuous infusion or repeated bolus administration, the risks of reaching a toxic plasma concentration or inducing local neural injury must be considered. Cumulative doses of up to 800 mg ropivacaine for surgery and postoperative analgesiaadministered over 24 hours were well tolerated in adults, as were postoperative continuous epidural infusions at rates up to 28 mg/hour for 72 hours. product info: pfizer When prolonged blocks are used, either through continuous infusion or through repeated bolus administration, the risks of reaching a toxic plasma concentration or inducing local neural injury must be considered. Experience to date indicates that a cumulative dose of up to 770 mg ropivacaine hydrochloride administered over 24 hours is well tolerated in adults when used for postoperative pain management: i.e., 2016 mg. Caution should be exercised when administering ropivacaine for prolonged periods of time, e.g., > 70 hours in debilitated patients

Answer 132

a) Ischaemic optic neuropathy Postoperative visual loss (POVL) occurs in 1/60 000–1/125 000 operations. Spinal surgery has the highest incidence of POVL. American Society of Anesthesiologists (ASA) Post Operative Visual Loss Registry, spinal surgery accounted for 93/131 (70%) of all cases of visual loss after non-ophthalmic surgery. Of these: > 83 were attributable to ischaemic optic atrophy (ION) > 10 were caused by central retinal artery occlusion (CRAO). CRAO - caused by direct pressure on the globe causing raised intraocular pressure and compromising retinal perfusion. - visual loss is usually unilateral and associated with other signs of pressure (e.g. ophthalmoplegia, ptosis, or altered sensation in the territory of the supraorbital nerve). - Initial careful positioning of the head and regular checks throughout the procedure in case of movement minimizes the risk - documentation of eye checks should occur every 30mins and horseshoe shaped head rests should be avoided in prone patients ION > associated with: - male gender - obesity - increasing blood loss - operative procedures >6 hrs in length. - The use of the Wilson frame has also been implicated. > final common pathway is thought to be hypoperfusion of the optic nerve, there is no clear association with either intraoperative systemic hypotension or with the presence of peripheral vascular disease or diabetes. > recently updated ASA practice advisory for POVL associated with spinal surgery recommends regular intraoperative testing of haemoglobin concentration. However, it was unable to suggest a transfusion threshold that would prevent POVL. Other possible causes of POVL: 1. Cortical ischaemia 2. Haemorrhage into a cerebral tumour. In high-risk cases, assessment of vision should be performed as soon as possible in PACU and an early ophthalmic opinion sought if there is a suggestion of visual compromise. Initial management 1. optimization of arterial pressure 2. oxygenation 3. correction of anaemia. Treatment with agents such as acetazolamide has not been beneficial and there is rarely any useful improvement in vision with either injury, so attention should be focused on preventative measures: 1. Careful positioning with the head at the same level as the heart 2. Meticulous haemostasis, 3. Possibly staging prolonged procedures should be considered. Because of the devastating nature of this complication, patients should be informed of an increased incidence of visual loss after spinal operations that are expected to be of prolonged duration and associated with significant blood loss.

Answer 133

c. 30cmH2O

Answer 134

dopamine - least likely to cause pulmonary vasodilation (all the others do to my knowledge) - From UP TO DATE: > At low doses of 1 to 3 mcg/kg per min, dopamine acts primarily on dopamine-1 receptors to dilate the renal and mesenteric artery beds > At 3 to 10 mcg/kg per min (and perhaps also at lower doses), dopamine also stimulates beta-1 adrenergic receptors and increases cardiac output, predominantly by increasing stroke volume with variable effects on heart rate. > At medium-to-high doses, dopamine also stimulates alpha-adrenergic receptors, although a small study suggested that renal arterial vasodilation and improvement in cardiac output may persist as the dopamine dose is titrated up to 10 mcg/kg per min *clinically, the haemodynamic effects of dopamine demonstrate individual variability Dobutamine (inodilator): - selective β1-agonist that increases cardiac contractility and reduces pulmonary vascular and systemic vascular resistances Vasopressin: - vasopressin may have pulmonary vasodilatory effects in addition to a systemic vasoconstrictive effect Milrinone (inodilator): - the phosphodiesterase-3 inhibitors, milrinone and enxoimone, have positive inotropic effects combined with the capacity to reduce RV afterload (‘inodilators’) without significant chronotropic effect, but they can be associated with significant systemic hypotension

Answer 135

a) 30 min If the anaesthesia machine requires electrical power for normal operation, a backup power supply must be a part of the machine and permit normal operation for at least 30 minutes after a mains power supply failure. An alarm must be activated at the time of the mains failure and the state of the reserve power supply must be indicated while it is in use. https://www.anzca.edu.au/getattachment/f05e02ec-2023-4c50-b57f-9549ea0c4183/PS54(A)-Position-statement-on-the-minimum-safety-requirements-for-anaesthesia-machines-and-workstations-for-clinical-practice-2021#page=

Answer 136

b. Insufficient fludrocortisone replacement In Primary Adrenal Insufficency, cortisol deficiency results in decreased feedback to the HPA axis, leading to increased secretion of ACTH to stimulate the adrenal cortex. Simultaneously, MCs deficiency causes increased release of renin by the juxtaglomerular apparatus of the kidneys.

Answer 137

8mg/hr Guidelines for mx of glucocorticoids during the perioperative period for patients with adrenal insufficiency https://associationofanaesthetists-publications.onlinelibrary.wiley.com/doi/10.1111/anae.14963

Answer 138

A The situation in adults is straightforward: there is convincing evidence that propofol is safe in patients who are allergic to peanut and/or soy and/or egg. BJA Ed https://academic.oup.com/bja/article/116/1/11/2566111

Answer 139

c) 15mg Oral Tapentadol 25mg = 8mg Oral Morphine Oral Oxycodone 5mg = 8mg Oral Morphine Oral Tramadol 25mg = Oral Morphine 5mg Oral Hydromorphone 4mg = Oral Morphine 20mg S/L Buprenorphine 200mcg = 8mg Oral Morphine IV Oxycodone 5mg = Oral Morphine 15mg IV Morphine 5mg = Oral Morphine 15mg IV Hydromorphone 1mg = Oral Morphine 15mg

Answer 140

gelofusin Anaphylaxis after vaccination is probably due to anaphylactic sensitivity to gelatin or neomycin, not an egg allergy

Answer 141

d) Reduce length of stay less time in aged care and reduced mortality Blue book 2019: "A referral to a geriatrician for further assessment and management may also be warranted in the preoperative period. Indeed, a meta-analysis of perioperative interventions to reduce delirium found that a geriatrics consultation before surgery was one of only two perioperative interventions that were associated with a reduction in delirium." Association of anaesthetists: The impact of pre-operative comprehensive geriatric assessment on postoperative outcomes in older patients undergoing scheduled surgery: a systematic review - reduced medical complications > reduced postop delirium, > reduced pneumonia > reduced pressure sores - fewer cancellations - reduced length of stay

Answer 142

b) PR indomethacin APMSE 5th edition 8.6.1.3: Only rectal NSAIDs are effective for reducing post ERCP pancreatitis, particularly indomethacin. Epidural > PCA for severe acute pancreatitis A Randomized Trial of Rectal Indomethacin to Prevent Post-ERCP Pancreatitis https://www.nejm.org/doi/full/10.1056/NEJMoa1111103 Nonsteroidal antiinflammatory drugs (NSAIDs) are potent inhibitors of phospholipase A2, cyclooxygenase, and neutrophil–endothelial interactions, all believed to play an important role in the pathogenesis of acute pancreatitis. NSAIDs are inexpensive and easily administered and have a favorable risk profile when given as a single dose, making them an attractive option in the prevention of post-ERCP pancreatitis. Preliminary studies evaluating the protective effects of single-dose rectal indomethacin or diclofenac in post-ERCP pancreatitis have been conducted, and a meta-analysis suggests benefit. Results A total of 602 patients were enrolled and completed follow-up. The majority of patients (82%) had a clinical suspicion of sphincter of Oddi dysfunction. Post-ERCP pancreatitis developed in 27 of 295 patients (9.2%) in the indomethacin group and in 52 of 307 patients (16.9%) in the placebo group (P=0.005). Moderate-to-severe pancreatitis developed in 13 patients (4.4%) in the indomethacin group and in 27 patients (8.8%) in the placebo group (P=0.03). Conclusions Among patients at high risk for post-ERCP pancreatitis, rectal indomethacin significantly reduced the incidence of the condition.

Answer 143

e. 200mmol K+ < 3.0 mmol/L: 200-400 mmol of potassium are required to raise it by 1 mmol/L K+ > 3.0 mmol/L: 100-200 mmol of potassium are required to raise it by 1 mmol/L Hypokalaemia P. GLOVER https://www.cicm.org.au/CICM_Media/CICMSite/CICM-Website/Resources/Publications/CCR Journal/Previous Editions/September 1999/05-Sept_1999_Hypokalaemia.pdf If the serum potassium level is greater than 3 mmol/L, 100-200 mmol of potassium are required to raise it by 1 mmol/L; 200 - 400 mmol are required to raise the serum potassium level by 1 mmol/L when the potassium concentration is less than 3mmol/L, assuming a normal distribution between cells and the intracellular space, and a linear relationship between plasma potassium and body deficit (which has been described, i.e. 0.27 mmol/L/100 mmol deficit/70 kg), exists. The rate of administration of potassium will be influenced by the presence and seriousness of the pathophysiological changes caused by hypokalaemia. The underlying disorder should also be treated simultaneously.

Answer 144

b. Sequentially increasing Na levels

Answer 145

a) Pulmonary embolism A bit about the RV in PE: The right ventricle drapes around the LV. In response to an acute Pulmonary Embolus (PE) it first dilates. The RV can’t generate much force without training, so when the Pulmonary Vascular Resistance (PVR) first rises with a PE, the pulmonary artery pressures don’t actually rise substantially because the RV can’t generate large pressures. Looking at the ventricle in short axis, the septum may bow towards the LV which will form a D shape in diastole, producing a “volume overloaded right ventricle” appearance. Only later when the RV has been trained will it be able to generate higher pressures. If the LV is D shaped in systole, this is a “pressure overloaded right ventricle”. Acute cor pulmonale with both pressure AND volume overload (D shape in systole AND diastole) is often absent.

Answer 146

6. Dorsal Scapular Nerve

Answer 147

b. 45ml/hr N saline w 5% dextrose Nsaline + 5% dextrose is fluid of choice A guide to paediatric anaesthesia fluid management -421 rule overestimates fluid resus -due to stress response from ADH release -post-op fluid maintenance is 2/3rds calculated due to increased ADH -never use hypotonic fluids https://www.rch.org.au/clinicalguide/guideline_index/Intravenous_fluids/

Answer 148

a) Accurate delivery of volatile concentration from vaporiser PS31 Level two check should be performed at the start of each anaesthetic list. 4.2.3.2 Inhalational anaesthesia delivery devices (vapouriser) 4.2.3.2.1 Ensure electricity is connected to vapourisers that require it. 4.2.3.2.2 Check the anaesthetic liquid level is within marked limits. 4.2.3.2.3 Ensure all filling ports are sealed. 4.2.3.2.4 Check correct seating, locking and interlocking of detachable vapourisers or casettes. 4.2.3.2.5 Test for circuit leaks with a cassette installed or for each vapouriser in the “on” and “off” state. 4.2.3.3 Check for machine leaks upstream from the common gas outlet or breathing system, using a protocol appropriate for the anaesthesia delivery system.

Answer 149

a) 50mg six times a day 42mg IV Morphine = 126mg Oral Morphine 126/8= 15.75 15.75 x 25 = 393.75 (*400mg/day Tapentadol) Option 50mg 6 times a day = 300mg As direct OME to tapentadol conversion is 400mg, a 300mg dose represents a 25% dose reduction, which is line with a 25-50% dose reduction due to incomplete cross-tolerance during opioid rotation. Oral Tapentadol 25mg = 8mg Oral Morphine Oral Oxycodone 5mg = 8mg Oral Morphine Oral Tramadol 25mg = Oral Morphine 5mg Oral Hydromorphone 4mg = Oral Morphine 20mg S/L Buprenorphine 200mcg = 8mg Oral Morphine IV Oxycodone 5mg = Oral Morphine 15mg IV Morphine 5mg = Oral Morphine 15mg IV Hydromorphone 1mg = Oral Morphine 15mg

Answer 150

D. Withdraw PAC 2 cm and insert DLT LITFL: Pulmonary haemorrhage after PAOP measurement a life threatening time-critical emergency pulmonary artery rupture caused by inflation of the pulmonary artery catheter (PAC) balloon during ‘wedging’ (measurement of the pulmonary artery occlusion pressure) some experts advise against measuring PAWP because of the risk of pulmonary artery rupture 0.2% risk, 30% mortality RISK FACTORS pulmonary hypertension mitral valve disease anticoagulants age >60 years MANAGEMENT Goals prevent further pulmonary haemorrhage stop bleeding resuscitate Call for help ICU consultant anaesthetist/ OT cardiothoracic surgeon interventional radiology Resuscitation A may have to be emergently intubated if not already B FiO2 1.0 controlled ventilation if able to recognize which lung is haemorrhaging may be able to perform lung isolation (insert single lumen tube into unaffected side, exchange for a double lumen tube or use bronchial blocker with bronchoscopic assistance) apply PEEP to tamponade wound C large bore IV cannulae, fluids, blood products, inotropes Specific therapy Lay the patient ruptured side down withdraw pulmonary catheter 2-3 cm with balloon down then refloat PAC with balloon inflated to occlude pulmonary artery (to try to tamponade bleeding) stop antiplatelet agents and anticoagulants give reversal agents: — protamine for heparin — platelets for anti-platelet agents give blood products as indicated by FBC, coags and clinical state interventions — angiogram or bronchoscopy to isolate pulmonary vessel involved — if bleeding doesn’t settle will require lobectomy

Answer 151

1,500 mL immediately OR 200 mL/hr in the first 2-4 hours

Answer 152

d) WPW Type B pattern LITFL: ECG features of WPW in sinus rhythm -> PR interval < 120ms -> Delta wave: slurring slow rise of initial portion of the QRS -> QRS prolongation > 110ms -> Discordant ST-segment and T-wave changes (i.e. in the opposite direction to the major component of the QRS complex) -> Pseudo-infarction pattern in up to 70% of patients — due to negatively deflected delta waves in inferior/anterior leads (“pseudo-Q waves”), or prominent R waves in V1-3 (mimicking posterior infarction Can be left-sided (Type A) or right-sided (Type B), and ECG features will vary depending on this: Left-sided AP: produces a positive delta wave in all precordial leads, with R/S > 1 in V1. (Dominant R Wave in V1) Sometimes referred to as a type A WPW pattern Right-sided AP: produces a negative delta wave in leads V1 and V2. Sometimes referred to as a type B WPW pattern Tachyarrhythmias in WPW There are only two main forms of tachyarrhythmias that occur in patients with WPW 1. Atrial fibrillation or flutter. -> Due to direct conduction from atria to ventricles via an AP, bypassing the AV node 2. Atrioventricular re-entry tachycardia (AVRT). -> Due to formation of a re-entry circuit involving the AP Breakdown of Type A example: - Sinus rhythm with a very short PR interval (< 120 ms) - Broad QRS complexes with a slurred upstroke to the QRS complex — the delta wave - Dominant R wave in V1 suggests a left-sided AP, and is sometimes referred to as “Type A” WPW - Tall R waves and inverted T waves in V1-3 mimicking right ventricular hypertrophy (RVH) — these changes are due to WPW and do not indicate underlying RVH - Negative delta wave in aVL simulating the Q waves of lateral infarction — this is referred to as the “pseudo-infarction” pattern

Answer 153

a. Cholecystitis Example and explanation taken from RACGP: The raised AlP relative to Alt suggests cholestasis and the high GGt confirms liver origin. The mild hyperbilirubinaemia confirms the clinical impression of jaundice. Biliary disease is highly likely with gallstones the most likely differential diagnosis. however, this clinical picture may also occur in drug reactions or infiltrative conditions. After a careful history, abdominal ultrasound is the most appropriate next investigation.

Answer 154

B. 20% 25% (a few studies have higher ranges but typically around 20-25%) https://doi.org/10.1192/bjp.bp.115.165498

Answer 155

b. Anterior communicating artery https://case.edu/med/neurology/NR/SubarachnoidHemorrhageAComm.htm

Answer 156

c) Breast milk 3 hours before, clear fluids 1 hour before 3mls/kg PS07 - patient preparation and preanaesthetic consultation appendix 1 2023 Children up to 16 years: Clear fluids of 3ml/kg up to 1 hour before. <6 months Formula 4 hours Breast 3 hours Clear 1 hour >6 months: solids and formula wait 6 hours. Breast milk 4 hours. Clear 1 hour

Answer 157

Hypoasthesia - Veldman criteria Pain distal to primary injury – Not mentioned specifically in Budapest criteria, but in Veldman Hypoaesthesia = reduced sensation to pain

Answer 158

D. Substance P Development of aprepitant, the first neurokinin-1 receptor antagonist for the prevention of chemotherapy-induced nausea and vomiting (2011) https://www.ncbi.nlm.nih.gov/pubmed/21434941 Aprepitant acts centrally at NK-1 receptors in vomiting centres within the central nervous system to block their activation by substance P released as an unwanted consequence of chemotherapy.

Answer 159

Honey (or sucralfate) - 10 mL every 10 minutes (maximum 6 times) while awaiting surgical retrieval Source QCH guidelines

Answer 160

a) Non-inferiority is not demonstrated Possible outcomes in a non-inferiority trial. In A (blue), non-inferiority is demonstrated. In B (green), non-inferiority is not demonstrated, and the trial is inconclusive. In C (red), the new treatment is inferior.

Answer 161

d) diltiazem Nondihydropyridine calcium channel blockers should be used cautiously in patients with HFrEF because of their negative inotropic effects, and the role of these agents in LVAD recipients remains unclear https://www.ahajournals.org/doi/10.1161/CIR.0000000000000673 Should also avoid sotolol

Answer 162

b. Unstable angina Not a Repeat, no Tropnin rise in this question making the answer unstable angina as opposed to NSTEMI UTD: Unstable angina (UA) and acute non-ST elevation myocardial infarction (NSTEMI) differ primarily in whether the ischemia is severe enough to cause sufficient myocardial damage to release detectable quantities of a marker of myocardial injury (troponins): ●UA is considered to be present in patients with ischemic symptoms suggestive of an ACS and no elevation in troponins, with or without electrocardiogram changes indicative of ischemia (eg, ST segment depression or transient elevation or new T wave inversion). ●NSTEMI is considered to be present in patients having the same manifestations as those in UA, but in whom an elevation in troponins is present. MINS: Myocardial injury after non-cardiac surgery (up to 30 days post-op): 1. Elevated postop troponin 2. Resulting from myocardial ischaemia (i.e. no evidence of a non-ischaemic aetiology), not requiring an ischaemic feature (i.e. no chest pain, no ECG change) VISION studies (Vascular Events in Noncardiac Surgery Patients Cohort Evaluation) demonstrated that severity of MINS strongly associated with 30-day mortality after NCS. hs-cTnT <20ng/L ~ 0.5% 30 day mortality 20-64ng/L ~3% 30 day mortality 65-999 ng/L ~9% 30 day mortality >1000ng/L ~30% 30 day mortality Whilst VISION trial identified MINS in at risk patients, the question now becomes what interventions are available to prevent this complication?

Answer 163

High frequency probe at 90 degrees to the skin - to best visualise superficial structures have the probe at 90 degrees to the skin with a high frequency transducer it is best to use high-frequency transducers (up to 10–15 MHz range) to image superficial structures (such as for stellate ganglion blocks) and low-frequency transducers (typically 2–5 MHz) for imaging the lumbar neuraxial structures that are deep in most adults.

Answer 164

a. 1% i.e. what is the positive predictive value (PPV) for this test PPV= TP/ TP +FP Negative Predictive Value = TN / TN + FN Prevalence of 1/1000 Sensitivity of 100% Specificity of 90% Of patients that are disease positive in population of 1000 TP = 1 FN = 0 -> 100% sensitivity Of patients that are disease negative in population of 1000 FP = 99 TN = 900 -> 90% Specificity PPV= TP/ TP + FP = 1/ 1 + 99 = 1/100 =1% NPV= TN/ TN + FN =900/ 900 + 0 = 1/1 = 100%

Answer 165

Dominant EEG frequency decreases, and amplitude increases with increasing concentrations of anaesthetic. End result is burst suppression https://academic.oup.com/bja/article/115/suppl_ 1/i27/234261 Figure 1 shows raw EEG waveforms during isoflurane anaesthesia. During light anaesthesia: -amplitude is shallow and frequency is high. When a higher concentration is administered: -amplitude deepens and EEG frequency slows. During deep anaesthesia: - a ‘burst and suppression’ pattern becomes apparent, characterized by extreme activity, represented by high-frequency, large-amplitude waves (bursts), alternating with flat traces (suppression). - This pattern, excluding brain ischaemia or other factors, indicates that anaesthesia is too deep. Beyond this, flat traces become dominant and, eventually waveforms are no longer apparent. During isoflurane, sevoflurane or propofol anaesthesia, this sequence of changes in pattern is almost identical. The major difference in EEG between the volatile agents (isoflurane or sevoflurane) and propofol is apparent in power in the theta range. During propofol anaesthesia, theta power remains low regardless of concentration, but during isoflurane or sevoflurane anaesthesia, it increases at surgical concentrations of anaesthesia.

Answer 166

e. 45ml/hr 0.9% NS 5% dextrose REPEAT 2/3rd standard full maintenance as unwell

Answer 167

a) muscolocutaneous

Answer 168

Answer: 3/100 In statistical analysis, the rule of three states that if a certain event did not occur in a sample with n subjects, the interval from 0 to 3/n is a 95% confidence interval for the rate of occurrences in the population. When n is greater than 30, this is a good approximation of results from more sensitive tests. For example, a pain-relief drug is tested on 1500 human subjects, and no adverse event is recorded. From the rule of three, it can be concluded with 95% confidence that fewer than 1 person in 500 (or 3/1500) will experience an adverse event. By symmetry, for only successes, the 95% confidence interval is [1−3/n,1]. The rule is useful in the interpretation of clinical trials generally, particularly in phase II and phase III where often there are limitations in duration or statistical power. The rule of three applies well beyond medical research, to any trial done n times. If 300 parachutes are randomly tested and all open successfully, then it is concluded with 95% confidence that fewer than 1 in 100 parachutes with the same characteristics (3/300) will fail.

Answer 169

less maternal bradycardia

Answer 170

c. Pharyngeal muscles Millers Anaesthesia: Reference artyicle from Millers: https://pubs.asahq.org/anesthesiology/article/92/4/977/710/The-Incidence-and-Mechanisms-of-Pharyngeal-and An adductor pollicis TOF ratio of 0.90 or less was associated with impaired pharyngeal function and airway protection, resulting in a four- to fivefold increase in the incidence of pharyngeal dysfunction causing misdirected swallowing. Moreover, pharyngeal function and airway protection may be impaired, even if the adductor pollicis muscle has recovered to a TOF ratio of more than 0.90.

Answer 171

Hypercalcaemia

Answer 172

c) Genitofemoral

Answer 173

Gilberts Gilbert’s syndrome is a benign genetic condition that commonly presents as incidental hyperbilirubinaemia or painless jaundice. It is relatively common with a population frequency of approximately 2–10%. Gilbert’s syndrome is caused by defective bilirubin clearance by the hepatic conjugating enzyme UDP-glucuronosyltransferase https://www.rcpa.edu.au/getattachment/8b9a8acf-f7f5-4088-951c-3f65f0c2f8fe/Interpreting-liver-function-tests.aspx

Answer 174

a) Flecanide WPW ECG = short PR, wide QRS, delta wave at start of QRS If WPW, need to prolong refractor period of accessory pathway with agents such as procainamide/flecainide/amiodarone/sotalol. Avoid verapamil (increases ventricular rate). Avoid beta blockers (don’t affect accessory pathway). https://litfl.com/wolff-parkinson-white-syndrome-ccc/

Answer 175

Unknown options but… Factors associated WITH difficulty during Gastroscopy were younger age, procedure indication, male sex, presence of a trainee, psychiatric history and benzodiazepine and opioid use. Factors associated with difficulty during COLONOSCOPY were younger age, female sex, BMI <25, procedure indication, tobacco, benzodiazepine, opioid and other psychoactive medication use

Answer 176

e) Muscular dystrophy - rhabdomyolysis risk if given to patients with Duchenne or Becker's muscular dystrophy - volatiles safe in all above, and also safe in patient's with myotonic dystrophy Malignant hyperthermia - high mortality uncoupling regulation of RyR1 to SR Duschenne muscular dystrophy - fatal rhabdo (hyperkalaemia)

Answer 177

c) 20mmHg Intra-abdominal hypertension is defined as a sustained intra-abdominal pressure of >12 mm Hg, and abdominal compartment syndrome occurs at a pressure >20 mm Hg in association with new organ dysfunction. Intra-abdominal hypertension is graded as follows: Grade 1=12–15 mm Hg; Grade 2=16–20 mm Hg; Grade 3=21–25 mm Hg; and Grade 4 >25 mm Hg. ## Footnote https://academic.oup.com/bjaed/article/12/3/110/258792

Answer 178

a) Sinus tachycardia BJA: Anorexia nervosa: perioperative implications https://academic.oup.com/bjaed/article/9/2/61/299563 Cardiovascular Typically anorexic patients are hypotensive and bradycardic. These physiological markers may be used as indications for hospitalization. Bradycardia reflects the decrease in basal metabolic rate that arises as an adaptive response to starvation. Although patients are usually in sinus rhythm, electrocardiographic abnormalities are common and may be found in >80% of strict dieters. These include: atrioventricular block, ST depression, T wave inversion, and QT prolongation. QT prolongation may be caused by hypocalcaemia, hypomagnesaemia, drugs, or directly by starvation itself. Electrolyte disturbances have a significant causal role in ECG abnormalities. Other factors, for example, atypical antipsychotics, may also contribute. Associated arrhythmias include: sinus arrest, wandering atrial pacemakers, nodal escape beats, supraventricular tachycardia, and ventricular tachycardia. The reported incidence of arrhythmias under anaesthesia is 16–62%. With respect to myocardial contractility, left ventricular function has been demonstrated to be impaired in a proportion of patients. Echocardiographic studies have also demonstrated a higher incidence of mitral valve prolapse in anorexic patients. The reasons for this are not entirely clear. It is postulated that the loss of left ventricular volume and mass leads to abnormal mitral valve motion. In addition to starvation-induced myocardial impairment, the myocardium may be specifically damaged by pharmacological agents. For example, emetogenic ipecac syrup is directly cardiomyotoxic and produces inflammatory changes and myocardial fibre degeneration when used long term. Rarely, antipsychotic drugs, for example, olanzapine, may cause cardiomyopathy. Myocardial impairment can be caused by hypophosphataemia which also reduces the threshold for arrhythmias. Compromised myocardial function requires judicious use of fluids perioperatively as there is an increased risk of congestive cardiac failure. Echocardiography along with invasive perioperative monitoring (central venous catheter) should be considered to prevent fluid overload.

Answer 179

a) polydipsia Hypocalcemia varies from a mild asymptomatic biochemical abnormality to a life-threatening disorder. Acute hypocalcemia can lead to paresthesia, tetany, and seizures (characteristic physical signs may be observed, including Chvostek sign, which is poorly sensitive and specific of hypocalcemia, and Trousseau sign). https://bestpractice.bmj.com/topics/en-us/160

Answer 180

Muscle relaxation or Recruitment maneuvers A, D and E are all appropriate for ARDS. Muscle relaxation and lung recruitment are controversial. Best answer is probably A muscle relaxation (not recommended unless there is dyssynchrony). Recruitment and higher PEEP are conditional. UP TO DATE: RE: Muscule relaxation: " Until a clear benefit is demonstrated, we suggest not routinely administering NMBs to patients with moderate to severe ARDS, unless other indications are present (eg, severe ventilator dyssynchrony, particularly if it leads to double triggering, or unwanted motor movement refractory to ventilator adjustment and sedation). " Recruitment manoeuvres – no positive influence on survival. https://derangedphysiology.com/main/required-reading/respiratory-medicine-and-ventilation/Chapter%20512/ventilation-strategies-ards Does this strategy improve survival? Probably not, according to this Cochrane review. In fact, in the ART trial (Cavalcanti et al, 2017) they probably caused harm. But, they can improve oxygenation temporarily. One can see the benefit of recruitment manoeuvres in patients who have accidentally become disconnected from the ventilator. The 2017 ATS guidelines were published in May of 20117, whereas the ART trial came out in September that year, and so the ATS guidelines still recommend recruitment manoeuvres whereas the rest of the world probably does not. In fact, in their answer to Question 8 from the first paper of 2018 the college remarked that if any trainee who confesses to the routine use of recruitment manouvres, "they were should be marked down" by the examiners.

Answer 181

a. Normal SpO2, Normal PaO2 ABG HbCO (elevated levels are significant, but low levels do not rule out exposure) lactate (tissue hypoxia) PaO2 should be normal, SpO2 only accurate if measured (not calculated from PaO2) MetHb (exclude) https://litfl.com/carbon-monoxide-poisoning/

Answer 182

d) Pulmonary embolism - fits with history of acute dyspnoea - PCWP normal, therefore precapillary PH - thus left heart disease unlikely to be the cause of elevated RVSP (clinical group 2) - COPD possible if cor pulmonale, but this is an unlikely cause of acute dyspnoea given history Normal PCWP excludes left heart disease as cause of pulmonary HTN (so not MR, MS or AS). The causes of pre-capillary pulm HTN are pulmonary arterial hypertension, pulmHTN secondary to lung disease, chronic thromboembolic pulmonaryHTN, pulmHTN with unclear/multifactorial mechanisms. Normal pulmonary capillary wedge pressure = 8- 12mmHg Normal PASP: 15-25mmHg Normal PADP: 8-15mmHg Pulmonary HTN is mPAP ≥25mmHg at rest. mPAP = PADP + (PASP-PADP/3) mPAP in this image is 43 mmHg Transpulmonary gradient = mPAP – PAWP 20B 20B

Answer 183

D. 4 * alternatively her Fisher score is: grade 2 (diffuse thin (<1 mm) SAH, no clots; which estimates an incidence of symptomatic vasospasm of 25%) Note the new modified Fischer scale. G0 No SAH or IVH (0%) G1 Focal or diffuse thin SAH but no IVH (6-24%) G2 Focal or diffuse thin SAH with IVH (15-33%) G3 Thick SAH no IVH (33-35%) G4 Thicc SAH with IVH (34-40%) The main differences between the Fisher scale and modified Fisher scale are: 1) Fisher scale, no SAH is grade 1, but 0 in modified Fisher scale 2) Fisher scale, thin SAH & no IVH is grade 2, but 1 in modified Fisher scale 3) Fisher scale, thick SAH with no IVH is grade 3 and the same 3 in modified Fisher scale 4) Fisher scale, any IVH is grade 4, irrespective of the presence of SAH but in modified Fisher scale it is either 2 if thin or no SAH, or grade 4 if thick SAH Modified Fisher Scale: grade 0 - no subarachnoid hemorrhage (SAH) - no intraventricular hemorrhage (IVH) - incidence of symptomatic vasospasm: 0% 3 grade 1 - focal or diffuse, thin SAH - no IVH - the incidence of symptomatic vasospasm: 24% grade 2 - focal or diffuse, thin SAH - IVH present - the incidence of symptomatic vasospasm: 33% grade 3 - thick SAH - no IVH - the incidence of symptomatic vasospasm: 33% grade 4 - thick SAH - IVH present - the incidence of symptomatic vasospasm: 40% Note: the original study did not include a specified measurement or criteria to define thick vs thin hemorrhage. REPEAT

Answer 184

Bonus question b. Early inflation Waveform features: > Diastolic augmentation (peak B) encroaches on the peak corresponding to unassisted systole (peak A) – the two peaks have merged and are barely distinguishable. > There is no ‘sharp V’ or dicrotic notch between peaks A and B. Early IAB inflation may result in: > Premature closure of the aortic valve and possible aortic regurgitation, thus impairing left ventricular emptying. There may be an increase in LVEDV, LVEDP and PCWP. > Increased left ventricular wall stress (afterload) and increased myocardial oxygen consumption will occur. how to correct: Delay the onset of IAB inflation, so that it inflates at the dicrotic notch resulting in a ‘sharp V’ (see the normal pressure waveform).

Answer 185

Bolus 1 IU oxytocin; start oxytocin infusion at 2.5–7.5IU.h (0.04–0.125 IU.min) EmLSCS; 3 IU oxytocinover≥30 s; start oxytocininfusion at 7.5–15 IU.h (0.125–0.25 IU.min). https://associationofanaesthetists-publications.onlinelibrary.wiley.com/doi/10.1111/anae.14757

Answer 186

c. Pain at site 1 month prior to surgery Pain itself is a risk factor: the strongest predictors of CPSP are chronic preoperative pain and the severity of acute postoperative pain https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5741327/#:~:text=Pain%20its

Answer 187

hydroxycobalamin

Answer 188

E. Pulmonary Stenosis DERANGED PHYSIOLOGY: Splitting of the first heart sound Right bundle branch block can produce a split first heart sound - because the contraction of the right ventricle is delayed- the conduction occurs via the left ventricle rather than the bundle of His- and thefore the closure of the tricuspid valve occurs after a substantial delay. Atrial septal defect can result in a fixed split of the first heart sound Splitting of the second heart sound It is normal for this sound to be split. The high pressure in the systemic circulation slams the aortic valve shut rather abruptly, almost angrily. In contrast, low pressure of the pulmonary circulation tends to close the pulmonary valve gently, and therefore the pulmonary component of the second heart sound (P2) is usually delayed by about 20-30 milliseconds. It is also normal for increased right ventricular filling to cause a widening of the split. The more blood in the RV, the longer it takes to eject, and therefore the greater the delay until pulmonary valve closure. n the spontaneously breathing patient, the delay is greatest during inspiration. Naturally, in the patient ventilated with positive pressure the delay is greatest during expiration (positive pressure being a barrier to diastolic filling). Increased normal splitting of S2 Anything that delays the end of right ventricular systole can cause this sort of picture. Right bundle branch block - the delay in conduction via the left ventricle causes a delay in right ventricular contraction, and therefore a delay in pulmonary valve closure. The S1 will also be split. Ventricular septal defect - because the right ventricle receives a large volume load directly from the left ventricle, and therefore takes longer to complete its systolic contraction. Pulmonary valve stenosis - because the right ventricle takes longer to empty though a narrowed valve Mitral regurgitation- not because right ventricular contraction is delayed, but because left ventricular contraction is shortened (as the LV empties in both the aortic and the atrial directuion, systole is over very quickly). Fixed splitting of S2 Atrial septal defect - the atria, joined by a gaping hole in their seput, act as one atrium. The result is a reasonably equal distribution in volume betweent the right and left atrium. This way, both sides of the circulation share the same diastolic filling pressure. Dragging more volume into the right atrium with respiratory activity will not cause an inequality of ventricular filling (between the right and left ventricles) because the venous return will be "shared". Reversed splitting of S2 In this situation, P2 occurs before A2, and splitting widens during expiration (or inspiration in the mechanically ventilated patient). This only happens if the conduction to the left ventricle is delayed, or if the left ventricle is massively volume overload (and the right ventricle is not). Left bundle branch block - the left ventricle depolarises after the right ventricle, and A2 is delayed Aortic stenosis - the left ventricle empties slowly though a narrow valve Large patent ductus arteriosus - the left ventricle receives a backflow of blood from the aorta, which causes it to become volume-overloaded

Answer 189

decompress the bladder Autonomic Dysreflexia: - medical emergency characterised by severe hypertension, - brought on by stimulation below the level of the lesion Factors affecting the development of ADR: 1. Level of spinal injury 2. Duration of injury 3. Whether injury is complete or incomplete Pathology: Stimuli arise from caudal roots below the level of the lesion leading to uncontrolled sympathetic activation below the level of the lesion ○ 80% being due to bladder distension ○ Other triggers include § bowel distension § acute abdo pathology § activation of pain fibres § sexual activity § uterine contractions

Answer 190

c. 1000 ml/hr 30% x 100kg x 4ml= 12000ml 50% in first 8hrs = 6000ml pt presents 2hrs late = 6000ml/6hrs = 1000ml/hr or 30% x 100kg x 3ml= 9000ml 50% in 1st 8 hrs= 4500ml pt presents 2hrs late= 4500ml/6hrs= 750ml/hr 750mls/hr EMSB recommends 3ml/kg, BJA recommends 4ml/kg -> go with 4ml/kg because electrical burn and more likely to require increased fluids anyway

Answer 191

a. Drugs that absolutely must not be used for pregnancy. (absolute contraindication) https://www.tga.gov.au/australian-categorisation-system-prescribing-medicines-pregnancy

Answer 192

a) Brachiocephalic artery Major vessels, most commonly the brachiocephalic artery, traverse the anterior tracheal wall in up to 53% patients at the suprasternal notch

Answer 193

b) 4yo 4 yo = wong baker faces score 3-18. 8 yo = Visual analogue scale. https://www.rch.org.au/rchcpg/hospital_clinical_guideline_index/Pain_assessment_and_measur ement/ APMSE 5 also

Answer 194

Haemodynamically unstable pelvic fracture

Answer 195

a. 1-3 days

Answer 196

B II ASA II Paediatric examples: Asymptomatic congenital cardiac disease, well controlled dysrhythmias, asthma without exacerbation, well controlled epilepsy, non-insulin dependent diabetes mellitus, abnormal BMI percentile for age, mild/moderate OSA, oncologic state in remission, autism with mild limitations

Answer 197

e) Remifentanil bolus Induction agents: Propofol: -0.75-2.5mg/kg - shortest seizure duration - improved CVS stability, less PONV, quicker emergence - pain on injection Etomidate - 0.15-0.3mg/kg - Prolonged seizure activity, may reduce seizure threshold - Useful in resistant seizures - Hyperdynamic response more pronounced compared with propofol, increased PONV, longer emergence time Methohexital - 0.5-1.5 mg/kg - "gold standard" for ECT seizure quality - long history of use - reduced availability; lack of familiarity with sue Thiopental - 2-5mg/kg - Seizure duration reduced but better than propofol - need to reconstitute, has increased dysrhythmias Ketamine - 0.7-2.8mg/kg - unclear effect on seizures: reduced and prolongesd in different studies - usefull in resistant seizures - emergence phenomena, reduced CVS stability and increases ICP Sevoflurane -6-8% inspired concentration; MAC1-2 - reduced seizure duration compared to methohexital - useful if difficult IV access, reduces uterine contractions in pregnancy - extra equipment needed; more time consuming Induction agents in the descending order of CMRO2 reducing ability: Propofol > sevoflurane > thiopental and methohexital > etomidate > ketamine. Induction agents in the descending order of CBF and ICP reducing ability: Propofol > thiopental and methohexital > etomidate > ketamine. Induction agents in the descending order of emergence time: Ketamine > etomidate > barbiturates > propofol > sevoflurane. Emergence time is the time from drug administration for general anaesthesia till eye opening or following commands. The differences in emergence time among induction agents suitable for ECT are small, and these small variations in emergence should not govern drug choice. Induction agents in descending order of seizure threshold reducing property are: Etomidate > ketamine > methohexital > thiopental > propofol. Opioid: - Alfentanil (10-20mcg/kg) or remifentanil (1mcg/kg) can be used along with the induction agent to increase the seizure duration and reduce haemodynamic response. - It is unclear if the effect on seizure duration is an inherent effect of the opioid or as a result of its dose sparing effect. NMB: -Neuromuscular blocking agents reduce muscular convulsions and decrease the risk of serious injury. - Sux at 0.5mg/kg most commonly used, larger doses upto 1.5mg/kg nay be required Adjuncts: - used to reduce dose of induction agent, or mitigate cardiovascular response to ECT in high risk patients - To treat adverse PNS effects Glycopyrolate: - superior anti-sialogogue effect - no adverse CNS effects - less post ECT tachycardia Atropine - routine atropine pre-medicattion is not recommended due to adverse effects of increased myocardial work and O2 demand To treat Adverse SNS effects: - B-blockers: atenolol (pre-ECT) or labetalol and esmolol (intra-ECT), this may reduce seizure duration -CCB: sublingual nifedapine and IV nicardipine for Htn but may reduce seizure duration - a-2 agonists: Dexmedetomidine blunts the hyperdynamic rsponse as does GTN and should be considered in patients at high risk of ischaemia - Dexmedetomidine reduces the incidence of post-ECT adverse effects such as headache, agitation, postictal delirium, or pain associated with propofol injection -IV lignocaine is not effective Emergence agitation: - Small doses of midazolam may be useful if simple measures such as a secluded, calm recovery environment do not help -However, we avoid administration of any benzodiazepine such as midazolam before performing an ECT procedure, due to known anticonvulsant properties that would make seizure induction more difficult - In patients with a history of severe postictal agitation, intravenous (IV) benzodiazepines or propofol may be administered at the end of the seizure Dexmedetomidine may be useful in the treatment of refractory cases

Answer 198

b) VA ECMO | CI is low, PaO2/FiO2 ratio is mild, PAWP is high PaO2/FiO2 ratio Mild: 200-300 = mortality 27% Moderate = 100-200 mortality 32% Severe < 100 = Mortality 45% Cardiac Index Normal: 2.5-4.2l/min PAWP: Normal 4-12mmHg

Answer 199

b) Internal SLN

Answer 200

d. pregnancy

Answer 201

C 3 hours for breast milk, 1 hour for clear fluids also B. 4 hours for formula, 1 hour clear fluids 0-6mo 4/3/1 Children > 6mo 6/4/1 Clear fluids 3mL/kg max

Answer 202

b. hypotension The use of dexmedetomidine did not increase the duration of PACU LOS but was associated with reduced emergence agitation, cough, pain, postoperative nausea and vomiting, and shivering in PACU. There was an increased incidence of hypotension but not residual sedation or bradycardia in PACU. https://pubmed.ncbi.nlm.nih.gov/35085107/#:~:text=Conclusions%3A%20The%20use%20of%20dexmedetomidine,sedation%20or%20bradycardia%20in%20PACU

Answer 203

2. Axillary Nerve

Answer 204

More bleeding with normal INR and APPT https://academic.oup.com/bja/article/117/suppl_3/iii18/2664400 Bleeding observed at reduced temperatures (33 – 37 °C) often occurs because of defects in platelet adhesion, while at temperatures below 33 °C, both reduced platelet function and coagulation enzyme activity contribute Also lab INR and APTT are not temperature corrected

Answer 205

E - SSRIs ANZCA PG12 Background Paper

Answer 206

9. Musculocutaneous Nerve

Answer 207

c) Cease clopidogrel for 5 days, continue aspirin - prostatic surgery, the risk of major bleeding may be greater than the risk of stent thrombosis - For clopidogrel, we stop five days before surgery - Clopidogrel, if stopped, should be restarted with a loading dose of 300 mg as soon as possible after surgery, perhaps later in the day if postoperative bleeding has stopped. Some experts recommend a higher loading dose of 600 mg to decrease time to effectiveness in the higher-risk postoperative setting - suggest that surgery be performed in centers with 24-hour interventional cardiology coverage UP TO DATE: Noncardiac surgery after PCI Nonemergency noncardiac surgery — For patients who have undergone previous stenting with either BMS or DES and who will need cessation of one or both antiplatelet agents, we prefer to defer planned nonemergency, nonurgent noncardiac surgery until at least six months after stent implantation. The risks of noncardiac surgery before six months are increased after both BMS and DES. For patients whose surgery requires cessation of one or both antiplatelet agents and cannot wait six months, and where the risks of delaying surgery outweigh the benefits, our recommended minimal duration of DAPT is four to six weeks, depending on the urgency of surgery and risk of thrombotic complication. This is based in part on evidence suggesting that the increased risk of MI and cardiac death is highest within the first month after stent placement and no clear difference in risk between BMS and DES. Although we prefer to wait at least six weeks when possible, in patients for whom earlier surgery is in their best interest after weighing risks and benefits, we sometimes refer patients as early as four weeks after stent placement. The proinflammatory and prothrombotic risks of surgery may increase the baseline risk of stent thrombosis even in the presence of DAPT and regardless of stent type during this early period after stenting. We believe this risk to be higher prior to the minimum duration of DAPT recommended above, but the final decision to continue or discontinue antiplatelet therapy in the perioperative period should be made only after an informed discussion among the surgeon, managing cardiologist (and other health care providers), and patient has taken place. In many cases, DAPT can be continued in the perioperative period, although for some surgeries, such as neurosurgery, posterior eye surgery, or prostatic surgery, the risk of major bleeding may be greater than the risk of stent thrombosis. In these patients who undergo noncardiac surgery before the recommended minimum duration of DAPT, a platelet P2Y12 receptor blocker should be discontinued for as brief a period as possible. Aspirin should be continued through the perioperative period, since the risk of stent thrombosis is further increased with the cessation of both aspirin and clopidogrel and surgery can usually be safely performed on aspirin. The rationale to continue aspirin comes in part from the POISE-2 trial (PCI subgroup analysis), which is discussed separately. However, as many neurosurgical patients, for whom bleeding might be life threatening or lead to severe adverse outcomes, were not enrolled in POISE-2, the optimal strategy is not known. ●Minor surgical and dental procedures usually do not require cessation of antiplatelet therapy. ●With regard to stopping P2Y12 inhibitor prior to noncardiac surgery, we generally follow recommendations found in the manufacturer's package insert for each drug. - For clopidogrel, we stop five days before surgery; that is, the last dose is taken on the sixth day before surgery. - For prasugrel, we stop seven days before surgery. - For ticagrelor, we stop three to five days before surgery. - Some experts are willing to recommend shorter discontinuation periods for procedures less likely to be associated with major bleeding. ●Clopidogrel, if stopped, should be restarted with a loading dose of 300 mg as soon as possible after surgery, perhaps later in the day if postoperative bleeding has stopped. Some experts recommend a higher loading dose of 600 mg to decrease time to effectiveness in the higher-risk postoperative setting. ●We suggest that surgery be performed in centers with 24-hour interventional cardiology coverage

Answer 208

C) Cease clopidogrel for 5 days, continue aspirin WFSA update document https://resources.wfsahq.org/wp-content/uploads/uia29-Perioperative-management-of-patients-with-coronary-stents-for-non-cardiac-surgery.pdf Dual antiplatelet therapy should be continued in all patients with coronary stents presenting for surgery. However, if there is a high risk of surgical bleeding then clopidogrel should be stopped 5-7 days before surgery and monotherapy with aspirin should be continued. Clopidogrel should be restarted as soon as possible post surgery. Cessation of aspirin therapy may be considered during intracranial surgery and transuretheral resection of prostrate as these procedures are associated with an increased risk of bleeding, but only after contemplating the risk-benefit ratio. 2014 AHA/ACC guidelines on perioperative medicine don't give a firm answer except: > 180 days since insertion = proceed (Level II b evidence)

Answer 209

c. myasthenia gravis

Answer 210

d) Von willebrand disease - autosomal dominant inheritance - may have normal or prolonged APTT, PT is normal *Haem A: X-linked recessive disorder; would expect prolonged aPTT, and normal PT *Haem B: X-linked recessive disorder; would expect normal aPTT and normal PT Up to date: Inheritance patterns — Most cases of VWD are transmitted as an autosomal dominant trait; this includes types 1 and 2B, and most types 2A and 2M. Baseline hemostasis assessment — Most patients will have a complete blood count (CBC) with platelet count and coagulation studies during the initial evaluation for excessive bleeding or bruising. ●Individuals with VWD generally have a normal CBC and a normal platelet count, with the exception of those with type 2B VWD, most of whom will have mild thrombocytopenia (eg, platelet count 100,000 to 140,000/microL). ●Individuals with VWD may have a normal or prolonged activated partial thromboplastin time (aPTT), depending on the degree of reduction of the factor VIII level. The prothrombin time (PT) is normal in VWD. Up to date: ●Hemophilia A – Inherited deficiency of factor VIII (factor 8 [F8]); an X-linked recessive disorder. ●Hemophilia B – Inherited deficiency of factor IX (factor 9 [F9]); also called Christmas disease; an X-linked recessive disorder. Laboratory findings — Hemophilia is characterized by a prolonged activated partial thromboplastin time (aPTT). However, the aPTT may be normal in individuals with milder factor deficiencies (eg, factor activity level >15 percent), especially in hemophilia B (factor IX deficiency), where even individuals with moderate disease may have a normal aPTT. In some individuals with hemophilia A, factor VIII levels may increase with stress, leading to a normalization of the aPTT or mis-categorization of factor levels and disease severity. In patients with hemophilia, the aPTT corrects in mixing studies, unless an inhibitor is present, which only applies to individuals who have received factor infusions or who have an autoantibody such as a lupus anticoagulant or an acquired factor inhibitor. Mixing studies that do not show correction of a prolonged aPTT suggest an alternative diagnosis such as an acquired factor inhibitor. The platelet count and prothrombin time (PT) are normal in hemophilia. Thrombocytopenia and/or prolonged PT suggest another diagnosis instead of (or in addition to) hemophilia. Measurement of the factor activity level (factor VIII in hemophilia A; factor IX in hemophilia B) shows a reduced level compared with controls (generally <40 percent). One exception is an individual with mild hemophilia A who undergoes testing when stressed or pregnant and has a falsely elevated factor level. If this is suspected, factor activity testing should be repeated under conditions of low stress. The plasma von Willebrand factor antigen (VWF:Ag) is normal in hemophilia. If VWF:Ag is reduced, this suggests the possibility of von Willebrand disease (VWD) rather than (or in addition to) hemophilia. Urinalysis is not done routinely, but if performed it may sometimes (but not always) show microscopic or macroscopic hematuria.

Answer 211

Line isolation monitor alarms when single fault in system. If the alarm is going off, the last piece of equipment plugged in is usually suspect and should be unplugged.

Answer 212

100 years Desflurane: 10yrs Sevoflurane 1yr ISO quoted about 3 to 5

Answer 213

A. Inhalational anesthesia or b. Clonidine Prospect: two studies focused on tonsillectomy, and those did not show any additional analgesic effect of clonidine when used on top of adequate baseline medication after tonsillectomy. PROSPECT https://associationofanaesthetists-publications.onlinelibrary.wiley.com/doi/10.1111/anae.15299#:~:text=The%20basic%20analgesic%20regimen%20should,analgesic%20and%20anti%2Demetic%20effects.

Answer 214

a) methylene blue Drugs to avoid: Antibiotics Sulphonamides (check with your doctor) Co-trimoxazole (Bactrim, Septrin) Dapsone Chloramphenicol Nitrofurantoin Nalidixic acid Antimalarials Chloroquine Hydroxychloroquine Primaquine Quinine Mepacrine Chemicals Moth balls (naphthalene) Methylene blue Foods Fava beans (also called broad beans) Other drugs Sulphasalazine Methyldopa Large doses of vitamin C Hydralazine Procainamide Quinidine Some anti-cancer drugs

Answer 215

midazolam - Opioids, benzodiazepines and pregabalin may also be used to alleviate symptoms. Perioperative treatment of symptoms If RLS symptoms occur perioperatively, patients should be allowed to walk or move their legs in bed as soon as possible. If prolonged bed rest is required, the frequency of RLS medications may be increased to three times a day. If oral intake is feasible, a patient’s usual oral medication may be given. Levodopa (a dopamine agonist) may be administered by nasogastric tube. Alternatively, parenteral apomorphine or a rotigotine patch may be used. Apomorphine (1 milligram) may be injected subcutaneously on an hourly basis. Nausea is a common side effect so it may need to be given with an antiemetic. Rotigotine patches may be used every 24 hours. Opioids, benzodiazepines and pregabalin may also be used to alleviate symptoms. Patients should be proactively investigated and treated for iron deficiency, targeting ferritin level greater than 300 micrograms/ litre in adults, and 50 micrograms/litre in children.

Answer 216

C) supine Vital capacity is increased in the supine position as abdominal wall paralysis permits greater displacement of abdominal contents during caudad diaphragmatic excursion. Patients will benefit from being recovered in the supine position. Effect of the level of the lesion Lesions above C3: complete dependence on mechanical ventilation because of phrenic nerve denervation causing complete diaphragmatic paralysis. Lesions between C3 and C5: variable dependence on ventilatory support because of variable effect on diaphragmatic and accessory muscle function. Lesions between C6 and C8: they may require intermittent non-invasive ventilatory support. Intact diaphragmatic function and accessory neck muscles enable adequate inspiratory effort. However, intercostals and abdominal wall muscles remain paralysed. Exhalation occurs via passive recoil of the chest wall, and cough is impaired. There is an increased risk of pneumonia because of poor mobilization of lung secretions. Thoracic injuries: little respiratory compromise; the main problems are attributable to an inefficient cough.

Answer 217

e) Maintain SBP 140-180 1. Tight control of BP, preferentially with IABP > goal of >140/90 mmHg and <180/105 mmHg. 2. Oxygen supplementation to maintain SpO2 >92%. 3. Maintenance of eucapnia to avoid cerebral vasoconstriction > (ETCO2 35- 45 mmHg) 4. Temperature maintained 35-37c 5. Euglycaemia (BGL 70-140 mg/dL (4-8 mmol/L)) and hourly monitoring

Answer 218

D) Cefaclor 1. Cephalexin? More so than Cephazolin (no B-lactam) 2. Cefaclor Source: UpToDate

Answer 219

b. Thoracodorsal Thoracodorsal nerve (C6-C8) is a branch of the posterior cord of the brachial plexus. Its primary function is motor innervation of the latissimus dorsi muscle. Its blockade is relevant in more extensive breast reconstruction procedures. The Pecs I, Pecs II and Serratus Plane blocks are superficial thoracic wall blocks which through blockade of the 1. Pectoral N. 2. Intercostal N. 3. Thoracodorsal N. 3. Long thoracic N. It can be used to provide analgesia for breast surgery and other procedures/surgery involving the anterior chest wall.

Answer 220

Increased latency, decreased conduction speed, decreased amplitude

Answer 221

D. Loss of pain/temperature Brown-Sequard syndrome: - Also known as Lateral hemi-section syndrome - Causes ○ Common § Knife or bullet injuries § Demyelination ○ Rare § Spinal cord tumours § Disc herniation § Infarction § infection Ipsilateral: - Motor weakness - Loss of vibration sensation - Loss of proprioception sensation Contralateral: - Loss of pain sensation - Loss of temperature Segmental Syndrome: - Pathologies that affect all functions of the spinal cord at one or more levels - Total cord transection: ○ Cessation of function in all ascending and descending spinal cord pathways ○ Loss of all types of sensation below the level of the lesion ○ Loss of movement below the level of the lesion - Acute transection: ○ Spinal shock ○ Flaccid paralysis ○ Urinary retention ○ Diminished tendon reflexes ○ This is usually temporary followed by: § Increased tone § Spasticity § Hyperrelfexia § supervene days or weeks after the event - Transverse injuries above C3 involve sensation of respiration and are often fatal if acute - Lesions above L2 will cause impotence and spastic paralysis of bladder - Causes: ○ Myelopathies § Traumatic injury § Spinal cord haemorrhage ○ Epidural or intramedullary abscesses or tumours and transverse myelitis may have a more subacute presentation Dorsal (posterior) cord syndrome: - Bilateral involvement of: ○ Dorsal Columns ○ Corticospinal tracts ○ Descending central autonomic tracts to bladder control centres in the sacral cord - Symptoms/signs: ○ Gait Ataxia (DC) ○ Paraesthesias (DC) ○ Weakness (CST) § Acute □ Muscle flaccidity □ Hyporeflexia § Chronic □ Muscle hypertonia □ Hyperreflexia ○ Extensor plantar response ○ Urinary incontinence (Auto) - Causes: ○ MS ○ Tabes dorsalis ○ Friedrich ataxia ○ Sub-acute combined degeneration ○ Vascular malformations ○ Epidural and intradural extrameduallry tumours ○ Atlantoaxial subluxation Ventral (anterior) cord syndrome - Involves cords in the anterior 2/3rds of the spinal cord ○ Corticospinal tract ○ Spinothalamic tract ○ Descending autonomic tracts to the sacral centers for bladder control - Signs/symptoms ○ Weakness (CST) ○ Reflex changes (CST) ○ B/L temp and pain sensation (Spino) ○ Tactile and vibratory sense are normal ○ Urinary incontinence (Auto) - Causes: ○ Spinal cord infarction ○ Intervertebral disc herniation ○ Radiation myelopathy

Answer 222

history of eczema

Answer 223

b) 4 Right lung: RUL: APA RML: LM RLL: SMALP Left lung: LUL: ASIA (S&I form the lingular lobe) LLL: ALPS Subsegments (total of 42) Left: 10 + 10 Right: 6 + 4 + 12

Answer 224

d) G6PD deficiency (contraindicated) Methylene blue PI: PROVEBLUE® is indicated: * for the treatment of drug-induced methaemoglobinaemia (e.g. prilocaine) * for the treatment of idiopathic methaemoglobinaemia (in which structural abnormality of haemoglobin is not present) * as a bacteriological stain * as a dye in diagnostic procedures such as fistula detection * for the delineation of certain body tissues during surgery. Contraindications: PROVEBLUE® is contraindicated in the following circumstances: * known hypersensitivity to the drug or any other thiazide dyes * patients with severe renal impairment * patients with glucose-6-phosphate dehydrogenase deficiency * methaemoglobinaemia due to chlorate poisoning * methaemoglobinaemia during treatment of cyanide poisoning Intrathecal and subcutaneous injection of methylene blue are also contraindicated as they can result in neural damage (intrathecal administration) and necrotic abscess (subcutaneous administration). Precautions: Methylene blue is a potent monoamine oxidase inhibitor. Serotonin syndrome. Dose: Adults and children: In the treatment of methaemoglobinaemia, methylene blue is administered intravenously as the 0.5 % solution in doses of 1 to 2 mg per kg bodyweight injected over a period of 5 minutes. A repeat dose may be given after one hour if required. A maximum dose of 7mg/kg bodyweight is recommended. The use of methylene blue is not recommended in infants under 4 months of age. STAT PEARLS :Methylene blue https://www.ncbi.nlm.nih.gov/books/NBK557593/ "Methylene blue is a safe drug at a therapeutic dose of <2 mg/kg; however, when levels are >7 mg/kg, many of the adverse effects it exhibits will occur. Serotonin syndrome has been found to occur when combining serotonergic agents with methylene blue at a dose of 5 mg/kg." Methylene blue: caution serotonin syndrome, G6PD deficiency Indications: vasoplegic syndrome, plasmodium falciparum, methaemoglobinaemia, diagnostic purposes. Safe at doses <2mg/kg. (used in vasoplegic syndrome on CPB at 3mg/kg - Up to date) Serotonin syndrome at >5m/kg Other adverse effects at >7mg/kg.

Answer 225

a) Urine osmolality <100mOsm/kg DIAGNOSTIC CRITERIA hypotonic hyponatraemia urine osmolality > plasma osmolality (<275mOsm/kg) (i.e. concentrated urine despite hypotonic blood) urinary Na+ > 20mmol/L normal renal, hepatic, cardiac, pituitary, adrenal and thyroid function euvolaemia (absence of hypotension, hypovolaemia, and oedema) correction by water restriction Source LITFL

Answer 226

c) p-value e) robustness of the statistics The power of a study is determined by: 1. Frequency of outcome being studied 2. magnitude of effect 3. study design 4. sample size. The greater the error variance (or standard deviation) the less the power BARASH: Experimental Medicine: Statistical Analysis POWER: The error of failing to reject a false null hypothesis (false-negative) is called a type II or β-error. (The power of a test is 1−β.) The probability of a type II error depends on four factors. 1. Unfortunately, the smaller the α, the greater the chance of a false-negative conclusion; this fact keeps the experimenter from automatically choosing a very small α. 2. The more variability there is in the populations being compared, the greater the chance of a type II error. This is analogous to listening to a noisy radio broadcast; the more static there is, the harder it will be to discriminate between words. 3. Increasing the number of subjects will lower the probability of a type II error. 4. The most important factor is the magnitude of the difference between the two experimental conditions. The probability of a type II error goes from very high, when there is only a small difference, to extremely low, when the two conditions produce large differences in population parameters. There are four options for decreasing type II error (increasing statistical power): (1) raise α, (2) reduce population variability, (3) make the sample bigger, and (4) make the difference between the conditions greater. What is Alpha: Alpha is also known as the level of significance. This represents the probability of obtaining your results due to chance. The smaller this value is, the more “unusual” the results, indicating that the sample is from a different population than it’s being compared to, for example. Commonly, this value is set to .05 (or 5%), but can take on any value chosen by the research not exceeding .05. Alpha also represents your chance of making a Type I Error. What’s that? The chance that you reject the null hypothesis when in reality, you should fail to reject the null hypothesis. In other words, your sample data indicates that there is a difference when in reality, there is not. Like a false positive.

Answer 227

a) case control https://www.cdc.gov/csels/dsepd/ss1978/lesson3/section5.html

Answer 228

a) Phosphate hypophosphate: Clinical symptoms range from muscle weakness and paraesthesia to severe cardiac failure, seizures and diaphragmatic paralysis Refeeding malnourished patients with anorexia nervosa can be associated with hypophosphatemia, cardiac arrhythmia and delirium. Phosphorus repletion should be started early with and serum levels maintained above 3 mg/dL weakness and fatigue, in the context of a recent history of starting a regular diet while in a state of chronic malnutrition, are concerning for refeeding syndrome, which typically occurs 2 to 5 days after beginning nutritional repletion. Depleted phosphate stores due to prolonged starvation, hypocalcemia, and hypokalemia can lead to impaired muscle contractility and subsequently weakness, myalgia, and tetany. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4168120/

Answer 229

e. Peripheral RICC line, 8.5 Fr

Answer 230

1st a) Atorvastatin 2nd c) Digoxin source of Atorvastatin > Digoxin https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5818856/ All of the DOACs are avid substrates for the excretory P-gp system of the gastrointestinal epithelial cells, and drugs that inhibit or induce the P-gp system may affect plasma DOAC levels Dabigatran and edoxaban are substrates for P-glycoprotein (P-gp) Apixaban and rivaroxaban are metabolised by cytochrome P450 enzyme CYP3A4 and are substrates for P-gp There is study evidence that among patients taking DOACs for non-valvular atrial fibrillation, concurrent use of amiodarone, fluconazole, rifampicin, and phenytoin compared with the use of DOACs alone, was associated with increased risk of major bleeding It is unlikely that clinically significant interactions occur between dabigatran and other drugs that are merely substrates for P-gp-mediated excretion. When dabigatran was coadministered with digoxin neither digoxin nor dabigatran plasma levels were significantly altered Rivaroxaban and apixaban are metabolised to an extent of 40–50 % in the liver to variable degrees by CYP3A4 and may interact with drugs that inhibit this enzyme. The metabolism of Apixaban and rivaroxaban can be decreased when combined with Atorvastatin which is also metabolised by CYP3A4

Answer 231

a) TXA Hyperfibrinolysis https://derangedphysiology.com/main/required-reading/haematology-and-oncology/Chapter%201.2.0.1/intepretation-abnormal-rotem-data

Answer 232

d. transverse cervical Supraclavicular nerve block. An initial injection of 3 mL local anesthetic is deposited at the midpoint of the sternocleidomastoid muscle, followed by 7 mL injected subcutaneously in a caudad and cephalad direction along the posterior border of the muscle. complications: 1.Infection 2.Hematoma 3.Phrenic nerve block 4.Local anesthetic toxicity 5.Nerve injury https://www.nysora.com/techniques/head-and-neck-blocks/cervical/cervical-plexus-block/

Answer 233

HOCM: pathopneumonic A person who has syncope during exertion is more likely to have an obstruction to blood flow (aortic stenosis or hypertrophic cardiomyopathy) or ventricular tachycardia as a cause. On the other hand, syncope after completion of exercise is more likely of reflex origin, such as the common faint. https://www.uptodate.com/contents/syncope-fainting-beyond-the-basics#:~:text=A%20person%20who%20has%20syncope,such%20as%20the%20common%20faint

Answer 234

D. Adductor Canal unclear phenomonenon prolonged exposure and high concentrations of local anaesthetic

Answer 235

a) PE D-shaped left ventricle

Answer 236

b. PECS I (PECS II Covers SA and will extend to the sternum)

Answer 237

a) No increased risk of surgical wound infection - Now, the Perioperative Administration of Dexamethasone and Infection Trial (PADDI), led by Professor Tomás Corcoran, Director of Research in the Department of Anaesthesia and Pain Medicine, Royal Perth Hospital has found that administering a low-dose of dexamethasone during anaesthesia for surgical operations does not increase the risk of surgical wound infections.

Answer 238

b. 0.4 BJA: Monitoring of neuromuscular block https://academic.oup.com/bjaed/article/6/1/7/347026 When neuromuscular monitoring is used, visual or tactile evaluation of the degree of neuromuscular block is unreliable. Even experienced anaesthetists are unable to detect fade when the TOF ratio is >0.4. It is now thought that significant residual curarization is still present if the TOF ratio is <0.97 (not 0.7 as previously suggested8).

Answer 239

d. Withdraw PAC 2cm and insert DLT Pulmonary rupture Miller: - Position pt with bleeding lung dependent - Perform endotracheal intubation, oxygenation, airway toilet - Isolate lung by endobronchial DLT or SLT or bronchial blocker - Withdraw PAC several centimetres, leaving it in the main PA. Do not inflate the balloon (except with fluoroscopic guidance) - Position pt with isolated bleeding lung nondependent. Administer PEEP to the bleeding lung if possible - Transport the patient to medical imaging for diagnosis and embolisation if feasible

Answer 240

B) fentanyl Drugs which have the least impact on SSEPs 1. Ketamine 2. Opioids 3. Dexmedetomidine Article in Anaesthesiology https://pubs.asahq.org/anesthesiology/article/99/3/716/40407/Pharmacologic-and-Physiologic-Influences-Affecting o SSEPs = small amplitude potentials measured over the sensory cortex or via epidural electrodes from stimuli applied to the posterior tibial nerves. SSEPs are transmitted via the posterior columns of the spinal cord in the territory of the posterior spinal arteries which supply the posterior 1/3 of the cord. As they are low amplitude they are affected by basal muscle tremor and the signal-to-noise ratio is improved by increasing the depth of muscle relaxation. Their use is not significantly affected by therapeutic concentrations of anaesthetic vapours o MEPs = series of short-duration constant current stimuli of 300-700 V applied to the motor cortex and measured via needle electrodes inserted into tibialis anterior, abductor halluces and vastus medialis muscles along with selected small muscles of the hands for reference. MEPs rely on corticospinal tract integrity which lies in the territory of the anterior spinal artery. MEPs therefore complement SSEPs in their assessment of spinal cord function. MEPs are large amplitude potentials and are incompatible with profound muscle relaxation. Neuromuscular blocking agents are therefore best avoided or given by infusion and dose optomised with discussion with the technicians (or just give remi). o All anaesthetic vapours reduce MEP amplitude in a dose-dependent manner, and more than 0.5 MAC are not compatible with reliable monitoring. Thus Propofol TIVA is preferred. * Remifentanil is commonly used due to low context sensitive half life and negligible effect on intraop evoked responses

Answer 241

Sx and exacerbations FEV1 GOLD ABE assessment tool

Answer 242

C. 3 Subject repeat but different stem

Answer 243

b. GA Independent predictors for severe BCIS were: ASA grade III—IV chronic obstructive pulmonary disease medication with diuretics or warfarin Source: BJA 2014 Article https://academic.oup.com/bja/article/113/5/800/2920080

Answer 244

d) Creatinine - Originally devised to predict outcomes in Cirrhotic patients undergoing portosystemic Surgery - Assess perioperative risk for patients with liver disease who undergo hepatic or non-hepatic surgery - Factors include: o Encepahlopathy § None +1 § Mild to moerate + 2 § Severe +3 o Ascites § None +1 § Mild to moderate (diuretic responsive) +2 § Severe (diuretic refractory) +3 o Bilirubin § <2 mg/dl +1 § 2-3mg/dl +2 § >3 mg/dl +3 o Albumin § >3.5g/dl +1 § 2.8-3.5g/dl +2 § <2.8g/dl +3 o INR § <1.7 +1 § 1.7-2.3 +2 § >2.3 +3 - Class A 5-6 points o 1-5yr survival rate 95% - Class B 7-9 points o 1-5 year survival rate 75% - Class C 10-15 points 1-5 yr survival rate 50% Original study Mortality rates in patients who undergo abdominal surgeries: - Class A 10% - Class B 82% - Class C 82% Newer Study mortality rates after surgery: - Class A 2% - Class B 12% - Class C 12% Drawbacks: - Subjective measurement of: o ascites o encephalopathy - Does not consider o Pre-op infection o Aetiology of cirrhosis o Surgery type

Answer 245

B. 29 PaCO2= 1.5 x 14 + 8 PaCO2= 21 + 8 PaCO2= 29 Winter’s formula: expected PaCO2 = [1.5 x (serum HCO3)] + [8±2] if PaCO2 lower, there is a concomitant primary respiratory alkalosis if PaCO2 higher, there is a concomitant primary respiratory acidosis

Answer 246

d) Pulmonary hypertension Normal spirometry + low DLCO Asthma: obstructive pattern and normal DLCO Obesity: restrictive pattern and normal DLCO Sarcoid: restrictive pattern and low DLCO

Answer 247

Warm ischaemia time: - Time from treatment withdrawal to the start of cold perfusion of the donated organs - Significance is the impact on graft function - Most important phase of WIT begins when the systolic BP is < 60mmHg - This includes the waiting period from the absence of circulation to the declaration of death and the time before initiating the flow of cold perfusate through the cannula Maximum WARM Ischaemia time - Heart 30 mins - Liver 30 mins - Pancreas 30 mins - Kidney 60 mins - Lungs 90 mins Maximum COLD Ischaemia time: - Heart = 4 hrs - Lungs = 6-8hrs - Liver/Pancreas = 12hrs (DBD)/6 hrs (DCD) - Kidneys = 18hrs (DBD)/ 12 hrs (DCD)

Answer 248

c) 20mcg Adr IV ANZAAG use Ring and Mesmer scale for anaphylactic reactions as a base for classifying anaphylaxis grade (see image) From sunny coast QH document With PAGS ‘Life Threatening Anaphylaxis’ can be distinguished from ‘Moderate Anaphylaxis’ in an adult by the presence of any one of these signs: * systolic blood pressure of <60 mmHg * life-threatening tachy- or bradyarrhythmia * oxygen saturation <90% * inspiratory pressures of >40 cmH2 | Life-threatening anaphylaxis

Answer 249

e) Decreased SVR - increased CO, increased SBP and decreased DBP with widened PP UP TO DATE: Cardiovascular effects of hyperthyroidism: - Thyroid hormone has important effects on cardiac muscle, the peripheral circulation, and the sympathetic nervous system that alter cardiovascular hemodynamics in a predictable way in patients with hyperthyroidism. - The main changes are : ●Increases in heart rate, cardiac contractility, systolic and mean pulmonary artery pressure, cardiac output, diastolic relaxation, and myocardial oxygen consumption ●Reductions in systemic vascular resistance and diastolic pressure

Answer 250

c) Medial cord

Answer 251

C Methionine Synthetase Inhibitor

Answer 252

Give 3mg of Vitamin K and re-check on day of surgery proceed if INR <1.5 on DOS

Answer 253

c) 93% ANZCOR suggests against the routine administration of oxygen in persons with chest pain.13 [2015 COSTR, weak recommendation, very-low certainty evidence] For persons with heart attack, routine use of oxygen is not recommended if the oxygen saturation is >93% [National Heart Foundation of Australia & Cardiac Society of Australia and New Zealand: practice advice].9

Answer 254

b) Factor VII Redcross: Cryoprecipitate contains most of the following found in fresh frozen plasma: 1. factor VIII 2. fibrinogen 3. factor XIII 4. von Willebrand factor 5. fibronectin Prothrombinex-VF® is a lyophilised concentrate of human coagulation factors it contains: Factors: II IX X small amount of factor VII. Also contains: plasma proteins (human) Antithrombin III (human) Heparin sodium (porcine) Sodium Phosphate Citrate Chloride

Answer 255

Nitrous oxide Halothane & isoflurane cause catalytic destruction of ozone, but halothane hardly used and isoflurane has short atmospheric lifetime. Desflurane + sevoflurane don’t cause ozone depletion.

Answer 256

a) Amputation Top 10 Rank order: 1. Amputation 30-85% 2. Thoracotomy 5-67% 3. Mastectomy 11-57% 4. Inguinal hernia repair 0-63% 5. Sternotomy 28-56% 6. Cholecystectomy 3-56% 7. Knee arthroplasty 19-43% 8. Breast Augmentation 13-38% 9. Vasectomy 0-37% 10. Radical prostatectomy 35%

Answer 257

a) hypoxaemia After LA administration, any abnormal cardiovascular or neurological symptoms and signs, including isolated cardiac arrest, should raise suspicion of LAST Presenting features of LAST vary widely. Cardiovascular collapse may occur without preceding neurological changes. Clinical features of LAST: CNS - 2 stage process of excitatory phase followed by a depressive phase - early signs: 1. perioral tingling 2. tinnitus 3. slurred speech 4. lightheadedness 5. tremor 6. change in mental state: confusion and agitation - excitatory phase culminates in generalised convulsions -Depressive phase: 1. Coma 2. Respiratory depression CVS - 3 phases: - initial phase: Htn and tachycardia - intermediate phase: myocardial depression and hypotension - terminal phase: peripheral vasodialtion severe hypotension arrhythmias: 1. sinus bradycardia 2. conduction blocks 3. VT 4. Asystole

Answer 258

d) Gentamicin Drugs in the anaesthetic trolley that may unmask or worsen MG: - NMBs - gentamicin - beta blockers (metoprolol) - magnesium Anaesthetic drugs to be cautious with: - dexamethasone - antipsychotics - anticonvulsants - antibiotics (vancomycin, metronidazole)

Answer 259

d) Fixed upper Airway obstruction Fixed upper airway obstruction (can be intrathoracic or extrathoracic): flow limitation and flattening are noted in both the inspiratory and expiratory limbs of the flow-volume loop.

Answer 260

7. Radial Nerve

Answer 261

c. 9 AHA guidelines 12 Months But 12 weeks minimum Although the evidence between surgical timing and stroke risk is limited to only these 2 studies, we suggest that elective noncardiac surgery be deferred at least 6 months after a prior stroke, and possibly as long as 9 months to reduce the risk of perioperative stroke in patients undergoing noncardiac surgery. Alternatively, patients who stand to gain significant improvements in quality of life with elective surgery may consider waiting only 6 months after a prior stroke REPEAT

Answer 262

d. Lumbosacral trunk

Answer 263

a) Increase PVR UTD: Low cardiac output "ebb," phase (resuscitative phase) – In the first 48 hours after a major burn, cardiac output (CO) is reduced up to 60 percent from baseline due to: 1. hypovolemia from permeability-induced plasma loss 2. reduced myocardial response to catecholamines 3. increased systemic vascular resistance due to elevated vasopressin levels 4. depressed myocardial contractility 5. possible myocardial ischemia due to decreased coronary blood flow The large volumes that these patients require can sometimes result in over-resuscitation, leading to pulmonary edema and right heart failure. High cardiac output "flow," phase (recovery phase) During the recovery phase 72 to 96 hours postburn, hyperdynamic and hypermetabolic responses result in: 1. increased CO 2. Tachycardia 3. increased myocardial oxygen consumption 4. decreased systemic vascular resistance Elevation of catecholamines in major burns produces: 1. hyperdynamic circulation 2. augments energy expenditure 3. romotes protein catabolism in skeletal muscle. Nonselective beta blocker therapy is sometimes used to block catecholamine receptors, treat cardiac dysfunction, and modulate the hyperdynamic response during this phase

Answer 264

C. Cryoprecipitate contains Factor VIII, XIII, fibrinogen (factor I), fibronectin, vWF ## Footnote https://www.lifeblood.com.au/health-professionals/products/blood-components/cryoprecipitate

Answer 265

hypoCALCEMIA Hydrofluoric acid: highly corrosive inorganic aacid of element fluorine - used in glass etching, electronics industry and cleaning solutions for metals, stone and marble - dilute solutions can rapidly penetrate the skin and exposure of even a small area can be fatal (2%TBSA) Fluoride ions bind with calcium and magnesium ions in the tissues -> significant hypocalcaemia and hypomagnesaemia -> Hyperkalaemia may also be seen Direct cardiotoxic effects of fluoride ions can lead to cardiac arrhythmias that are difficult to treat

Answer 266

d. Early deflation https://litfl.com/intra-aortic-balloon-pump-trouble-shooting/ Waveform features: > There is a sharp drop in pressure immediately following the peak of diastolic augmentation (peak B). > Diastolic augmentation may be suboptimal but it is difficult to confirm in the absence of a pressure scale or comparison to an unassisted waveform. > Assisted aortic end-diastolic BP may be sub-optimally increased (trough C), but it is difficult to say based on the information given. With early deflation a widened U-shaped trough is typically seen. > Early deflation can lead to an assisted aortic end-diastolic BP that equals or exceeds the unassisted aortic end-diastolic BP (trough F), although this is not the case in this scenario. > Assisted SBP (peak D) is the same or higher than the unassisted SBP (peak A) – it should be slightly less. Early IAB deflation may result in: > inadequate coronary perfusion, with the potential for retrograde coronary blood flow. This may result in angina due to decreased myocardial oxygen supply. > suboptimal afterload reduction and increased myocardial oxygen demand How to correct: Prolong the IAB inflation time, so that it deflates at the end of diastole, just before the onset of isovolumetric systolic contraction.

Answer 267

D. 30 ml/kg Identification and Management of Obstetric Hemorrhage Anesthesiology Clinics - Obstetric Anesthesia (2017) https://www.anesthesiology.theclinics.com/article/S1932-2275(16)30074-X/fulltext Although FFP, cryoprecipitate, and fibrinogen concentrates can all be used to increase fibrinogen levels, the optimal strategy for managing hypofibrinogenemia in obstetric hemorrhage is unclear. The relatively low concentration of fibrinogen in FFP limits its usefulness in the treatment of significant hypofibrinogenemia. To increase fibrinogen plasma level by 1 g/L, 30 mL/kg of FFP is necessary, increasing the risk of pulmonary edema and other hypervolemic complications. Cryoprecipitate, which is a concentrated source of fibrinogen, factor VIII, fibronectin, von Willebrand factor (vWF), and factor XIII, will increase fibrinogen levels by ~0.7 to 1 g/L for every 100 mL given. Although cryoprecipitate is associated with a lower transfusion volume, the standard “dose” (10 U) is typically prepared by pooling concentrates from multiple donors. Given the risk of infectious disease transmission and/or an immunologic reaction from exposure to multiple donors, several countries preferentially use purified, pasteurized fibrinogen concentrate for the treatment of congenital and/ or acquired hypofibrinogenemia. Fibrinogen concentrates are also prepared from large donor pools, but subsequent processing removes or inactivates potentially contaminating viruses, antibodies, and antigens. Studies comparing cryoprecipitate and fibrinogen concentrates utilization in hemorrhage resuscitation suggest fibrinogen concentrates are associated with lower blood loss, decreased RBC transfusion, and greater increases in plasma fibrinogen levels. Although the most appropriate method of fibrinogen replacement is somewhat controversial, the critical role of fibrinogen in reversing the coagulopathy accompanying obstetric hemorrhage is clear. As such, close monitoring and replacement of fibrinogen are crucial in the management of the bleeding parturient.

Answer 268

a. 35 Major updates (2022) to 1991 National Institutes of Health guidelines for bariatric surgery Metabolic and bariatric surgery (MBS) is recommended for individuals with a body mass index (BMI) 35 kg/m2 , regardless of presence, absence, or severity of co-morbidities. MBS should be considered for individuals with metabolic disease and BMI of 30-34.9 kg/m2 BMI thresholds should be adjusted in the Asian population such that a BMI 25 kg/m2 suggests clinical obesity, and individuals with BMI 27.5 kg/m2 should be offered MBS. Long-term results of MBS consistently demonstrate safety and efficacy. Appropriately selected children and adolescents should be considered for MBS. https://www.soard.org/article/S1550-7289(22)00641-4/fulltext#:~:text=The%201991%20NIH%20Consensus%20Statement,surgery%20that%20is%20applied%20universally.

Answer 269

A or D International subarachnoid aneurysm trial (ISAT) of neurosurgical clipping versus endovascular coiling in 2143 patients with ruptured intracranial aneurysms: a randomised comparison of effects on survival, dependency, seizures, rebleeding, subgroups, and aneurysm occlusion Findings: In patients with ruptured intracranial aneurysms suitable for both treatments, endovascular coiling is more likely to result in independent survival at 1 year than neurosurgical clipping; the survival benefit continues for at least 7 years. The risk of late rebleeding is low, but is more common after endovascular coiling than after neurosurgical clipping.

Answer 270

b. 60 BJA Article - Management of cardiac arrest following cardiac surgery - BJA Education In the CICU, the effectiveness of ECC is confirmed by monitoring the arterial pressure trace with a target compression rate and depth to achieve a systolic impulse of > 60 mm Hg to maintain a mean perfusion pressure, preventing ventricular distension, LV wall stress, and ischaemia.

Answer 271

D Na 154, 308 mOsm/L

Answer 272

a) Bleeding ECMO complications: - patient complications: bleeding & coagulopathy most common - mechanical complications: access insufficiency common Blue book 2017

Answer 273

c. Pneumonia Complete white-out of left lung with air bronchogram sign consistent with total consolidation. Patchy areas of ground glass opacities in right lung. There is silhouetting of the left heart border and left hemi-diaphragm. There is no rib crowding to suggest atelectasis. Complete white-out of the hemithorax with air bronchograms and trachea in a central position is consistent with consolidation secondary to pneumonia. The patient is on linezolid, micafungin, and piperacillin-tazobactam pending culture and susceptibility studies. Differential diagnosis of hemithorax white-out with a midline trachea include: - consolidation - pulmonary edema/ARDS - pleural mass - chest wall mass

Answer 274

Hypoplastic mandible (micrognathia) – difficult intubation § Pierre Robin sequence § Treacher Collins § Hemifacial microsomia (Goldenhar syndrome) Midface hypoplasia – difficult bag-mask ventilation § Apert syndrome § Crouzon syndrome § Pfeiffer syndrome § Saethre-Chotzen syndrome Macroglossia – difficult bag-mask ventilation AND difficult intubation § Hurler’s/Hunter’s syndrome (mucopolysaccharidoses) § Beckwith-Wiedemann syndrome § Down’s syndrome https://www.frca.co.uk/Documents/250%20The%20Difficult%20Paediatric%20Ai Mucopolysaccharidoses, Down syndrome, muscular dystrophies, and other neurologic disorders have been associated with obstructive sleep apnea Prevalence of OSAS. Genetic Disorder Prevalence of OSAS Neuromuscular diseases 69.2% Prader–Willi syndrome 94.7% Arnold–Chiari syndrome 80% Achondroplasia 100% Crouzon syndrome 100% https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8156845/ | https://www.frca.co.uk/Documents/250%20The%20Difficult%20Paediatric%20Ai

Answer 275

b. 18ml 3mg/kg max dose as per RCH guidelines 3mg x 30kg = 90mg 90mg/5mg/ml = 18ml or 0.6ml/kg of 0.5% Lignocaine 0.6ml x 30kg = 18ml https://www.rch.org.au/clinicalguide/guideline_index/Bier_block/

Answer 276

Acromegaly IGF-2 is consistently elevated GH should be suppressed by glucose load in healthy pt. The continued elevation of GH despite glucose is suggestive of acromegaly

Answer 277

B: Vastus Medialis

Answer 278

e Plasma esterases Plasma esterases (not cholinesterase) Esmolol metabolism is via RBC esterases.

Answer 279

400mls of clear fluids pre op Safe upper limit - definitely has not not been identified and will vary from patient to patient. Clear fluids Water / CHO rich fluids / pulp free fruit juice / clear cordial / black tea and coffee

Answer 280

c. Full stomach with liquids and Air

Answer 281

a. Proceed with lobectomy or pneumonectomy FEV1 surgical suitability: - >80% or >2l pneumonectomy ○ no further testing required - >80% or >1.5l lobectomy ○ no further testing required - <80% or <2l for pneumonectomy ○ -> calculate ppoFEV1 - <80% or <1.5l for lobectomy ○ -> perform DLCO and express as % of predicted DLCO ○ Saturations on air - ppoFEV1 < 40% and DLCO <40% = High Risk - ppoFEV1 >40% and DLCO >40% and SaO2 >90% = Average risk (no further testing)

Answer 282

B. Normal 2,3 DPG higher Hct-60% No immunimodulation require reinfusion within 6hrs pause with sement, caution metal fragments

Answer 283

4. Medial Cutaneous nerve of the forearm

Answer 284

b) Diaphragm

Answer 285

Extensive Brachial plexus anatomy questions produced in 2022.2 paper on Brainscape

Answer 286

c. 5mg/kg Methylene blue due to its monoamine oxidase(MAO) inhibiting property may precipitate potentially fatal serotonin toxicity at doses >5mg/kg. Source: STAT PEARLS - Methylene blue https://www.ncbi.nlm.nih.gov/books/NBK557593/

Answer 287

b) Myasthenia Gravis

Answer 288

d) Warfarin Warfarin – no effect on thrombin time Heparin - causes considerable prolongation of TT. LMWH, fondaparinux or direct factor Xa inhibitors have no effect on TT as the predominantly inhibit factor Xa. -> However LMWH in very high concentration can affect TT. Dabigatran, Bivalirudin and other direct thrombin inhibitors prolong TT considerably. The thrombin time (TT), also known as the thrombin clotting time (TCT) is a blood test that measures the time it takes for a clot to form in the plasma of a blood sample containing anticoagulant, after an excess of thrombin has been added. Warfarin prevents thrombin synthesis but does not inhibit it, therefore no effect on TT.

Answer 289

c) lateral antebrachial https://anatomytool.org/content/radiopaedia-drawing-contents-superficial-cubital-fossa-english-labels ## Footnote double check - no reference

Answer 290

d. Noradrenaline Supportive Management of Massive PE Coexisting left ventricular systolic dysfunction and diastolic dysfunction complicate the management of heart failure patients with massive PE. Although a common strategy in response to systemic arterial hypotension is to prescribe a fluid bolus, volume loading may worsen biventricular failure, pulmonary edema, and hypoxemia. An initial trial of volume expansion, limited to 250 to 500 mL, may be attempted in those heart failure patients without evidence of increased right-sided filling pressures or pulmonary edema.6 Although non–heart failure patients generally respond well to pure vasopressors for hemodynamic support in massive PE, many heart failure patients will not tolerate the isolated increase in systemic vascular resistance. PE patients with heart failure may require an agent with mixed vasopressor and inotropic properties such as norepinephrine, epinephrine, or dopamine. Whereas LV function often becomes hyperdynamic to compensate for RV failure, the presence of underlying LV systolic dysfunction in heart failure patients may limit the patient’s ability to maintain normal systemic cardiac output and may necessitate the addition of inotropes. https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.108.803965

Answer 291

c) Normothermia - TTM to 32-36 degrees is recommended for those that remain unresponsive

Answer 292

PTx Commented from example image: The stratosphere sign. Absent lung sliding on M-mode in a patient with a pneumothorax. Notice the absence of T lines (the lung pulse) LITFL The ultrasound appearance of pneumothorax 1. Loss of lung sliding and the movement artefact deep to the pleural line - A pneumothorax lies deep to the smooth parietal pleural surface. - The gas interface creates a highly reflective surface reflecting all ultrasound energy. - This prevents imaging of structures lying below the pneumothorax. The movement of the lung, deep to the pneumothorax is completely hidden – lung sliding is lost. 2. Loss of characteristic B-lines - B-lines (vertical short path reverberation artefacts) are created by alveolar and interstitial fluid or fibrosis at the lung surface. - In the same way that pneumothorax hides lung sliding it also hides any B-lines lying below. 3. Increased clarity of A-lines - A-lines (horizontal long path reverberation artefacts) are echogenic horizontal artifactual lines deep to the pleural surface that are characteristic of pneumothorax. - The mirror like, flat parietal pleura overlying the pneumothorax reflects the ultrasound which often then reverberates between the pleural surface and other horizontal reflecting surfaces above. These include fascial planes and the transducer surface itself. - Multiple reflections cause horizontal linear artefacts mirroring the flat surfaces above the pleural surface, deep to the pleural surface. 4. Lung Point - Pneumothorax separates the visceral and parietal pleural surfaces. - The point at which these surfaces meet is known as the lung point

Answer 293

b. Rocuronium 1.2mg/kg Cis not appropriate for intubation Sux with K 6.3 is risky. (I've never heard of reduced dose)

Answer 294

d. Ferritin ANZCA blue book: ACD caused primarily by inflammation Mechanism: 1. Iron - Inflammation reduces Iron availabilty as a protective mechanism whereby Iron is sequestered and stored in macrophages to limit availability to microbial pathogens - Hepcidin expression is increased, this prevents the release of Iron by reticuloendothelial system resulting in "functional iron deficiency" with reduced tissue availability of iron, despite apparently normal total body iron stores. (hence increased Ferritin) 2. Response to erythropoietin - mechanism not clear suspect blunting of response to erythropoietin 3. Therapeutic agents chemotherapies that impair bone marrow response to erythropoiesis 65% of patients with lung and gynae cancer treated with platinum based drug develop anaemia RCPA advice on interpretation of Soluble Transferrin Receptor: Soluble transferrin receptor levels in plasma are elevated if there is increased iron demand due to Iron deficiency, increased erythropoiesis (eg, Haemolysis) or dyserythropoiesis (eg, Megaloblastic anaemia), regardless of other, coexistent states. Thus, it can be used to demonstrate iron deficiency in patients who also have an acute phase response and it can distinguish Iron deficiency from the Anaemia of chronic disease. Patients with an acute phase response have reduced plasma iron and transferrin with elevation of Ferritin, making these usual indicators unreliable.

Answer 295

a. Sevoflurane, morphine, phenylephrine Moclobemide = MAOi

Answer 296

E. Maintain sBP 140-180 https://journals.lww.com/jnsa/Fulltext/2014/04000/Society_for_Neuroscience_in_Anesthesiology_and.1.aspx We recommend that hemodynamic monitoring and management, as outlined below, should be started as soon as diagnosis of AIS has been made (class IIa, level of evidence C). Heart rate and cardiac rhythm should be monitored continuously and blood pressure should be monitored continuously or measured at least once every 3 minutes. We recommend that systolic blood pressure should be maintained >140mm Hg (fluids and vaso- pressors) and <180mm Hg (with or without IV tPA), and diastolic blood pressure <105 mm Hg (class IIa, level of evidence B). Cause of hypotension should be investigated (volume depletion, myocardial infarction, cardiac arrhythmia, blood loss, retroperitoneal hemorrhage, and aortic dissection) and treated if possible. We also recommend that blood pressure targets may be adjusted (lowered) in communication with the neuro- interventionalists and neurologists following successful recanalization of occluded vessel(s) (class IIb, level of evidence C), as reperfused brain often lacks autor- egulation leading to high risk of hyperperfusion leading potentially to hemorrhagic conversion.

Answer 297

e) Decreased 40% Infra-renal aortic cross-clamping leads to a reduction in renal blood flow by up to 40%, as a result of an increase in renal vascular resistance of up to 75%. The mechanism underlying this increased resistance is uncertain but may, in part, be a result of the associated decrease in cardiac output during aortic cross-clamping, as well as because of humoral mechanisms, which lead to increased release of renin. After declamping, there is a maldistribution of renal blood flow away from the cortex for at least 60 min.

Answer 298

e) Protamine The interpretation of this graph is not especially laborious. The cardinal abnormality is the massively prolonged CT and CF of the INTEM graph, which suggests that something has killed the intrinsic pathway of the clotting cascade. The CT returns to normal in the HEPTEM graph, which is essentially just an INTEM test with adde heparinase. The presence of heparinase seems to have reversed all of the coagulopathy - the CFT, alpha-angle and MCF have all returned to normal. Therefore, this patient has no coagulation problems other than the heparin. https://derangedphysiology.com/main/required-reading/haematology-and-oncology/Chapter 1.2.0.1/intepretation-abnormal-rotem-data

Answer 299

c) Vasopressin https://emcrit.org/ibcc/pressors/ - From UP TO DATE: > At low doses of 1 to 3 mcg/kg per min, dopamine acts primarily on dopamine-1 receptors to dilate the renal and mesenteric artery beds > At 3 to 10 mcg/kg per min (and perhaps also at lower doses), dopamine also stimulates beta-1 adrenergic receptors and increases cardiac output, predominantly by increasing stroke volume with variable effects on heart rate. > At medium-to-high doses, dopamine also stimulates alpha-adrenergic receptors, although a small study suggested that renal arterial vasodilation and improvement in cardiac output may persist as the dopamine dose is titrated up to 10 mcg/kg per min *clinically, the haemodynamic effects of dopamine demonstrate individual variability Dobutamine (inodilator): - selective β1-agonist that increases cardiac contractility and reduces pulmonary vascular and systemic vascular resistances Vasopressin: - vasopressin may have pulmonary vasodilatory effects in addition to a systemic vasoconstrictive effect Milrinone (inodilator): - the phosphodiesterase-3 inhibitors, milrinone and enxoimone, have positive inotropic effects combined with the capacity to reduce RV afterload (‘inodilators’) without significant chronotropic effect, but they can be associated with significant systemic hypotension

Answer 300

d. PCA https://case.edu/med/neurology/NR/SubarachnoidHemorrhag3%20Pcom.htm

Answer 301

d) Supraclavicular Axillary nerve innervates skin to inferior deltoid (regimental badge)+ motor to terres minor and deltoid. Lateral pectoral nerve innervates the anterosuperior part of the glenohumeral joint. Subscapular nerves - upper subscapular nerve serves the upper portion of the subscapularis muscle; the middle subscapular nerve (thoracodorsal nerve) innervates latissiumus dorsi; lower subscapular nerve innervates subscapularis and terres major. Supraclavicular nerve - sensory only and innervates skin across entire shoulder and trapezius in a ‘cape-like’ fashion - sometimes missed in interscalene block. Suprascapular nerve sensory innervation to glenohumeral joint and acromiovlavicular joint + motor to supraspinatus/infraspinatous (rotator cuff) https://pubmed.ncbi.nlm.nih.gov/32712453/

Answer 302

A Couldn't find a clear source but we know; A - will decrease venoplegia and improve venous return B - Would not help, decrease VR C - Don't drop FiO2 when desatting... D - increases PVR (unless below FRC) and reduces pulmonary flow E - Same as above, increased PVR and reduces flow through pulmonary circuit B. Decreasing the ventilator tidal volumes. Patients who have undergone the Fontan procedure depend on blood flow through the pulmonary circulation without the assistance of the right ventricle. The difference between central venous pressure and systemic ventricular end-diastolic pressure (termed the “transpulmonary gradient”) is the primary force promoting pulmonary blood flow and, more importantly, cardiac output. Circulation in the Fontan patient is promoted by low pulmonary vascular resistance. Positive-pressure ventilation with increased tidal volumes, as described above, can result in excessive intrathoracic pressures, leading to decreased venous return to the heart and increased pulmonary vascular resistance. In periods of low oxygen saturation, 100% inspiratory oxygen is appropriate. The addition of PEEP will increase intrathoracic pressure, reducing venous return. Trendelenberg positioning would increase CVP and therefore bloodflow through pulmonary circulation.

Answer 303

b. Myaesthenia gravis | ED95 is 0.8mg/kg in a MG patient

Answer 304

b) Variable extra-thoracic obstruction

Answer 305

Hypophosphataemia Ferric carboxymaltose (Ferinject) for iron-deficiency anaemia https://www.nps.org.au/radar/articles/ferric-carboxymaltose-ferinject-for-iron-deficiency-anaemia In this set of patients administered FCM (n = 5799), treatment-related side effects that occurred in more than 1% of the group included: - nausea (3.1%) - hypophosphataemia (1.9%) - injection-site reactions (1.6%) - headache (1.4%) - hypertension (1.3%) - dizziness (1.2%)

Answer 306

B Morphine Histamine-releasing

Answer 307

d. Stop volatile, calcium ?Duchenne muscular dystrophy? This patient most likely has Anaesthesia Induced Rhabdomyolysis (AIR) given the peaked Twaves and slow rise in ETCO2 Immediate MH Management: Stop administering Sevo, flush machine (or new), charcoal filters. Dantrolene.

Answer 308

b) flaccid paralysis Guillain–Barré syndrome (GBS) is an inflammatory disease of the PNS and is the most common cause of acute flaccid paralysis

Answer 309

R-wave peak

Answer 310

increased SVR EMSB handbook CO is reduced after Burn injury 2ry to: - myocardial depressant mediators - decreased blood volume - reduced venous return - increased pulmonary and systemic vascular resistance due to increased levels of catecholamines In the first 24hrs reduced cardiac output persists even after restoration of blood volume Between 24-48hrs post burn a hyperdynamic state develops with reduced peripheral resistance, increased oxygen consumption and increased cardiac output

Answer 311

e) Left lingula LEFT LUNG: ASIA ALPS Apical Posterior Superior lingula Inferior lingula Apical Anterior Anterior basal Lateral basal Posterior basal Superior RIGHT LUNG: A PALM Seed Makes Another little Palm RUL: Apical Posterior Anterior RML: Lateral Medial RLL Superior Medial basal Anterior basal Lateral basal Posterior basal

Answer 312

Repeat c) Breast milk 3 hours, clear fluids 1 hour to max 3ml/kg Infants <6 months having elective procedure * 4 hours for formula * 3 hours for breast milk * 1 hour for clear fluids (≤3 ml/kg/hr) Children > 6 months having elective procedure * 6 hours for limited solid food or formula * 4 hours for breast milk * 1 hour for clear fluids (≤ 3ml/kg/hr)

Answer 313

b) Pulmonary oedema B-lines >Vertical echogenic short path reverberation artefacts originating at the pleural line and extending to the deepest part of the ultrasound image. >They interrupt any horizontal A-lines. >Occasional B-lines are considered normal. >More than 3 B-lines in any single view is considered pathological. >Where there are numerous B-lines in close proximity they become confluent. >B-lines move with lung movement. >They are caused by ultrasound energy reverberating in a fluid filled focus that is surrounded by air. These foci may be interstitial or alveolar. >Cardiogenic and noncardiogenic oedema may have very similar appearances. >Interstitial thickening due to fibrosis or lymphangitis can also create the sonographic appearance of diffuse B-lines.

Answer 314

d) 100 x PPmax - PPmin / PPmean

Answer 315

d. Lateral Femoral Cutaneous

Answer 316

multiple sclerosis. https://academic.oup.com/bjaed/article/11/4/119/266998 Anaesthetic considerations. - Local anaesthetics may exacerbate symptoms due to the increased sensitivity of demyelinated axons to local anaesthetic toxicity. - Non-depolarizing neuromuscular blocking agents may be used in normal doses. Caution should be exercised when using depolarizing neuromuscular blocking agents if the patient is debilitated. - Temperature maintenance is important as symptoms can deteriorate with an increase in temperature, as demyelinated axons are also more sensitive to heat.

Answer 317

a) 100-200 2012 BERLIN DEFINITION OF ARDS ARDS is an acute diffuse, inflammatory lung injury, leading to increased pulmonary vascular permeability, increased lung weight, and loss of aerated lung tissue…[with] hypoxemia and bilateral radiographic opacities, associated with increased venous admixture, increased physiological dead space and decreased lung compliance. Key components - acute, meaning onset over 1 week or less - bilateral opacities consistent with pulmonary edema must be present and may be detected on CT or chest radiograph - PF ratio <300mmHg with a minimum of 5 cmH20 PEEP (or CPAP) - “must not be fully explained by cardiac failure or fluid overload,” in the physician’s best estimation using available information — an “objective assessment“ (e.g. echocardiogram) should be performed in most cases if there is no clear cause such as trauma or sepsis. Severity - ARDS is categorized as being mild, moderate, or severe:

Answer 318

a) Posterior Cord

Answer 319

Rectal indomethacin APMSE 5th edition 8.6.1.3: Only rectal NSAIDs are effective for reducing post ERCP pancreatitis, particularly indomethacin. Epidural > PCA for severe acute pancreatitis

Answer 320

a. Calcium (unless hyppocalcaemia is causing your seizures) Deranged Physiology: First line agents - Benzodiazepines: boluses every 2-5 minutes - Phenytoin: 20mg/kg loading dose Phenytoin on its own is useless. Or rather, it is inferior to benzodiazepines as a solitary agent. Always, both must be used simultaneously. Second line agents - Midazolam infusion - Phenytoin (well, rather, the American study recommends fosphenytoin) - Phenobarbital and levetiracetam are also in this second line of attack Third line agents: for refractory status epilepticus - Propofol infusion, or midazolam infusion, or thiopentone infusion. - At this stage, continuous EEG monitoring becomes mandatory - The role of traditional antiepileptic drugs is also exhausted at this stage, as there will probably be no benefit from adding them into a situation where a constantly observed burst suppression is already achieved by high dose anaesthetic infusion. Fourth line agents: for these, there is little evidence. - Volatile anaesthetic agents - Desflurane and Isoflurane - Ketamine - Lignocaine - Magnesium - Pyridoxine Fifth line therapies: - Hypothermia - Ketogenic diet - Deep brain stimulation - Surgical management

Answer 321

Phenoxybenzamine UpToDate Phenoxybenzamine is the preferred drug for preoperative preparation to control blood pressure and arrhythmia in most centers in the United States. It is an irreversible, long-acting, nonspecific alpha-adrenergic blocking agent. With their more favorable side-effect profiles and lower financial cost, selective alpha-1-adrenergic blocking agents (eg, prazosin, t erazosin, or d oxazosin) are utilized in many centers or are preferred to phenoxybenzamine when long-term pharmacologic treatment is indicated (eg, for metastatic pheochromocytoma).

Answer 322

A. Magnesium TdP UTD - BB specifically propanolol or nadolol if Hx of syncope / seizures or resus SCA ## Footnote https://www.uptodate.com/contents/congenital-long-qt-syndrome-treatment

Answer 323

A. Pecs 1 Sternum is innervated by intercostal nerves, which are branches of spinal nerves T1 to T11. PECS 1: hydrodissection of the plane between the pectoral muscles with local anesthetic to nerve block the lateral and medial pectoral nerves. PECS 2: Two fascial compartments by dividing the dose of local anesthetic between the pectoral nerves (the pectoral fascia and clavipectoral fascia) and under the pectoralis minor muscle (between the clavipectoral fascia and the superficial border of the serratus muscle). The local anesthetic should cover two important compartments of the fascias involved: The pectoral compartment with the pectoral nerves and the intercostal branches for the axilla and chest https://www.nysora.com/topics/regional-anesthesia-for-specific-surgical-procedures/thorax/pectoralis-serratus-plane-blocks/

Answer 324

b) 3 months | ANZCA PS09 2014 ## Footnote NB: PG09 was updated in 2022 and no longer states a minimum timeframe, so this is unlikley to return as an MCQ

Answer 325

e) Hydromorphone

Answer 326

d. 65 to 85 per hundred 85% of australians are CMV positive by the age of 40 https://www.blood.gov.au/system/files/documents/cmv-blood-components.pdf

Answer 327

Endothelial damage due to ischaemia

Answer 328

Cardiac Arrest Source: LITFL

Answer 329

A. Aspirin 150mg daily (option was definitely 150mg not 100mg) or D. Ca Aspirin should be given at a dose between 75 and 150 mg per day, started preferably before 16 weeks, possibly taken at night, and continued until delivery; https://www.somanz.org/content/uploads/2023/06/SOMANZ_Hypertension_in_Pregnancy_Guideline_2023.pdf Calcium supplementation (1.5g/day) should therefore be offered to women with moderate to high risk of preeclampsia, particularly those with a low dietary calcium intake (247)

Answer 330

Nebulised Adrenaline 1mg 0.5ml/kg of 1:1000 Adrenaline nebulised once adrenaline given consider dose of Steroid dexamethasone or hydrocortisone

Answer 331

A. Digitalis toxicity Miller’s The ECG made easy http://lifeinthefastlane.com/ecg-library/pmi/ Normal Q waves - Due to depolarisation of the interventricular septum from left to right - Seen in the left-sided leads (I, aVL, V5, V6) Pathological Q waves - > 1 mm depth - > 1 mm (= 40 ms) across Digoxin ECG changes - Therapeutic: prolonged PR interval (AV nodal delay), shortened QTC intervals (rapid ventricular repolarisation), ST depression (↓ slope of phase 3), T wave inversion - Toxic: atrial or ventricular arrhythmias (↑ automaticity), prolonged PR interval → heart block, SA node inhibition → sinus arrest - Atrial tachycardia with block = most common arrhythmia attributed to digoxin toxicity - VF = most frequent cause of death - QRS = normal! Q waves in MI - Occur with transmural infarctions, and are less likely with subendocardial infarctions - Develops days after the onset of AMI, and is usually permanent - Indicates the part of the heart that has been damaged LBBB ECG changes - Wide QRS - Wide QS complex in lead V1 - Wide R wave in lead V6 with slight notching at the peak and TWI - The axis is highly variable: can be normal or deviated to the left or right Wolff-Parkinson-White syndrome - Due to the presence of an accessory bundle between the atrium and ventricle, which has no AV node to delay conduction - Short PR interval - Early slurred upstroke of the QRS complex due to delta wave - Reciprocal leads will have Q wave like appearance

Answer 332

a) Closing capacity see graph in Millers

Answer 333

NIM tube: Neural Integrity Monitor Electromyogram Tracheal Tube

Answer 334

c. 30cmH2O paeds 20cmH20

Answer 335

Oscillations in the tube will be diminished

Answer 336

c) 5 back, 5 chest 4.1 Assess Severity The simplest way to assess severity of a FBAO is to assess for effective cough. 4.2 Effective Cough (Mild Airway Obstruction) The person with an effective cough should be given reassurance and encouragement to keep coughing to expel the foreign material. If the obstruction is not relieved the rescuer should call an ambulance. 4.3 Ineffective Cough (Severe Airway Obstruction) Conscious person If the person is conscious send for an ambulance and perform up to five sharp, back blows with the heel of one hand in the middle of the back between the shoulder blades. Check to see if each back blow has relieved the airway obstruction. The aim is to relieve the obstruction with each blow rather than to give all five blows. An infant may be placed in a head downwards position prior to delivering back blows, i.e. across the rescuer’s lap [Class B; LOE IV].1,2 If back blows are unsuccessful the rescuer should perform up to five chest thrusts. To perform chest thrusts, identify the same compression point as for CPR and give up to five chest thrusts. These are similar to chest compressions but sharper and delivered at a slower rate. The infant should be placed in a head downwards and on their back across the rescuer’s thigh, while children and adults may be treated in the sitting or standing position [Class B; LOE IV].1,2 With each chest thrust, check to see whether the airway obstruction has been relieved. The aim is to relieve the obstruction rather than deliver all five chest thrusts. If the obstruction is still not relieved and the person remains responsive, continue alternating five back blows with five chest thrusts. Unconscious person If the person becomes unresponsive a finger sweep can be used if solid material is visible in the airway.1,2 [Class A; LOE IV] Call an ambulance and start CPR.

Answer 337

d. autoimmune disease (with potential vascular complications) RANZCOG Maternal characteristics that are associated with an increased likelihood of pre-eclampsia include: - previous pre-eclampsia, particularly when more serious or early onset before 34 weeks - pre-existing medical conditions (including chronic hypertension, underlying renal disease, or pre-gestational diabetes mellitus), - underlying antiphospholipid antibody syndrome, - multiple pregnancy UTD: Preeclampsia: Prevention https://www.uptodate.com/contents/preeclampsia-prevention Based on the available data (see 'Evidence of efficacy' above), we recommend low-dose aspirin prophylaxis for women at high risk for preeclampsia. There is no consensus on the exact criteria that confer high risk. It is reasonable to use the US Preventive Services Task Force (USPSTF) high-risk criteria, which are also endorsed by the American College of Obstetricians and Gynecologists (ACOG). The incidence of preeclampsia is estimated to be at least 8 percent for pregnant women with any one of these high risk factors: ●Previous pregnancy with preeclampsia, especially early onset and with an adverse outcome ●Multifetal gestation ●Chronic hypertension ●Type 1 or 2 diabetes mellitus ●Chronic kidney disease ●Autoimmune disease with potential vascular complications (antiphospholipid syndrome, systemic lupus erythematosus)

Answer 338

b. AR https://litfl.com/oesophageal-doppler/

Answer 339

b. Femoral

Answer 340

d) Maintaining MAP >70 Recommends maintaining equal or greater than pts usual, or at least a SBP> 100mmHg https://www.resus.org.nz/assets/Uploads/ANZCOR-Guideline-11.7-Jan16.pdf

Answer 341

C. Between lowest renal artery to bifurcation of aorta https://litfl.com/reboa-in-resuscitation/ Anatomy: The aorta is divided into three separate zones for the purposes of REBOA (aortic length varies between individuals) Zone I of the aorta extends from the origin of the left subclavian artery to the coeliac artery (approx 20cm long in a young adult male) Zone II extends from the coeliac artery to the most caudal renal artery (approx 3cm long) Zone III extends distally from the most caudal renal artery to the aortic bifurcation (approx 10cm long) REBOA location based on injury: >suspected or diagnosed intra-abdominal haemorrhage due to blunt trauma or penetrating torso injuries (Zone I REBOA), or >blunt trauma patients with suspected pelvic fracture and isolated pelvic haemorrhage (Zone III REBOA), or >patients with penetrating injury to the pelvic or groin area with uncontrolled haemorrhage from a junctional vascular injury (iliac or common femoral vessels) (Zone III REBOA) Simplistic rendering of aorta. Zone 1 (from left subclavian artery to the upper border of the celiac trunk), Zone 2 (the upper border of the celiac trunk to the lower border of the distal take-off of the renal arteries), and Zone 3 (from the lower border of the lower renal artery to the aortic bifurcation). Zone 1 is occluded in the case of cardiac arrest or life-threatening intra-abdominal hemorrhage; Zone 2 has no current indication; and Zone 3 is occluded in the case of life-threatening pelvic or lower limb haemorrhage7. REBOA Resuscitative Endovascular Balloon Occlusion of the Aorta.

Answer 342

Bonus question e. Late deflation https://litfl.com/intra-aortic-balloon-pump-trouble-shooting/ Waveform features: > The peak corresponding to diastolic augmentation (peak C) is widened. > Assisted aortic end-diastolic BP (trough E) is the same as, not lower than, the unassisted aortic end-diastolic BP (trough G). > The upstroke of assisted systolic BP (peak F) has a gentle gradient resulting in a prolonged rise. Late deflation of the IAB has these effects: > There is no afterload reduction. The inflated balloon may actually impede left ventricular ejection and increase the afterload. > Myocardial oxygen consumption will increase because the left ventricle experiences a longer period of isovolumetric contraction (when most myocardial oxygen consumption occurs) and has to contract against greater resistance (afterload). How to correct: > Shorten the IAB inflation time, so that the IAB deflates at the end of diastole – just before isovolumetric contraction of the left ventricle.

Answer 343

Arndt bronchial blocker - use with SLT - 9fr, loop around scope for positioning - suction to deflate lung

Answer 344

age Domains: 1. Cognition 2. General health status 3. Functional independance 4. social support 5. Medication use 6. Nutrition 7. Mood ?interpreted as mental illness in stem? 8. Continence 9. Functional performance Scoring 0-5= Not frail 6-7= Vulnerable 8-9= Mild Frailty 10-11= Moderate Frailty 12-17= Severe Frailty Easy way to remember is CONFUSION Cognition Overall Health Nutrition Function performance Urine incontinence Social support Independence Oral Meds Nightmares

Answer 345

a) Variable intra-thoracic obstruction Dynamic (or variable, nonfixed) intrathoracic obstruction: flow limitation and flattening are noted on the expiratory limb of the loop.

Answer 346

a) Normal lungs M-mode image demonstrating seashore sign seen with normal lung sliding.

Answer 347

b) severe dermatographia

Answer 348

? no recalled ? MPAP – PCWP = Transpulmonary gradient 27mmHg TPG = mPAP – PCWP

Answer 349

b) Propofol BJA: No evidence for contraindications to the use of propofol in adults allergic to egg, soy or peanut "No connection between allergy to propofol and allergy to egg, soy or peanut was found. The present practice of choosing alternatives to propofol in patients with this kind of food allergy is not evidence based and should be reconsidered."

Answer 350

a. Increases NIRS , decreases peripheral SctO2 up, SpO2 down. Source: Korean Journal Anaesthesia https://www.researchgate.net/publication/274570990_Effects_of_intravenously_administered_indocyanine_green_on_near-infrared_cerebral_oximetry_and_pulse_oximetry_readings

Answer 351

E. distance from anterior surface of dens to posterior surface of anterior arch of atlas The atlantodental interval is used in the diagnosis of atlanto-occipital dissociation injuries and injuries of the atlas and axis. The anterior atlantodental interval is the horizontal distance between the posterior cortex of the anterior arch of the atlas (C1) and the anterior cortex of the dens in the median (midsagittal) plane Normal values for anterior atlantodental interval are: radiographs: adults: males: <3 mm females: <2.5 mm 1 (although most authors describe <3 mm ref) children: <5 mm ref CT: adults: <2 mm

Answer 352

B) analyse the difference between the means of more than two groups

Answer 353

a. codeine Oxycodone B Morphine C Tramadol C Fentanyl C

Answer 354

Warm ischaemia time: - Time from treatment withdrawal to the start of cold perfusion of the donated organs - Significance is the impact on graft function - Most important phase of WIT begins when the systolic BP is < 60mmHg - This includes the waiting period from the absence of circulation to the declaration of death and the time before initiating the flow of cold perfusate through the cannula Maximum WARM Ischaemia time - Heart 30 mins - Liver 30 mins - Pancreas 30 mins - Kidney 60 mins - Lungs 90 mins Maximum COLD Ischaemia time: - Heart = 4 hrs - Lungs = 6-8hrs - Liver/Pancreas = 12hrs (DBD)/6 hrs (DCD) - Kidneys = 18hrs (DBD)/ 12 hrs (DCD)

Answer 355

a) Smaller bolus smaller total dose Marsh = more, Schnider = sparing Marsh based on mass alone = MMA Schnider includes senescence, sex = SSS

Answer 356

(base rate is 10%, experimental group is 8% (20% below 10%) therefore 100/ 2 = 50 or 1 divided by risk reduction population risk = 10/100 patients get PONV population risk + new antiemetic = 8/100 patients get PONV (8/100 as reduction by 20% with new drug) RR= 0.10-0.08=0.02 NNT= 1/RR =1/0.02 =50

Answer 357

b. 100mg QID 42mg IV Morphine = 126mg Oral Morphine 126/8= 15.75 15.75 x 25 = 393.75 (*400mg/day Tapentadol) Oral Tapentadol 25mg = 8mg Oral Morphine Oral Oxycodone 5mg = 8mg Oral Morphine Oral Tramadol 25mg = Oral Morphine 5mg Oral Hydromorphone 4mg = Oral Morphine 20mg S/L Buprenorphine 200mcg = 8mg Oral Morphine IV Oxycodone 5mg = Oral Morphine 15mg IV Morphine 5mg = Oral Morphine 15mg IV Hydromorphone 1mg = Oral Morphine 15mg

Answer 358

decreased SVR Hyperthyroidism causes a hyperdynamic circulation, characterized by increased cardiac contractility and heart rate, increased preload, and decreased systemic vascular resistance (SVR), resulting in significantly increased cardiac output https://www.sciencedirect.com/science/article/pii/S0735109718333795#:~:text=Hyperthyroidism%20causes%20a%20hyperdynamic%20circulation,in%20significantly%20increased%20cardiac%20output.

Answer 359

MR?? See UpToDate PAC interpreting

Answer 360

e) 54 ANZCA PS 29: 1. Ex-preterm infants at risk of post-op apnoea should not be considered for same day discharge unless they are medically fit and have reached a PMA of 54 weeks. 2. Term infants should not be considered for same day discharge unless they are medically fit and have reached a PMA of 46 weeks. SPANZA PS29 BP: Apnoea significant if: - lasts more than 15 seconds - HR <100 (or <30 from baseline) - SpO2 <90% Apnoea risks are: PMA, anaemia, chronic lung disease, pre-operative apnoea of prematurity Most post-op apnoea occur within first 2 hours In healthy infants, after 12 apnoea free hours, apnoea risk approaches preop levels in health infants infants should be monitored for 12 apnoea free hours high risk infants need to be admitted for a longer period of monitoring

Answer 361

b) Clear Proximal, Blue Distal https://www.medtronic.com/content/dam/covidien/library/us/en/product/intubation-products/shiley-laser-oral-nasal-tracheal-tube-information-sheet.pdf

Answer 362

Anaemia of chronic inflamation with iron deficiciency

Answer 363

Tramadol APMSE 5th edition: Tramadol is an effective treatment for neuropathic pain with NNT of 4.4 (95%CI 2.9 to 8.8) Alpha-2-delta ligands (gabapentinoids) are the only anticonvulsants with proven efficacy in the treatment of chronic neuropathic pain. At doses of 1,800 mg to 3,600 mg/d, gabapentin is effective in treating neuropathic pain, in particular caused by postherpetic neuralgia (NNT 6.7; 95%CI 5.4 to 8.7) Pregabalin Postherpetic neuralgia: 300 mg/d pregabalin (NNT 5.3; 95%CI 3.9 to 8.1) (4 RCTs, n=713) and 600 mg/d (NNT 3.9; 95%CI 3.1 to 5.5) (4 RCTs, n=732); * Painful diabetic neuropathy: 600 mg/d pregabalin (NNT 7.8; 95% CI 5.4 to 14) (5 RCTs, n=1,015); * Mixed or unclassified post-traumatic neuropathic pain: 600 mg/d pregabalin (NNT 7.2; 95%CI 5.4 to 11) (4 RCTs, n=1,367); * Central neuropathic pain (mainly SCI): 600 mg/d pregabalin (NNT 9.8; 95%CI 6.0 to 28) (3 RCTs, n=562). Amitriptyline NNT 4.6 (TCAs are effective in treatment of neuropathic pain (amitrip NNT 4.6)) Amitriptyline By order of favourable NNT: 1. TCAs (amitriptyline) NNT: 3.6, NNH: 9 2. Strong opioids NNT 4.3 NNH 11.7 3. Tramadol NNT: 4.7, NNH 12.6 4. SNRIs (duloxetine and venlafaxine) NNT 6.4, NNH 11.8 5. Gabapentin NNT: 7.2 NNH 25.6 6. Pregabalin NNT:7.7, NNH 13.9 ANZCA Pain book Treatment of chronic neuropathic pain after SCI (Guy 2016 GL). These guidelines recommend: * First line: pregabalin, gabapentin and amitriptyline; * Second line: tramadol and lamotrigine (in incomplete SCI); * Third line: Transcranial direct current stimulation (tDCS) alone and combined with visual illusion; * Fourth line: TENS, oxycodone and dorsal root entry zone lesions.

Answer 364

c) Wipe with detergent Laryngoscope handles: -non-critical devices -should be cleaned with detergent and water between each patient use. -If contaminated with blood, they should be washed and disinfected. Laryngoscope blades: -considered critical equipment because they may penetrate skin or mucous membranes, require sterilisation. Bougies: -Re-use of these items has been associated with cross-infection. -It is preferable that alternative single-use intubation aids are employed when possible Face Masks: -In contact with intact skin, these items are frequently contaminated by secretions -considered semi-critical, requiring cleaning and thermal disinfection

Answer 365

B. Aspiration Aspiration was the single commonest cause of death in anaesthesia events. Poor judgement was the likely root cause in many cases which included elements of poor assessment of risk (patient and operation) and failure to use airway devices or techniques that would offer increased protection against aspiration. Several major events occurred when there were clear indications for a rapid sequence induction but this was not performed.

Answer 366

b. Octreotide 50mcg bolus Vasoactive hormone release intra-operatively is best treated with intravenous boluses of 20–50 µg of octreotide, titrated to haemodynamic response. Vasopressin as an alternative vasoconstrictor that may be useful if prolonged vasoconstriction is required; however, the evidence base is small. It must be borne in mind that concomitant fluid losses, especially bleeding, may be responsible for intra-operative instability rather than hormone excess and that fluid resuscitation may be the answer rather than further octreotide therapy https://academic.oup.com/bjaed/article/11/1/9/285683

Answer 367

b. valsalva Fluid and magnesium - fixes all. But could also be conscious VT or something stupid....

Answer 368

CP b. Cerebral palsy ->sux and volatiles are not contraindicated -> presence of extrajunctional receptors may cause hyperkalaemia a. Becker muscular dystrophy -> essentially milder Duchenne's (see duchenne response to Sux) b. Cerebral palsy -> Sux and volatiles not contraindicated -> reduced MAC requirement -> increased sensitivity to muscle relaxants c. Guillain Barre -> sux contraindicated due to risk of hyperkalaemia -> increased sensitivity to Non depolarising NB d. Frederich’s ataxia -> sux should be avoided due to risk of hyperkalaemia e. Duchenne muscular dystrophy -> sux and volatiles contraindicated due to rick of hyperkalaemia and rhabdomyolysis

Answer 369

d) Reduced time to resumption of oral intake The effect of preoperative dexamethasone on early oral intake, vomiting and pain after tonsillectomy https://pubmed.ncbi.nlm.nih.gov/15979735/ Conclusion: Preoperative dexamethasone use significantly reduces early posttonsillectomy pain, improves oral intake and facilitates meeting the discharge criteria while using standard anesthesia technique and sharp dissection tonsillectomy without any significant side effects.

Answer 370

hypoxia Hypoxia Acidosis co morbidities: CVS ischaemia arrhythmias conduction abnormalities low ejection fraction Other extremes of age frailty conditions that cause mitochondrial dysfunction (e.g., carnitine deficiency); liver (delayed onset) kidney disease (delayed onset) Smaller patient Non-US guided blocks https://www.apsf.org/article/local-anesthetic-systemic-toxicity-last-revisited-a-paradigm-in-evolution/ Understanding factors that increase risk is vital, as identifying patients with an elevated susceptibility to LAST enables clinicians to modify treatment and reduce the risk. Hypoxia and acidosis were recognized decades ago as factors predisposing to LAST.5 More recently identified co-morbidities include pre-existing heart disease (especially ischemia, arrhythmias, conduction abnormalities, and low ejection fraction), extremes of age, frailty, and conditions that cause mitochondrial dysfunction (e.g., carnitine deficiency); liver or kidney disease can also increase the risk of delayed LAST by depressing local anesthetic metabolism or disposition.5 Interestingly, Barrington and Kruger2 examined a registry of ~25,000 peripheral nerve blocks performed in Australia from January 2007 to May 2012 and identified 22 cases of LAST (overall incidence, 0.87 per 1000). They found that ultrasound guidance lowered the risk of LAST (odds ratio, 0.23, CI: 0.088–0.59, p=0.002)—presumably a result of fewer unidentified intravascular injections and possibly lower volumes of the drug used to achieve a block. Nevertheless, no single method can completely eliminate these events and roughly 16% of reported LAST occurred despite the use of ultrasound. Barrington and Kruger also noted that small patient size was a risk factor for LAST. The role of skeletal muscle as a large reservoir compartment for local anesthetic may explain this phenomenon and was confirmed in a rat model by Fettiplace et al.6 It is reasonable to adjust local anesthetic dose in all such “at-risk” patients or possibly avoid peripheral nerve block or local anesthetic infusion entirely if the risk is deemed too consequential. Surprisingly, Barrington and Kruger found 16 cases involving ropivacaine and the remainder were lidocaine-induced; notably, the LAST rate with lidocaine was approximately 5 times greater than that for ropivacaine. NYSORA: LAST NYSORA Tips There is a greater likelihood for LA systemic toxicity in petite patients (small muscle mass), those at the extremes of age, and patients with preexisting heart disease or carnitine deficiency. Roughly half the cases of LAST are atypical, with no seizures (other CNS symptoms), only CV toxicity or delayed onset. The incidence of toxicity increases with injections near richly vascular areas. It is highest with paravertebral injections, followed by upper and lower extremity PNBs. Prevention of LAST-related morbidity requires optimizing a complete system for regional anesthesia: patient selection, nerve block choice, drug and dose, complete monitoring and use of USGRA when possible, and preparing for LAST by having a kit available and practicing with simulation. Prevention also includes raising awareness and educating our non-anesthesiology colleagues about proper use of LAs and risks, including management of LAST.

Answer 371

VA ecmo VA - bleeding (large bore arterial puncture)

Answer 372

E. Upper GI bleed Incompressible sites, large volume blood loss and mortality risk are a few of the things that made GI bleeds seem like a natural fit for TXA administration. Early research seemed promising, but trials were small. The HALT-IT trial examined over 15,000 patients to see if TXA reduced death [14]. Not only did TXA have no effect on mortality, it increased the risk of seizure and thromboembolic events. Take home: No demonstrated benefit with TXA in GI bleeding ## Footnote https://www.ems1.com/research-reviews/articles/understanding-txa-AFkqRLajUv46X7xV/

Answer 373

e) ERV e) ERV - diaphragm displaced by gravid uterus = reduced ERV and RV = decreased FRC FRC decreases by approximately 20 percent during the latter half of pregnancy, due to a decrease in both ERV and residual volume Chest wall configuration — Outward flaring of the ribs, which begins early in pregnancy, and the progressively enlarging uterus raise the diaphragm up to 4 cm above its usual resting position [6]. However, diaphragmatic excursion during respiration is not impaired and actually increases by up to 2 cm.

Answer 374

d) myasthenia gravis In contrast to other neuromuscular disorders, succinylcholine may be used in myasthenia gravis. The required dose may need to be increased by up to two-fold, as those with the disease show a relative resistance to the drug. Sux is not recommended in patients with neuromuscular disease due to: 1. presence of extrajunctional receptors and risk of hyperkalaemia and rhabodmyolysis 2. fasiculations causing temperomandibular muscle spasm preventing intubation Suxamethonium is contraindicated in patients with recent burns or spinal cord trauma causing paraplegia (can be given immediately after the injury, but should be avoided from approximately day 10 to day 100 after the injury), | ED95 is 0.8mg/kg in a MG patient

Answer 375

Addendum: Dabigatran is cleared by dialysis, which leads to a precipitous drop in the drug level, whereas rivaroxaban is not cleared by dialysis because 95% of rivaroxaban is protein bound. Apixaban is not removed by haemodialysis.4 Rivaroxaban has ~30% renal excretion and is not removed by dialysis Canberra Health Services https://www.canberrahealthservices.act.gov.au › Hemodialysis does not significantly influence the effects of dual antiplatelet therapy with aspirin or clopidogrel. Common Dialyzable Drugs Mnemonics BLISTMED and ISTUMBLED: B - Barbiturates L - Lithium I - Isoniazid S - Salicylates T - Theophyline/Caffeine (both are methylxanthines) M - Methanol, metformin E - Ethylene glycol D - Depakote, dabigatran Others - Carbamezepine I - INH/isopropyl alcohol S - Salicylates T - Theophylline U - Uremia M - Methanol B - Barbiturates L - Lithium E - Ethylene glycol D - Dabigatran, depakote

Answer 376

B RR = 0.25-0.2 = 0.05 NNT = 1/RR = 20

Answer 377

c) Ocular massage Hyalase Mixing with lignocaine Higher concentration Higher volume Occular pressure (spread and IOP reduction) Source: 2x BJA Ed articles

Answer 378

Answer: e) Bernoulli equation using tricuspid peak + RAP i.e. RVSP = 4v2 + RAP (~PAP in absence of RVOTO)

Answer 379

Fluoxetine

Answer 380

) Hypertension Talley & O'Connor CVS Exam: S3: Physiological in pregnancy; sign of LV failure; AR & MR S4: Never physiological, most often due to systemic hypertension Atrial gallop - stiff LV - hypertrophy or ischaemic ventricle Source CV phys

Answer 381

RCA Source: LITFL RCA occlusion is suggested by: ST elevation in lead III > lead II Presence of reciprocal ST depression in lead I Signs of right ventricular infarction: STE in V1 and V4R

Answer 382

= ΔP = 4v2 = 4 x 9 = 36

Answer 383

a. Bleeding repeat

Answer 384

RWMA Echocardiographic images recorded during ischemia show abnormalities of wall motion, thus allowing for the detection of significant coronary artery disease https://www.sciencedirect.com/topics/nursing-and-health-professions/stress-echocardiography

Answer 385

CO2 Laser danger is proportional to penetration. Penetration inversely proportional to the laser wavelength. CO2 laser has very little penetration (~ 10micrometres), as it has a wavelength of 10 600nm. Helium-Neon laser also has very little penetration. Nd:YAG is the most powerful, with a penetration of 2-6mm, as it has a wavelength of 1064nm.

Answer 386

c. dobutamine ## Footnote UTD

Answer 387

Dilated RA and RV

Answer 388

3 months full time Source: ANZCA PG 09

Answer 389

Size 7.0 The Tube The endotracheal tube has a length and diameter. The endotracheal tubes size (“give me a 6.0 tube”) refers to its internal diameter in millimeters (mm). The ETT will typically list both the inner diameter and outer diameter on the tube (for example, a 6.0 endotracheal tube will list both the internal diameter, ID 6.0, and outer diameter, OD 8.8).

Answer 390

a) Azygos vein Correct positioning in image

Answer 391

d) Encephalitis Complications of dural puncture include: 1. PDPH 2. hearing loss 3. pneumocephalus (if LOR to air) 4. chronic headache 5. chronic back pain 6. subdural haematoma 7. cerebral vein thrombosis 8. bacterial meningitis 9. diplopia 10. cranial nerve palsy 11. seizures

Answer 392

d) SpO2 88–92% oxygen administration/ low fio2 assumed bleomycin Bleomycin Bleomycin is a particularly important chemotherapy drug for the anaesthetist to be aware of. Bleomycin is often used to treat germ cell tumours and Hodgkin's disease in a curative setting. The major limitation of bleomycin therapy is the potential for subacute pulmonary damage that can progress to life-threatening pulmonary fibrosis. Pulmonary toxicity occurs in 6–10% patients and can be fatal.2 Exposure to high-inspired concentration oxygen therapy, even for short periods, as experienced during anaesthesia, is often implicated in causing rapidly progressive pulmonary toxicity in patients previously treated with bleomycin.3 These claims have been considered controversial by some, but it is the authors' recommendation that any patient previously exposed to bleomycin therapy should be treated as high risk, and summary guidance regarding oxygen therapy is shown in Table 4. Summary guidance—oxygen therapy for patients who have received bleomycin > Patients have a life-long risk of bleomycin-induced lung injury > Oxygen therapy should be avoided if at all possible > Clinical procedures (and leisure activities) involving a high should be avoided If a patient is hypoxic > O2 therapy should be minimized to maintain O2 saturation of 88–92% > High oxygen concentrations should be used with extreme caution for immediate life-saving indications only (to maintain O2 saturation of 88–92%)

Answer 393

Emboli Blue book repeat

Answer 394

albumin ALBUMIN AND PHOSPHATE the normal anion gap depends on serum phosphate and serum albumin the normal AG = 0.2 x [albumin] (g/L) + 1.5 x [phosphate] (mmol/L) albumin is the major unmeasured anion and contributes almost the whole of the value of the anion gap. every 1g/L decrease in albumin will decrease anion gap by 0.25 mmoles a normally high anion gap acidosis in a patient with hypoalbuminaemia may appear as a normal anion gap acidosis. this is particularly relevant in ICU patients where lower albumin levels are common Effects of albumin: Anion gap may be underesitmated in hypoalbuminaemia, because if albumin decreased by 1g/L then the anion gap decreases by 0.25 mmol To overcome the effects of the hypoalbuminaemia on the AG, the corrected AG can be used which is AG + (0.25 X (40-albumin) expressed in g/L

Answer 395

c) Normal 23 DPG https://www.bjaed.org/article/S2058-5349(20)30157-8/fulltext Advantages of Cell salvage: 1. reduction in need for donor blood transfusion 2. no restrictive transfusion triggers 3. superior oxygen delivery compared to donor blood -> red cells retain elliptical profiles and retain deformability -> increased concentrations of 2,3 DPG and ATP -> evidence supports early transfusion as oxygen carriage and deformability degrade over time 4. lack of adverse immunolgical effects -> no sensitisation to antigens; Kell, duffy or Lutheran -> donor blood transfusion causes dose-dependant transfusion related immunosupression (TRIM) this can lead to increased risk of post-op infection and posible increased risk of tumour growth in patients undergoing cancer surgery 5. Fulfills criteria for certain cultural groups to receive blood transfusion (JW) 6. Financial benefits despite equipment and staffing costs Disadvantages: 1. The salvaged blood contains clinically insignificant concentrations of clotting factors and platelets, and when large volumes of blood are processed, the use of clotting factors, platelets, and calcium may be necessary. 2. High initial cost of equipment and training 3. Processing of blood requires a few minutes, blood may not be immediately available in time critical scenariois 4. REinfusion hypotension can occur and can be very marked requiring vasopressors 5. More labor intensive than donor blood, increased diligence required when collecting blood 6. May not be appropriate for all situations of operative blood loss ->Malignancy: use is controversial but supported in some instances (cystectomy radical prostatectomy, nephrectomy) ->Sepsis: not absolute contraindication but colume of contaminated material and pus must be limited ->Haemaglobonpathy: relative contraindication in sickle cell trait/disease and thalassaemia due to red cell fragility and potential for haemolysis

Answer 396

f)Cricothyroid Nerve supply of larynx: 1. Superior laryngeal nerve: - Cricothyroid muscle - sensory supply to the interior of larynx down to vocal cords 2. internal laryngeal nerve - 3. Recurrent laryngeal nervs - motor supply to the intrinsic muscles of the larynx apart from cricothyroid - sensory supply to laryngeal mucosa inferior to the cords Intrinsic muscles of the larynx a) Posterior Cricoarytenoid - abducts the cords, opens the glottis - only muscle to open glottis b) Lateral Cricoarytenoid - adducts the cords and closes the glottis c) Interarytenoid - only unpaired muscle - closes the glottis - continues upwards to form the aryepiglottic muscle which acts as a weak sphincter d) Thyroarytenoid - relaxes vocal cords e) Vocalis -adjusts tension in the cords f) Cricothyroid - only intrinsic muscle that lies outside the cartilagenous framework - only tensor of the vocal cords actions of intrinsic laryngeal muscles 1. Abductor of the cords: posterior cricoarytenoids 2. Adductors of the cords: lateral cricoarytenoids, interarytenoids 3. Sphincter to the vestibule: aryepiglottics, thyroepiglotics 4. Tension regulators of the cords: Cricothyroids (tensors), Thyroarytenoids (relaxors), Vocales (fine adjustment)

Answer 397

Bonus question a. Correct timing https://derangedphysiology.com/main/required-reading/cardiothoracic-intensive-care/Chapter%20634/normal-iabp-waveform

Answer 398

a) 41mmHg Answer: RVSP = 4v2 + CVP 4x3x3+5 = 41

Answer 399

L hypoglossal The hypoglossal nerve innervates all the extrinsic and intrinsic muscles of the tongue, except the palatoglossus which is innervated by the vagus nerve. Injury to the hypoglossal nerve causes ipsilateral tongue deviation (pathognomonic), with dysarthria and dysphagia in severe cases. The tongue deviates towards the side that is affected due to the unopposed action of the contralateral genioglossus The symptoms and signs of hypoglossal neurapraxia are often self-limiting and 43% of diagnosed patients achieve resolution within 6 weeks of surgery and an additional 40% are symptom free within 6 months after surgery Nerves injured by SAD - Lingual nerve (2ry to tube) - Hypoglossal nerve (2ry to cuff) - Recurrent laryngeal nerve (2ry to cuff) Presenting symptoms and signs Lingual nerve: - loss of taste and sensation to tip of tongue Hypoglossal nerve: - dysphagia - dysarthria - tongue deviation in unilateral injury Recurrent laryngeal nerve: - altered voice - rarely: stridor Risk factors for injury: - use of nitrous oxide-> over inflation - selection of SAD that is too small-> over inflation - LMA maximum inflation pressure 60cmH2O

Answer 400

c) non-tunneled CVL UTD: In a systematic review that included 200 studies, the risk of catheter-related blood stream infection per 1000 catheter-days and varied by types of intravascular catheter were as follows [38]: ●Peripherally inserted central catheters (PICCs) – 1.1 (95% CI 0.9-1.3) ●Cuffed and tunneled central venous catheters – 1.6 (95% CI 1.5-1.7) ●Noncuffed central venous catheters *Nonmedicated and tunneled – 1.7 (95% CI 1.2-2.3) *Nonmedicated and nontunneled – 2.7 (95% CI 2.6-2.9) However, there was no adjustment for severity of illness. Therefore, a particular type of catheter could be associated with an increased risk of infection if it was preferentially used in more severely ill or vulnerable patients.

Answer 401

ALTERED 22.1 QUESTION D Spirometry FEV1 only GOLD 1 > 80% Pred GOLD 2 50-79% Pred GOLD 3 30-49% Pred GOLD 4 < 30% Pred

Answer 402

E. Decreased acute kidney injury Restrictive had more AKI Otherwise no outcome significant statistically https://www.thebottomline.org.uk/summaries/relief/

Answer 403

b. COHb level 10%

Answer 404

increased incidence of major bleeding

Answer 405

a) <1% low risk for 30 day adverse cardiovascular event. >5% high. 1-5% therefore moderate. https://www.ahajournals.org/doi/10.1161/circ.105.10.1257 Based on surgery type c) 10-15% (unlikely this) Based on patient factors alone, adults can be categorized into low (<5%), borderline (5 to <7.5%), intermediate (≥7.5 to <20%), or high (≥20%) 10-year CVD risk. Source: ACC/AHA Guideline 2019 https://www.acc.org/latest-in-cardiology/ten-points-to-remember/2019/03/07/16/00/2019-acc-aha-guideline-on-primary-prevention-gl-prevention https://www.jacc.org/doi/epdf/10.1016/j.jacc.2019.03.010

Answer 406

Vastus Medialis

Answer 407

B. NSTEMI https://resources.wfsahq.org/atotw/perioperative-myocardial-ischaemia-in-non-cardiac-surgery/ MI is defined as myocardial cell death due to prolonged myocardial ischaemia. It is diagnosed by22 a rise of cardiac biomarker value above the 99th percentile limit with at least 1 of the following: 1. Symptoms of ischaemia, 2. New ST-segment T wave changes or new left bundle branch block, 3. New pathological Q waves, 4. Imaging evidence of new loss of viable myocardium or new regional wall motion abnormality 5. Identification of an intracoronary thrombus by angiography or autopsy OR: Cardiac death with symptoms suggestive of myocardial ischaemia. It is important to note that the above diagnostic criteria have not been created for the perioperative setting. An elevated troponin after noncardiac surgery, even without other features of ischaemia independently increases the risk of 30-day mortality.21 With this in mind, a new perioperative diagnosis has been created—myocardial injury after noncardiac surgery (MINS). MINS is diagnosed by a postoperative peak troponin T of 0.03 ng/mL or greater due to myocardial ischaemia.21 Although a diagnosis of MINS has prognostic significance, the clinical utility remains uncertain. MINS is defined as myocardial cell injury during the first 30 days after noncardiac surgery due to an ischemic etiology (ie, no evidence of a nonischemic etiology like sepsis, rapid atrial fibrillation, pulmonary embolism, cardioversion, chronically elevated troponin, etc) and is independently associated with mortality. MINS includes MI (both symptomatic and non-symptomatic) and patients with postoperative elevations in troponin but who do not have symptoms, electrocardiographic abnormalities, or other criteria that meet the universal definition described above, and have no evidence of a nonischemic etiology for their troponin elevation) Circulation https://www.ahajournals.org/doi/10.1161/CIR.0000000000001024 MINS includes myocardial infarction and ischemic myocardial injury that do not fulfill the Universal Definition of Myocardial Infarction (myocardial injury with a rise or fall of cTn above the 99th percentile of the upper reference limit and at least 1 of the following: ischemic symptoms, new ischemic electrocardiographic changes, development of new pathological Q waves on ECG, imaging evidence of myocardial ischemia, or angiographic or autopsy evidence of coronary thrombus). MINS is defined by at least 1 postoperative cTn concentration that exceeds the 99th percentile upper reference limit of the cTn assay as a result of a presumed ischemic mechanism (ie, supply-demand mismatch or atherothrombosis) in the absence of overt nonischemic causes (eg, pulmonary embolus; Table 1). Such elevations in cTn must be identified within the first 30 days after surgery but nearly always occur within the first 2 postoperative days. Clinical symptoms and electrocardiographic changes are not required to establish a diagnosis of MINS, which includes myocardial infarction and ischemic myocardial injury.

Answer 408

E) ulnar nerve

Answer 409

c) Lowest FiO2 possible Bleomycin Bleomycin is a particularly important chemotherapy drug for the anaesthetist to be aware of. Bleomycin is often used to treat germ cell tumours and Hodgkin's disease in a curative setting. The major limitation of bleomycin therapy is the potential for subacute pulmonary damage that can progress to life-threatening pulmonary fibrosis. Pulmonary toxicity occurs in 6–10% patients and can be fatal. Exposure to high-inspired concentration oxygen therapy, even for short periods, as experienced during anaesthesia, is often implicated in causing rapidly progressive pulmonary toxicity in patients previously treated with bleomycin. These claims have been considered controversial by some, but it is the authors' recommendation that any patient previously exposed to bleomycin therapy should be treated as high risk, and summary guidance regarding oxygen therapy is shown:

Answer 410

D) Age Can Grandma Functionally Support Medication Nutrition Mood Continence Self i.e. C (cognition) G (general health) F (functional independence) S (social support) M (medication use) N (nutritional status) M (mood, presence of mental illness) C (continence) S (self reported performance)

Answer 411

100 < PaO2/FiO2 ≤ 200 with PEEP ≥5 cmH2O https://link.springer.com/article/10.1007/s00134-012-2682-1/tables/3

Answer 412

e) hypoglycaemia

Answer 413

d. Use lower frequency probe

Answer 414

b) Adrenaline -You do not use full dose adrenaline (rather, give smaller doses) -You do three "stacked shocks" -You try pacing (rate of 90, DDD) in asystole if pacing wires are available -If they are already paced and in PEA, you turn off the pacing to "unmask" VF. -These shocks and attempted pacing are all measures you take before starting CPR, which is a departure from the ACLS norms. -If you can't control a shockable rhythm with three stacked shocks, you give amiodarone immediately rather than after three cycles. -Amiodarone is the only drug in the protocol, which makes it easy to remember. - -After five minutes of unsuccessful resuscitation the chest should be re-opened. ---External CPR is pointless in all of the common causes of arrest in this scenario. Therefore, CPR is something you do while waiting to re-open the chest. -Non-surgical staff are encouraged to re-open the chest in an emergency ## Footnote https://derangedphysiology.com/main/required-reading/cardiac-arrest-and-resuscitation/Chapter%20221/cardiac-arrest-following-cardiac-surgery

Answer 415

photosensitivity Gliolan (PI): - Aminolevulinic acid hydrochloride (ALA) - Natural precurore of haeme, metabolised into fluorescent prophyrins - The fluorescence in certain tissue targets for photodynamic diagnosis - Increased fluorescent porphyrin formation by malignant glioma tissue (i.e. GBM) - After excitation with blue light (λ=400‑410 nm), PPIX is strongly fluorescent (peak at λ=635 nm) and can be visualised after appropriate modifications to a standard neurosurgical microscope. - Avoid exposure of eyes and skin to light sources afterwards (photosensivity). Contraindications: - hypersensitivity - porphyria - pregnancy Precautions: - After administration of Gliolan, exposure of eyes and skin to strong light sources (e.g. operating illumination, direct sunlight or brightly focused indoor light) should be avoided for 24 hours. - Co-administration with other potentially phototoxic substances (e.g. tetracyclines, sulfonamides, fluoroquinolones, hypericin extracts) should be avoided - Within 24 hours after administration, other potentially hepatotoxic medicinal products should be avoided. - In patients with pre-existing cardiovascular disease, Gliolan should be used with caution since literature reports have shown decreased systolic and diastolic blood pressures, pulmonary artery systolic and diastolic pressure as well as pulmonary vascular resistance.

Answer 416

C. 3 - if male CHA2DS2-VASc score ≥2 to be recommended chronic OAC (Grade 1A). - if female CHA2DS2-VASc score ≥3 to be recommended chronic OAC (Grade 1A). * non-sex risk factor also holds bearing: - For patients with CHA2DS2-VASc score of 1 in males and 2 in females based on age 65 to 74 years, we recommend chronic OAC (Grade 1A). Up to date: Our approach to deciding whether to prescribe anticoagulant therapy for patients with AF (excluding those with rheumatic mitral stenosis that is severe or clinically significant [mitral valve area ≤1.5 cm2], a bioprosthetic valve [surgical or bioprosthetic] within the first three to six months after implantation, or a mechanical heart valve) is as follows: *For a CHA2DS2-VASc score ≥2 in males or ≥3 in females, we recommend chronic OAC (Grade 1A). *For a CHA2DS2-VASc score of 1 in males and 2 in females: -For patients with CHA2DS2-VASc score of 1 in males and 2 in females based on age 65 to 74 years, we recommend chronic OAC (Grade 1A). Age 65 to 74 years is a stronger risk factor than the other factors conferring one CHA2DS2-VASc score point. -For patients with other risk factors, the decision to anticoagulate is based upon the specific nonsex risk factor and the burden of AF. For patients with very low burden of AF (eg, AF that is well documented as limited to an isolated episode that may have been due to a reversible cause such as recent surgery, heavy alcohol ingestion, or sleep deprivation), it may be reasonable to forgo chronic OAC and institute close surveillance for recurrent AF, although it may not be possible to reliably estimate AF burden from surveying symptoms or infrequent monitoring. The frequency and duration of AF episodes vary widely over time, and episodes are often asymptomatic. *For patients with a CHA2DS2-VASc of 0 in males or 1 in females, we suggest against OAC (Grade 2C). Patient values and preferences may impact the decision. For example, a patient who is particularly stroke averse and is not at increased risk for bleeding may reasonably choose anticoagulation, particularly if the patient is a candidate for treatment with a direct oral anticoagulant (DOAC). 2019 AHA/ACC/HRS Focused Update of the 2014 AHA/ACC/HRS Guideline

Answer 417

c) Prothrombinex | Has factors 2, 9, 10, heparin, ATIII

Answer 418

d) 7500mls Compared with the blood volume (65 to 70 mL/kg) in nonpregnant women, the blood volume in pregnant women at term is increased to 100 mL/kg

Answer 419

d) No difference Repeat Conclusions In patients undergoing mechanical ventilation, the rate of survival at 90 days associated with the use of an energy-dense formulation for enteral delivery of nutrition was not higher than that with routine enteral nutrition. (Funded by National Health and Medical Research Institute of Australia and the Health Research Council of New Zealand; TARGET ClinicalTrials.gov number, NCT02306746. opens in new tab.) https://www.nejm.org/doi/full/10.1056/NEJMoa1811687

Answer 420

c. Doxycycline 400mg Insertion of Mirena-> no antibiotics exception is acute PID-> clindamycin https://ranzcog.edu.au/wp-content/uploads/2022/05/Prophylactic-Antibiotics-in-Obstetrics-and-Gynaecology.pdf

Answer 421

b) Desflurane Atmospheric heat absorbed by a substance compared with CO2 is its GWP GWP CO2 = 1 GWP N20 = 265 (atmospheric lifetime of 114yrs) GWP sevo = 130 (atmospheric lifetime of 1.1yrs) GWP desflurane = 2540 (atmospheric lifetime of 14yrs)

Answer 422

Chronic obstructive pulmonary disease (COPD) is the most common cause of cor pulmonale leads to an increase in RV afterload secondary to changes in pulmonary vascular structure and mechanics, and lung hyperinflation. Patients with COPD who subsequently develop RV dysfunction have an increased risk of admission to hospital and mortality

Answer 423

d) The pooled data from all of the studies Forest plots or blobbograms are used in order to show graphically the studies which have been included in the meta-analysis. They demonstrate the differences between studies and provide an estimate of the overall result.

Answer 424

c) 1.0 Clinicians should consider DKA/euDKA in patients taking SGLT2i who have one or more of: - symptoms of abdo pain, nausea, vomiting, fatigue or metabolic acidosis (a normal or only modestedly elevated plasma glucose level does not exclude diagnosis) - finger prick capillary blood ketone ( or blood beta-hydroxybutyrate) level >1/0mmol/l with or without hyperglycaemia - Low (negative) Base Excess <-5mmol/l indicating metabolic acidosis on arterial or venous blood gasses If the blood ketone leve is >1.0mmol/l in an unwell patient on SGLT2i, take arterial or venous blood gases to measure the BE. If ketones >1.0mmol/l and BE <-5mmol/l the patient has presumed DKA If the BSL is <14mmol/l it is presumed euDKA > for a ward patient a MET team should be activated or ICU contacted for review in collaboration with endocrinology services > management priorities include: 1. Rehydration 2. IV insulin with added dextrose if BSL <15mmol/l 3. hourly monitoring of blood glucose, ketones and blood gases 4. All should be reviewed by an endocrinologist or on-call physician and critical care specialist

Answer 425

b. Probability of something Isoboles are two-dimensional graphs showing drug combinations throughout a clinical range that evoke some predefined effect (e.g. the 50% probability of tolerance to surgical incision). Response surface models are more complex but more informative.40 They predict the probability of clinical effect of the full clinical range of combinations of two drugs. This is often illustrated by a three-dimensional representation of the interaction throughout a spectrum of drug doses and drug effects. In this respect, a response surface model represents an infinite number of isoboles, representing numerous drug plasma concentration combinations https://academic.oup.com/bja/article/118/1/44/2763298

Answer 426

4 hours Redcross: "Transfusion of each pack should be completed prior to the labelled expiry or within four hours, whichever is sooner. " Shelf life of platelets: 5 days (Stored at 20-24 degrees, must be agitated gently and continuously) FFP: Once FFP is thawed, must use within 24 hours. Albumin administration: At RCH we allow the product to be administered within 6 hours of piercing the bottle. (from RCH.org) Cryoprecipitate Thawed cryoprecipitate should be maintained at 20°C to 24°C until transfused. Once thawed, should be used within six hours if it is a closed single unit, or within four hours if it is an open system or units have been pooled.

Answer 427

Hypotension Citrate is the anticoagulant used in blood products. It is usually rapidly metabolised by the liver. Rapid administration of large quantities of stored blood may cause hypocalcaemia and hypomagnesaemia when citrate binds calcium and magnesium. This can result in myocardial depression or coagulopathy. Patients most at risk are those with liver dysfunction or neonates with immature liver function having rapid large volume transfusion https://litfl.com/citrate-toxicity/ Hypocalcaemia resulting in long QT, reduced inotropy, hypotension systemic hypocoag Metabolic Met alk with HCO3 formation HAGMA with citrate accumulation Hypernatraemia from Na citrate Hypomag due to citrate chelation Hypokalaemia due to low mag and met alk

Answer 428

ASA 3 Source: ASA Classification https://www.asahq.org/standards-and-guidelines/asa-physical-status-classification-system

Answer 429

d) Suprascapular Suprascapula nerve (C5,6) - innervates supra and infraspinatus - comes off superior trunk of the brachial plexus, and is usually anaesthetised by an interscalene block - sensory innervation to 70% posterior-superior shoulders and portion of the anterior axilla and the ACJ Supraclavicular nerve (C3,4) - provides sensory to the 'cape' of the shoulder - component of the cervical plexus block - lies outside the brachial plexus - commonly missed during supraclavicular brachial plexus blocks Subscapular nerve: - subscapularis - medial rotation shoulder Dorsal scapular nerve: - branch of the brachial plexus - supplies rhomboid major muscle, rhomboid minor muscle, and levator scapulae muscle - causes the scapula to be moved medially towards the vertebral column - Dorsal scapular nerve syndrome can cause a winged scapula, with pain and limited motion Thoracodorsal nerve: - thoracodorsal nerve also branches from the posterior division of the brachial plexus - this nerve innervates the latissimus dorsi muscle.

Answer 430

b) hypertension from splanchnic vasoconstriction below the level of the lesion ADR: - increased SNS below - increased PSNS above Hypertension (>25 mmHg increase) >40 mmHg increase or SBP > 150 is severe

Answer 431

c) inf alveolar The conventional inferior alveolar nerve block is the most commonly used nerve block technique in dentistry The nerves anesthetized are the inferior alveolar, incisor, mental, and lingual nerves. The mandibular teeth to the midline, the body of the mandible, the lower part of the mandibular ramus, buccal periosteum and mucous membrane to the premolars, anterior 2/3 of the tongue, oral floor, lingual soft tissue, and the periosteum are all anesthetized ## Footnote https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6218392/

Answer 432

c) Foetal RBC All others removed with leukodepletion filter

Answer 433

a. Dysaesthesia Chronic pain that may involve itchiness, burning, electric shock, or a general tightening in any part of the body. Allodynia Pain from stimuli which are not normally painful. The pain may occur other than in the area stimulated. Hyperalgesia is an abnormally increased sensitivity to pain Hyperesthesia is a condition that involves an abnormal increase in sensitivity to stimuli of the sense https://www.iasp-pain.org/resources/terminology/#:~:text=DYSESTHESIA,sen

Answer 434

c) ASD closure device Amplatzer Device

Answer 435

Cefazolin A first-generation cephalosporin is recommended, such as 2g intravenous cefazolin. The dose should be increased to 3g for women weighing over 120kg. Consideration should also be given to a repeat dose if the procedure is prolonged (over 3 hours). * For women with a history of immediate or delayed nonsevere hypersensitivity to penicillins, cefazolin, as above, remains appropriate. * For women with a history of immediate or delayed severe hypersensitivity to penicillins, use Clindamycin 600mg iv plus Gentamicin 2mg/kg iv. * For women colonised with Methicillin-resistant Staphylococcus aureas (MRSA) or at increased risk of being colonised with MRSA, add Vancomycin 15mg/kg iv. * Azithromycin may be considered at caesarean sections performed during labour or at least four hours after rupture of membranes (2). Administration of azithromycin 500mg has been shown to reduce a composite outcome of endometritis, wound infection or other infection (3). However, a strong recommendation in favour of routine use is not yet warranted given the concerns around the external validity of the paper, inducing resistance to azithromycin and possible effects on the establishment of the indigenous microbiome.

Answer 436

c) Junctional rhythm Up to date: Anaesthesia for elective eye surgery Oculocardiac reflex manifestations — Manifestations of the oculocardiac reflex commonly occur when pressure is applied to extraocular muscles. These include bradycardia (a decrease of 10 to 20 percent in the basal heart rate), junctional rhythms, hypotension, and, rarely, asystole. This reflex can occur during injection of local anesthesia or during the surgical procedure itself. Management includes stopping the stimulus (eg, release of traction or manipulation of the extraocular muscles). If this is ineffective, an anticholinergic medication (eg, atropine or glycopyrrolate) is administered. The risk of inducing this reflex may be reduced by an effective regional anesthetic block or general anesthesia with adequate depth.

Answer 437

B - prevention of electrocution. BJA Education https://academic.oup.com/bjaed/article/11/6/224/263710

Answer 438

a) Acute fatty liver Key differences between AFLP and HELLP - Coagulopathy with deranged INR in AFLP Vs. Thrombocytopenia in HELLP - Thrombocytopaenia in HELLP, Plts tend to be unaffected in AFLP - Degree of transaminitis in stem consistent with aFLP Swansea Criteria for AFLP: Atleast 6 or more of the features described: - Vomiting - Abdominal pain - Polydypsia/polyuria - Encephalopathy - Elevated Bilirubin - Hypoglycaemia - Elevated urate - Leucocytosis - Ascites/ Bright liver on US scan - Elevated transaminases - Elevated Amonia - Renal impairment - Coagulopathy - Microvesicular streatosis on liver biopsy AFLP: Pathophysiology - Variant of pre-eclampsia - presents in the late 3rd trimester - more common in women with multiple pregnancies and lower BMI - Women with the condition are more likely to have children with disorders of B-fatty oxidation - Associated with high maternal mortality, on average 1 death per year Daignosis and presentation: - Diagnosis by Swansea criteria in absence of another explanation - Imaging with CT or MRI a liver biopsy or fat stain may support diagnosis - present with non-specific symptoms of: Nausea and vomiting Malaise Associated Htn and proteinuria - Renal impairment develops in 90% of patients - Fulminant hepatic failure can occur - Patients may develop hepatic encephalopathy, coagulopathy and profound hypoglycaemia - Metabolic acidosis and elevated lactate are not part of diagnostic criteria but are important features - Pancreatitis and ARDS are other rare complications Delivery and Anaesthetic concerns: - Delivery must be expedited once the patient is stablized due to high foetal mortality - Specific anaesthetic concerns are top correct hypoglycaemia and coagulopathy before delivery - Plt function tends to remain stable unlike HELLP syndrome - Uneventful regional anaesthesia has been reported and may improve hepatic blood flow but is often precluded due to coagulopathy - Symptoms can deteriorate post-partum with worsening liver, renal function and coagulopathy for 48hrs

Answer 439

d) Encephalitis UTD: OTHER COMPLICATIONS OF DURAL PUNCTURE PDPH is the most common adverse outcome of dural puncture and is generally self-limited and benign. -Hearing loss (hypoacusia) may occur after dural puncture, and has been variably reported in up to 10 to 50 percent of patients after spinal anesthesia - unilateral or bilateral, and may occur even in the absence of headache. - Hearing loss is usually transient, but there are reported cases of hearing loss lasting for years after spinal anesthesia, unintentional dural puncture (UDP) and diagnostic lumbar puncture (LP). - thought to relate to intracranial hypotension, with risk factors similar to risk factors for PDPH. - In small studies, larger needle size and cutting needles have been associated with increased incidence of hearing loss. - Epidural blood patch (EBP) has been performed with resolution of hearing loss. - Injection of air into the subarachnoid space during placement of neuraxial block may result in acute onset of severe headache and other neurologic signs and symptoms. - This complication may occur with an UDP if air, rather than saline, is used for loss of resistance to identify the epidural space. - A pneumocephalus headache can occur within a few seconds if the epidural is placed with the patient in the sitting position, but may be delayed until the patient sits up if the epidural is placed in the lateral decubitus position. - Regardless of onset delay, the headache is usually maximal at onset (ie, "thunderclap"). - Treatment of pneumocephalus headache is symptomatic. - Limited data suggest that normobaric oxygen therapy leads to more rapid resolution; hyperbaric oxygen therapy may be indicated for more severe cases of pneumocephalus. - Dural puncture is rarely associated with long-lasting complications. - Cases of persistent headache have been reported, some of which have required surgical repair of the dural rent or fluoroscopically-guided blood patch. - Increased chronic back pain has also been reported in patients who have had UDP, with no increased risk conferred by EBP as treatment for the PDPH. - PDPH may also be associated with persistent headache, chronic low back pain, bacterial meningitis, and postpartum depression. - EBP is not indicated as treatment for any of these complications. - In rare cases, dural puncture has been associated with reversible cerebral vasoconstriction syndrome (RCVS) and posterior reversible encephalopathy syndrome (PRES), but causation is uncertain; several of these reports involved obstetric patients with possible preeclampsia or eclampsia, which are also associated with RCVS and PRES.

Answer 440

b) diclofenac LIthium perioperative concerns: - Prolongation of NMB - Reduction in anaesthetic agent requirement - Avoid NSAIDs - No withdrawl symptoms - Discontinue 24hrs before surgery NSAIDs differentially alter lithium concentrations by multiple mechanisms, and one of these is to reduce prostaglandin E2 BJA: perioperative advice for psychotropic drugs

Answer 441

b. Procainamide BJA: Perioperative cardiac arrhythmias https://academic.oup.com/bja/article/93/1/86/265716 - Paroxysmal SVT (PSVT) due to re‐entrant circuits that involve accessory pathways (congenital electrical connections between the atrium and ventricle that bypass the AV node, such as Wolff–Parkinson–White Syndrome) pose caveats in the management of SVT. - It should be noted that patients with accessory pathways, in addition to PSVT, may also develop atrial fibrillation, and in the latter situation are at increased risk for developing ventricular fibrillation (VF) upon exposure to classic AV‐nodal blocking agents (digoxin, calcium channel blockers, beta blockers, adenosine) because these agents reduce the accessory bundle refractory period. - In such cases, i.v. procainamide, which slows conduction over the accessory bundle, is an acceptable option. Flecainide and amiodarone should also be considered, and cardiology consultation may be helpful.2

Answer 442

d 60cm H2O

Answer 443

1. Ulnar Nerve

Answer 444

c) propofol https://anaesthetists.org/Portals/0/PDFs/Guidelines%20PDFs/Guideline_management_severe_local_anaesthetic_toxicity_v2_2010_final.pdf?ver=2018-07-11-163755-240&ver=2018-07-11-163755-240

Answer 445

a) Dopamine receptor MOA: central acting anticholinergic

Answer 446

b. serum separating tube (gold top tube or red) Potassium EDTA (purple) -> FBC sodium citrate (blue) -> clotting screen/Rotem sodium oxalate (green) -> heavy metals (lead copper zinc)

Answer 447

a) reintubate from the mouth ? couldn't find other recalled answers ? Will depend on the remembered answers ? The key principles of the algorithm are: 1.Waveform capnography has a prominent role at an early stage in emergency management. 2.Oxygenation of the patient is prioritised. 3.Trials of ventilation via a potentially displaced tracheostomy tube to assess patency are avoided. 4.Suction is only attempted after removing a potentially blocked inner tube. 5.Oxygen is applied to both potential airways. 6.Simple methods to oxygenate and ventilate via the stoma are described. 7.A blocked or displaced tracheostomy tube is removed as soon as this is established and not as a ‘last resort’ BJA: Update on management of tracheostomy https://www.bjaed.org/article/S2058-5349(19)30125-8/fulltext https://www.tracheostomy.org.uk/storage/files/Patent%20Airway%20Algorithm.pdf

Answer 448

c) LAD LIFL: Myocardial Ischaemia https://litfl.com/myocardial-ischaemia-ecg-library/ More Myocardial Ischaemia ECG Examples: Example 1 Subendocardial ischaemia: The most striking abnormality is the widespread ST depression, seen in leads I, II and V5-6. This is consistent with widespread subendocardial ischaemia. There is also some subtle ST elevation in V1-2 and aVR with small Q waves in V1-2, suggesting that the cause of the widespread ischaemia is a proximal LAD occlusion.

Answer 449

c. Low potassium diet (high K diet - dec HTN)

Answer 450

D Inhalational anaesthetic https://resources.wfsahq.org/atotw/emergence-delirium-in-pediatric-patients/

Answer 451

neurological damage due to methionine deficit

Answer 452

brachiocephalic artery BJA: Emergency FONA in airway management "Major vessels, most commonly the brachiocephalic artery, traverse the anterior tracheal wall in up to 53% patients at the suprasternal notch."

Answer 453

c) pharyngeal muscles Millers Anaesthesia: Reference artyicle from Millers: https://pubs.asahq.org/anesthesiology/article/92/4/977/710/The-Incidence-and-Mechanisms-of-Pharyngeal-and An adductor pollicis TOF ratio of 0.90 or less was associated with impaired pharyngeal function and airway protection, resulting in a four- to fivefold increase in the incidence of pharyngeal dysfunction causing misdirected swallowing. Moreover, pharyngeal function and airway protection may be impaired, even if the adductor pollicis muscle has recovered to a TOF ratio of more than 0.90.

Answer 454

e) discarding not required

Answer 455

c) Increased mortality Use of perioperative metoprolol was associated with: * Decreased rate of myocardial infarction * Decreased rate of revascularisation * Decreased rate of developing new atrial fibrillation * INCREASED rate of death * INCREASED rate of stroke * INCREASED rate of significant hypotension INCREASED rate of significant bradycardia

Answer 456

d. Able to turn head 45 deg NEXUS criteria: One easy mnemonic for these criteria is NSAID: Neuro Deficit Spinal Tenderness (Midline) Altered Mental Status/Level of Consciousness Intoxication Distracting Injury

Answer 457

c. transfuse for Hb >100 Emergency fixation means there is no time for an exchange transfusion perioperative goals: - planning and optimisation - ensuring adequate O2 delivery - hydration - analgesia - performed at a centre with a multidisciplinary sickle cell team Children presenting for high-risk surgery (for example neurosurgical, cardiothoracic, or complex orthopaedic surgery) or high-risk children (previous stroke, acute CS, or end-organ damage), who were not included in this study, commonly receive an exchange transfusion or top-up transfusion, aiming for a preoperative haemoglobin concentration of 10 g dl−1 and Hb SS <30%. There is less evidence available for the role of transfusion in children with other forms of SCD. Exchange transfusion vs. top-up transfusion Exchange Transfusion: - slowly removing the person’s blood and replacing with fresh donor blood or plasma - Performed in cycles lasting a few minutes with slow removal of 5-20ml of blood and an equal amount of fresh pre-warmed blood or plasma flows into the person’s body - in sickle cell disease blood is removed and replaced with donor blood to achieve a specific concentration of HbSS blood with a usual target of <30% - Exchange transfusion removes HbS and increases HBA Top-up transfusion: - standard transfusion process of giving donor blood - advantages of simple top-up include: 1. Increase oxygen carrying capacity 2. Decrease proportion of sickle haemoglobin HbS relative to Haemoglobin A (HBA) 3. Prevent or reverse complications of vast-occlusion 4. Can be given acutely - disadvantages include: 1. Hyperviscosity if the Hb is increased to significantly over the patients baseline (target Hb should be 100g/l) 2. HbS is not removed, only diluted

Answer 458

Aortic stenosis

Answer 459

150mcg IM Then commence adrenaline infusion 0.1mcg/kg/min to 2mcg/kg/min Refractory management: Additional IV fluid 20-40ml/kg, Noradrenaline infusion 0.1- 2mcg/kg/min Vasopressin infusion 0.02-0.06 units/kg/hr, glucagon 40mcg/kg IV

Answer 460

c) 110 Brain trauma foundation Level III recommendation. To decrease mortality and improve outcomes: Maintain SBP at >100mmHg for patients 50 - 69 Maintain SBP at >110 for patients 15 - 49 Maintain SBP at >110 for patients 70 or older

Answer 461

C) Onsite oxygen liquid evaporator (VIE) VIE Pros and Cons Pros - Cheapest option for oxygen delivery and storage - Storing oxygen as a liquid is much more efficient than as a gas - Does not require power Cons - Set-up costs are expensive - Requires a back-up setup - Will waste large volumes of oxygen if not being used continuously - Fire and explosion risk

Answer 462

a) Greater occipital

Answer 463

pancreatic fistula -> should cause NAGMA HAGMA: Lactate Toxins Ketones Renal failure NAGMA Chloride Addison's, adrenal insuffiency, acetazolamide GI loss (pancreatic fistula) Extra: RTA Anion gap: - Anion Gap = Na+ – (Cl- + HCO3-) - The Anion Gap (AG) is a derived variable primarily used for the evaluation of metabolic acidosis to determine the presence of unmeasured anions - The normal anion gap is assumed to be 12, and the normal HCO3 is assumed to be 24 Delta ratio: - can check delta ratio in the presence of a high anion gap metabolic acidosis (HAGMA) to determine if it is a ‘pure’ HAGMA or if there is coexistant normal anion gap metabolic acidosis (NAGMA) or metabolic alkalosis.

Answer 464

Postpone 3 months and give oral iron

Answer 465

No answer provided. ?encephalitis These are all complications of dural puncture. Encephalitis most likely answer https://www.uptodate.com/contents/post-dural-puncture-headache Complications of PDPH 1. Chronic Back pain 2. Hearing loss 3. Acute onset headache consider pneumopcephalus headache 4. Persistent headache 5. Increased risk of subdural haematoma 6. postpartum depression 7. bacterial meningitis 8. Reversible cerebral vasoconstriction syndrome (RCVS) 9. Posterior reversible encephalopathy syndrome (PRES)

Answer 466

d) TXA VWD Types: 1 - quantitative - minor effect on bleeding - DDAVP useful 2 - qualitative - spectrum of effects on bleeding - (2a,2b,2m,2n) - DDAVP may be useful in consult with haem 3 - absence - major bleeding - no effect of DDAVP factors not recommended in Type 1 TXA and DDAVP are recommended but DDAVP not in list TXA 10mg/kg IV q8h DDAVP 300mcg intranasal 90-120 mins preop (DDAVP increases factor VIII levels 2-5x via release of VWF which binds VIII and prevents its clearance) Treatment of bleeding in an individual with von Willebrand disease (VWD) depends on: 1. Severity of bleeding 2, Site of bleeding 3. the type of VWD 4. the previous responses to therapy. The two main approaches: 1. Increasing the level of normal von Willebrand factor (VWF) activity via DDAVP 2. Replacing the defective VWF with VWF concentrates VWF concentrates have been demonstrated to provide excellent to good hemostasis in a number of patient populations and a number of bleeding types. DDAVP is only effective in some individuals, produces a smaller increase in VWF activity, and has a later onset and shorter duration of action.

Answer 467

12 puffs 6puffs< 6yrs 12 puffs> 6 yrs

Answer 468

b) Aortic Stenosis

Answer 469

Gloves, goggles, gown, mask, hand hygiene CDC

Answer 470

c) Reduced due to increased volume of distribution and clearance 2010 Paper on major burns The pharmacokinetic characteristics of a propofol bolus administered in patients with major burns were enhanced clearance and expanded volume of distribution. BURN and WT were the important covariates. For sedation or anesthesia induction, a higher than recommended dose of propofol may be required to maintain therapeutic plasma drug concentrations in patients with severe burns. Vigilance regarding the burned individual and careful titration of hypnotics to the desired effect cannot be overemphasized. https://pubmed.ncbi.nlm.nih.gov/20510522/

Answer 471

Deep Posterior Compartment Source: UpToDate

Answer 472

a) LUSCS Rates of VAE by surgical procedure: LUSCS: 10%-97% Neurosurgery: Posterior Fossa: 76% Cervical Laminectomy: 7-25% Lateral/Prone Neurosurgery: 15-25 % Total Hip Replacement: 30% Lap Cholecystectomy: 69%

Answer 473

a. medial cutanous brachial nerve C8/T1 roots are often missed. Therefore, interscalene blocks tend to fail on the ulnar side of the arm Medial brachial cutaneous nerve (C8-T1, arises from the medial cord of the brachial plexus): upper medial arm ## Footnote NYSORA

Answer 474

b) vasoplegia

Answer 475

Answer: This time thought to be posterior cerebral (previously middle cerebral)

Answer 476

d) Trendelenberg c) Supine Moving from upright to supine affects the respiratory function of the tetraplegic and high paraplegic individual differently to the able-bodied person. The increase in abdominal girth when sitting in tetraplegia is secondary to decreased abdominal muscle strength and the associated increased abdominal wall compliance. In the seated position, the abdominal contents are less supported by the decreased abdominal wall muscle tone and fall forward, increasing the waist size and lowering the diaphragm. In able-bodied subjects, the FVC is reduced in the supine position, whereas in tetraplegia it is increased. Postural changes are associated with symptoms; patients with an acute, high SCI report less breathlessness when supine compared to sitting. In the supine position, the weight of the abdominal contents forces the diaphragm to a higher resting level so that contraction produces greater absolute excursion of the diaphragm; an effect that can be increased when the person with tetraplegia is tipped 15° head down from supine such that the vital capacity rises by a further 6%

Answer 477

e) Normal Normal flow-volume loop: the expiratory portion of the flow-volume curve is characterized by a rapid rise to the peak flow rate, followed by a nearly linear fall in flow. The inspiratory curve is a relatively symmetrical, saddle-shaped curve.

Answer 478

c. Decreased platelet function

Answer 479

e) Fluconazole Among patients taking NOACs for nonvalvular atrial fibrillation, concurrent use of amiodarone, fluconazole, rifampin, and phenytoin compared with the use of NOACs alone, was associated with increased risk of major bleeding JAMA 2017 ACC/AHA

Answer 480

a) 15 mins 50UI/kg, Prothrombinex-VF is able to completely reverse a supratherapeutic INR within 15 minutes however, vitamin K is also required to sustain the reversal effect as the half-lives of the infused clotting factors are similar to endogenous factors. ## Footnote https://www.mja.com.au/journal/2013/198/4/update-consensus-guidelines-warfarin-reversal#:~:text=Prothrombinex%2DVF%20is%20able%20to,similar%20to%20endogenous%20clotting%20factors.

Answer 481

a) turn left lateral UTD: Cardiac herniation is usually seen within three days of surgery, presenting as sudden onset of hypotension and shock, cyanosis, chest pain, and superior vena cava syndrome. The acute event is usually preceded immediately by coughing, moving the patient, vomiting, or extubation. Treatment involves emergent surgery to reposition the heart and close the pericardial defect to prevent recurrence. ?bleeding Rapid filling of the PPS with blood can occur within 24 hours of surgery. This complication is more common after pleuropneumonectomy or pneumonectomy for suppurative lung disease. The clinical presentation may be with hypotension and shock due to the loss of intravascular blood volume. The mainstay of treatment is surgical reexploration and control of bleeding sources.

Answer 482

strained broth ANZCA PS07: "Clear fluids are regarded as water, carbohydrate rich fluids, specifically developed for perioperative use, pulp free fruit juice, clear cordial, black tea and coffee. It excludes fluids containing particulate matter, soluble fibre, milk-based drinks and jelly"

Answer 483

c) Lung protective ventilation A congenital diaphragmatic hernia (CDH) occurs when a defect in the diaphragm allows abdominal organs to protrude into the thoracic cavity (Fig. 1). It affects approximately 1 in 3600 registered births and is a potentially life-threatening condition, the severity of which is primarily related to the extent of lung hypoplasia and pulmonary hypertension. Advances in management strategies include protective ventilation, careful timing of surgery, the judicious use of extracorporeal membrane oxygenation (ECMO) and the introduction of both thoracoscopic and fetal intervention, but it remains a challenging condition to treat successfully with overall mortality rates still around 30% A validated scoring system has been proposed based on various measurements, including: (i) birth weight <1.5 kg, (ii) Apgar score at 5 mins <7, (iii) presence of chromosomal abnormality, (iv) presence of major cardiac abnormality, and (v) suprasystemic pulmonary hypertension on echocardiography. This scoring system enables patients to be stratified into low (<10%), intermediate (∼25%) or high risk (∼50%) mortality groups. Cardiac defects have been shown to worsen outcome regardless of the severity of the hernia The presence of a small contralateral lung or a bilateral CDH are also poor prognostic signs. Ventilation Historically, aggressive ventilation was used to induce hypocapnia and alkalosis and thereby reduce pulmonary hypertension; however, protective ventilation strategies that avoid further injury to damaged lung tissue have reduced mortality in CDH. The CDH EURO Consortium advocates aiming for the limitation of peak inspiratory pressures to 25 cm H2O with PEEP kept at 3–5 cm H2O and allowing permissive hypercapnia. High-frequency oscillatory ventilation High frequency oscillatory ventilation (HFOV) is classically used as a rescue strategy when hypoxia and severe hypercapnia persist despite maximal conventional ventilation. The VICI trial (2016) randomised 171 neonates to conventional ventilation or HFOV as the initial mode of ventilation and found no significant difference in mortality, but those who had conventional ventilation were ventilated for shorter periods, needed less nitric oxide, sildenafil and ECMO, and had lower requirements for inotropic drugs. Timing of surgery Historically, CDH repair was treated as a surgical emergency. However, the degree of pulmonary hypoplasia is the major influence on prognosis and emergency surgery therefore confers little benefit. There is much debate but little consensus within the literature regarding the optimal timing of surgery. Recommendations from the CDH EURO Consortium state that the following physiological parameters should be met before surgery: (i) mean arterial pressure normal for gestation, (ii) preductal oxygen saturation consistently 85–95% on FiO2 <0.5, (iii) lactate below 3 mmol litre−1, and (iv) urine output more than 1 ml kg−1 h−1 12 These recommendations do, however, acknowledge that repair on ECMO is a viable treatment strategy in the context of appropriate patient selection. Little evidence Thorascopic approach has improved mortality compared to open approach BJA Education Article - Anaesthetic management of patients with a congenital diaphragmatic hernia https://www.bjaed.org/article/S2058-5349(18)30013-1/fulltext

Answer 484

3b Category GFR ml/min/1.73 m2 Terms G1 ≥90 Normal or high G2 60-89 Mildly decreased* G3a 45-59 Mildly to moderately decreased G3b 30-44 Moderately to severely decreased G4 15-29 Severely decreased G5 <15 Kidney failure Assign Albuminuria category as follows: Albuminuria categories in CKD Category ACR (mg/g) Terms A1 <30 Normal to mildly increased A2 30-300 Moderately increased* A3 >300 Severely increased** Abbreviations: ACR, albumin-to-creatinine ratio; CKD, chronic kidney disease. *Relative to young adult level. **Including nephrotic syndrome (albumin excretion ACR >2220 mg/g) **Collectively referred to as “CGA Staging”

Answer 485

d) Sarcoidosis Pulmonary hypertension: Normal spirometry + low DLCO Asthma: obstructive pattern and normal DLCO Obesity: restrictive pattern and normal DLCO Sarcoid: restrictive pattern and low DLCO

Answer 486

e. VOO >Asynchronous mode most often the result of magnet application. In a ventricular PPM, this means VOO >However, various sources recommend against use of magnet for PPM management due to inconsistent effects on different devices Equipment in Anaesthesia and Critical Care: > The use of a magnet as a solution for pacemaker problems, either in theatre or otherwise is not recommended. >The application of a magnet to the pacemaker can have unpredictable results, from causing it to change to a back-up mode such as VOO, to reverting to factory settings, to performing various self-tests, to switching off entirely.

Answer 487

B. bronchospasm Blue book 2017 article (see image) CLASS short acting anti-arrhythmic naturally occurring purine nucleoside MECHANISM OF ACTION depression of SA & AV nodal activity antagonises cAMP-mediated catecholamine stimulation of ventricular muscle -> negative chronotropy & dromotropy direct agonist at specific cell membrane receptors (A1 & A2) A1 = coupled to K+ channels by a guanine nucleotide-binding protein in supraventricular tissue. PHARMACEUTICS clear, colourless 3mg/mL in saline DOSE rapid IV bolus followed by saline flush 3mg -> 6mg -> 12mg (adult) 0.04 to 0.25mg/kg (children) INDICATIONS diagnosis and treatment of paroxysmal SVT ADVERSE EFFECTS bronchospasm flushing SOB Chest pain CONTRAINDICATIONS second and third degree AV block allergy care with asthma and COPD PHARMACOKINETICS Onset – 10 seconds Duration – 10 seconds Absorption – must be given IV Distribution Metabolism – absorbed by RBC’s and endothelium Elimination – t ½ = 10 seconds

Answer 488

A. cesarean section rate. Blue Book 2021 PCEA benefits include a decrease in motor blockade and decreased total local anaesthetic consumption. PCEA also reduces anaesthetic workload by significantly decreasing the requirement for clinician boluses while delivering similar analgesia, patient satisfaction and obstetric outcomes44. PCEA is most frequently used in combination with either PIB or CEI. There is an associated decrease in instrumental deliveries in nulliparous women with intermittent bolus techniques with no difference in caesarean section rate. Caesarean section rates are unchanged for women with either type of epidural, compared to those without. https://www.ncbi.nlm.nih.gov/books/NBK69143/ Unscheduled anaesthetic interventions (6 RCTs): significantly fewer patients required clinician top-ups with PCEA compared with CEI. The RD was 27% (95% CI: 18, 36, p<0.00001). Similar findings were obtained when only studies with a quality score of 3 or more were analysed (RD 35%, 95% CI: 19, 51, p<0.0001). No heterogeneity was detected (p=0.36). Amount of local anaesthetic (8 RCTs): different regimens were used and significant heterogeneity was detected (p<0.0001). All studies found that higher local anaesthetic doses were used with CEI than with PCEA. Motor block (4 RCTs): significantly fewer patients had 'no motor weakness' with PCEA than with CEI; the RD was 18% (95% CI: 6, 31, p=0.003). Analgesia: there was no difference in the visual analogue scores between the treatments in the 7 RCTs that used them. There was no significant difference between PCEA and CEI for: patient satisfaction (5 RCTs); total duration of first and second stage of labour (3 RCTs); incidence of Caesarean section or instrumental delivery (9 RCTs); incidence of low Apgar scores at 1 and 5 minutes after birth (6 RCTs); hypotension (6 RCTs); high block (3 RCTs); pruritus (2 RCTs); shivering (1 RCT) or nausea (1 RCT). The results for all of these outcomes were reported in the review. Both PCEA and CEI appear to be safe for the mother and the neonate. Patients who receive PCEA are less likely to require anaesthetic intervention, require lower doses of local anaesthetic and have less motor block than those who receive CEI. https://www.ncbi.nlm.nih.gov/books/NBK69143/

Answer 489

e) ensure leads securely attached https://journals.lww.com/nursing/Citation/2006/11000/Cables_and_electrodes_can_burn_patients_during_MRI.12.aspx#:~:text=The%20radiofrequency%20fields%20that%20occur,enough%20to%20require%20plastic%20surgery. https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.107.187256#d1e281

Answer 490

I:E ration 1:3 BJA Lung-protective ventilation for the surgical patient: international expert panel-based consensus recommendations: An expert consensus was reached for 22 recommendations and four statements. The following are the highlights: (i) a dedicated score should be used for preoperative pulmonary risk evaluation; and (ii) an individualised mechanical ventilation may improve the mechanics of breathing and respiratory function, and prevent PPCs. The ventilator should initially be set to a tidal volume of 6–8 ml kg−1 predicted body weight and positive end-expiratory pressure (PEEP) 5 cm H2O. PEEP should be individualised thereafter. When recruitment manoeuvres are performed, the lowest effective pressure and shortest effective time or fewest number of breaths should be used. Inspiratory/expiratory ratio: Several studies have compared prolonged inspiratory-to-expiratory (I:E) ratios to the 1:2 ratio commonly used during mechanical ventilation. An I:E ratio of 1:1, which has been characterised as providing a ‘balanced stress to time product’, was associated with attenuation of lung damage. Prolonged I:E ratio increases mean airway pressure and concomitantly reduces peak airway pressure. Studies using prolonged inspiratory times have described beneficial effects, including increased CRS and PaO2, lower alveolar–arterial gradient, and reduced inflammatory markers. Given the lack of evidence for a clear benefit of a specific I:E ratio, no recommendation was offered by the panel. However, the panel noted that optimisation of inspiratory time for individual patients can be achieved by monitoring parameters, such as oxygenation, CRS, and ΔP. Intraoperative FIO2 Increased FIO2 during mechanical ventilation is administered to prevent or correct hypoxaemia, but may result in hyperoxia. The negative effects of hyperoxia are not clear, but it has been suggested that it may increase oxidative stress, peripheral vascular and coronary artery vasoconstriction, decrease cardiac output, increase resorption atelectasis, and increase the rate of PPCs. Recommendations for optimal use of oxygen and current evidence regarding the association between hyperoxaemia and clinically relevant outcomes during intraoperative mechanical ventilation are lacking. Few studies have revealed a protective effect of hyperoxaemia, some report an association with mortality, whilst others show no association with clinically relevant outcomes. Therefore, in the absence of evidence, the most prudent course of action during mechanical ventilation is to maintain normoxaemia. SpO2 monitoring can assist in the detection of hypoxaemia, but during oxygen therapy SpO2 cannot detect hyperoxia. Whilst SpO2 monitoring reduces the incidence of hypoxaemia, it does not improve the overall patient outcomes and does not reduce morbidity and mortality. Therefore, once the airway is secured, FIO2 should be set to ≤0.4 with the goal of using the lowest possible FIO2 to achieve normoxia (or SpO2 ≥94%) Unnecessarily high FIO2 should be avoided. Administering lower FIO2 will not only decrease the risk of hyperoxia, but will also reduce the masking effect of oxygen therapy and allow for earlier diagnosis of gas-exchange impairment.

Answer 491

c) 1000 ml/hr 4ml/kg/hr x 30%TBSA x 100kg = 12,000mL 1/2 within the first 8hrs, remainder over the next 16 hours (starting at 6 hour mark in this stem so beware) 6,000mL/6hrs = 1000 mL/hr which is the rate you would run it over the next 6 hours.

Answer 492

c Haemophilia b

Answer 493

c) bradycardia | from PI

Answer 494

R hand probe should be attached to a preductal location (ie, the right upper extremity, usually the wrist or medial surface of the palm) N.B right foot - post ductal ## Footnote https://www.ahajournals.org/doi/pdf/10.1161/CIRCULATIONAHA.110.971119

Answer 495

b) Lateral cord

Answer 496

A) level of consciousness In any patient who is given an opioid, oversedation should be considered to indicate OIVI until proven otherwise, regardless of a patient’s respiratory rate or oxygen saturation levels. Source ANZCA PS 41

Answer 497

B. Diazepam UTD Discontinuation of all serotonergic agents ●Supportive care aimed at normalization of vital signs ●Sedation with benzodiazepines ●Administration of serotonin antagonists ●Assessment of the need to resume use of causative serotonergic agents after resolution of symptoms *Should actually be rocuronium* https://www.bjaed.org/article/S2058-5349(19)30153-2/fulltext

Answer 498

e) 100mg hydrocortisone IV > note: alternatively, 6-8mg dexamethasone IV would suffice

Answer 499

d) myasthenia gravis or d) Cerebral palsy ->sux and volatiles are not contraindicated -> presence of extrajunctional receptors may cause hyperkalaemia if responses remembered incorrectly but of this list CP is probably the answer a. Becker muscular dystrophy -> essentially milder Duchenne's (see duchenne response to Sux) b. Cerebral palsy -> Sux and volatiles not contraindicated -> reduced MAC requirement -> increased sensitivity to muscle relaxants c. Guillain Barre -> sux contraindicated due to risk of hyperkalaemia -> increased sensitivity to Non depolarising NB d. Frederich’s ataxia -> sux should be avoided due to risk of hyperkalaemia e. Duchenne muscular dystrophy -> sux and volatiles contraindicated due to rick of hyperkalaemia and rhabdomyolysis In contrast to other neuromuscular disorders, succinylcholine may be used in myasthenia gravis. The required dose may need to be increased by up to two-fold, as those with the disease show a relative resistance to the drug. Sux is not recommended in patients with neuromuscular disease due to: 1. presence of extrajunctional receptors and risk of hyperkalaemia and rhabodmyolysis 2. fasiculations causing temperomandibular muscle spasm preventing intubation REPEAT

Answer 500

60 mmol 1mmol/kg The 8.4% bottles of sodium bicarbonate provide 1 mmol/mL of sodium and bicarbonate

Answer 501

70-80ml/ kg/ min Controlled ventilation https://www.frca.co.uk/article.aspx?articleid=100141 A fresh gas flow of only 70 ml/kg is required to produce normocarbia. Bain and Spoerel have recommended the following: 2 L/min fresh gas flow in patients <10 kg 3.5 L/min fresh gas flow in patients 10-50 kg 70 ml/kg fresh gas flow in patients >60 kg The recommended tidal volume is 10 ml/kg and respiratory rate is 12-16 breaths/minute.

Answer 502

RUL APALM APIS APAL

Answer 503

Physical dependence Physical dependence = presence of withdrawal symptoms when the drug is not taken.

Answer 504

a. Teicoplanin

Answer 505

a) face, legs, activity, cry, consolability

Answer 506

c= Drugs which, owing to their pharmacological effects, have caused or may be suspected of causing, harmful effects on the human fetus or neonate without causing malformations. These effects may be reversible. Category A Drugs which have been taken by a large number of pregnant women and women of childbearing age without any proven increase in the frequency of malformations or other direct or indirect harmful effects on the fetus having been observed. Category B1 Drugs which have been taken by only a limited number of pregnant women and women of childbearing age, without an increase in the frequency of malformation or other direct or indirect harmful effects on the human fetus having been observed. Studies in animals have not shown evidence of an increased occurrence of fetal damage. Category B2 Drugs which have been taken by only a limited number of pregnant women and women of childbearing age, without an increase in the frequency of malformation or other direct or indirect harmful effects on the human fetus having been observed. Studies in animals are inadequate or may be lacking, but available data show no evidence of an increased occurrence of fetal damage. Category B3 Drugs which have been taken by only a limited number of pregnant women and women of childbearing age, without an increase in the frequency of malformation or other direct or indirect harmful effects on the human fetus having been observed. Studies in animals have shown evidence of an increased occurrence of fetal damage, the significance of which is considered uncertain in humans. Category C Drugs which, owing to their pharmacological effects, have caused or may be suspected of causing, harmful effects on the human fetus or neonate without causing malformations. These effects may be reversible. Accompanying texts should be consulted for further details. Category D Drugs which have caused, are suspected to have caused or may be expected to cause, an increased incidence of human fetal malformations or irreversible damage. These drugs may also have adverse pharmacological effects. Accompanying texts should be consulted for further details. Category X Drugs which have such a high risk of causing permanent damage to the fetus that they should not be used in pregnancy or when there is a possibility of pregnancy.

Answer 507

30ml/cm H2O 600/32-(8+4) = 30 Static lung compliance (Cstat), mL/cm H2O = TV / (Plateau pressure (Pplat) – TotalPEEP) remembered parameters included PEEP = 8 and autop PEEP = 4 if actual answer states TotalPEEP= 8 then no need to add 4 to the calculation

Answer 508

e. 1:136,000 https://www.bjanaesthesia.org/article/S0007-0912%2817%2930746-8/fulltext 1/670 E-LSCS 1/8000 with muscle relaxation 1/8600 CTS 1/8200 Volatile + neuromuscular blocking Overall 1:19000

Answer 509

B. Programability ? Multi-site pacing?

Answer 510

Raised ICP *also associated with a difficult airway (Difficult BMV Ventilation) Apert syndrome: Autosomal dominant abnormality of first branchial arch causing premature closure of cranial sutures, midface hypoplasia, choanal atresia, cleft palate, fusion of cervical spine (mainly C5-C6) and syndactyly. May have associated cardiac and renal abnormalities as well as intellectual impairment due to megalocephaly, hypoplasia of white matter and agenesis of the corpus callosum. Obstructive sleep apnea is present in 50% and there may be an increased incidence of upper airway obstruction at induction, which is mostly overcome by routine maneuvers. Classically, craniosynostosis release with fronto-orbital advancement is completed at 6 to 12 months of age if intracranial pressure (ICP) is normal [24-26]. However, elevated ICP may occur in up to 43 percent of cases. In this event, prompt surgical advancement and potentially ventriculoperitoneal shunt placement is required

Answer 511

B. 2 ( CVA, Insulin use) ## Footnote UTD CHF Renal impairment Insulin use Stroke Ischaemic heart Surgically high risk

Answer 512

d) Alprostadil https://www.rch.org.au/piper/neonatal_medication_guidelines/Alprostadil_(Prostin_VR)_%E2%80%93_(Prostaglandin_E1)/ Alprostadil (PROSTAGLANDIN E1) is a synthetic prostaglandin used to relax the ductus arteriosus in early post-natal life, where a patent ductus is critical for survival, including Tetralogy of Fallot, pulmonary atresia, pulmonary stenosis, tricuspid atresia and transposition of the great arteries. Dose To open a closed ductus arteriosus: 0.1 micrograms/kg/minute (100 nanograms/kg/min). An effect is usually seen within 30-60 minutes. Reduce the dose once an effect is seen or as directed by a Consultant.1 Doses > 0.1 micrograms/kg/minute are rarely more effective and may cause serious adverse effects.3 To maintain patency of ductus arteriosus: 0.01 to 0.02 micrograms/kg/minute (10-20 nanograms/kg/min).1, 2 For persistent pulmonary hypertension of the newborn (PPHN): 0.01 to 0.05 micrograms/kg/minute (10-50 nanograms/kg/min).2

Answer 513

E) High C-spine fracture Contraindications 1. Oesophageal stricture because of the risk for esophageal perforation 2. Basilar skull fracture or facial fracture due to the potential for intracranial misplacement 3. Avoided in patients with oesophageal varices because tube placement may trigger variceal bleeding 4. Patients with a bleeding diathesis, minimal trauma to the pharynx, esophagus, or stomach from nasogastric tubes can also lead to severe bleeding, and, thus, tubes are avoided whenever possible.

Answer 514

bottle A = fluid trap or collection bottle, can be independently emptied and allows accurate record of drainage amount - first tube connecting drain to drainage bottles must be wide to decreased resistance - volume capacity of this tube should exceed ½ of patient’s maximum inspiratory volume (otherwise H2O may enter chest) bottle B = underwater seal drain, maintained at a predetermined level whilst still allowing for drainage of pleural fluid (if bubbling continuously -> bronchopleural fistula) - volume of H2O in bottle B should exceed ½ patient’s maximum inspiratory volume to prevent indrawing of air during inspiration bottle C = manometer or pressure-regulating bottle allows suction to be attached and should bubble continuously - The maximum negative pressure (in cm H2O) generated by suction equals to the distance (in cm) the vent tube is below the water line (this can be adjusted) -The negative pressure generated by the vent tube is independent of the amount of pleural drainage that is collected in the trap bottle - If suction is turned off then tubing must be unplugged -> so air can escape into atmosphere

Answer 515

Adductor Magnus

Answer 516

A. Offering an epidural on a patient who is labouring spontaneously with a normal pregnancy and no comorbidities, upon request

Answer 517

a) 10 Dose of Dantrolene = 2.5mg/kg Repeat every 10 minutes to a Maximum dose of 10mg/kg (Total Vials = 35) Each Vial Dantrolene = 20mg 80 x 2.5mg = 200mg Therefore 10 Vials of 20mg Dantrolene Or, TBW(kg)/8 = number of vials required for initial dose

Answer 518

b) conscious state No mention of BP or HR in ANZCA OIVI monitoring document In many published reports of patient deaths resulting from OIVI, undue reliance has been placed on respiratory rate as a unidimensional measure of OIVI, either without formal assessment of patient sedation, or without recognising the significance of excessive sedation Respiratory rate and oxygen saturation levels are not direct measures of adequacy of ventilation. Sedation scores should be assessed repeatedly at intervals that are appropriate to the route of opioid administration Continuous measurement of a patient’s carbon dioxide concentrations is more likely to identify OIVI than continuous pulse oximetry

Answer 519

Normal Lung

Answer 520

C. Left heart failure causing PulmHTN Normal PAPs/d is 25/7. This would be classed as severe (55) - (if image is correct) PAWP >15 means ‘ post-capillary’ cause or combined pre- and post. This is either group 2 or 5. A PVR might help differentiate. All other options (group 1,3,4 and 5) would likely have a isolated ‘pre-capillary’ PAWP of <15 LITFL and blue book 2015 article

Answer 521

B peak of T wave Triggering of the IABP is usually set according to the patient’s ECG tracing. When an R wave is detected the balloon is triggered to automatically start inflating in the middle of the T wave. Triggering can be impaired if the patient develops an arrhythmia, is paced or has a poor ECG trace. LITFL

Answer 522

c. Warfarin It is also a potent inducer of hepatic cytochrome P450 CYP3A4 isoform. Hence, it may significantly increase the metabolism of many concomitantly administered drugs such as alfentanil, midazolam, and lidocaine. It also induces the P450 2C9 isoform that results in the reduction in effect of warfarin and NSAIDs

Answer 523

The lungs are hyperinflated with relatively flat diaphragms - a sign of pulmonary emphysema. There is a dense triangular opacity overlying the cardiac shadow with increased lucency of the left upper zone relative to the right upper zone. This is the "sail sign" of left lower lobe collapse with subsequent left upper lobe hyper-expansion.

Answer 524

C. Normal lung - shows sandy shore sign of normal lung sliding Alternative: Absent sliding & PTx: Stratosphere sign

Answer 525

a. Lupus anticoagulant Factor VII -> prolonged PT but not APTT Cold Agglutinins -> prolonged PT and APTT -> "sole abnormality" Haemophilia A -> isolated prolonged APTT -> associated with bleeding and not clotting Lupus Anticoagulation -> increased risk of clotting -> prolonged APTT and normal PT

Answer 526

A. 2.5mg/kg/hr Associated with high doses >4mg/kg/hr and prolonged use (>48hrs) Safe doses of propofol infusion for sedation in ICU are considered to be 1-4mg/kg/hr -> fatal Cases pf PRIS have been reported after infusion doses as low as 1.9-2.6mg/kg/hr Risk factors: i. Young age ii. Critical illness iii. High fat and low Carbohydrate intake iv. Inborn errors of mitochondrial fatty acid oxidation v. Catecholamine infusion/ High catecholamine and glucocorticoid levels vi. Steroid therapy vii. Severe head injuries Characteristics: i. Bradycardia ii. Severe metabolic acidosis iii. Cardiovascular collapse iv. Rhabdomyolysis v. Hyperlipidaemia vi. Renal failure vii. Hepatomegaly Management: - Routine monitoring of CK and triglycerides should be performed for the at risk population ○ Daily CK and triglyceridees after 48hrs of propofol infusion ○ Increasing CK in the absence of other pathology triggers suspiscion of PRIS - Propofol immediately stopped and alternative (midazolam and alfentanil) are used - PRIS is difficult to treat once it occurs - CVS support provided as needed - Renal replacement therapy may be required to treat lactic acidosis, clear propofol and its metabolites from the patient rapidly - Catecholamine resistant shock has been reported - Pacing has been used with limited success ECMO has been reported and successfully used in the CVS support of PRIS

Answer 527

a. Empty stomach

Answer 528

b) VV ECMO VV ECMO Disadvantages - no cardiac support - local recirculation though oxygenator at high flows - reverse gas exchange in lung if FiO2 low - limited power to create high systemic arterial oxygen tension

Answer 529

b) 2 - if male CHA2DS2-VASc score ≥2 to be recommended chronic OAC (Grade 1A). - if female CHA2DS2-VASc score ≥3 to be recommended chronic OAC (Grade 1A). * non-sex risk factor also holds bearing: - For patients with CHA2DS2-VASc score of 1 in males and 2 in females based on age 65 to 74 years, we recommend chronic OAC (Grade 1A). Up to date: Our approach to deciding whether to prescribe anticoagulant therapy for patients with AF (excluding those with rheumatic mitral stenosis that is severe or clinically significant [mitral valve area ≤1.5 cm2], a bioprosthetic valve [surgical or bioprosthetic] within the first three to six months after implantation, or a mechanical heart valve) is as follows: *For a CHA2DS2-VASc score ≥2 in males or ≥3 in females, we recommend chronic OAC (Grade 1A). *For a CHA2DS2-VASc score of 1 in males and 2 in females: -For patients with CHA2DS2-VASc score of 1 in males and 2 in females based on age 65 to 74 years, we recommend chronic OAC (Grade 1A). Age 65 to 74 years is a stronger risk factor than the other factors conferring one CHA2DS2-VASc score point. -For patients with other risk factors, the decision to anticoagulate is based upon the specific nonsex risk factor and the burden of AF. For patients with very low burden of AF (eg, AF that is well documented as limited to an isolated episode that may have been due to a reversible cause such as recent surgery, heavy alcohol ingestion, or sleep deprivation), it may be reasonable to forgo chronic OAC and institute close surveillance for recurrent AF, although it may not be possible to reliably estimate AF burden from surveying symptoms or infrequent monitoring. The frequency and duration of AF episodes vary widely over time, and episodes are often asymptomatic. *For patients with a CHA2DS2-VASc of 0 in males or 1 in females, we suggest against OAC (Grade 2C). Patient values and preferences may impact the decision. For example, a patient who is particularly stroke averse and is not at increased risk for bleeding may reasonably choose anticoagulation, particularly if the patient is a candidate for treatment with a direct oral anticoagulant (DOAC). 2019 AHA/ACC/HRS Focused Update of the 2014 AHA/ACC/HRS Guideline

Answer 530

C https://ranzcog.edu.au/wp-content/uploads/2022/05/Prevention-and-Management-of-Postpartum-Haemorrhage.pdf

Answer 531

E. The colour depends on the angle you hold the probe at Radiopaedia article: change of wording may change the answer to the question

Answer 532

C. Increased minute ventilation Cerebral blood flow Cardiac output Acid–base status Major haemorrhage Arterial inflow/venous outflow obstruction Oxygen content Haemoglobin concentration Haemoglobin saturation Pulmonary function Inspired oxygen concentration Inspired oxygen concentration

Answer 533

D - AB Group AB plasma or group A plasma that is high-titre negative can be given in an emergency when the blood group is unknown. Group AB plasma is universal but in short supply.

Answer 534

b) pKa Onset = pKa Duration = Lipophilicity Offset = protein binding BJA: Basic pharmacology of local anaesthetics https://www.bjaed.org/article/S2058-5349(19)30152-0/fulltext Local anaesthetic agents are amphipathic molecules. They bind primarily to sodium channels but also to potassium and calcium channels, and G-protein-coupled receptors. Structural modifications alter the physicochemical characteristics of a local anaesthetic. Speed of onset, potency, and duration depend on the pKa, lipid solubility and protein binding, respectively. All local anaesthetic agents carry a risk of toxicity.

Answer 535

b) 20mcg Grade (ANZAAG) 1 - mucocutaneous only (mild) 2 - mucocutaneous and hypotension and/or bronchospasm (moderate) 3 - life threatening hypotension and/or high airway pressure (severe) 4 - arrest For adults, put 3mg into a 50ml syringe (or 6mg into 100mls saline; and running in mls/hr = mcg/min) Doses: - 20mcg = Grade 2 - 100-200mcg = Grade 3 - 1mg = Grade 4 For Paediatrics: - put 1mg into 50ml syringe, (20mcg/ml; run @ 0.3ml/kg/hr = 0.1mcg/kg/min) - 2mcg/kg = Grade 2 (0.1ml/kg of this dilution) - 4-10 mcg/kg = Grade 3 - 10 mcg/kg = Grade 4 (0.1ml/kg of 1:10 000 (i.e. 100mcg/ml concentration)) - IM doses are: > 150mcg if <6 yrs > 300mcg if 6-12yrs;

Answer 536

e. Obstructive w/ reduced FEV1 Mucous narrowing airways = obstructive Parenchymal damage = restrictive Obstructive PFP remains the most common pulmonary function pattern in adult CF and is associated with -decrease FEV1 & FVC/FEV1 For patients with CF, an obstructive pattern is generally seen, with a decrease in forced expiratory volume in 1 s (FEV1), and forced vital capacity (FVC) to FEV1 ratio. https://academic.oup.com/bjaed/article/11/6/204/263786

Answer 537

c) initial bradycardia ANS Stimulation (PNS first, then SNS) - Bradycardic/Tachycardic - Hypertensive Neuro - Increased CMR/CBF/ICP - Increased IOP Increased Gastric pressure

Answer 538

d. Hyalase/hyaluronidase reaction/allergy https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4850816/

Answer 539

d) pregnancy A third heart sound reflects rapid left ventricular distention along with an increased atrioventricular flow Heard in Congestive heart failure Associated with Dilated Cardiomyopathy with dilated ventricles Less commonly valvular regurgitation and left to right shunts May be normal physiological finding in patients less than 40yrs old

Answer 540

c. 9 AHA guidelines 12 Months But 12 weeks minimum Although the evidence between surgical timing and stroke risk is limited to only these 2 studies, we suggest that elective noncardiac surgery be deferred at least 6 months after a prior stroke, and possibly as long as 9 months to reduce the risk of perioperative stroke in patients undergoing noncardiac surgery. Alternatively, patients who stand to gain significant improvements in quality of life with elective surgery may consider waiting only 6 months after a prior stroke

Answer 541

d) No difference no observed beneficial effect of sevoflurane on the composite endpoint of prolonged ICU stay, mortality, or both in patients undergoing high-risk cardiac surgery

Answer 542

b. Iliohypogastric

Answer 543

b) Decreased mortality due to bleeding TXA decreased death due to bleeding. No difference in all cause mortality. No difference in use of blood products. No difference in surgical interventions. No difference in thromboembolic events.

Answer 544

a) Less transfusion, same thrombosis ●A 2019 meta-analysis of randomized trials comparing preoperative administration of EPO versus placebo (32 trials; 4750 patients, mostly orthopedic and cardiac surgery) found reduced blood transfusions in the EPO groups. Decreased blood transfusions were seen in the entire population (RR 0.59, 95% CI 0.47-0.73; 28 trials), as well as the subgroups undergoing cardiac surgery (RR 0.55, 95% CI 0.47-0.73; nine trials) and major orthopedic surgery (RR 0.36, 95% CI 0.28-0.46; five trials). In addition, the EPO group had increased hemoglobin levels. There was no increase in the incidence of thromboembolic events with EPO.

Answer 545

PCA e) Posterior cerebral ischaemia UTD: Postoperative visual loss after anaesthesia for nonocular surgery Pupillary light reflexes* Unilateral central retinal artery occlusion, ischemic optic neuropathy, and retrobulbar hematoma result in a poor or absent pupillary response to light ("direct" response) with a normal response when light is directed to the other pupil ("indirect" response); this "relative afferent pupillary defect" is revealed when tested with the swinging flashlight maneuver; if these processes are bilateral, there will be poor or absent direct pupillary responses and a relative afferent pupillary defect only if asymmetric. Mid-dilated and nonreactive pupils are consistent with acute angle-closure glaucoma, while sluggish to fixed and dilated pupils are seen with glycine-induced visual loss. Pupillary light reflexes are normal in cases of corneal abrasion, cerebral or cortical visual loss, and in cases of PRES. Examination of pupils is discussed more fully separately.

Answer 546

Longer length Different cuff size/ length: The MLT® has a cuff size/ length that would be typical for an adult-sized 'standard' ETT. A 'standard' pediatric 5.0 enndotracheal tube has a smaller cuff made for a pediatric-sized trachea (see picture below). Distance of cuff from tube tip: In an MLT® the cuff is further away from the tube tip which is acceptable as the adult trachea is obviously longer than the pediatric one (see picture below). ## Footnote https://aam.ucsf.edu/microlaryngoscopy-tube-mlt%C2%AE

Answer 547

b) 20mg hydromorphone PO: morphine PO = 1: 5 So 12mg x 5= 60mg Morphine PO Which to convert to PO morph: IV morph is 3:1, so 60mg/3 = 20mg of parenteral morphine IV hydromorphone: IV hydromorphone 1mg = 15mg PO Morphine = 5mg IV morphine. How to remember this: - hydromorphone PCA is a 200mcg (1ml) bolus; 20mg into 100mls for PCA; therefore 20mg IV hydromorphone = 100mg IV morphine (i.e. 300mg PO morphine) - vial in recovery for pain protocol also comes as 2mg (i.e. 10mg IV morphine equivalent)

Answer 548

B. 50J ? In internal defibrillation, an initial dose of 20 joules is recommended to avoid burn-like injury to the myocardium. Care should be taken to avoid coronary vessels to prevent vessel damage. Subsequent doses can be increased to a maximum of 40 joules. Sterile internal pads must be used for internal defibrillation and should be readily available during any thoracotomy procedures Manufacturing manual for internal definition paddles say 50J maximum as higher has been shown to be damaging ## Footnote https://www.ncbi.nlm.nih.gov/books/NBK499899/

Answer 549

a. Tricuspid regurg Regurgitant CV waves: tricuspid regurgitation In tricuspid regurgitation, the backflow of blood out of the right ventricle obliterates the normal x descent. The c wave becomes accentuated and fuses with the v wave, as both are the results of right ventricular contraction (and the v wave peak pressure is often the same as the right ventricular peak systolic pressure). the reality is that they usually fuse completely to produce huge mutant waves, as seen here:

Answer 550

a) R1 side chain UP TO DATE: - sensitisation to R1 side chain in cephalosporins important in determining cross reactivity with penicillins.

Answer 551

b) Central retinal occlusion SE's from HBOT: - progressive myopia (reversible) - seizures - hypoglycaemia - sinus bradycardia from stimulation of vagal activity bassociated with hyperbaric pressures

Answer 552

Unclear: age of patient not given in question, real answer for patient >70yrs old appears to be lack of net benefit but this is not a remembered option Answer: A) increased incidence of major bleeding Low-dose aspirin should not be administered on a routine basis for primary prevention of ASCVD among adults >70 years. Low-dose aspirin should not be administered on a routine basis for primary prevention of ASCVD among adults >70 years. 2019 ACC/AHA Guideline on the Primary Prevention of Cardiovascular Disease Aspirin Candidates — For the secondary prevention of ASCVD in patients with diabetes, we recommend aspirin (75 to 162 mg daily). For the primary prevention of ASCVD in patients with diabetes at increased cardiovascular risk (10-year risk >10 percent), we suggest aspirin (75 to 162 mg daily), although the evidence supporting this approach is weak and needs to be balanced with the increased risk of gastrointestinal bleeding. We do not routinely use aspirin for the prevention of ASCVD in adults with diabetes at low risk (10-year ASCVD risk <10 percent). (See 'Guidelines' below.) 2019 ACC/AHA Guideline on the Primary Prevention of Cardiovascular Disease Aspirin Aspirin is well established for secondary prevention of ASCVD and is widely recommended for this indication, but recent studies have shown that in the modern era, aspirin should not be used in the routine primary prevention of ASCVD due to lack of net benefit. Most important is to avoid aspirin in persons with increased risk of bleeding including a history of GI bleeding or peptic ulcer disease, bleeding from other sites, age >70 years, thrombocytopenia, coagulopathy, chronic kidney disease, and concurrent use of nonsteroidal anti-inflammatory drugs, steroids, and anticoagulants. The following are recommendations based on meta-analysis and three recent trials: Low-dose aspirin might be considered for primary prevention of ASCVD in select higher ASCVD adults aged 40-70 years who are not at increased bleeding risk. Low-dose aspirin should not be administered on a routine basis for primary prevention of ASCVD among adults >70 years. Low-dose aspirin should not be administered for primary prevention among adults at any age who are at increased bleeding risk.

Answer 553

a) -30 Normal Axis https://litfl.com/super-axis-man-sam/ LITFL

Answer 554

C Ipsilateral deviation https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4308816/

Answer 555

Codeine Source Appendix ANZCA PG 07

Answer 556

Fibrinolysis In APTEM, coagulation is also activated as in EXTEM. By the addition of aprotinin or tranexamic acid in the reagent, fibrinolytic processes are inhibited in vitro. The comparison of EXTEM and APTEM allows for a rapid detection of fibrinolysis. Furthermore, APTEM enables the estimation if an antifibrinolytic therapy alone normalises the coagulation or if additional measures have to be taken (e.g. administration of fibrinogen).

Answer 557

c. 50% 0.25mg/kg (Half) Source: PolioSA And ANZCA bulletin 2015 ‘Anaesthetists need to be wary of post polio syndrome’ -“twice as sensitive to non-depolarising muscle relaxants”

Answer 558

Repeat d) Sarcoidosis Normal FEV1/FVC ratio = no obstruction Low FVC = restrictive pattern Low DLCO = interstitial lung disease Asthma and emphysema would have obstructive pattern. Myasthenia gravis would have normal DLCO Pulmonary HTN would have normal spirometry and low DLCO.

Answer 559

d. 65 to 85 per hundred Risk of acquiring CMV through a leucodepleted blood product is estimated at around 1 in 13,575,000. This compares to a community acquired risk where 85% of Australian adults are infected by the age of 40. 85% of australians are CMV positive by the age of 40 https://www.blood.gov.au/system/files/documents/cmv-blood-components.pdf

Answer 560

Answer: b. rocuronium anaphylaxis NB RadioAllergoabsorbentSpecificTesting is a serum test for specific IgE antibodies RAST morphine is both more sensitive and more specific than the RAST for individual NMBDs (due to reaction with quaternary ammonium) and is being used increasingly to determine NMBDs as cause of anaphylaxis. IKR! http://www.anzaag.com/anaphylaxis-management/testing-guidelines.pdf

Answer 561

d) major haemorrhage - blood loss is significantly less with RALP Up to date: RALP

Answer 562

a. Not safe or c. safe only in 1st trimester While relatively safe in early and mid pregnancy, NSAIDs can precipitate fetal cardiac and renal complications in late pregnancy, as well as interfere with fetal brain development and the production of amniotic fluid; they should be discontinued in gestational wk 32 APMSE

Answer 563

Answer: Hypocalcaemia ● AMH ○ Increased risk of adverse effects related to volume depletion(e.g. hypotension, fainting) ○ UTI

Answer 564

Answer: d. Rocuronium BJA Anaphylaxis to neuromuscular blocking drugs: incidence and cross-reactivity in Western Australia from 2002 to 2011 https://academic.oup.com/bja/article/110/6/981/245571 Rocuronium has a higher rate of IgE-mediated anaphylaxis compared with vecuronium, a result that is statistically significant and clinically important. Cisatracurium had the lowest rate of cross-reactivity in patients who had previously suffered anaphylaxis to rocuronium or vecuronium. Anaphylaxis rates (highest to lowest) Primary anaphylaxis: rocuronium > atracurium > vecuronium > pancuronium = cisatracurium Cross-reactivity: suxamethonium > rocuronium > vecuronium > pancuronium > atracurium > cisatracurium

Answer 565

d. none Increase in presence of mycobacterium vaginosis, doxycylcine will kill commensal bacteria Doxycycline is used for copper IUD in the setting of emergency insertion with PID

Answer 566

C. Elevated ICP - No Absolute contraindications - Relative contraindications 1. Raised ICP or space occupying lesion 2. MI within the last 3 months 3. Severe arterial hypertension 4. Acute Glacoma 5. Changes in the cerebral arteries e.g. aneurysm Pregnancy and Pacemakers are not contraindications to ECT Indications: 1. Depression (most common) 2. MDD with psychotic features 3. Schizoaffective disorder 4. Schizophrenia with catatonia 5. Highly suicidal or depressed pregnant patients (not first line) 6. Bipolar affective disorder 7. Neuroleptic malignant syndrome

Answer 567

b. von willebrand's disease - autosomal dominant inheritance - may have normal or prolonged APTT, PT is normal *Haem A: X-linked recessive disorder; would expect prolonged aPTT, and normal PT *Haem B: X-linked recessive disorder; would expect normal aPTT and normal PT REPEAT | vWD can have prolonged APTT or normal APTT. Haemophilias are X-linked

Answer 568

5 mmol bolus KCl 3.6 Potassium Potassium is an electrolyte essential for membrane stability. Low serum potassium, especially in conjunction with digoxin therapy and hypomagnesaemia, may lead to life threatening ventricular arrhythmias. Consider administration for: * Persistent VF due to documented or suspected hypokalaemia. [Class A; Expert consensus opinion] ANZCOR Guideline 11.5 August 2016 Page 9 of 13 Adverse effects: * Inappropriate or excessive use will produce hyperkalaemia with bradycardia, hypotension and possible asystole * Extravasation may lead to tissue necrosis. Dosage: A bolus of 5 mmol of potassium chloride is given intravenously

Answer 569

5d ANZCA - CrCl >80 (3D) 80-50 (4D) <50 (5D)

Answer 570

a) Pulsus paradoxus electric alternans Physical findings in Tamponade: - A number of findings may be present on physical examination, depending upon the type and severity of cardiac tamponade - None of the findings alone are highly sensitive or specific for the diagnosis. Beck's triad 1. Low arterial blood pressure 2. Dilated neck veins 3. Muffled heart sounds - Are present in only a minority of cases of acute cardiac tamponade. Physical findings of sinus tachycardia and the absence of frank hypotension may indicate significant hemodynamic compromise from cardiac tamponade and serve as an indication for immediate pericardiocentesis. In contrast, Kussmaul sign (the absence of an inspiratory decline in jugular venous pressure) is not usually seen in cardiac tamponade. Tachycardia and hypotension - Sinus tachycardia is seen in almost all patients, in an attempt to maintain cardiac output - Hypotension is somewhat more variably present - One exception is when the underlying disease is associated with bradycardia, as with a pericardial effusion and subacute cardiac tamponade associated with hypothyroidism. - Tachycardia also may not be seen in patients with early cardiac tamponade even though they have signs of a hemodynamically significant effusion, such as an elevated jugular venous pressure. Elevated jugular venous pressure - The JVP is almost always elevated in cardiac tamponade and may be associated with venous distension in the forehead and scalp. - CVP wave form: ->x descent is preserved ->y descent is attenuated or absent (due to the limited or absent late diastolic filling of the ventricle) Pulsus paradoxus -defined as: abnormally large decrease in systolic blood pressure (>10 mmHg) on inspiration - common finding in moderate to severe cardiac tamponade and is the direct consequence of ventricular interdependence. - not all patients with cardiac tamponade have pulsus paradoxus (eg, those with chronic hypertension leading to elevated ventricular diastolic pressures or those with a co-existent atrial septal defect). Pericardial rub — A pericardial rub may be heard in patients with cardiac tamponade due to inflammatory pericarditis. Electrocardiography - ECG in cardiac tamponade typically shows sinus tachycardia and may also show low voltage. - If pericarditis is present, the ECG findings typical of that disorder are also seen. - Electrical alternans is characterized by beat-to-beat alterations in the QRS complex and, in some cases, other electrocardiographic waves that reflect the swinging of the heart in the pericardial fluid. - Electrical alternans is relatively specific but not very sensitive for cardiac tamponade; rarely, this phenomenon is seen with very large pericardial effusions alone. Diagnosis: Clinical diagnosis is usually suspected based on the history and physical examination findings, which may include: ●Chest pain ●Syncope or presyncope ●Dyspnea and tachypnea ●Hypotension ●Tachycardia ●Peripheral edema ●Elevated jugular venous pressure ●Pulsus paradoxus Presence of a pericardial effusion on echocardiography with evidence of cardiac chamber collapse, flow variation, or dilation of the inferior vena cava is consistent with, and highly suggestive of, cardiac tamponade. However, the diagnosis of cardiac tamponade can only be confirmed by the hemodynamic and clinical response to pericardial fluid drainage.

Answer 571

d) 4 - WFNS is 4 * alternatively her Fisher score is: grade 2 (diffuse thin (<1 mm) SAH, no clots; which estimates an incidence of symptomatic vasospasm of 25%) Note the new modified Fischer scale. G0 No SAH or IVH (0%) G1 Focal or diffuse thin SAH but no IVH (6-24%) G2 Focal or diffuse thin SAH with IVH (15-33%) G3 Thick SAH no IVH (33-35%) G4 Thicc SAH with IVH (34-40%) The main differences between the Fisher scale and modified Fisher scale are: 1) Fisher scale, no SAH is grade 1, but 0 in modified Fisher scale 2) Fisher scale, thin SAH & no IVH is grade 2, but 1 in modified Fisher scale 3) Fisher scale, thick SAH with no IVH is grade 3 and the same 3 in modified Fisher scale 4) Fisher scale, any IVH is grade 4, irrespective of the presence of SAH but in modified Fisher scale it is either 2 if thin or no SAH, or grade 4 if thick SAH

Answer 572

e) Prothrombinex may potentiate DIC due to increasing thrombotic tendancy Australian redcross

Answer 573

D. perindopril Acute hypotensive transfusion reaction (AHTR) is characterized by the abrupt onset of hypotension immediately after the start of transfusion and usually resolves when transfusion ceases. Recent studies have shown an association with pre-operative treatment with an angiotensin-converting enzyme (ACE) inhibitor https://www.lifeblood.com.au/health-professionals/clinical-practice/adverse-events/hypotension

Answer 574

c) 420 ms i.e. RR interval = 60 / HR; therefore RR interval is 60/60 = 1 420 / square root of 1 is 420ms From LITFL: The corrected QT interval (QTc) estimates the QT interval at a standard heart rate of 60 bpm QT: Time from the start of the Q wave to the end of the T wave Represents time taken for ventricular depolarisation and repolarisation, effectively the period of ventricular systole from ventricular isovolumetric contraction to isovolumetric relaxation The QT interval is inversely proportional to heart rate: The QT interval shortens at faster heart rates The QT interval lengthens at slower heart rates An abnormally prolonged QT is associated with an increased risk of ventricular arrhythmias, especially Torsades de Pointes Corrected QT interval (QTc) The corrected QT interval (QTc) estimates the QT interval at a standard heart rate of 60 bpm This allows comparison of QT values over time at different heart rates and improves detection of patients at increased risk of arrhythmias Bazett formula: QTC = QT / √ RR Note: The RR interval is given in seconds (RR interval = 60 / heart rate).

Answer 575

b. high HDL-C ## Footnote https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.105.169405

Answer 576

20mg 12mg PO hydromorphone = 60mg PO morphine (Factor of 5) PO - IV Morphine = factor of 3 FPM App

Answer 577

PAPi goes down in acute RVF - actually designed to prognosticate in acute MI E is the answer https://www.ahajournals.org/doi/10.1161/CIRCHEARTFAILURE.121.009085#:~:text=The%20pulmonary%20artery%20pulsatility%20index,left%20ventricular%20assist%20device%20implantation.

Answer 578

e. 60g Each 20mg dantrolene contains 3g mannitol

Answer 579

b) 100 Brain trauma foundation Level III recommendation. To decrease mortality and improve outcomes: Maintain SBP at >100mmHg for patients 50 - 69 Maintain SBP at >110 for patients 15 - 49 Maintain SBP at >110 for patients 70 or older

Answer 580

b) 4% albumin - SAFE study (2004) showed increased mortality at 24 months when albumin used as resuscitation fluid cf normal saline. - Also caused higher ICP at 1 week post injury. - 4% albumin (274 mOsm/L & 266 mOsm/kg) is hypotonic and hypoosmolar.

Answer 581

Supraclavicular nerve – it is a superficial sensory nerve arising from C3/C4. Long thoracic nerve innervates serratus anterior muscle. Paralysis of this leads to medial winging of scapula (weakness of shoulder abduction). Lateral winging of scapula (where lateral side protrudes) is due to weakness of trapezius or rhomboid muscles which are innervated by spinal accessory nerves and dorsal scapular nerve respectively. Dorsal scapular nerve -> winging Accessory nerve -> winging S uprascapular nerve -> maybe Subscapular nerve - > maybe

Answer 582

5 days Previous MCQ2015A – cryoprecipitate once thawed must use within 4 hours. Previous MCQ2015B – FFP must be transfused within 4 hours once thawed, or stored at 2-6 degrees for 5 days.

Answer 583

e. Spinal level of drain According to AANN2 and SNACC4 Guidelines: * Patient positioning and leveling is crucial to prevent complications from lumbar drainage * The head of the bed, height of drainage chamber, and changes in patient positioning must be monitored closely to prevent sudden overdrainage * While making changes to the patient’s positioning, the lumbar drainage device should be clamped so that overdrainage does not occur https://www.integralife.com/file/general/1604065981.pdf (manufacturer's instructions)

Answer 584

e) haloperidol Bluebook - suggest antipsychotics with caution

Answer 585

Taking > 1 month https://associationofanaesthetists-publications.onlinelibrary.wiley.com/doi/full/10.1111/anae.14963 Daily doses of prednisolone of 5 mg or greater in adults and 10–15 mg.m−2 hydrocortisone equivalent or greater in children may result in hypothalamo–pituitary–adrenal axis suppression if administered for 1 month or more by oral, inhaled, intranasal, intra-articular or topical routes; this chronic administration of glucocorticoids is the most common cause of secondary adrenal suppression, sometimes referred to as tertiary adrenal insufficiency All children who have known glucocorticoid deficiency (primary or secondary), or who are at risk of glucocorticoid deficiency (on significant exogenous dose of glucocorticoid >10–15 mg.m-2 per day) 38, should receive an i.v. dose of hydrocortisone at induction (2 mg.kg−1 for minor or major surgery under general anaesthesia).

Answer 586

1% the overall cross-reactivity rate is approximately 1% when using first-generation cephalosporins or cephalosporins with similar R1 side chains." J Emerg Med. 2012 May;42(5):612-20. doi: 10.1016/j.jemermed.2011.05.035.Epub 2011 Jul 13.

Answer 587

c) Incidence of staphyloma But also reduced space between globe and orbit Axial eye length: implications for globe perforation during regional block – - The axial length of the eye (distance from the cornea to the retina) is routinely measured by ultrasound before cataract surgery to determine the proper intraocular lens size to be implanted. - It has been noted that patients with long eyes (axial length >25 mm) have an increased risk of needle injury during a retrobulbar (intraconal) block, usually due to penetration of the posterior pole of the globe. - Indications that the eye may be longer than average include a history of myopia in childhood (confirmed by an affirmative answer to the question, "Did the patient need to wear glasses as a child to see distant objects?") or the presence of globe-enveloping intraorbital hardware, such as a scleral buckle. - Also, patients with an abnormal outpouching of the eye called a staphyloma, which is usually associated with an axial length >25 mm and is usually located in the posterior portion of the globe, are at increased risk for globe perforation by a retrobulbar needle - In such patients, retrobulbar block is usually avoided in favor of a peribulbar (extraconal) or sub-Tenon block, topical anesthesia, or general anesthesia.

Answer 588

C) Adverse event—a clinical incident in which unintended or unneccessary harm resulted. Sentinel event: Sentinel events are a subset of adverse patient safety events that are wholly preventable and result in serious harm to, or the death of, a patient Adverse event—a clinical incident in which unintended or unneccessary harm resulted. Harm—impairment of structure or function of the body and/or any deleterious effects arising there from. Harm includes disease, injury, suffering, psychological harm, disability and death.* Near miss: an incident or potential incident that was averted and did not cause harm, but had the potential to do so. Near miss = an act that could have caused harm but was avoided Sentinel event = serious permanent harm (there are 12 listed) Adverse event = preventable event that did result in harm Malfeasance = less clear, more lawyer talk, but caused harm Misconduct = deliberate wrongful act

Answer 589

b) Posterior tibial and superficial peroneal If answer includes: Posterior Tibial, Sural and superficial peroneal this would be the most appropriate Or Posterior Tibial + Sciatic nerve as Sural, deep and superficial peroneal are all branches of the sciatic nerve

Answer 590

c) FEV1 43% In pulmonary function testing, a post-bronchodilator FEV1/FVC ratio of <0.70 is commonly considered diagnostic for COPD. The Global Initiative for Chronic Obstructive Lung Disease (GOLD) system categorises airflow limitation into stages. In patients with FEV1/FVC <0.70: GOLD 1 - mild: FEV1 ≥80% predicted GOLD 2 - moderate: 50% ≤ FEV1 <80% predicted GOLD 3 - severe: 30% ≤ FEV1 <50% predicted GOLD 4 - very severe: FEV1 <30% predicted.

Answer 591

No change in Mortality, no change in POD No evidence was found that mortality or serious complication were modified by targeting either a BIS of 50 or 35 A broad range of anaesthetic depth can be delivered safely when using volatile anaesthetic agents and processed electroencephalographic monitoring https://www.thebottomline.org.uk/summaries/pom/balance/

Answer 592

c Quincke Needles for spinal anesthesia or lumbar puncture can be classified according to the needle tip. Cutting-tip, or Quincke, needles have sharp, cutting tips, with the hole at the end of the needle. Whitacre and Sprotte needles are two types of pencil point, or noncutting tip needles. They have a closed tip shaped like a pencil, with the hole on the side of the needle near the tip. Pencil point needles are designed to minimize leak of cerebrospinal fluid after puncture and reduce the chance of postdural puncture headache.

Answer 593

a) NT ProBNP Sacubitril inhibits the enzyme neprilysin, which is responsible for the degradation of atrial and brain natriuretic peptide, two blood pressure–lowering peptides that work mainly by reducing blood volume. Neprilysin breaks down AT2 which leads to an accumulation, therefore an ARB is required in combination to block the effects of increased AT2. BNP may increase with treatment - particularly in the early phase. NT-proBNP is not a substrate of neprolysin and so will not increase. Successful treatment will show a fall in NT-ProBnP. “patients receiving LCZ696 had consistently lower levels of NTproBNP (reflecting reduced cardiac wall stress) and troponin (reflecting reduced cardiac injury) throughout the trial.” ## Footnote https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.114.013748?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed

Answer 594

b) Alcoholic liver disease - AST>ALT In hepatitis and paracetamol toxicity would expect ALT>AST. In cholecystitis, would expect a cholestatic picture with raised conjugated bilirubin and raised GGT/ALP. LITFL: Overall analysis of Liver Function Tests (LFT) Transaminitis: Aminotransferases (AST, ALT) - Generally associated with hepatocellular damage - Generally not associated with cholestasis Ratio of AST and ALT can be useful in differential ALT is more specific for liver damage than AST AST: ALT =1 -> Associated with ischaemia (CCF and ischaemic necrosis and hepatitis) AST: ALT >2.5 -> Associated with Alcoholic hepatitis -> Alcohol induced deficiency of pyridoxal phosphate AST: ALT <1 -> High rise in ALT specific for Hepatocellular damage -> Paracetamol OD with hepatocellular necrosis -> Viral hepatitis, ischaemic necrosis, toxic hepatitis -> Elevation with cholestasis (ALP, GGT) ALP – primarily associated with cholestasis and malignant hepatic infiltration Marker of rapid bone turnover and extensive bony metastasis GGT – sensitive to alcohol ingestion Marker of hepatocellular damage but non-specific Sharpest rise associated with biliary and hepatic obstruction

Answer 595

c) Decreased clearance – same dose

Answer 596

physical dependance BARASH: Physical dependence is a “physiologic state of adaptation to a specific psychoactive substance characterized by the emergence of a withdrawal syndrome during abstinence, which may be relieved in total or in part by re-administration of the substance.”

Answer 597

Chronic neurological symptoms from methionine depletion

Answer 598

Labetalol RANZCOG first line drugs are > methyldopa > labetalol > oxprenolol. Second line agents are: - hydralazine - nifedipine - prazosin. Acute Rx: Labetalol: 20-40mg IV q10min Nifedipine 10-20mg PO Q45min Hydralazine 5-10mg IV q20min

Answer 599

d) Knee extension weakness -> this is femoral innervation The sciatic nerve block results in anesthesia of the - posterior aspect of the knee - hamstring muscles - entire lower limb below the knee, both motor and sensory block, with the exception of skin on the medial leg and foot (supplied by the saphenous nerve). The skin of the posterior aspect of the thigh is supplied by the posterior femorocutaneous nerve, which deviates away from in the sciatic nerve proximal to the level of the anterior approach, and is therefore not blocked. NYSORA

Answer 600

E) LV hypertrophy ECHO FINDINGS intimal flap TYPING (type A): aortic regurgitation (acute dilatation of the aortic root, aortic leaflet prolapse, dissection flap prolapse, pre-existing disease, e.g. bicuspid valve) pericardial effusion and/or tamponade regional wall motion abnormality heralding coronary artery occlusion DOPPLER identifies true and false lumen detect aortic branch occlusion/ dissection (absent flow) Source LITFL

Answer 601

d) sciatic Sciatic best answer given dermatomes and osteotomes

Answer 602

a) Alprostadil Prostin (PGE1)

Answer 603

Intellectual impairment No solid refs

Answer 604

remembered options Airway pressure release ventilation (APRV) is an open-lung mode of invasive mechanical ventilation mode, in which spontaneous breathing is encouraged. APRV uses longer inspiratory times; this results in increased mean airway pressures, which aim to improve oxygenation. Brief releases at a lower pressure facilitate carbon dioxide clearance. The terminology and methods of initiation, titration, and weaning are distinct from other modes of mechanical ventilation. The use of APRV is increasing in the UK despite a current paucity of high-quality evidence high intrathoracic pressure decreases the transmural left ventricular pressure, reducing the work of contraction and increasing cardiac output. In the context of hypoxaemia, a mode of mechanical ventilation that improves arterial oxygenation will improve myocardial oxygen delivery, myocardial function and cardiac output. As APRV is a spontaneous breathing mode, in addition to the benefits of spontaneous ventilation, reduced doses of sedative drugs can often be used, with subsequent reduction of requirement for vasoactive drugs and improvement in haemodynamic state. Airway pressure release ventilation (APRV) is an open-lung mode of invasive mechanical ventilation mode, in which spontaneous breathing is encouraged. APRV uses longer inspiratory times; this results in increased mean airway pressures, which aim to improve oxygenation https://www.bjaed.org/article/S2058-5349(19)30178-7/fulltext https://derangedphysiology.com/main/required-reading/respiratory-medicine-and-ventilation/Chapter%20518/airway-pressure-release-ventilation-aprv-ards

Answer 605

b) cohort study What is a Cohort Study design? - Cohort studies are longitudinal, observational studies, which investigate predictive risk factors and health outcomes. - They differ from clinical trials, in that no intervention, treatment, or exposure is administered to the participants. - The factors of interest to researchers already exist in the study group under investigation. - Study participants are observed over a period of time. The incidence of disease in the exposed group is compared with the incidence of disease in the unexposed group. - Because of the observational nature of cohort studies they can only find correlation between a risk factor and disease rather than the cause. Cohort studies are useful if: - There is a persuasive hypothesis linking an exposure to an outcome. - The time between exposure and outcome is not too long (adding to the study costs and increasing the risk of participant attrition). - The outcome is not too rare.

Answer 606

d. 7 days A bolus dose of sugammadex is thought to have the following consequences: (i) the equivalent of missing one daily dose of oral contraceptives, and (ii) reduced efficacy of other hormonal contraceptives (e.g. implant, vaginal ring, or intrauterine system) requiring additional non-hormonal contraception be used for 7 days. https://www.bjanaesthesia.org/article/S0007-0912(18)30198-3/fulltext

Answer 607

a) Midazolam 0.15mg/kg 1st line: Midazolam IV/IO/IM --> 0.15mg/kg 2nd line: Midazolam IV/IO/IM --> 0.15mg/kg 3rd line: Keppra 40mg/kg (max 3g) 4th line: Phenytoin 20mg/kg or phenobarbitone 5th line: Intubation and deep sedation with midazolam, propofol +/- phenobarbitone

Answer 608

b. pneumonia Air bronchogram

Answer 609

Inconclusive/Noninf not demonstrated

Answer 610

C 3L/min LVOT area x VTI = SV 3cm2 x 10cm = 30ml SV x HR = CO 30 x 100 = 3000

Answer 611

Maximum P-wave corresponds to placement in the Cavo-atrial Junction (CAJ) Benefits of CAJ placement - furthest distance from "high risk" areas - Largest vein diameter - highest blood flow capacity - minimal risk for catheter migration and looping Too short placement: Increased risk of: - DVT - Phlebitis Too long placement: Increased risk of: - arrhythmias - tricuspid valve dysfunction atrial dysfunction ECG and corresponding anatomy: - Normal P-wave = upper vasculature prior to CAJ - Max P-wav= CAJ - Initial negative P-wave deflection = Right Atrium - Biphasic P-wave = Right Atrium - Inverted P-wave = Right Ventricle

Answer 612

c) Continuation leads to increased risk of major bleeding Aspirin in patients undergoing non cardiac surgery https://www.nejm.org/doi/full/10.1056/nejmoa1401105 Conclusions Administration of aspirin before surgery and throughout the early postsurgical period had no significant effect on the rate of a composite of death or nonfatal myocardial infarction but increased the risk of major bleeding. (Funded by the Canadian Institutes of Health Research and others; POISE-2 ClinicalTrials.gov number

Answer 613

c. 90 Warm ischaemia time: - Time from treatment withdrawal to the start of cold perfusion of the donated organs - Significance is the impact on graft function - Most important phase of WIT begins when the systolic BP is < 60mmHg - This includes the waiting period from the absence of circulation to the declaration of death and the time before initiating the flow of cold perfusate through the cannula Maximum WARM Ischaemia time - Heart 30 mins - Liver 30 mins - Pancreas 30 mins - Kidney 60 mins - Lungs 90 mins Maximum COLD Ischaemia time: - Heart = 4 hrs - Lungs = 6-8hrs - Liver/Pancreas = 12hrs (DBD)/6 hrs (DCD) - Kidneys = 18hrs (DBD)/ 12 hrs (DCD)

Answer 614

Creatinine Model for End-stage Liver Disease - Estimates disease severity and survival in patients with Liver Disease - Objective assessment - Score from 6-40 - Validated across a number of liver diseases and surgeries - MELD score is used as a method of allocation of organs to estimate survival MELD uses the following parameters: - Bilirubin - INR - Creatinine - [Hyponatraemia] ○ Part of the MELD-Na score update in 2016 ○ Sodium (Na) Values < 125 are set to 125 and values >137 are set to 137 4 MELD levels are: - >/=25 (gravely ill) - 24-19 - 18-11 - 15 should avoid elective surgery Calculation: MELD = 3.8*loge(serum bilirubin [mg/dL]) + 11.2*loge(INR) + 9.6*loge(serum creatinine [mg/dL]) + 6.4 MELD-Na = MELD + 1.32 * (137-Na) - [0.033*MELD * (137-Na)]

Answer 615

E. Urine output For adults with sepsis or septic shock, we suggest using dynamic measures to guide fluid resuscitation over physical examination or static parameters alone. Weak recommendation, very low-quality evidence. Remarks: Dynamic parameters include response to a passive leg raise or a fluid bolus, using stroke volume (SV), stroke volume variation (SVV), pulse pressure variation (PPV), or echocardiography, where available. https://journals.lww.com/ccmjournal/Fulltext/2021/11000/Surviving_Sepsis_Campaign__International.21.aspx

Answer 616

b) 90 PAO2: 0.4 (760 - 47) - 48/0.8 = 285 - 60 = 225mmHg 225 - 135 = 90mmHg.

Answer 617

Ventilate and wait for recovery

Answer 618

b) fibrinogen concentrate bleeding and low fib = concentrate not bleding and low = cryo

Answer 619

Thrombin rivaroxiban 10 dabigatran thrombin

Answer 620

e) Reversible hypermetropia

Answer 621

a) DDAVP Polyuria Low urine osm High serum osm High Na post transsphenoidal sx = Central DI

Answer 622

d) Knee extension weakness - most correct based on answers remembered - this is femoral innervation Superficial peroneal nerve injury (L4–5 S1–2) Mechanism of injury Lithotomy and the lateral position are the common risk factors as the nerve is potentially compressed at the fibular head. Length of time in lithotomy has not been associated with an increased risk of developing a PPNI. Clinical presentation There is loss of dorsiflexion and eversion of the foot (equinovarus deformity). Sensory manifestations are described along the anterolateral border of the leg and the dorsum of the digits except those supplied by saphenous and sural nerves. Orthobullets: Common peroneal nerve - superficial & deep branches Deep peroneal - motor: extensor digitorum longus, extensor hallucis longus (dorsiflexion) - sensory: 1st dorsal webspace Superficial peroneal - motor: peroneus longus and brevis (eversion) - sensory: dorsum foot (except for 1st dorsal webspace & 5th toe) Lower limb peripheral nerve injuries Sciatic nerve injury (L4–S3) Mechanism of injury Stretch, compression, ischaemia, and direct damage are the primary mechanisms. The lithotomy, frog leg, and sitting positions have been implicated in perioperative injury to this nerve (hyperflexion of the hip, abduction, and extension of the leg causes stretching). Regional anaesthetic techniques and hip arthroplasty may also cause injury. A higher incidence is seen in men aged 45–55 yr and in patients suffering with diabetes mellitus. The common peroneal component is usually affected, as this is more superficial compared with the tibial component. Clinical presentation Injury manifests as paralysis of the hamstring muscles and all the muscles below the knee leading to weak knee flexion and foot drop. All sensation below the knee except the medial aspect of the leg and foot is impaired.

Answer 623

A A - Alcohol is a common cause of macrocytosis and macrocytic anemia. (UpToDate) B - No - normally normocytic chronic disease anaemia C - No - microcytic D - I can't find anything on macrocytosis with thyrotoxicosis, but hypothyroidism definitely does E - Possibly.... https://hemonc.mhmedical.com/content.aspx?bookid=1783§ionid=121720217

Answer 624

Saphenous nerve It is a purely sensory nerve - rapid onset more suggestive or direct injury to nerve, later onset suggestive of ischaemia relating to oedema - mulscular injury related to tourniquet results in swelling/pain/weakness of affected muscle - post tourniquet syndrome - swollen, pale, stiff, weakness but not paralysis - L5 radiculopathy would affect knee flexion, but would have presented immediately post op if spinal related

Answer 625

Hereditary spherocytosis. Auto-haemolytic, intraplenic haemolysis. High reticulocyte count (6-20%) (normal range 0.5-2%)

Answer 626

renal tubular acidosis-> NAGMA HAGMA: Causes CATMUDPILES - CO/CN - Alcoholic ketoacidosis/ starvation ketoacidosis - Toluene (paint thinners) - Metformin/Methanol - Uraemia - DKA - Pyroglutamic Acidosis/paracetamol/ phenformin/propylene glycol/paraldehyde - Iron/ Isoniazid - Ethylene glycol (anti-freeze) - Salicylic Acid NAGMA: Causes CAGE: - Chloride - Acetazolamide and Addison's - GI causes (vomiting, diarrhoea, fistula) Extras: RTA

Answer 627

Left heart failure (pulmonary htn with raised Left sided pressure (PCWP 24mmHg) PCWP >15mmHg. Therefore post-capillary or combined pre-and post-capillary PH = Left heart failure (clinical group 2) Other Options are clinical groups 1,3,4 of PH and therefore not correct (as characteristic is PAWP<15mmHg). WHO pulmonary Htn classification 1: Primary arterial Hypertension 2: 2ry to left heart disease 3: 2ry to lung disease/hyypoxia 4: Chronic Thromboembolic disease 5: Unclear/multifactorial

Answer 628

a) saphenous

Answer 629

d) Peak of R wave The appropriate energy level is then selected, and the discharge/shock button is pressed and held. The defibrillator does not release the shock immediately. Instead, it waits for the next R-wave to appear and delivers the shock at the time of the R-wave. This allows the shock to be provided safely away from the T wave, avoiding the R-on-T phenomenon.

Answer 630

Poorly remembered options Definitely do not give Painstop as contains codeine Opioids should be PRN only c or d -go with D - tramadol versus oxycodone re OSA paracetamol 15mg/kg (360mg) QID ibuprofen 10mg/kg (240mg) TDS tramadol 1mg/kg (24mg) QID oxycodone 0.1-0.2mg/kg (2.4-4.8mg) 4hourly Codeine should not be used. Deaths. Ultrafast metabolisers --> high levels of morphine. Nonselective NSAIDs may increase the risk of any bleeding-related outcome after tonsillectomy in adults (U) (Level I); however, not in paediatric patients Prospect advice: The basic analgesic regimen should include paracetamol and non-steroidal anti-inflammatory drugs (NSAIDs) administered pre-operatively or intra-operatively and continued postoperatively. A single dose of intravenous (i.v.) dexamethasone is recommended for its analgesic and anti-emetic effects. Pre-operative gabapentinoids, intra-operative ketamine (only in children) and dexmedetomidine are recommended in patients with contra-indications to the basic analgesic regimen. Analgesic adjuncts such as intra-operative and postoperative acupuncture and postoperative honey are recommended. Opioids should be reserved as rescue analgesics in the postoperative period

Answer 631

B. 200 nanometers (0.2 micrometres)

Answer 632

d) 1:19000 The estimated incidence of patient reports of AAGA was ~1:19,000 anaesthetics. However, this incidence varied considerably in different settings. The incidence was ~1:8,000 when neuromuscular blockade was used and ~1:136,000 without it. Two high risk surgical specialties were Cardiothoracic anaesthesia (1:8,600) and Caesarean section (~1:670).

Answer 633

D) WPW B Sinus rhythm with very short PR interval (< 120 ms) Broad QRS complexes with a slurred upstroke to the QRS complexes — the delta wave Dominant S wave in V1 indicates a right-sided accessory path — sometimes referred to as “Type B” WPW Tall R waves and inverted T waves in the inferior leads and V4-6 mimic the appearance of left ventricular hypertrophy (LVH) — again, this is due to WPW and does not indicate underlying LVH

Answer 634

0.05-0.1mA Source: LITFL Macro is 100mA

Answer 635

d. acetazolamide acetazolamdie has been known to cause lactic acidosis but is less common than the other drugs listed unless there is a 5th option not remembered

Answer 636

c) Alcohol 70% - only suitable for short-term cannulation (<24 hours)

Answer 637

f) Increased SVR

Answer 638

Uncertain SIADH: 1. hypotonic hyponatraemia 2. urine osmolality > plasma osmolality (<275mOsm/kg) (i.e. concentrated urine despite hypotonic blood) 3. urinary Na+ > 20mmol/L 4. normal renal, hepatic, cardiac, pituitary, adrenal and thyroid function 5. euvolaemia (absence of hypotension, hypovolaemia, and oedema) 6. correction by water restriction Addison's Hypo natraemia HYPER kalaemia Hypo glycaemia Acidosis Diuretics Hypo natraemia Hypo kalaemia High urinary Na and K https://www.derangedphysiology.com/files/Electrolyte%20Disturbance.pdf JAMA article on hyponatraemia https://emergencymed.org.il/wp-content/uploads/2022/08/jama_adrogu_2022_rv_220011_1657919726.49616.pdf

Answer 639

a) anterior third of the tongue

Answer 640

Answer: A Aortic regurgitation - lack of dichrotic notch, high pulse pressure https://www.ahajournals.org/doi/full/10.1161/CIRCULATIONAHA.111.060319#d1e195

Answer 641

Ergometrin increases PVR and SVR

Answer 642

c) 30ml/kg After a dose of 10 to 15 mL/kg of FFP, plasma clotting factors rise about 15%, and the fibrinogen level rises by 40 mg/dL (0.4g/l) https://www.sciencedirect.com/topics/medicine-and-dentistry/fresh-frozen-plasma 1g/0.4g= 2.5 2.5 x 10ml/kg= 25ml/kg 2.5 x 15ml/kg= 37.5ml/kg 30ml/kg best answer For cryoprecipitate: One unit of Cryo is 15-20 mL in volume and contains 150-250 mg of fibrinogen. Cryo is generally transfused in pools of 10 units, which should increase an adult recipient's fibrinogen level by 50-100 mg/dL. (0.5-1g/l) 10 units of cryo= 200-300ml 200ml/70kg= 2.8ml/kg 300ml/70kg= 4.2ml/kg

Answer 643

c. Dobutamine In 2017 a similar questions was asked and an option for metaraminol was given, metaraminol could be a better answer as it will increase systemic pressure and reduce heart rate maintaining RCA perfusion at induction. Dobutamine and Milrinone can cause systemic vasodilation leading to reduction in systemic blood pressure and RCA perfusion pressure, Both adrenaline and Dopamine do not cause pulmonary vasodilation and can lead to tachyarhythmias Pulmonary hypertension and its management in patients undergoing non-cardiac surgery https://associationofanaesthetists-publications.onlinelibrary.wiley.com/doi/10.1111/anae.12831 Vasoconstrictors, inotropes and inodilators Maintaining the gradient between aorta and right ventricle is achieved by using sympathomimetic and non-sympathomimetic vasopressors. Noradrenaline and vasopressin improve perfusion of the right coronary artery, reduce the pulmonary/systemic vascular resistance ratio, enhance right ventricular performance and marginally improve cardiac output However, the evidence of their impact on mortality related to right heart failure is weak. Inotropes that enhance right ventricular performance, such as adrenaline, dobutamine and levosimendan are effective in treating right-sided heart failure. The use of inotropes has a modest impact in reducing the overall mortality related to PH, and their wide availability and ease of administration make this group of drugs very attractive for use in the peri-operative setting. Inodilators, such as the phosphodiesterase-3 inhibitors milrinone and enoximone, have been shown to be beneficial when compared with conventional inotropic support only. It appears that the influence of phosphodiesterase-3 inhibitors on reducing pulmonary vascular resistance is more pronounced than the reduction in systemic vascular resistance. However, reduction in systemic vascular resistance can compromise right coronary artery blood flow in patients with severe PH and therefore they should be administered cautiously. Treatment of pulmonary hypertensive crisis: General principles - Avoid hypoxic pulmonary vasoconstriction - Avoid hypercarbia, acidosis and hypothermia - Avoid high airway pressures - Optimise right ventricular preload - Reduce right ventricular afterload - Maintain coronary blood flow - Maintain sinus rhythm - Maintain arterial blood pressure and cardiac output Vasopressors– noradrenaline; vasopressin Inotropes– adrenaline; dobutamine Inodilators– milrinone; enoximone Intravenous vasodilators (caution if low systolic blood pressure) - Milrinone (25–50 μg.kg−1 bolus, followed by 0.5–0.75 μg.kg−1.min−1 continuous infusion) - Prostacyclin (4–10 ng.kg−1.min−1 continuous infusion) - Iloprost (1–3 ng.kg−1.min−1 continuous infusion) - Sildenafil (10 mg bolus three times a day) Selective pulmonary vasodilation - Iloprost (5–10 μg diluted in 10 ml saline, nebulised over 10 min, repeated every 2–4 h) - Prostacyclin (25–50 μg diluted in 50 ml saline, nebulised over 15 min, repeated every hour) - Nitric oxide (5–40 ppm continuously)

Answer 644

a) day of and 2 days prior

Answer 645

Proprioception Ventral (anterior) cord syndrome - Involves cords in the anterior 2/3rds of the spinal cord ○ Corticospinal tract ○ Spinothalamic tract ○ Descending autonomic tracts to the sacral centers for bladder control - Signs/symptoms ○ Weakness (CST) ○ Reflex changes (CST) ○ B/L temp and pain sensation (Spino) ○ Tactile and vibratory sense are normal ○ Urinary incontinence (Auto) - Causes: ○ Spinal cord infarction ○ Intervertebral disc herniation ○ Radiation myelopathy

Answer 646

Leave in situ and contact vascular surgeons

Answer 647

e. Hypocalcemia UTD: > HF penetrates quickly through the epidermal layer into the dermis and deeper. > Fluoride ions complex with calcium and magnesium, which can lead to hypocalcemia and hypomagnesemia. > These electrolyte abnormalities and the direct cardiotoxic effects of fluoride ions contribute to the development of cardiac arrhythmias, which are the primary cause of death in HF burns. > Hypocalcemia may stimulate an efflux of potassium ions from cells resulting in hyperkalemia, and predisposing to cardiotoxicity. > QTc interval prolongation, due to hypokalemia, hypomagnesemia, and/or hypocalcemia may be seen. > Calcium salts are the mainstay of treatment of hydrofluoric acid burns; the dose and route depend upon the clinical situation

Answer 648

b) Lingual nerve | Has fibres from both mandibular branch of CN V3 and CN VII

Answer 649

Dopamine - least likely to cause pulmonary vasodilation (all the others do to my knowledge) - From UP TO DATE: > At low doses of 1 to 3 mcg/kg per min, dopamine acts primarily on dopamine-1 receptors to dilate the renal and mesenteric artery beds > At 3 to 10 mcg/kg per min (and perhaps also at lower doses), dopamine also stimulates beta-1 adrenergic receptors and increases cardiac output, predominantly by increasing stroke volume with variable effects on heart rate. > At medium-to-high doses, dopamine also stimulates alpha-adrenergic receptors, although a small study suggested that renal arterial vasodilation and improvement in cardiac output may persist as the dopamine dose is titrated up to 10 mcg/kg per min *clinically, the haemodynamic effects of dopamine demonstrate individual variability Dobutamine (inodilator): - selective β1-agonist that increases cardiac contractility and reduces pulmonary vascular and systemic vascular resistances Vasopressin: - vasopressin may have pulmonary vasodilatory effects in addition to a systemic vasoconstrictive effect Milrinone (inodilator): - the phosphodiesterase-3 inhibitors, milrinone and enxoimone, have positive inotropic effects combined with the capacity to reduce RV afterload (‘inodilators’) without significant chronotropic effect, but they can be associated with significant systemic hypotension ## Footnote https://pubs.asahq.org/anesthesiology/article/121/5/914/13855/VasopressinThe-Perioperative-Gift-that-Keeps-on

Answer 650

b. Unstable angina UTD: Unstable angina (UA) and acute non-ST elevation myocardial infarction (NSTEMI) differ primarily in whether the ischemia is severe enough to cause sufficient myocardial damage to release detectable quantities of a marker of myocardial injury (troponins): ●UA is considered to be present in patients with ischemic symptoms suggestive of an ACS and no elevation in troponins, with or without electrocardiogram changes indicative of ischemia (eg, ST segment depression or transient elevation or new T wave inversion). ●NSTEMI is considered to be present in patients having the same manifestations as those in UA, but in whom an elevation in troponins is present. MINS: Myocardial injury after non-cardiac surgery (up to 30 days post-op): 1. Elevated postop troponin 2. Resulting from myocardial ischaemia (i.e. no evidence of a non-ischaemic aetiology), not requiring an ischaemic feature (i.e. no chest pain, no ECG change) VISION studies (Vascular Events in Noncardiac Surgery Patients Cohort Evaluation) demonstrated that severity of MINS strongly associated with 30-day mortality after NCS. hs-cTnT <20ng/L ~ 0.5% 30 day mortality 20-64ng/L ~3% 30 day mortality 65-999 ng/L ~9% 30 day mortality >1000ng/L ~30% 30 day mortality Whilst VISION trial identified MINS in at risk patients, the question now becomes what interventions are available to prevent this complication?

Answer 651

c) Lower airway obstruction Peripheral or lower airways obstruction: expiratory limb demonstrates concave upward, also called "scooped-out" or "coved" pattern.

Answer 652

c. inc extracellular fluid https://derangedphysiology.com/main/required-reading/electrolytes-and-fluids/Chapter%20531/hyponatremia-lazy-mans-classification

Answer 653

EXCEPT C) RV dilation Echo findings in Aortic Dissection: 1. Intimal flap 2. Type A dissection: - Aortic regurgitation -Acute dilation of aortic root -Aortic leaflet prolapse -Dissection flap prolapse -Pre-existing disease -Pericardial Effusion/Tamponade -RWMA 3. Colour flow doppler -identifies true and false lumen -aortic branch occlusion/dissection

Answer 654

Ultrasound view of right axillary brachial plexus AA = axillary artery AV = axillary vein McN = musculocutaneous nerve RN = radial nerve UN = ulnar nerve MN = median nerve CoBM = coracobrachialis muscle CT = conjoint tendon

Answer 655

D. Substance P Development of aprepitant, the first neurokinin-1 receptor antagonist for the prevention of chemotherapy-induced nausea and vomiting (2011) https://www.ncbi.nlm.nih.gov/pubmed/21434941 Aprepitant acts centrally at NK-1 receptors in vomiting centres within the central nervous system to block their activation by substance P released as an unwanted consequence of chemotherapy. REPEAT

Answer 656

d. Right middle lobe

Answer 657

e) sinus tachycardia https://academic.oup.com/bjaed/article/9/2/61/299563 Typically anorexic patients are hypotensive and bradycardic. Bradycardia reflects the decrease in basal metabolic rate that arises as an adaptive response to starvation Electrocardiographic abnormalities are common and may be found in >80% of strict dieters. These include: 1. atrioventricular block 2. ST depression 3. T wave inversion 4. QT prolongation.

Answer 658

E. 100 mcg/L ?? < 30mcg/L < 100mcg/L IF CRP > 5 and/or Transferrin saturation < 20 https://associationofanaesthetists-publications.onlinelibrary.wiley.com/doi/10.1111/anae.13773#:~:text=Recommendations%20for%20best%20clinical%20practice,-Physicians%20should%20consider&text=The%20presence%20of%20anaemia%20should,identification%20of%20absolute%20iron%20deficiency.

Answer 659

A. AION Answer is more likely ‘A - Anterior Ischaemic Optic Neuropathy, because: 1. Most common 2. One or two days post - up to 12 3. Optic disc oedema (CRAO - fundoscopic appearance is that retina appears pale with cherry red central spot). PION fundoscopy is normal at first but has late developing oedema. It is less common than AION. https://eyewiki.aao.org/Non-Arteritic_Anterior_Ischemic_Optic_Neuropathy_(NAION) As mentioned earlier, optic disc edema is always present in the acute phase of NAION (the reason will be discussed in the section under Pathophysiology) and comes in two varieties, diffuse or segmental. Posterior ischemic optic neuropathy (PION) encompasses those conditions that result in ischemia to any portion of the optic nerve posterior to the optic disc. By definition, PION will not cause disc edema. Symptoms: The classic description of patients with NAION presenting with acute, painless unilateral vision loss that is often described as a blurring or cloudiness of vision, often inferiorly, has been expanded. Although the majority of patients do not have accompanying pain, headache or periocular pain is reported in 8-12% of patients, which can make it difficult to differentiate from optic neuritis

Answer 660

e) 6-13 MHz Atlas of Ultrasound-Guided Procedures in Interventional Pain Management, 13 (2011) The wavelength and frequency of US are inversely related, i.e., ultrasound of high frequency has a short wavelength and vice versa. US waves have frequencies that exceed the upper limit for audible human hearing, i.e., greater than 20 kHz.3 High-frequency ultrasound waves (short wavelength) generate images of high axial resolution. Increasing the number of waves of compression and rarefaction for a given distance can more accurately discriminate between two separate structures along the axial plane of wave propagation. However, high-frequency waves are more attenuated than lower frequency waves for a given distance; thus, they are suitable for imaging mainly superficial structures.5 Conversely, low-frequency waves (long wavelength) offer images of lower resolution but can penetrate to deeper structures due to a lower degree of attenuation. For this reason, it is best to use high-frequency transducers (up to 10–15 MHz range) to image superficial structures (such as for stellate ganglion blocks) and low-frequency transducers (typically 2–5 MHz) for imaging the lumbar neuraxial structures that are deep in most adults.

Answer 661

b) Trigeminal, greater and lesser occipital nerves 2005 blue book article: six nerves need to be blocked bilaterally - supratrochlear - supraorbital - zygomaticotemporal - auriculotemporal - lesser occipital nerve - greater occipital nerve Minor contributions from the greater auricular nerve and third occipital nerve rarely encroach into the surgical field

Answer 662

b) Male gender Patient-related risk factors for OIVI are older age, female gender, sleep disordered breathing (SDB), obesity, renal impairment, pulmonary disease (in particular chronic obstructive pulmonary disease), cardiac disease, diabetes, hypertension, neurologic disease, two or more comorbidities, genetic variations in opioid metabolism, and opioid-tolerant patients. Modifiable risk factors include: * Coadministration of sedatives (e.g. benzodiazepines, gabapentinoids, antipsychotics and sedating antihistamines) * Simultaneous use of multiple opioid agents (this does not include verified doses of opioids taken for management of chronic pain, where the patient has developed a tolerance to and physical dependence on these medications) * Continuous infusions of opioids * Initiation of long-acting opioid preparations (including methadone) * Multiple prescribers * Inadequate nursing assessments or responses * Reliance on unidimensional pain scores alone to assess adequacy of analgesia, and chasing’ pain scores – that is, titrating opioids to pain scores alone to reduce them to a predetermined acceptable number * Using opioids for pain that is not opioid-responsive Source ANSCA PS 41

Answer 663

b. hepatic vein Pringle Manoeuvre = clamping hepatoduodenal ligament (clamps hepatic artery, portal vein, CBD)

Answer 664

C: Adductor Longus

Answer 665

B. distal to LSCA The appropriate performance of the IABP is dependent on proper position. Ideally, the tip of the balloon should be positioned 2–3 cm distal to the origin of the left subclavian artery (LSCA) ## Footnote https://academic.oup.com/bja/article/110/2/316/228037

Answer 666

d) Rhomboid

Answer 667

a) inhalational anaesthesia https://resources.wfsahq.org/atotw/emergence-delirium-in-pediatric-patients/

Answer 668

a) Greater auricular

Answer 669

TXA DDAVP for T1 Factor 8 for T2/3 or unresponsive DDAVP (RCH Guidelines)

Answer 670

a) Open repair Flow chart from Blue book https://jamanetwork.com/journals/jamasurgery/fullarticle/1741862

Answer 671

Answer: a) Codeine TGA Pregnancy categories https://www.tga.gov.au/prescribing-medicines-pregnancy-database Category A ■ Codeine Category C ■ Methadone ■ Tramadol ■ Oxycodone ■ Morphine

Answer 672

Tracheal stenosis

Answer 673

a) Vertebral orange = vertebral blue = basilar purple = PCA red arrows = AICA yellow = pontine arteries Circle of Willis:

Answer 674

c) Pleural effusion Source: BJA Ultrasound in critical care Thoracic US revealing a large pleural effusion (E) that has displaced the lung. The diaphragm (D) and liver (L) are visualized. The depth from the skin to the fluid has been measured. Insertion of the needle at this site is not advised; given the proximity to the liver, a more superior approach should be marked.

Answer 675

b. increased bleeding and normal aptt and inr Bleeding because cold = we know this Haemtology analyzer in labs warms blood to 37.2 degrees (fixes hypothermia on sample)

Answer 676

Repeat b. GA Grade 1: moderate hypoxia (Spo2<94%) or hypotension [fall in systolic blood pressure (SBP) >20%]. Grade 2: severe hypoxia (Spo2<88%) or hypotension (fall in SBP >40%) or unexpected loss of consciousness. Grade 3: cardiovascular collapse requiring CPR. Patient Risk factors: 1. old age 2. poor pre-existing physical reserve 3. impaired cardiopulmonary function -> NYHA 3 or 4 4. pre-existing pulmonary htn 5. Male Sex 6. Diuretics 7. ASA grade 3 or 4 8. osteoporosis 9. bony metastases 10. concomitant hip fractures (particularly pathological and intertrochanteric) (latter due to abnormal vascular channels through which marrow contents can enter the circulation) Surgical Risk factors 1. patients with previously un-instrumented femoral canal > revision surgery 2. Use of long-stem femoral component Anaesthetic Risk reduction: - discussion between surgeons and anaesthetists over uncemented vs. cemented based on patient Hx particularly if lon-stem prosthesis, femoral fracture or patients with cardiorespiratory disease - no clear evidence regarding the impact of anaesthetic technique - increase inspired O2 considered in all patients at time of cementation - avoid intravascular volume depletion - Higher level of haemodynamic monitoring in high risk patients Factors NOT predictive of severe BCIS include: Arteriosclerosis Angina pectoris Congestive heart failure Beta-blockers Angiotensin-converting enzyme inhibitors.

Answer 677

b) No difference NEJM: Timing of Renal-Replacement Therapy in Patients with Acute Kidney Injury and Sepsis Among patients with septic shock who had severe acute kidney injury, there was no significant difference in overall mortality at 90 days between patients who were assigned to an early strategy for the initiation of renal-replacement therapy and those who were assigned to a delayed strategy.

Answer 678

b. 1 or more RF In this iteration of the PONV guideline, one of the major changes is that we now recommend the use of multimodal prophylaxis in patients with one or more risk factors. This decision was made due to the concern over inadequate prophylaxis as well as the availability of antiemetic safety data.

Answer 679

d. L5/S1 disc prolapse with compression of interveterbral foramina pathology BJA: Chronic BAck Pain https://academic.oup.com/bjaed/article/6/4/152/387156?itm_medium=sidebar&itm_source=trendmd-widget&itm_campaign=BJA_Education&itm_content=BJA_Education_0 Neurological examination may reveal sensory, motor and reflex abnormalities. Nerve root pain can be caused by disc herniation, spinal stenosis and epidural adhesions. The nerve roots leave the spinal canal via the intervertebral foramina.

Answer 680

suxamethonium Organophosphate nerve agent poisoning: https://www.bjanaesthesia.org.uk/article/S0007-0912(19)30401-5/fulltext The depolarising neuromuscular blocking agent suxamethonium: - may have a longer onset (i.e. 2 min) and - duration of action (up to 12 h) secondary to the OP inhibition of BuChE. Caution should be exercised with non-depolarising neuromuscular blocking agents for up to 2 yr and lower doses used to avoid prolonged paralysis. Caution should also be exercised when using other BuChE metabolised drugs such as ester local anaesthetics and mivacurium Mainstay of treatment Pralidoxime and Atropine (5-10mg IV every 5-10mins until reversal of 3 B's) Benzodiazepines used for seizure termination Glycopyrolate not mentioned in treatment but could be useful

Answer 681

d. hyalase reaction/allergy

Answer 682

b. Gelofusin Gelatin

Answer 683

RCA (Inferior STEMI) - 80% RCA - 18% LCx - 2% rare wrap around LAD ST elevation in lead III > lead II Presence of reciprocal ST depression in lead I Signs of right ventricular infarction: STE in V1 and V4R Source LITFL

Answer 684

a) Lean body weight FROM SOBA: LBW exceeds IBW in obese and plateaus at ~100kg in men and ~70kg in females IBW used to calculate the adjusted body weight for maintenance infusion of propofol (IBW +40%). IBW calculated using Broca formula (Ht in cm - 100; Ht in cm =105; as optimal weights for men and women respectively in kg)

Answer 685

e. Basilar https://case.edu/med/neurology/NR/SubarachnoidHemorrhag3%20Bas2.htm

Answer 686

A - Modified WHO class 4 B - Modified WHO class 3 (4 if ANY complication) C - Modified WHO class 2-3 (if severe AS - 4) D - Modified WHO class 1 Class 4 = 40-100% risk of event Source https://academic.oup.com/eurheartj/article/39/34/3165/5078465 Table: https://academic.oup.com/view-large/186437995

Answer 687

a) Amiodarone 150mg over 30minutes, then 1mg/min for 6 hours UP TO DATE: Arrhythmias in COPD For patients with atrial fibrillation and COPD, we suggest using verapamil or diltiazem rather than metoprolol in patients who require ventricular rate control (Grade 2C). Metoprolol is reserved for patients who do not respond to the calcium channel blockers and do not have uncontrolled bronchoconstriction. For those with an accessory pathway or heart failure, amiodarone or digoxin may be preferred as outlined in the table (table 3). Addition of Digoxin in this answer stem could be prefered over Amiodarone

Answer 688

d) ECG ECG – have AVAILABLE for every anaesthetised patient. Should be used for patients undergoing general and major regional anaesthesia AS CLINICALLY INDICATED. Oxygen analyser – continuous operation for every patient when anaesthesia breathing system in use. Pulse oximeter – use for every patient undergoing general anaesthesia or sedation. Carbon dioxide monitor – use for every patient undergoing general anaesthesia, and have immediately available for sedation cases. ET Volatile – should be in use for every patient undergoing general anaesthesia from an anaesthesia delivery system where inhalational anaesthetic agents are delivered.

Answer 689

b. 0.5% Chlorhexidine/ETOH For skin preparation, 0.5 per cent chlorhexidine in alcohol, where available, is recommended for neuraxial techniques although it should be noted that very small quantities of neuraxial chlorhexidine have been implicated in cases of severe neurotoxicity

Answer 690

E LAFB: > Left axis deviation (usually -45 to -90 degrees) > qR complexes in leads I, aVL > rS complexes in leads II, III, aVF > Prolonged R wave peak time in aVL > 45ms LPFB: > Right axis deviation (RAD) (> +90 degrees) > rS complexes in leads I and aVL > qR complexes in leads II, III and aVF > Prolonged R wave peak time in aVF

Answer 691

a) Arterial puncture - thoracic duct injury is a risk with left sided IJ CVC insertion, but it is a rarer complication.

Answer 692

c. Long E time Spont vent not appropriate for this surgery as will require RSI so spont vent can't be ensured BJA: fontan circulation: For relatively short procedures, Fontan patients are probably better off breathing spontaneously, as long as severe hypercarbia is avoided. For major surgery, or when prolonged anaesthesia is required, control of ventilation and active prevention of atelectasis is usually advisable. Potential disadvantages of mechanical ventilation in Fontan patients relate to the inevitable increase in mean intrathoracic pressure. This causes decreased venous return, decreased pulmonary blood flow, and hence, decreased cardiac output. Low respiratory rates, short inspiratory times, low PEEP, and tidal volumes of 5–6 ml kg−1 usually allow adequate pulmonary blood flow, normocarbia, and a low PVR. Hyperventilation tends to impair pulmonary blood flow, despite the induced respiratory alkalosis, because of the increased mean intrathoracic pressure. https://academic.oup.com/bjaed/article/8/1/26/277637

Answer 693

30 (2 mg/kg) CEACCP Laryngospasm in anaesthesia (2014) https://academic.oup.com/bjaed/article/14/2/47/271333 Intravenous (IV): - 0.1-2 mg/kg - lower doses used to break laryngospasm, but keep patient spont vent Intramuscular (IM): - 4 mg/kg (max 200 mg) - break laryngospasm: 45-60 seconds - full paralysis: 3-4 minutes Intralingual (IL): - 2 mg/kg - an IM injection into body of tongue - full relaxation after 75 seconds Intraosseous (IO): - 1 mg/kg - onset 35 seconds

Answer 694

15-methyl-PGF2α (carboprost; Prostinfenem) which may be administered in one of two ways: Intra-muscular injection of 0.25mg, in repeated doses as required at intervals of not less than 15 minutes to a maximum total cumulative dose of 2.0mg (ie up to 8 doses) Source RANZCOG PPH Guideline 2021

Answer 695

c) Medial Cord

Answer 696

c. Genitofemoral

Answer 697

d) Hypercalcaemia SGLT2 inhibitors are relatively new and have several side effects that warrant caution, including the unique risks of diabetic ketoacidosis (DKA), mycotic genital infections and possibly lower limb amputations. Also polyuria, volume depletion, hypoT Hypoglycaemia As the glucose-lowering mechanism of SGLT2 inhibitors is glycaemia-dependent, hypoglycaemia risk is low. However, hypoglycaemia may occur when SGLT2 inhibitors are used in conjunction with sulphonylurea or insulin therapy. https://www1.racgp.org.au/ajgp/2021/april/use-of-sodium-glucose-co-transporter-2-inhibitors#:~:text=Safety%20and%20tolerability,and%20possibly%20lower%20limb%20amputations.

Answer 698

repeat a) Less transfusion, same thrombosis ●A 2019 meta-analysis of randomized trials comparing preoperative administration of EPO versus placebo (32 trials; 4750 patients, mostly orthopedic and cardiac surgery) found reduced blood transfusions in the EPO groups. Decreased blood transfusions were seen in the entire population (RR 0.59, 95% CI 0.47-0.73; 28 trials), as well as the subgroups undergoing cardiac surgery (RR 0.55, 95% CI 0.47-0.73; nine trials) and major orthopedic surgery (RR 0.36, 95% CI 0.28-0.46; five trials). In addition, the EPO group had increased hemoglobin levels. There was no increase in the incidence of thromboembolic events with EPO.

Answer 699

b) Rocuronium based on LBW

Answer 700

b) 250mcg IM q15mins, up to 2mg | QLD maternity guidelines Carpoprost 250mcg IM Repeat every 15-90min as r

Answer 701

c. 200mg hydrocortisone 200mg Hydrocortisone or 25mg Prednisolone Conversion Prednisone 1mg = Hydrocortisone 4mg = Dexamethasone 0.15mg = Triamcinolone 0.8mg = Methylprednisolone 0.8mg = Betamethasone 0.15mg = (https://litfl.com/corticosteroids-overview/)

Answer 702

d) >6 Medical emissions of N2O account for <4% of all emissions of N2O, the majority originating from microbial action on nitrogenous fertilizers

Answer 703

Chemosis is NOT a sign of arterial retrobulbar haemorrhage Signs of arterial retrobulbar haemorrhage: 1. Sudden onset proptosis 2. Raised IOP 3. Reduced acuity.

Answer 704

c. Two sets of pads, <1 second apart For DSED, to avoid possible defibrillator damage caused by shocks applied at the same instant, a short delay (<1 second) between shocks was created by having a single paramedic depress the “shock button” on each defibrillator in rapid sequence (anterior–lateral followed by anterior–posterior) Among patients with refractory ventricular fibrillation, survival to hospital discharge occurred more frequently among those who received DSED or VC defibrillation than among those who received standard defibrillation. https://www.nejm.org/doi/full/10.1056/NEJMoa2207304

Answer 705

Answer: a) 1:700 NAP5 Summary The incidence of reports of AAGA after general anaesthetic Caesarean section was much higher, ~1:670.

Answer 706

a) over-expansion The first graphic (loop a) shows the pattern of a typical pressure-volume loop, which rises in a counterclockwise direction until forming a complete loop. It also displays inflection points, which display rapid changes to the slope of the limb. The lower inflection point (LIP) occurs due to the opening of collapsed alveoli, resulting in a sharp increase in volume. The upper inflection point (UIP) occurs near the end of inspiration when more pressure leads to only a minimal increase in volume. The second graphic (loop b) displays how overdistension and hysteresis appear on a pressure-volume loop. Overdistention occurs when the lungs receive too much volume or pressure and can result in injury. Hysteresis refers to lung tissue that behaves differently on inspiration and expiration. In other words, it takes more energy for the lungs to inflate than it does to deflate. Therefore, hysteresis on a pressure-volume loop refers to the space between the inspiratory and expiratory limbs. When the patient’s lung compliance or airway resistance changes, so will the hysteresis and, thus, the appearance of the loop. Note: A pressure-volume loop under normal conditions should resemble the shape of a football (American). A curve with a flat appearance indicates decreased lung compliance. A steep curve, on the other hand, indicates increased lung compliance. A wide curve indicates increased airway resistance, whereas the opposite is true if the loop appears more narrow. https://www.respiratorytherapyzone.com/ventilator-waveforms/#:~:text=Note%3A%20A%20pressure%2Dvolume%20loop,hand%2C%20indicates%20increased%20lung%20compliance.

Answer 707

Glossopharyngeal

Answer 708

C. No Anticoagulation - if male CHA2DS2-VASc score ≥2 to be recommended chronic OAC (Grade 1A). - if female CHA2DS2-VASc score ≥3 to be recommended chronic OAC (Grade 1A). * non-sex risk factor also holds bearing: - For patients with CHA2DS2-VASc score of 1 in males and 2 in females based on age 65 to 74 years, we recommend chronic OAC (Grade 1A). Up to date: Our approach to deciding whether to prescribe anticoagulant therapy for patients with AF (excluding those with rheumatic mitral stenosis that is severe or clinically significant [mitral valve area ≤1.5 cm2], a bioprosthetic valve [surgical or bioprosthetic] within the first three to six months after implantation, or a mechanical heart valve) is as follows: *For a CHA2DS2-VASc score ≥2 in males or ≥3 in females, we recommend chronic OAC (Grade 1A). *For a CHA2DS2-VASc score of 1 in males and 2 in females: -For patients with CHA2DS2-VASc score of 1 in males and 2 in females based on age 65 to 74 years, we recommend chronic OAC (Grade 1A). Age 65 to 74 years is a stronger risk factor than the other factors conferring one CHA2DS2-VASc score point. -For patients with other risk factors, the decision to anticoagulate is based upon the specific nonsex risk factor and the burden of AF. For patients with very low burden of AF (eg, AF that is well documented as limited to an isolated episode that may have been due to a reversible cause such as recent surgery, heavy alcohol ingestion, or sleep deprivation), it may be reasonable to forgo chronic OAC and institute close surveillance for recurrent AF, although it may not be possible to reliably estimate AF burden from surveying symptoms or infrequent monitoring. The frequency and duration of AF episodes vary widely over time, and episodes are often asymptomatic. *For patients with a CHA2DS2-VASc of 0 in males or 1 in females, we suggest against OAC (Grade 2C). Patient values and preferences may impact the decision. For example, a patient who is particularly stroke averse and is not at increased risk for bleeding may reasonably choose anticoagulation, particularly if the patient is a candidate for treatment with a direct oral anticoagulant (DOAC). 2019 AHA/ACC/HRS Focused Update of the 2014 AHA/ACC/HRS Guideline

Answer 709

?? XR Reviews

Answer 710

b. Clonidine PROSPECT 2021 https://associationofanaesthetists-publications.onlinelibrary.wiley.com/doi/full/10.1111/anae.15299 Pre-operative and intra-operative interventions that improved postoperative pain were: - paracetamol; - non-steroidal anti-inflammatory drugs; - intravenous dexamethasone; - ketamine (only assessed in children); - gabapentinoids; - dexmedetomidine; - honey; - acupuncture. Inconsistent evidence was found for: - local anaesthetic infiltration; - antibiotics; - magnesium sulphate. Limited evidence was found for - clonidine. The analgesic regimen for tonsillectomy should include: 1. paracetamol; 2. non-steroidal anti-inflammatory drugs; and 3. intravenous dexamethasone, 4. with opioids as rescue analgesics. Analgesic adjuncts such as: 1. intra-operative and postoperative acupuncture as well as 2. postoperative honey are also recommended. 3. Ketamine (only for children); dexmedetomidine; or gabapentinoids may be considered when some of the first-line analgesics are contra-indicated

Answer 711

c) Lateral bladder wall resection obturator nerve stimulation BARASH: A serious intraoperative complication of TURBT is bladder perforation by the rigid cystoscope during tissue resection, which occasionally occurs owing to unexpected patient movement. For this reason, muscle relaxation is preferred during general anesthesia, particularly in lateral wall resections, where the obturator nerve may be stimulated by electrocautery, producing a violent contraction of the ipsilateral thigh muscles. Neuraxial anesthesia to the T9 to T10 dermatomal level also provides adequate anesthesia for the procedure and prevents the obturator reflex. Regional anesthesia may facilitate detection of bladder perforation. Postoperative pain is usually minimal and responds well to nonopiate and opiate medications.

Answer 712

e. haloperidol Clonidine-> no mention in the evidence dexmedetomidine-> as an infusion seems to reduce risk of post-op delerium and could be used to treat but not necessarily practical in combative patient Propofol-> not mentioned Midazolam-> avoid benzos as can worsen delerium If pharmacological approaches are required to reduce risk of harm to the person with agitated delirium, then haloperidol can be administered in incremental 0.5-mg doses. Benzodiazepines should be used for people with alcohol-related cognitive disorders or in people with Parkinsonian dementia. There is no evidence to support the use of prophylactic pharmacological measures (cholinesterase inhibitors, antipsychotics, melatonin) in routine peri-operative care for patients at risk of POD https://anaesthetists.org/Portals/0/PDFs/Guidelines%20PDFs/Guideline_Perioperative_care_of_people_with_dementia_2019.pdf?ver=2019-02-11-121238-777×tamp=1549888049165&ver=2019-02-11-121238-777×tamp=1549888049165 Duan and colleagues conducted a meta-analysis of 18 clinical trials and found that intraoperative and postoperative dexmedetomidine administration significantly reduces the risk postoperative delirium (odds ratio 0.35). -> https://www.bjanaesthesia.org/article/S0007-0912(20)30566-3/fulltext

Answer 713

d) less maternal bradycardia (repeat)

Answer 714

b) O2 consumption when sitting One metabolic equivalent (MET) is defined as the amount of oxygen consumed while sitting at rest and is equal to 3.5 ml O2 per kg body weight x min.

Answer 715

Right lateral Decubitus BJA: ultrasound

Answer 716

a) neostigmine infusion Consider this Ogilve's Syndrome Psuedo-obstruction. If > 9cm dilation, would need surgical management. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3168359/#!po=17.5000

Answer 717

phaeochromatoma

Answer 718

Adenosine (effect is exagerated)

Answer 719

Repeat a) Midazolam Blue Book 2019 RLS Definition -Common neurological sensorimotor disorder characterised by the urge to move ones legs -It is associated with unpleasnat paraesthesias deep within the legs during periods of rest or inactivity, whihc are relieved by movement Pathophysiology > RLS can be primary (idiopathic) or secondary > patients with secondary RLS develop symptoms secondary to another disease process or drug > causes of 2ry RLS include Iron deficiency, pregnancy, kidney disease, rheumatic disease and medications > 1ry RLS Pathophysiology is partially known and includes genteic component along with theories of dopamine and brain iron dysregulation Anaesthetic implications - RLS may worsen recur or present perioperatively - Common triggers include sleep deprivation and immobilisation - Drug therapy for RLS shopuld be continued perioperatively where possible - interuptions to treatment should be for the shortest time possible to prevent rebound effects - if imobilised for a long period of time, dopamine agonists such as rotigotone may be required - premedication with benzodiazepines or pregabalin may be useful - prolonged medical imaging procedures or procedures under local anaesthetic alone may not be possible. - post-op agitation 2ry to akathisia may be misinterpretted as delerium and treated with dopamine antagonists such as haloperidol which will worsen symptoms, Benzodiazepines should be used instead. Drugs that may exacerbate RLS 1. Classic neuroleptics - Haloperidol, prochlorperazine, promethazine 2. Atypical antipsychotics - clozapine, olanzapine, quetiapine 3. Antidepressants - amitriptyline, citalopram, lithium 4. Antihistamines - promethazine 5. Dopamine antagonist anti-emetics - metoclopramide 6. opioids - Tramadol (serotonin), naloxone/naltrexone (antagonists) > Opioids, oxycodone, fentanyl, morphine etc generally have a beneficial effect > IV anaesthetics, Inhalational anaesthetics, muscle relaxants, local anaesthetics, NSAIDs, Antiemetics have no effect Goals: 1. Prevent RLS exacerbation - avoid drug triggers - premedicate with benzos - use benzos for sedation - continue treatment for RLS - consider topical dopamine agonists when oral route unavailable 2. Alleviate post-op exacerbations - use parenteral opioids - Apomorphine - mobilise patient ASAP 3. Alleviate long-term exacerbation of RLS after surgery - monitor ferritin levels - If ferritin level < 75mcg/ml treat with oral or IV iron replacement - transiently increase dopamine agonist dose to TDS or QID if unable to leave bed

Answer 720

d) Fetal cells Does not remove foetal red cells or vasoactive molecules (eg don’t use in pheochromocytoma surgery).

Answer 721

B 6 hours 20 x 25 x 4 = 2000 L (Parklands) In first 8 hours 50% 1 L in 8 hours FROM TIME OF BURN So in 6 hours.

Answer 722

Less phrenic nerve block

Answer 723

a) Normal lungs Probe selection Linear probe (8–12 MHz) These high-frequency probes give good resolution of superficial structures. As the anterior pleura is relatively superficial, excellent images of the pleura and lung sliding can be obtained. The poor penetration of high-frequency US and the narrow sector width mean deeper structures are poorly imaged. Curvilinear probe (3–5 MHz) This is the best all-round probe for LU. Lung sliding can be easily visualized as can IS. Effusions, consolidated lung, and the diaphragm are also well imaged because of the good penetration and large sector width. The large footprint of the probe means some angulation is needed to avoid the ribs when scanning postero-laterally. Phased array (3–4.5 MHz) These probes have a useful footprint for getting in between the ribs. They can be used to demonstrate all the signs of LU but the clarity of the images is not as good. General points The clearest images are obtained by having the image as shallow as possible with the focus point at the level of interest. The frequency can be adjusted to enhance the image, depending on the depth. Increasing the frequency on a curvilinear probe will improve the appearance of lung sliding whilst worsening the appearance of a consolidated lung base.

Answer 724

a. Diclofenac LIthium perioperative concerns: - Prolongation of NMB - Reduction in anaesthetic agent requirement - Avoid NSAIDs - No withdrawl symptoms - Discontinue 24hrs before surgery NSAIDs differentially alter lithium concentrations by multiple mechanisms, and one of these is to reduce prostaglandin E2 BJA: perioperative advice for psychotropic drugs

Answer 725

a. Reduced Myoglobinaemia Repeat but its not myoglobinuria it was myoglobinaemia - There is NOT reduced myoglobinuria with AIR compared to MH (both have myoglobinuria) - There IS less increase in ETCO2 - There IS less muscle rigidity

Answer 726

a) Smaller bolus smaller total dose

Answer 727

b. Celecoxib The ANZCA pain booklet also references this study: Risk of acute myocardial infarction with NSAIDs in real world use: bayesian meta-analysis of individual patient data With use for one to seven days the probability of increased myocardial infarction risk (posterior probability of odds ratio >1.0) was 92% for celecoxib, 97% for ibuprofen, and 99% for diclofenac, naproxen, and rofecoxib. The corresponding odds ratios (95% credible intervals) were 1.24 (0.91 to 1.82) for celecoxib, 1.48 (1.00 to 2.26) for ibuprofen, 1.50 (1.06 to 2.04) for diclofenac, 1.53 (1.07 to 2.33) for naproxen, and 1.58 (1.07 to 2.17) for rofecoxib. Greater risk of myocardial infarction was documented for higher dose of NSAIDs. With use for longer than one month, risks did not appear to exceed those associated with shorter durations. The ANZCA pain booklet also references this study https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6281031/ Naproxen OR 1, Celecoxib OR 1.3, Ibuprofen OR 1.49, Diclofenac OR 1.63 in UK study 2016 investigating NSAID use in knee OA.

Answer 728

b) Suprahyoid Extrinsic Muscles of the larynx: 1. Sternothyroid muscle 2. Thyrohyoid muscle 3. Inferior constrictor of the pahrynx Indirect elevators of the larynx: 1. Mylohyoid 2. Stylohyoid 3. geniohyoid Indirect depressors of the larynx: 1. Sternohyoid 2. Omohyoid Intrinsic Muscles of the larynx: 1. Posterior Cricoarytenoid 2. Lateral Cricoarytenoid 3. Interarytenoid 4. Thyroarytenoid 5. Vocalis 6. Cricothyroid actions of intrinsic laryngeal muscles 1. Abductor of the cords: posterior cricoarytenoids 2. Adductors of the cords: lateral cricoarytenoids, interarytenoids 3. Sphincter to the vestibule: aryepiglottics (interarytenoid), thyroepiglotics 4. Tension regulators of the cords: Cricothyroids (tensors), Thyroarytenoids (relaxors), Vocales (fine adjustment)

Answer 729

a) Femoral nerve Nerve roots: L2-L4 Motor functions: Innervates the anterior thigh muscles that flex the hip joint (pectineus, iliacus, sartorius) and extend the knee (quadriceps femoris: rectus femoris, vastus lateralis, vastus medialis and vastus intermedius), Sensory functions: Supplies cutaneous branches to the anteromedial thigh (anterior cutaneous branches of the femoral nerve) and the medial side of the leg and foot (saphenous nerve).

Answer 730

c Laparotomy, Right thoracotomy Ivor-Lewis transthoracic esophagectomy — The Ivor-Lewis transthoracic esophagectomy can be used to resect cancers in the lower third of the esophagus but is not the optimal approach for cancers located in the middle third because of the limited proximal margin that can be achieved. This procedure combines a laparotomy with a right thoracotomy and an intrathoracic esophagogastric anastomosis. This approach permits direct visualization of the thoracic esophagus and allows the surgeon to perform a full thoracic lymphadenectomy. We prefer a minimally invasive Ivor-Lewis approach to a thoracotomy. Transhiatal esophagectomy — A transhiatal esophagectomy (THE) can be performed to resect cervical, thoracic, and esophagogastric junction (EGJ) esophageal cancers; it is performed through an upper midline laparotomy incision and a left neck incision, typically without a thoracotomy. Modified Ivor-Lewis transthoracic esophagectomy (left thoracoabdominal esophagogastrectomy) — A modification of the Ivor-Lewis transthoracic esophagectomy includes a left thoracoabdominal incision with a gastric pull-up and an esophagogastric anastomosis in the left chest. This approach is most useful for tumors involving the gastroesophageal junction. Only one incision is required, but disadvantages include a high incidence of complications such as postoperative reflux and limitation of the proximal esophageal margin by the aortic arch. Tri-incisional esophagectomy — The tri-incisional esophagectomy combines the transhiatal and transthoracic approaches into a transthoracic total esophagectomy with a thoracic lymphadenectomy and cervical esophagogastric anastomosis. The three-incisional technique allows the surgeon to perform a complete two-field (mediastinal and upper abdominal) lymphadenectomy under direct vision and a cervical esophagogastric anastomosis. We prefer a thorascopic approach to the chest rather than a thoracotomy to minimize the risk of respiratory complications. Esophagectomy is a technically difficult operation, and the complication rate is high due to the anatomic challenges of the procedure. The choice of surgical approach depends upon many factors, including: ●Tumor location, length, submucosal extension, and adherence to surrounding structures ●The type or extent of lymphadenectomy desired ●The conduit to be used to restore gastrointestinal continuity ●Postoperative bile reflux ●The preference of the surgeon

Answer 731

D. Cerebral Abscess HBOT Indications: - Indications are related to need for enhanced Pressure or oOxygenation and treatment of infection: Pressure - air or gas embolism - Decompression sickness Oxygenation: - arterial insufficiencies (central retinal artery occlusion, enhancement of healing in wound problems) - Carbon monoxide poisoning - Compromised grafts and flaps - Acute traumatic ischaemia - Delayed radiation injuries - Sudden sensorineural hearing loss - Severe Anaemia - Thermal burns Infection: - Clostridium myonecrosis (gas gangrene) - Intracranial abscess - Necrotising soft tissue infections - Refractory osteomyelitis Absolute Contraindications to HBOT: - untreated PTx - Premature Infants - Bleomycin - Disulfiram (antabuse) - Cisplatin Relative contraindications: - Pregnancy - Asthma - Thoracic Surgery - Emphysema with CO2 retention - upper respiratory tract infections - History of middle ear surgery or disorder - History of seizures - Fevers - Congenital spherocytosis - Optic neuritis

Answer 732

a. Cerebral oedema Cerebral Oedema Source: UpToDate

Answer 733

c) gas trapping Specific features of increased airway resistance seen here are: High peak airway pressure, but a normal plateau pressure Slow return of the flow-time curve to baseline The flow-time curve does not reach baseline (indicating that emptying is incomplete)

Answer 734

c. Iliacus

Answer 735

Life threatening organ dysfunction caused by a dysregulated host response to infection

Answer 736

c) Decreased CO, Increased SVR It is plausible that a case of pre-eclampsia that occurs earlier in gestation and is associated with fetal growth restriction is related to low cardiac output and high peripheral vascular resistance with a much similar profile as observed in women with fetal growth restriction without HDP. In cases of later and term gestation pre-eclampsia, babies tend to be larger and there is a predominantly high cardiac output, low peripheral vascular resistance and raised intravascular volume state. Certainly, the clinical phenotype of a very ‘dry’, intravascularly depleted woman at 26 weeks with a growth restricted baby and conversely of a well-perfused oedematous woman with a bounding pulse and large baby at 38 weeks rings true: both have hypertension, but the mechanisms may be diametrically opposite. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5569150/

Answer 737

Death in bleeding trauma patients Early administration of TXA safely reduced the risk of death in bleeding trauma patients and is highly cost-effective. Treatment beyond 3 hours of injury is unlikely to be effective. - Reduced death due to bleeding x 0.85 - Equivocal blood transfusion - Equivocal thromboembolism

Answer 738

B. Intrathecal spread c) = d) ?! possible, but respiratory function not effected until very late ATOTW: COMPLETE SPINAL BLOCK FOLLOWING SPINAL ANAESTHESIA (2010) CARDIO- RESPIRATORY Hypotension* Bradycardia* Respiratory compromise* Apnoea* Reduced oxygen saturation Difficulty speaking/coughing Cardiac arrest (asystole) NEUROLOGICAL Nausea and anxiety* Arm/hand dysaesthesia or paralysis* High sensory level BLOCK Cranial nerve involvement Loss of consciousness* CEACCP Paraveterbral Block (2009) The overall incidence of reported complications with PVBs is between 2.6% and 5%; however, the risk of long-term morbidity is exceedingly low. No fatality directly attributable to PVBs has been reported. The failure rate in experienced hands varies between 6.8% and 10%, which is broadly comparable with epidural analgesia. Other specifically reported complications include: hypotension 4.6%, vascular puncture 3.8%, pleural puncture 1.1%, and pneumothorax 0.5%. Inadvertent pleural puncture may not be recognized, as a short but effective interpleural block will result. The actual frequency of this complication may therefore exceed 1.1%, particularly with the cranial approach. If pleural puncture is appreciated, an interpleural block can be performed intentionally and a catheter inserted to prolong analgesia. Pneumothorax only rarely follows pleural puncture but when it occurs, it is usually small and can therefore be managed conservatively. Tension pneumothorax is a potential complication in ventilated patients, but no cases have as yet been reported. Bilateral block has been reported in up to 10% of cases, which is usually due to epidural spread and less commonly to mass movement of the drug across the midline in the prevertebral plane. Epidural spread is more common with a more medial injection site and with catheter techniques, although block distribution tends to be less on the contralateral side. Ipsilateral Horner’s syndrome is a common side-effect with blocks extending to T1 and T2. Total spinal anaesthesia is very rare and has only been reported twice in the world literature. However, if the plane of approach of the needle is close to the midline, the dural cuff surrounding the intercostal nerve can be penetrated.

Answer 739

ION Post - spinal Ant - cardiac repeat

Answer 740

c. Late inflation

Answer 741

Answer: 3%. (5%/240) x 160 Principle: If Vaporizer specific for agent with low SVP (Enflurane or Sevoflurane) is misplaced with an agent that has high SVP (halothane or isoflurane) then actual output concentration will be greater than the concentration indicated by dial. (inverse is also true) Administration of sevoflurane using other agent-specific vaporizers: The current study investigated the concentration of sevoflurane that could be achieved when sevoflurane was administered using standard agent-specific halothane, isoflurane, and enflurane vaporizers. An artificial lung analog model was made by attaching the 3-L reservoir bag to the 15-mm end of the anesthesia circle system. The lung analog was attached and ventilated with oxygen and air at flow rates of 2 L/min each (total gas flow = 4 L/min), a tidal volume of 800 mL, a rate of 10 breaths/min, and an inspiratory-to-expiratory ratio of 1:2. The vaporizer was filled with sevoflurane and the dial turned to 1%. After a 10-minute equilibration period, the concentration of sevoflurane was measured. The vaporizer concentration was increased in 1% increments, and after a 10-minute equilibration, the sevoflurane concentration was recorded. The dial was increased from 1% to 5% for the halothane and isoflurane vaporizer and from 1% to 7% for the enflurane vaporizer. Each study was repeated five times at each incremental increase of 1% for each of the three vaporizers. The series of studies were repeated using a total gas flow of 8 L/min (oxygen 4 and air 4) instead of 4 L/min (oxygen 2 and air 2). Using the halothane or isoflurane vaporizers at the 5% setting, the maximum sevoflurane concentrations achieved were 3.0% and 3.1%, respectively. The sevoflurane concentration was a maximum of 6% using the enflurane vaporizer set at 7%. The sevoflurane concentration decreased significantly when using any of the three vaporizers at all concentrations when the gas flow was increased from 4 to 8 L/min. The current study demonstrates that clinically useful concentrations of sevoflurane can be achieved with the administration of sevoflurane through an enflurane vaporizer. Although this is not routinely recommended, in specific circumstances it may allow the use of sevoflurane in third-world countries if sevoflurane vaporizers are not available and the use of sevoflurane is clinically necessary.

Answer 742

a. Anterior Cerebral Artery https://case.edu/med/neurology/NR/ACAaneur.html

Answer 743

Category GFR ml/min/1.73 m2 Terms G1 ≥90 Normal or high G2 60-89 Mildly decreased* G3a 45-59 Mildly to moderately decreased G3b 30-44 Moderately to severely decreased G4 15-29 Severely decreased G5 <15 Kidney failure Assign Albuminuria category as follows: Albuminuria categories in CKD Category ACR (mg/g) Terms A1 <30 Normal to mildly increased A2 30-300 Moderately increased* A3 >300 Severely increased** Abbreviations: ACR, albumin-to-creatinine ratio; CKD, chronic kidney disease. *Relative to young adult level. **Including nephrotic syndrome (albumin excretion ACR >2220 mg/g) **Collectively referred to as “CGA Staging” REPEAT

Answer 744

b) pulmonary trunk

Answer 745

a. Calcium gluconate

Answer 746

d. Cardiac tamponade Deranged physiology In summary The CVP is raised All CVP waveform components are elevated a and v waves are tall x descent is steep y descent is (usually) absent

Answer 747

D. Albumin ## Footnote https://www.tamingthesru.com/blog/r1-diagnostics/labs-in-hepatic-failure

Answer 748

c) Lowest FiO2 possible oxygen administration/ low fio2 assumed bleomycin

Answer 749

C. Oedema Blue book 2017 The aetiology of UAO differs from that of airway compromise seen after thyroid or carotid surgery. Haematoma formation and cerebrospinal fluid leak are potential complications of CSS that usually present early in the postoperative period, whereas upper airway obstruction most commonly develops in the late postoperative period (days rather than hours). UAO occurs because of prevertebral tissue swelling that evolves late in the postoperative course. The danger is that the onset can be insidious in a ward environment, leading to late recognition and limited availability of practitioners with airway expertise12. Development of prevertebral oedema has been implicated in several near misses and deaths, which became the sentinel events that stimulated creation of departmental protocols to safely manage these patients postoperatively

Answer 750

Answer: c. Urgent transfer to theatre BJA Anaesthesia for interventional neuroradiology https://academic.oup.com/bjaed/article/8/3/86/293346 Clinical signs of a rise in ICP or a sudden rise in blood pressure with or without a fall in heart rate should alert the anaesthetist to this possibility. Extravasation of contrast may also be seen. The goals are to increase coagulability by reversing heparin, decrease bleeding by lowering blood pressure (to the level before the bleed), control ICP with hyperventilation, head elevation, steroids and osmotic agents, control seizures, and initiate cerebral protection. Once the bleeding is controlled, the pressure may be raised to check for leaks. Usually, the coiling continues; rarely, a ventriculostomy may be required. If the coiling is unsuccessful, a rescue craniotomy and clipping will be required. Management may also involve performance of CT scans and subsequent transfer to ICU.

Answer 751

No change in outcomes repeat

Answer 752

b) no limitation in neck movement

Answer 753

e) Pneumonia Signs of Pneumonia on lung ultrasound: > Early Pneumonia - B-lines and areas of sub pleural consolidation - Fluid filled alveoli surrounded by air-filled lungs cause a short path reverberation and B-lines can be seen - localised patches of numerous B-lines indicate sub-pleural consolidation > Hepatization: solid appearing consolidated lung - inflammatoy and purulent fluid filled alveoli makes the lung appear solid, with homogenous relatively fine echotexture similar to liver - Atelectasis can also cause solid non-aerated lung and it can be difficult to distinguish the two conditions > Shred sign: irregular consolidation/ air interface - consolidated areas adjacent to aerated areas where the consolidated areas will be linear and well defined > Air bronchograms and dynamic air bronchograms - Air within consolidated area may remain in small aerated patches of lung or more commonly air remains within small bronchi, small air bubbles all lined up within a bronchus are known as sonographic air bronchograms - when air bubbles are seen to bubble in and out with each breath the term "dynamic air bronchogram" is used > Colour doppler interrogation: flow remains - pulmonary arterial and venous vasculature are well demonstrated in areas of consolidation Associated pleural effusion or empyema - small hyperechoic parapneumonic effusion are frequently demonstrated - echogenic debris within the effusion suggest empyema

Answer 754

First degree heart block + Left Anterior hemiblock ECG criteria for LAFB/LAHB Left axis deviation (usually -45 to -90 degrees) qR complexes in leads I, aVL rS complexes in leads II, III, aVF Prolonged R wave peak time in aVL > 45ms

Answer 755

d. 7 weeks UPDATE: 2-3 weeks PG68(A) https://www.anzca.edu.au/getattachment/af1fb728-5e87-413a-b006-c54cecf282b1/PG68(A)-Guideline-surgical-patient-safety-SARS-CoV-2 For most patients, it is safe to proceed with surgery TWO TO THREE WEEKS post SARS-CoV-2 infection provided no ongoing symptoms are present. For high-risk patients, it is recommended to perform an individualised risk assessment and utilise Shared Decision Making to determine optimal timing of surgery post SARS-CoV-2 infection. Patients who are asymptomatic, have returned back to baseline, are vaccinated, aged <70 years and without comorbidity can proceed with non-urgent elective minor surgery (day case) and endoscopy procedures without delay beyond the infectious period (timeframe as per local guideline and expertise ALL patient with ongoing symptoms, especially those who have not returned to baseline function and those patients with a history of moderate or more severe25 SARS-CoV-2 infection: recommended delay for non-urgent elective surgery is still 7 weeks

Answer 756

ANSWER: d. Ferritin <100mcg/L Serum ferritin level < 30 μg.l−1 is the most sensitive and specific test used for the identification of absolute iron deficiency. However, in the presence of inflammation (C-reactive protein > 5 mg.l−1) and/or transferrin saturation < 20%, a serum ferritin level < 100 μg.l−1 is indicative of iron deficiency. International consensus statement on peri-operative management of anaemia and iron deficiency https://associationofanaesthetists-publications.onlinelibrary.wiley.com/doi/10.1111/anae.13773#:~:text=Recommendations%20for%20best%20clinical%20practice,-Physicians%20should%20consider&text=Serum%20ferritin%20level%20%3C%2030%20%CE%BCg,serum%20ferritin%20level%20%3C%20100%20%CE%BCg.

Answer 757

Tell surgeon to deflate / remove pneumoperitoneum ?endobronchial intubation caused by pneumoperitoneum-> loss of lung sliding but continual lung pulse? Lung pulse: Cardiac contraction is sufficiently forceful as to move the lung in synchrony with the cardiac cycle. This movement is readily detected as cardiophasic movement of the pleural line. It has the same implication as detection of respirophasic movement of the pleural line which termed lung sliding (ie, there is no pneumothorax at the site of probe application on the chest wall).

Answer 758

c Oral iron and defer or d give IV iron - most assume its IV iron and proceed but - Assuming IDA and raised CRP then iron therapy but 'deferable' surgery? then oral and come again in 6 weeks if not deferrable then IV iron - surely a revision THR is deferable?? - If give IV iron and defer was an option I would choose that one, it would allow assessment of inflammatory process and to confirm Hb and ferritin are at an acceptable level International consensus statement on the peri-operative management of anaemia and iron deficiency https://associationofanaesthetists-publications.onlinelibrary.wiley.com/doi/10.1111/anae.13773 However, many patients will not respond to oral iron, especially those with functional iron deficiency and chronic illness or infection and those with ongoing blood loss 15, 25. Others will not tolerate oral iron due to gastro-intestinal side-effects. Once oral iron has been commenced, the Hb should be measured again, at least 4 weeks before surgery. In the absence of an increased Hb or if the patient is intolerant, i.v. iron is the preferred replacement route. If surgery is planned in less than 6 weeks time, i.v. iron may also be the most effective option.

Answer 759

C: 120ml/min An observational, prospective study comparing tibial and humeral intraosseous access using the EZ-IO. - humeral flow rates were significantly faster using a pressure bag (153 mL/min) compared with humeral those achieved without pressure bag (84 mL/min) - tibial flow rates to be significantly faster using a pressure bag (165 mL/min) compared with those achieved without a pressure bag (73 mL/min)

Answer 760

c. sinus tachy with prolonged QRS

Answer 761

B. 30 min P1x V1= P2xV2 150bar x 2l = 1bar x Unknown Volume 150 x 2/1= Unknown Volume 300L = unknown volume 300/10l/min = 30mins

Answer 762

d. Asthma What are the causes of an elevated DL CO ? The causes of an elevated DLCO are numerous, but is most commonly caused by asthma and obesity (increased pulmonary blood flow). Pulmonary hemorrhage is an additional important cause. https://www.atsjournals.org/doi/pdf/10.1513/AnnalsATS.201605-355CC

Answer 763

d) contraindicated as it won’t work Type 1: -Quantitative defect of VWF Type 2: -Qualitative Defect of VWF -Type 2 subclassification depending on plt binding function, F8 binding capcacity, number of high molecular weight VWF multimers Type 3: - complete absence of VWF Treatment: - do not need blood components to control haemorrhage -F8 plasma concentration >100 for major surgery and >50 for minor surgery -DDAVP approved for use in Type 1, no use in type 3, discuss its use with haematology in type 2 due to its variable effect -DDAVP given atleast 90mins before operation -TXA may be useful -VWF/F8 concentrates indicated in severe cases, type 3 and qualitiative defects in VWF -Plt infusions should be considered in persistent bleeding -Cryo has an unpredictable effect, only used if other treatments have failed

Answer 764

B. Left central maxillary incisor BJA Education Dental Knowledge for Anaesthetists 2016 Abeysundera "Direct laryngoscopy is implicated in 50-75% of all cases of dental injury. Maxillary incisors are the most commonly injured under GA. Representing 50% of cases, they are particularly prone to fracture, being small-rooted, of narrow cross-sectional area with a slight anterior axis. The left central maxillary incisor is most vulnerable to damage from the flange of the laryngoscope blade if used as a fulcrum, usually when attempting to improve the view during a difficult intubation."

Answer 765

b) Pulmonary hypertension Up to date: Overview of pulmonary function testing in adults Diffusing capacity — Measurement of the single-breath diffusing capacity for carbon monoxide (DLCO; also known as transfer factor or TLCO) is quick, safe, and useful in the evaluation of restrictive and obstructive lung disease, as well as pulmonary vascular disease. The technique and interpretation are discussed separately. In the setting of restrictive disease, the diffusing capacity helps distinguish between intrinsic lung disease, in which DLCO is usually reduced, and other causes of restriction, in which DLCO is usually normal. In the setting of obstructive disease, the DLCO helps distinguish between emphysema, in which it is usually reduced, and other causes of chronic airway obstruction, like asthma or chronic bronchitis, where it is usually normal. The DLCO is also used in the assessment of pulmonary vascular disease (eg, thromboembolic disease, pulmonary hypertension), which typically causes a reduction in DLCO in the absence of significant restriction or obstruction

Answer 766

anaemia Iron deficiency can be caused by depletion of total Iron stores or a chronic loss of blood. Metabolism of Iron is also influenced by disease states including inflammation and malignancy. Raised Iron stores and inflammation upregulate the production of HEPCIDIN, a hormone responsible for the inhibition of enteral Iron absorption HEPCIDIN degrades iton trans-membrane transporter ferroportin on duodenal enterocyte membranes. it also inhibits the transport of stored iron from hepatocytes and macrophages into plasma in a similar manner. Upregulation of HEPCIDIN can produce functional iron deficiency, lading to what has been tradionally known as the anaemia of chronic disease HEPCIDIN deficiency is the cause of iron overload in hereditary hemochromatosis, iron-loading anemias, and hepatitis C HEPCIDIN is suppressed in iron deficiency, allowing increased absorption of dietary iron and replenishment of iron stores. Increased erythropoietic activity also suppresses HEPCIDIN production. HEPCIDIN is decreased in iron deficiency anemia, hemolytic anemia, and anemias with ineffective erythropoiesis

Answer 767

c. Anterior to erector spinae and posterior to transverse process 5th rib Midpoint between T5-6 (Usual Incision T4-5, ICC T6) Source - Blue book 2019

Answer 768

c. MCA https://case.edu/med/neurology/NR/mcaanery.htm

Answer 769

Answer : e. 75cm DLT exchange catheter is 100cm long (AEC, extra firm with soft tip) Mouth to carina ~28cm Outside of mouth ~72cm Aintree Catheter 56cm outside of mouth 31cm

Answer 770

Serotonin Syndrome Hyper reflexia Usually has hypertension and hyperthermia https://static1.squarespace.com/static/5e6d5df1ff954d5b7b139463/t/617242e2ab18df2dee31f417/1634878179720/ICU_one_pager_hyperthermic_toxidromes.png

Answer 771

remove the inner cannula The key principles of the algorithm are: 1.Waveform capnography has a prominent role at an early stage in emergency management. 2.Oxygenation of the patient is prioritised. 3.Trials of ventilation via a potentially displaced tracheostomy tube to assess patency are avoided. 4.Suction is only attempted after removing a potentially blocked inner tube. 5.Oxygen is applied to both potential airways. 6.Simple methods to oxygenate and ventilate via the stoma are described. 7.A blocked or displaced tracheostomy tube is removed as soon as this is established and not as a ‘last resort’ BJA: Update on management of tracheostomy https://www.bjaed.org/article/S2058-5349(19)30125-8/fulltext

Answer 772

b) Alcoholic liver disease A raised serum tryptase (hypertryptasemia) has numerous diagnostic uses. The main use is in the diagnosis of anaphylactic reactions; however, it does not distinguish between IgE-mediated versus non-IgE-mediated reactions. Tryptase is a serine protease primarily produced by MCs, and to a lesser extent by mature basophils and myeloid progenitors. (Eosinophils have myeloid progenitor) Elevated serum tryptase is an independent prognostic factor for progression to ESRF in patients treated with ACEi or ARB https://associationofanaesthetists-publications.onlinelibrary.wiley.com/doi/10.1111/j.1365-2044.2004.03757.x Systemic Anaphylaxis: levels peak at 15-120mins and with half life of 1.5-2.5hrs histamine levels peak at 5 mins and decrease to baseline within 15-30mins B-Tryptase testing can be performed on blood samples obtained 1-6hrs after onset Hihg tryptase concentration can be found 3 days after death from suspected anaphylaxis Other allergic conditions: Asthma In asthma, β-tryptase is usually overexpressed or released from mast cells prematurely. It causes a cascade of events such as airway inflammation and bronchoconstriction. A mutation of the β-tryptase gene causes the overexpression Sudden Infant Death Syndrome: Anaphylaxis has been suggested to be a cause of the sudden infant death syndrome (SIDS), although allergen sensitivity and mast cell activation have not been demonstrated. Elevated postmortem levels of β-tryptase in victims of SIDS have been reported. Amniotic Fluid Embolism: A case study of an autopsy-proven fatal case of amniotic fluid embolism reported a significantly elevated serum β-tryptase level, suggesting possible mast cell activation. However, there are other reported cases of amniotic fluid embolism diagnosed clinically whose tryptase levels were not elevated. Systemic Mastocytosis: Characterised by mast cell hyperplasia in bone marrow, skin, liver, spleen and gastrointestinal mucosa. A study of tryptase levels in patients with biopsy-proven mastocytosis reported concentrations of total tryptase > 20 ng.ml−1 and ratios of total tryptase to β-tryptase > 20, whereas normal patients had total tryptase levels < 14 ng.ml−1 MC activation Syndrome These heterogeneous conditions are often associated with biochemical evidence of MC activation, but total tryptase may be normal. Urticaria/Agioedema: Basal total serum tryptase tends to be higher in patients with chronic urticaria over atopic and non-atopic healthy controls, likely due to increased MC burden and/or greater release of tryptase per MC. Other studies have found tryptase ≥15 μg/L in 12% of patients with urticaria/angioedema without anaphylaxis Familial Hypertryptasaemia These patients have a baseline tryptase of >8 μg/L and commonly have complaints of arthralgias, gastroesophageal reflux disease, flushing, urticaria, hypermobility, postural orthostatic tachycardia syndrome, increased risk of anaphylaxis to stinging insects, and irritable bowel syndrome CKD and ESRF Tryptase may be raised in patients with chronic kidney disease (CKD), accounting for around 7% of all elevated tryptase samples in one laboratory’s retrospective review of elevated tryptases. It tends to be elevated with more severe CKD, correlating with other markers of CKD including creatinine and proteinuria Haematological conditions: Hypereosinophilic syndrome (HES) is a heterogeneous group of systemic diseases of unknown cause characterised by excessive eosinophils invading the heart, lungs, brain and nerves, causing organ damage Patients with HES and elevated serum tryptase levels were more likely to develop fibroproliferative end organ damage and had a shorter life expectancy. Myelodysplastic syndrome (MDS) is a large group of acquired neoplastic disorders of the bone marrow most common in the elderly and is caused by an abnormal differentiation and maturation of haemopoietic cells. Elevated levels of total tryptase (α-tryptase and β-tryptase) are found in a group of patients with MDS Parasitic infection MCs and tryptase play a significant role in parasitic infections [72], so it is of no surprise that serum tryptase can be elevated in these infections. Gausher's disease Rare genetic disorder caused by the deficiency of β-glucocerebrosidase, an enzyme for the catabolism of glucocerebroside, a component of cell membranes. A single case report exists of an 18-month-old boy who had an immediate hypersensitivity to imiglucerase enzyme replacement and an elevated baseline tryptase of 63.2 μg/L.

Answer 773

labetalol https://www.bjaed.org/article/S2058-5349(20)30114-1/fulltext The threshold for initiating antihypertensive treatment for all hypertensive disorders in pregnancy has been lowered. A sustained BP ≥140/90 mmHg warrants treatment, targeting a BP ≤135/85 mmHg. The main aim of controlling the maternal BP is the prevention of intracerebral haemorrhage and stroke. The rate of stroke during the peripartum period in women with pre-eclampsia is 133 per 100,000, with haemorrhagic stroke being more common than ischaemic stroke. NICE recommends offering oral labetalol as initial therapy, followed by nifedipine and then methyldopa as alternatives. Second- and third-line agents include hydralazine and prazosin. Women with severe hypertension (SBP ≥160 mmHg, DBP ≥110 mmHg, or both) should be admitted to hospital for assessment and treatment in a monitored setting. Hypertensive emergencies can be treated with intravenous labetalol, hydralazine and immediate-release oral nifedipine without the need for invasive cardiac monitoring. Labetalol 20 mg i.v. can be given over 2 min, and increased incrementally up to 80 mg i.v. If the BP remains high, another antihypertensive agent such as hydralazine can be added. An initial dose of hydralazine 5–10 mg i.v. over 2 min can be followed by a further 10 mg i.v. after 20 min if the BP remains high. A suggested initial dose of immediate-release oral nifedipine is 10 mg, followed by a further 20 mg if the BP remains high after 20 min.

Answer 774

d. Accessory Obturator

Answer 775

A. Move medial

Answer 776

a. Reduced myoglobinuria weird double negative question, answers don't quite fit grammatically, however - There is NOT reduced myoglobinuria with AIR compared to MH (both have myoglobinuria) - There IS less increase in ETCO2 - There IS less muscle rigidity Anesthesia-induced rhabdomyolysis or malignant hyperthermia: is defining the crisis important? College library drop "is defining the crisis important?" from search https://onlinelibrary-wiley-com.ezproxy.anzca.edu.au/doi/full/10.1111/pan.13130?sid=worldcat.org

Answer 777

d) 6 months ANZCA PS 12 perioperative smoking https://www.anzca.edu.au/getattachment/5deb6800-e8f9-453f-b9a6-a151a9323249/PG12(POM)-Guideline-on-smoking-as-related-to-the-perioperative-period-(PS12) Effects of quitting 1 day - Reduced HbCO3-> increased O2 content - Reduced nicotine/ SNS stimulation 3 weeks - Increased wound healing 6-8 weeks - Reduced sputum volume - Increased lung function 6 months - Increased immune function

Answer 778

high level of education BJA: CPSP Previous chronic pain is the most important clinical risk factor. Other risk factors for CPSP include: 1. Young age 2. alcohol use 3. smoking 4. unemployed 5. disability 6. obesity 7. type of surgery. Risk factors for CPSP Pre-op 1. existence and intensity of pre-op pain is a risk factor for developing CPSP after: - Hernia repair - Thoracotomy - amputation - mastectomy - for mastectomy and amputation continuous pre-operative pain for more than 1 month predicts CPSP 2. Genetic susceptibility 3. Psychosocial factors Intraoperative factors: 1. longer operations 2. Laparoscopic surgical approaches result in less chronic pain 3. Repeat surgery (for hernias) has higher incidene of moderate to severe pain Post-operative factors: 1. Radiotherapy increases risk factors 2. Severity of postoperative pain predicts development of CPSP - repetitive nociceptive stimulation during perioperative period resul;ts in nervous system changes e.g central sensitization

Answer 779

a) Spinal Makarla Epidural and vaginal delivery ? GA all are safe in MS The MAN I think is to signify advanced MS (Really there isn’t heaps of evidence) Source World Fed Anaesthetists https://resources.wfsahq.org/wp-content/uploads/359_english.pdf (What a terrible question)

Answer 780

e) Lingual Nose The nose is entirely innervated by branches of the trigeminal nerve. Septum and anterior parts of the nasal cavity are affected by the anterior ethmoidal nerve (a branch of the ophthalmic nerve). The rest of the nasal cavity is innervated by the greater and lesser palatine nerves (branches of the maxillary nerve). Pharynx The pharynx is largely innervated by the glossopharyngeal nerve. Innervation of the whole pharynx, posterior third of tongue, the fauces, tonsils, and epiglottis is from the glossopharyngeal nerve. Oropharynx The oropharynx is innervated by branches of the vagus, trigeminal, and glossopharyngeal nerves. The posterior third of the tongue, vallecula, and anterior surface of the epiglottis are innervated by the tonsillar nerve (a branch of the glossopharyngeal nerve). The posterior and lateral wall of the pharynx are innervated by the pharyngeal nerve (a branch of the vagus nerve). The tonsillar nerve affects the tonsils. The anterior twothirds of the tongue are innervated by the lingual nerve (branch of the mandibular division of the trigeminal nerve). Larynx The larynx is innervated by the vagus nerve Above the vocal cords (base of tongue, posterior epiglottis, aryepiglottic folds, and arytenoids), the internal branch of the superior laryngeal nerve (a branch of the vagus nerve) supplies innervation. For the vocal cords and below the vocal cords, the recurrent laryngeal nerve (a branch of the vagus nerve) is the supplier.

Answer 781

a. Ilioinguinal

Answer 782

c. pneumothorax

Answer 783

d. 54 Ex-preterm infants at risk of post-operative apnoea should not be considered for same day discharge unless they are medically fit and have reached a postmenstrual age of 54 weeks. Term infants should not be considered for same day discharge unless they are medically fit and have reached a postmenstrual age of 46 weeks.d) 54 weeks ## Footnote https://www.anzca.edu.au/getattachment/568bad2d-7517-4eea-9c5d-cb7aa1c60

Answer 784

POSTERIOR CUTANOUS NERVE OF THE THIGH lat / int and medial cutaneous of the thigh femoral nerve (posterior division) saphenous obturator (post branch) tibial nerve - articulates to the knee sciatic (common perineal nerve) L3/4 = extensors of knee L5/S1 = flexors of the knee Anatomy for Anaesthetists

Answer 785

C) AMI The association between OSA and perioperative mortality is unclear [19], with various studies showing increased [12,23] or comparable [14] mortality. While decreased mortality [7,18,43] has been reported in retrospective studies, this may be due to unrecognized or undiagnosed OSA in the control or non-OSA groups, and/or the possibility that patients with diagnosed OSA received monitoring and treatment of their OSA. SOBA 2015: Severe OSA occurs in 10–20% of patients with BMI > 35 kg.m2 and is often undiagnosed. Overall, a diagnosis of OSA is associated with a greater than doubling of the incidence of postoperative desaturation, respiratory failure, postoperative cardiac events and ICU admission [16]. The presence of multiple and prolonged oxygen desaturations increases the sensitivity to opioid-induced respiratory depression [17]. However, if identified pre-operatively and treated appropriately with continuous positive airway pressure (CPAP), the risk of complications is much reduced [18]. Obesity has no influence on the rate of unanticipated admission, postoperative complications, readmission or other unplanned contact with health professionals after home discharge.

Answer 786

a) Suxamethonium

Answer 787

d) Danazol https://www.allergy.org.au/hp/papers/hereditary-angioedema C1 esterase inhibitors is not a remembered option Treatment options: Plasma derived C1-esterase inhibitor = Berinert/Cinryze, Androgens = Danazol B2 Bradykinin REceptor antagonist = Icatibant FFP. Danazol (an androgen) is recommended as first line PROPHYLAXIS for planned procedures (need to give for 5-10 days prior and 2-5 days post) For emergency or high risk procedures C1 esterase inhibitor concentrate (Berinert or Cinryze) is recommended - give 1 hour before procedure - more effective than danazol but more expensive Berinert: - 20units/kg IV over 10 min - Symptoms usually stabilise in 30 mins - 2nd dose uncommon, but may be given 30mins to 2hrs after 1st dose Icatibant: - 30mg slow subcut infusion in abdominal area Due to the risk of precipitating laryngeal oedema, oropharyngeal procedures should usually involve general anaesthesia with endotracheal intubation Short answer: - if you have days before surgery increase danazole, if complex surgery increase danazole and give C1Inh - If you have acute emergency surgery give C1Inh Concentrate (Berinert/Cinryze) before and after - if you have an acute attack use C1Inh or Bradykinin antagonist (Icatibant) - If C1 Inh and Bradykinin antagonoist are not available then use FFP but this may worsen the attack due to the presence of C4 in the FFP - Has Cetirizine been misremembered instead of Cinryze as an option in this question? No it wasn't -> adrenaline, steroids, antihistamines have no role in treatment of HAE acute attack

Answer 788

e) Low resistance

Answer 789

B) general anaesthesia Grade 1: moderate hypoxia (Spo2<94%) or hypotension [fall in systolic blood pressure (SBP) >20%]. Grade 2: severe hypoxia (Spo2<88%) or hypotension (fall in SBP >40%) or unexpected loss of consciousness. Grade 3: cardiovascular collapse requiring CPR. Patient Risk factors: 1. old age 2. poor pre-existing physical reserve 3. impaired cardiopulmonary function -> NYHA 3 or 4 4. pre-existing pulmonary htn 5. Male Sex 6. Diuretics 7. ASA grade 3 or 4 8. osteoporosis 9. bony metastases 10. concomitant hip fractures (particularly pathological and intertrochanteric) (latter due to abnormal vascular channels through which marrow contents can enter the circulation) Surgical Risk factors 1. patients with previously un-instrumented fenoral canal > revision surgery 2. Use of long-stem femoral component Anaesthetic Risk reduction: - discussion between surgeons and anaesthetists over uncemented vs. cemented based on patient Hx particularly if lon-stem prosthesis, femoral fracture or patients with cardiorespiratory disease - no clear evidence regarding the impact of anaesthetic technique - increase inspired O2 considered in all patients at time of cementation - avoid intravascular volume depletion - Higher level of haemodynamic monitoring in high risk patients Factors NOT predictive of severe BCIS include: Arteriosclerosis Angina pectoris Congestive heart failure Beta-blockers Angiotensin-converting enzyme inhibitors.

Answer 790

c. Hypocalcaemia Laryngospasm is a rare, but serious and potentially lethal, complication of hypocalcemia in adults. In every adult presenting with acute dyspnea and stridor, the possibility of hypocalcemia should be considered. Hypocalcemia should be treated promptly.

Answer 791

e. AAA Osteoarthritis nerve compression syndrome due to bony overgrowth, and carpal tunnel syndrome Hypertension Diabetes mellitus Cardiomyopathy/HF Colorectal cancer Sleep Apnea Thyroid nodules and thyroid cancer Hypogonadism Compression of the optic chiasm Source: BJA

Answer 792

d) Knee extension weakness - this is femoral innervation BJA: Perioperative peripheral nerve injuries https://academic.oup.com/bjaed/article/12/1/38/260058 Lower limb peripheral nerve injuries Sciatic nerve injury (L4–S3) Mechanism of injury Stretch, compression, ischaemia, and direct damage are the primary mechanisms. The lithotomy, frog leg, and sitting positions have been implicated in perioperative injury to this nerve (hyperflexion of the hip, abduction, and extension of the leg causes stretching). Regional anaesthetic techniques and hip arthroplasty may also cause injury. A higher incidence is seen in men aged 45–55 yr and in patients suffering with diabetes mellitus. The common peroneal component is usually affected, as this is more superficial compared with the tibial component. Clinical presentation Injury manifests as paralysis of the hamstring muscles and all the muscles below the knee leading to weak knee flexion and foot drop. All sensation below the knee except the medial aspect of the leg and foot is impaired.

Answer 793

HCO3- is derived from pCO2 and pH Base excess is derived from pH SaO2 is derived from oxyHb and Hb Source LITFL

Answer 794

b) 100 Brain trauma foundation Level III recommendation. To decrease mortality and improve outcomes: Maintain SBP at >100mmHg for patients 50 - 69 Maintain SBP at >110 for patients 15 - 49 Maintain SBP at >110 for patients 70 or older

Answer 795

b) IgE mediated (i.e. anaphylaxis) rocuronium allergy Morphine RAST is most sensitive (88%) and specific (100%) test for NMBD as cause of anaphylaxis (quaternary ammonium epitope)

Answer 796

d. Downs Syndrome

Answer 797

Mechanical allodynia Allodynia IASP definition: pain due to a stimulus that does not normally provoke pain “The term allodynia was originally introduced to separate from hyperalgesia and hyperesthesia, the conditions seen in patients with lesions of the nervous system where touch, light pressure, or moderate cold or warmth evoke pain when applied to apparently normal skin.” References IASP https://www.iasp-pain.org/resources/terminology/?ItemNumber=1698 And APMSE 5th Ed pg64. Dysaesthesia: spontaneous and unpleasant sensation

Answer 798

C. Shockable: Adrenaline 1mg after 2nd shock Then every second cycle Amioderone 300mg after 3 shocks Non-shockable Adrenaline 1mg immediately (then every second cycle)

Answer 799

Previous Q (23.1) with different options. ANSWER C (INR)

Answer 800

a) low profile Resource: ANZCA PG56(A)BP Difficult airway equipment BP 2021 First generation SADs (page 19) “classic design LMAs (cLMAs) with their low profile and lack of preformed curve have several advantages.”

Answer 801

A High risk of creating a false passage Blue book 2017 page 21 No reference

Answer 802

No remembered options. Answer could be: Traumatic Brain injury Direct allergy Cardiac Failure SAFE trial

Answer 803

c) TXA TXA first line treatment and patient has a response to Aprotinin on the APTEM. Patient also has low fibrinogen and requires fibrinogen replacement.

Answer 804

b) Long thoracic

Answer 805

d) VT Negative concordance https://litfl.com/ventricular-tachycardia-monomorphic-ecg-library/

Answer 806

a) Spinal Makarla Epidural and vaginal delivery ? GA all are safe in MS The MAN I think is to signify advanced MS (Really there isn’t heaps of evidence) Source World Fed Anaesthetists https://resources.wfsahq.org/wp-content/uploads/359_english.pdf (What a terrible question)

Answer 807

d) 0.9% Saline Other fluids are all electrolyte free except 0.9% Saline

Answer 808

none of the remembered options Airway pressure release ventilation (APRV) is an open-lung mode of invasive mechanical ventilation mode, in which spontaneous breathing is encouraged. APRV uses longer inspiratory times; this results in increased mean airway pressures, which aim to improve oxygenation. Brief releases at a lower pressure facilitate carbon dioxide clearance. The terminology and methods of initiation, titration, and weaning are distinct from other modes of mechanical ventilation. The use of APRV is increasing in the UK despite a current paucity of high-quality evidence high intrathoracic pressure decreases the transmural left ventricular pressure, reducing the work of contraction and increasing cardiac output. In the context of hypoxaemia, a mode of mechanical ventilation that improves arterial oxygenation will improve myocardial oxygen delivery, myocardial function and cardiac output. As APRV is a spontaneous breathing mode, in addition to the benefits of spontaneous ventilation, reduced doses of sedative drugs can often be used, with subsequent reduction of requirement for vasoactive drugs and improvement in haemodynamic state. Airway pressure release ventilation (APRV) is an open-lung mode of invasive mechanical ventilation mode, in which spontaneous breathing is encouraged. APRV uses longer inspiratory times; this results in increased mean airway pressures, which aim to improve oxygenation https://www.bjaed.org/article/S2058-5349(19)30178-7/fulltext https://derangedphysiology.com/main/required-reading/respiratory-medicine-and-ventilation/Chapter%20518/airway-pressure-release-ventilation-aprv-ards

Answer 809

b) Pain score Aldrete score, which includes five elements (activity, respiration, circulation, consciousness, oxygen saturation) [16]. The original scoring system was developed before the invention of pulse oximetry and used the patient's colouration as a surrogate marker of their oxygenation status. A modified Aldrete scoring system was described in 1995 which replaces the assessment of skin colouration with the use of pulse oximetry to measure SpO2. The Modified Aldrete system includes five additional elements that are particularly useful during the Phase II recovery period prior to discharge to home (dressing, pain, ambulation, feeding, urine output)

Answer 810

C) Obstructive Pattern https://thoracickey.com/ventilator-graphics/ Image 9.6

Answer 811

a) No increased risk of bleeding There is no evidence that pre-operative aspirin administration resulted in a lower risk of death or thrombotic complications, or a higher risk of haemorrhage. The study aim (and title) was to compare stopping vs continuing aspirin, however the design insisted on all patients stopping aspirin and then being given a single dose of aspirin or placebo prior to surgery (and presumably all patients were given aspirin after surgery) – this method hasn’t really investigated the theory TheBottomLine.org.uk

Answer 812

E3 V3 M4 = GCS 10

Answer 813

c) residual sedation https://pubmed.ncbi.nlm.nih.gov/35085107/#:~:text=Conclusions%3A%20The%20use%20of%20dexmedetomidine,sedation%20or%20bradycardia%20in%20PACU

Answer 814

D. Amitriptyline Amitriptyline (used in low doses for 90 days from onset of the herpes zoster rash) reduces the incidence of postherpetic neuralgia N.B Antiviral agents started within 72 hours of onset of the herpes zoster rash accelerate the resolution of acute pain (U) (Level I) but **do not reduce** the incidence, severity and duration of postherpetic neuralgia UTD Both Gabapentinoids and TCAs are effective at TREATING postherpetic neuralgia. The former have lower risk of discontinuation due to adverse side effects. For moderate or severe pain, use gabapentinoids.

Answer 815

Idarucizumab (Praxbind) is a monoclonal antibody to dabigatran Dabigatran bleeding may be treated with: - idarucizumab - haemodialysis -PCC 25-50IU/kg - TXA will decrease fibrinolysis and has some effect - FFP also has some effect Humanized monoclonal antibody fragment (Fab) indicated in patients treated with dabigatran (Pradaxa) when reversal of the anticoagulant effects are needed for emergency surgery or urgent procedures, or in the event of life-threatening or uncontrolled bleeding - very high affinity for dabigatran (300x vs affinity for thrombin) - 5 g IV, provided as 2 separate vials each containing 2.5 g/50 mL (see Administration) - RE-VERSE-AD trial: undetectable levels <20ng/ml within minutes and for 24 hours - Limited data support administration of an additional 5 g depending on clinical situation Dosage Modifications Renal impairment: Renal impairment did not impact the reversal effect of idarucizumab; no dosage adjustment required Hepatic impairment: Dosing Considerations This indication is approved under accelerated approval based on a reduction in unbound dabigatran and normalization of coagulation parameters in healthy volunteers; continued approval for this indication may be contingent upon the results of an ongoing cohort case series study

Answer 816

C. Increased minute ventilation Cerebral blood flow Cardiac output Acid–base status Major haemorrhage Arterial inflow/venous outflow obstruction Oxygen content Haemoglobin concentration Haemoglobin saturation Pulmonary function Inspired oxygen concentration Inspired oxygen concentration

Answer 817

https://www.anzca.edu.au/resources/professional-documents/professional-document-appendix-topics/appendix-1-pg18(a).pdf Appendix 1 - Intravenous access and blood pressure monitoring in patients with previous axillary nodal dissection Recommendations 1. Shared decision-making: * Anaesthetists should communicate the importance of safety and optimisation of anaesthesia administration in this setting to allow patients to make informed decisions. 2. Institutional considerations. * To facilitate shared decision-making, as well as staff and patient education, institutions should remove universal recommendations, such as wrist-band or standardised alerts, that relate to patients who have a history of axillary dissection. 3. For patients who have had axillary nodal dissection and do not have lymphoedema of the affected arm, there is no contraindication to: * Non-invasive blood pressure monitoring using the affected arm. * Peripheral intravenous cannulation in the affected arm. * Arterial line insertion and monitoring in the affected arm if clinically indicated. 4. For patients WITH lymphoedema of the affected arm following axillary nodal dissection (Stages 0-III): * An alternative site should be contemplated where practicable, considering the relative risk associated with more invasive procedures. There is no absolute contraindication to using the affected limb for monitoring and intravenous access. * Ongoing monitoring of peripheral intravenous cannulae should be done in accordance with the ACSQHC Clinical Care Standard.

Answer 818

C- Multifocal Atrial Tachycardia Cardioversion is contraindicated in MAT. Due to the multiple atrial foci, direct current (DC) cardioversion is not effective in restoring normal sinus rhythm and can precipitate more dangerous arrhythmias. - https://emedicine.medscape.com/article/155825-overview#a10 DCCV is indicated for 1. Any haemodynamically unstable narrow or wide QRS complex tachycardia 2. AF <48hrs 3. AF >48hrs with adequate anticoag/TOE to exclude thrombus 4. SVTs and monomorphic TVs not responding to trial of IV medical therapy DCCV is CONTRAindicated in: a. Digitalis toxicity and associated tachycardia b. AF >48hrs without adequate anticoagulation/TOE -BJAEducation 2017 https://academic.oup.com/bjaed/article/17/5/166/2669966

Answer 819

A - GLP1 receptor agonist (rest of options made up) “Dulaglutide binds to glucagon-like peptide 1 receptors, slowing gastric emptying and increases insulin secretion by pancreatic Beta cells. Simultaneously the compound reduces the elevated glucagon secretion by inhibiting alpha cells of the pancreas, as glucagon is known to be inappropriately elevated in diabetic patients. GLP-1 is normally secreted by L cells of the gastrointestinal mucosa in response to a meal” - Wikipedia, Dulaglutide - Once weekly injection, “trulicity” https://www.asahq.org/about-asa/newsroom/news-releases/2023/06/american-society-of-anesthesiologists-consensus-based-guidance-on-preoperative

Answer 820

c) 2 minutes

Answer 821

d) diplopia Bilateral visual loss associated with insufficiency to posterior circulation so: parieto-occipital ischaemia, signs of stroke, visual agnosia, ophthalmoplegia or diplopia.

Answer 822

a) case control https://www.cdc.gov/csels/dsepd/ss1978/lesson3/section5.html

Answer 823

d) Atropine Blue book 2019

Answer 824

c) 3b Stage 1 >90 Stage 2 60-89 Stage 3a 45-59 Stage 3b 30-44 Stage 4 15-29 Stage 5 <15

Answer 825

New question. a) 30 day mortality Postoperative myocardial injury was associated with an increased risk of death. Twenty-seven of the 315 patients (8.6%; 95% CI, 6.0–12.2%) with myocardial injury died within 30 days compared with 29 of the 1312 patients (2.2%; 95% CI, 1.5–3.2%) with normal troponin I levels (P<0.01) Reference: Myocardial Injury After Noncardiac Surgery and its Association With Short-Term Mortality (Circulation 2013)

Answer 826

d) Hypotension The commonest presenting feature of perioperative anaphylaxis by far was hypotension (accounting for 46%), followed by bronchospasm/high airway pressure (18%), tachycardia (9.8%), flushing/non-urticarial rash 6.6% and cyanosis/oxygen desaturation (4.7%).

Answer 827

You are inducing anaesthesia in a 20-year-old female through a cannula which was inserted in the right antecubital fossa while she was in the emergency department. After 10 ml of propofol has been injected, she complains of severe pain and it becomes clear that the cannula is intra-arterial. The most appropriate management is https://www.anztadc.net/Publications/Images/ANZCA/Unintended%20Intraarterial%20injection%20WebAIRS%20news%20ANZCA%20Bulletin%20September%202019.pdf

Answer 828

midazolam - Opioids, benzodiazepines and pregabalin may also be used to alleviate symptoms. Perioperative treatment of symptoms If RLS symptoms occur perioperatively, patients should be allowed to walk or move their legs in bed as soon as possible. If prolonged bed rest is required, the frequency of RLS medications may be increased to three times a day. If oral intake is feasible, a patient’s usual oral medication may be given. Levodopa (a dopamine agonist) may be administered by nasogastric tube. Alternatively, parenteral apomorphine or a rotigotine patch may be used. Apomorphine (1 milligram) may be injected subcutaneously on an hourly basis. Nausea is a common side effect so it may need to be given with an antiemetic. Rotigotine patches may be used every 24 hours. Opioids, benzodiazepines and pregabalin may also be used to alleviate symptoms. Patients should be proactively investigated and treated for iron deficiency, targeting ferritin level greater than 300 micrograms/ litre in adults, and 50 micrograms/litre in children.

Answer 829

a) Deepen with propofol and insert LMA Nasal continuous positive airway pressure (CPAP) is contraindicated after transsphenoidal surgery due to the risk of tension pneumocephalous. The level of consciousness, eye movements, visual fields, and acuity should be tested frequently and any deterioration discussed with the surgeon, and radiological investigation and/or re-exploration considered. https://academic.oup.com/bjaed/article/11/4/133/266875#3195876

Answer 830

New question Measures to avoid venous air embolism when inserting an internal jugular central venous catheter in an awake patient include all of the following EXCEPT c) Insert during inspiration Negative pressure generated by inspiration in an AWAKE patient https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5126790/

Answer 831

d) Pulmonary haemorrhage Rewording of 21.2 Question Won't increase in Myasthenia Gravis Causes of HIGH value include: Asthma Left-right intracardiac shunt polycythaemia Pulmonary haemorrhage Obesity - Dlco will increase but kco will not

Answer 832

90mg PO morphine Oral Tapentadol 25mg = 8mg Oral Morphine Oral Oxycodone 5mg = 8mg Oral Morphine Oral Tramadol 25mg = Oral Morphine 5mg Oral Hydromorphone 4mg = Oral Morphine 20mg S/L Buprenorphine 200mcg = 8mg Oral Morphine IV Oxycodone 5mg = Oral Morphine 15mg IV Morphine 5mg = Oral Morphine 15mg IV Hydromorphone 1mg = Oral Morphine 15mg

Answer 833

b) 30mcg Moderate = 2mcg/kg Life threatening = 4-10mcg/kg file:///Users/jbjon/Downloads/Australian_and_New_Zealand_Anaesthetic_Allergy_Gro.pdf

Answer 834

Answers could also possibly be COPD, Acute stroke or Neonates c) Bleomycin toxicity Bleomycin is a particularly important chemotherapy drug for the anaesthetist to be aware of. Bleomycin is often used to treat germ cell tumours and Hodgkin's disease in a curative setting. The major limitation of bleomycin therapy is the potential for subacute pulmonary damage that can progress to life-threatening pulmonary fibrosis. Pulmonary toxicity occurs in 6–10% patients and can be fatal.2 Exposure to high-inspired concentration oxygen therapy, even for short periods, as experienced during anaesthesia, is often implicated in causing rapidly progressive pulmonary toxicity in patients previously treated with bleomycin.3 These claims have been considered controversial by some, but it is the authors' recommendation that any patient previously exposed to bleomycin therapy should be treated as high risk, and summary guidance regarding oxygen therapy is shown in Table 4. Summary guidance—oxygen therapy for patients who have received bleomycin > Patients have a life-long risk of bleomycin-induced lung injury > Oxygen therapy should be avoided if at all possible > Clinical procedures (and leisure activities) involving a high should be avoided If a patient is hypoxic > O2 therapy should be minimized to maintain O2 saturation of 88–92% > High oxygen concentrations should be used with extreme caution for immediate life-saving indications only (to maintain O2 saturation of 88–92%)

Answer 835

d) Vastus Lateralis Anteromedial: sartorius Lateral: vastus medialis Posterior: adductor longest and magnus

Answer 836

Repeat e) Ulnar nerve The cubital fossa is triangular in shape and consists of three borders, a roof, and a floor: Lateral border – medial border of the brachioradialis muscle. Medial border – lateral border of the pronator teres muscle. Superior border – horizontal line drawn between the epicondyles of the humerus. Roof – bicipital aponeurosis, fascia, subcutaneous fat and skin. Floor – brachialis (proximally) and supinator (distally). Contents: - radial nerve - biceps tendon - brachial artery - median nerve Mnemonic for contents of the cubital fossa: Really Need (radial nerve) Beer To (biceps tendon) Be At (brachial artery) My Nicest (median nerve).

Answer 837

d) 24hrs Extrajunctional receptors are not found in normal active muscle but appear very rapidly whenever muscle activity has ended or after injury has been sustained. They can appear within 18 h of injury and an altered response to neuromuscu- lar blocking drugs can be detected within 24 h of the insult. They disappear when muscle activity returns to normal.

Answer 838

b) Stop/stop antibiotics For adults with suspected sepsis or septic shock, we suggest AGAINST using procalcitonin plus clinical evaluation to decide when to start antimicrobials, as compared to clinical evaluation alone. Weak, very low quality of evidence For adults with an initial diagnosis of sepsis or septic shock and adequate source control where optimal duration of therapy is unclear, we suggest using procalcitonin AND clinical evaluation to decide when to discontinue antimicrobials over clinical evaluation alone. Weak, low quality of evidence

Answer 839

10mins PG18

Answer 840

Increased alpha and slow delta power During general anaesthesia with sevoflurane, the EEG shows increased α (8–12 Hz) and slow-δ oscillation power.9 This dynamic also closely approximates the EEG of general anaesthesia with propofol.9 Alpha oscillations are likely to originate from a mechanism similar to that proposed for the β oscillations. An increase in GABAA decay time and conductance results in cortical α oscillations and enhanced rebound spiking of thalamic relay cells, strengthening the intrinsic α oscillatory dynamic of the thalamus. The net result is reciprocal thalamic–cortical α oscillation coupling.13 Mechanisms to explain the slow-δ oscillations are being investigated. However, slow-δ oscillations may be associated with an alternation between ‘on’ states, in which neurones are able to fire, and ‘off’ states, in which neurones are silent.9 Different from propofol, sevoflurane general anaesthesia is also associated with increased frontal θ (4–8 Hz) oscillation power.1,9 The increase in θ oscillation power creates a distinctive pattern of distributed EEG power from the slow-δ oscillation through to the α oscillation range. At an end-tidal sevoflurane concentration of 1.1%, the EEG shows increased slow-δ (0.1–4 Hz) and β (13–33 Hz) oscillations BJA Ed C) Anteriorisation of Alpha Waves is the most correct answer as per BJA alpha rhythms observed during anaesthesia or natural sleep are mostly observed in the frontal region. This alpha rhythm shift is referred to as anteriorization of the alpha rhythm, and is common during isoflurane, sevoflurane or propofol anaesthesia.5 Usually, anteriorization of the alpha rhythm predominates when anaesthesia is adequate for surgery, and is not clearly apparent just after loss of responsiveness https://academic.oup.com/bja/article/115/suppl_1/i27/234261?login=false

Answer 841

Size 7.0 The Tube The endotracheal tube has a length and diameter. The endotracheal tubes size (“give me a 6.0 tube”) refers to its internal diameter in millimeters (mm). The ETT will typically list both the inner diameter and outer diameter on the tube (for example, a 6.0 endotracheal tube will list both the internal diameter, ID 6.0, and outer diameter, OD 8.8).

Answer 842

d) Dopamine Dobutamine (β1 and β2), dopexamine (DA1, some β2) and low-dose dopamine (DA1 and DA2, β1 and β2, α1 in high dose) all have vasodilatory effects on the splanchnic circulation, and have been shown to improve markers of perfusion. For many years, low-dose infusions of dopamine were used as a prophylactic and therapy for acute renal failure, using the logic that DA1- and DA2-mediated vasodilation in renal and splanchnic beds would be protective. https://pubmed.ncbi.nlm.nih.gov/12794401/

Answer 843

NOT for this question (base rate is 10%, experimental group is 8% (20% below 10%) therefore 100/ 2 = 50 or 1 divided by risk reduction population risk = 10/100 patients get PONV population risk + new antiemetic = 8/100 patients get PONV (8/100 as reduction by 20% with new drug) RR= 0.10-0.08=0.02 NNT= 1/RR =1/0.02 =50

Answer 844

a) Torsades 2ry to prolonged QT leading to R on T PETKOV

Answer 845

e) Propofol https://www.bjanaesthesia.org/article/S0007-0912(20)30547-X/pdf

Answer 846

b) Factor VII Redcross: Cryoprecipitate contains most of the following found in fresh frozen plasma: 1. factor VIII 2. fibrinogen 3. factor XIII 4. von Willebrand factor 5. fibronectin Prothrombinex-VF® is a lyophilised concentrate of human coagulation factors it contains: Factors: II IX X small amount of factor VII. Also contains: plasma proteins (human) Antithrombin III (human) Heparin sodium (porcine) Sodium Phosphate Citrate Chloride https://litfl.com/cryoprecipitate/ Fractionated plasma product consisting of Fibrinogen (Factor I), von Willebrand Factor, Factor VIII, and small amounts of Factor XIII and Fibronectin https://www.anzca.edu.au/getattachment/9ec71c61-8a66-4f81-b0f8-c87d65e36298/Australasian-Anaesthesia-2023

Answer 847

Warm ischaemia time: - Time from treatment withdrawal to the start of cold perfusion of the donated organs - Significance is the impact on graft function - Most important phase of WIT begins when the systolic BP is < 60mmHg - This includes the waiting period from the absence of circulation to the declaration of death and the time before initiating the flow of cold perfusate through the cannula Maximum WARM Ischaemia time - Heart 30 mins - Liver 30 mins - Pancreas 30 mins - Kidney 60 mins - Lungs 90 mins Maximum COLD Ischaemia time: - Heart = 4 hrs - Lungs = 6-8hrs - Liver/Pancreas = 12hrs (DBD)/6 hrs (DCD) - Kidneys = 18hrs (DBD)/ 12 hrs (DCD)

Answer 848

c. No need to bridge ?D Dabigatran needs testing of renal function. Warfarin needs testing of INR Higher risk of bleeding with Dabigatran c/f other DOACs See ETG recommendations https://www.ahajournals.org/doi/full/10.1161/JAHA.120.017559

Answer 849

a) C1-esterase inhibitor Treatment options: Plasma derived C1-esterase inhibitor = Berinert/Cinryze, Androgens = Danazol B2 Bradykinin Receptor antagonist = Icatibant FFP. Danazol (an androgen) is recommended as first line PROPHYLAXIS for planned procedures (need to give for 5-10 days prior and 2-5 days post) For emergency or high risk procedures C1 esterase inhibitor concentrate (Berinert or Cinryze) is recommended - give 1 hour before procedure - more effective than danazol but more expensive Berinert: - 20units/kg IV over 10 min - Symptoms usually stabilise in 30 mins - 2nd dose uncommon, but may be given 30mins to 2hrs after 1st dose Icatibant: - 30mg slow subcut infusion in abdominal area Due to the risk of precipitating laryngeal oedema, oropharyngeal procedures should usually involve general anaesthesia with endotracheal intubation Short answer: - if you have days before surgery increase danazole, if complex surgery increase danazole and give C1Inh - If you have acute emergency surgery give C1Inh Concentrate (Berinert/Cinryze) before and after - if you have an acute attack use C1Inh or Bradykinin antagonist (Icatibant) - If C1 Inh and Bradykinin antagonoist are not available then use FFP but this may worsen the attack due to the presence of C4 in the FFP - Has Cetirizine been misremembered instead of Cinryze as an option in this question? No it wasn't -> adrenaline, steroids, antihistamines have no role in treatment of HAE acute attack

Answer 850

Depth of tube in water in bottle 3

Answer 851

c) pelvic splanchnic -> visceral not somativ nerve

Answer 852

24hrs Oxford handbook

Answer 853

A) Type 1 MI Clinical classification based on the assumed proximate cause of the MI: - Type 1 ○ MI caused by atherothrombotic coronary artery disease ○ And usually precipitated by atherosclerotic plaque disruption ( rupture or erosion) - Type 2 ○ MI consequent to a mismatch between oxygen supply and demand ○ Multiple potentional mechanisms: § Coronary dissection § Vasospasm § Emboli § Microvascular dysfunction § Increases in demand without underlying coronary artery disease - Type 3 ○ Patient with typical presentation of MI (ECG changes or VF) with unexpected death before blood samples for biomarkers could be drawn - Type 4a ○ MI associated with Percutaneous Coronary intervion (PCI) - Type 4b ○ Subcategory of PCI related MI related to stent/scaffold thrombosis - Type 5 CABG related MI

Answer 854

d) continue to avoid cognitive decline post-op Donepezil is in a class of medications called cholinesterase inhibitors. It improves mental function https://www.ukcpa-periophandbook.co.uk/medicine-monographs/donepezil

Answer 855

a) renal failure '...phosphate containing laxatives can lead to acute phosphate nephropathy' https://academic.oup.com/bjaed/article/16/9/305/1743822#35669023 - BJA Ed article Phosphate binds to calcium leading to crystal calcium phosphate deposition in tubules. Old repeat 2020 https://academic.oup.com/bjaed/article/16/9/305/1743822#35669023

Answer 856

a) propofol

Answer 857

c) falsly low SpO2 Effects of hihg dose hydroxycobalamin: - red urine - thrombocytosis - leukopenia

Answer 858

B. 20% 25% (a few studies have higher ranges but typically around 20-25%) https://doi.org/10.1192/bjp.bp.115.165498

Answer 859

D> Myocardial ischaemia An inverted U wave may represent myocardial ischemia (and especially appears to have a high positive predictive accuracy for left anterior descending coronary artery disease[7] ) or left ventricular volume overload. ^Wikipedia -------- U-wave inversion is abnormal (in leads with upright T waves) A negative U wave is highly specific for the presence of heart disease Common causes of inverted U waves Coronary artery disease Hypertension Valvular heart disease Congenital heart disease Cardiomyopathy Hyperthyroidism In patients presenting with chest pain, inverted U waves: Are a very specific sign of myocardial ischaemia May be the earliest marker of unstable angina and evolving myocardial infarction Have been shown to predict a ≥ 75% stenosis of the LAD / LMCA and the presence of left ventricular dysfunction ^LITFL: https://litfl.com/u-wave-ecg-library/

Answer 860

D) Mitral Stenosis (Rheumatic, moderate to severe) DOAC use is contraindicated in certain clinical conditions, notably, in patients who have a mechanical heart valve and those with rheumatic mitral stenosis. Moderate to severe renal impairment or significant hepatic disease is also a contraindication to DOAC treatment Bioprosthetic valves are less thrombogenic thus DOAC use is acceptable. https://www.ahajournals.org/doi/epdf/10.1161/JAHA.120.017559

Answer 861

8mg/hr Guidelines for mx of glucocorticoids during the perioperative period for patients with adrenal insufficiency https://associationofanaesthetists-publications.onlinelibrary.wiley.com/doi/10.1111/anae.14963

Answer 862

b) O2 consumption when sitting One metabolic equivalent (MET) is defined as the amount of oxygen consumed while sitting at rest and is equal to 3.5 ml O2 per kg body weight x min.

Answer 863

C:3 (Pt is GCS 14 E4V4M6, with motor deficit) The WFNS scale: Grade 1: GCS 15, no motor deficit. Grade 2: GCS 13-14 without deficit Grade 3: GCS 13-14 with focal neurological deficit Grade 4: GCS 7-12, with or without deficit. Grade 5: GCS <7 , with or without deficit. (BJA Education, Deranged Physiology)

Answer 864

e) Liver transplantation - Oxygen therapy for symptom relief - Liver transplant provides long term survival benefit - All other therapies tried but no conclusive evidence of benefit/nil are FDA approved Hepatopulmonary Syndrome Article https://www.ncbi.nlm.nih.gov/books/NBK562169/ Hepatopulmonary syndrome (BJA) - Prevalence up to 20% (end stage liver disease) - Characterised by: disordered pulmonary capillary vasodilation and VQ mismatch - Present with hypoxia, ortheodeoxia (decrease in PaO2 when standing) - Diagnosis w/bubble echocardiography - Risk factor for early post-transplant mortality - If transplant successful, will resolve over time

Answer 865

d) Ibuprofen 400mg - Ibuprofen (I think, because of the single oral dose statement) APMSE 5th edition Acute pain after third molar extraction is the most extensively studied model for testing postoperative analgesics in single-dose investigations. Nonselective NSAIDs or coxibs are recommended as “first-line” analgesics following third molar extraction (Derry 2011 Level I, 155 RCTs, n=16,104), however paracetamol is also safe and effective with a dose of 1,000 mg providing better pain relief than lower doses (Weil 2007 Level I [Cochrane], 21 RCTs, n=1,968). The best available evidence suggests the use of NSAIDs either with or without paracetamol is effective and well-tolerated (Moore 2018 Level I, 5 SRs, n unspecified). Nonselective NSAIDs are more effective than paracetamol or codeine (either alone or in combination) (Ahmad 1997 Level I, 33 RCTs, n=5,171). Ibuprofen (200–512 mg) specifically is superior to paracetamol (600–1,000 mg) in this setting and combining these two drugs improves analgesia further (Bailey 2014 Level I [Cochrane], 7 RCTs, n=2,241)

Answer 866

e) Remove vaporiser https://anaesthetists.org/Portals/0/PDFs/Guidelines%20PDFs/Guideline%20Malignant%20hyperthermia%202020.pdf?ver=2021-01-13-144236-793 as per guidelines, see link and attached image As per anaesthetic crisis manual 1. Call for help, communicate and delegate 2. Stop any volatile and remove vaporiser 3. Allocated task cards 4. Give dantrolene 5. Hyperventilate with 100% high flow oxygen 6. Use activated charcoal filters on both limbs 7. Maintain anaesthesia with TIVA 8. Insert IAL +/- CVC 9. Actively cool if temperature > 38.5 10. Treat associated hyperkalaemia, acidosis, arrhythmias

Answer 867

e. peak of R wave https://derangedphysiology.com/main/required-reading/cardiothoracic-intensive-care/Chapter%20634/normal-iabp-waveform https://litfl.com/intra-aortic-balloon-pump-trouble-shooting/

Answer 868

b) Hypoglycaemia Stoelting: Prader-Willi syndrome is a rare genetic disorder characterized by hypothalamic-pituitary abnormalities with severe hypotonia during the neonatal period and during the first two years of life, hyperphagia with a risk of morbid obesity during infancy and adulthood, learning difficulties and behavioural problems or severe psychiatric problems. The disease affects 1/25,000 births. https://www.orphananesthesia.eu/en/rare-diseases/published-guidelines/prader-willi-syndrome/1339-prader-willi-syndrome-2/file.html Prader-Willi syndrome is a rare genetic disorder characterized by hypothalamic-pituitary abnormalities with severe hypotonia during the neonatal period and during the first two years of life, hyperphagia with a risk of morbid obesity during infancy and adulthood, learning difficulties and behavioural problems or severe psychiatric problems. The disease affects 1/25,000 births.

Answer 869

e) decreased afterload https://academic.oup.com/bjaed/article/13/6/208/246828#2904603 Aortic cross-clamping and physiological considerations The physiological effect of aortic cross-clamping during surgery varies with the level of the clamp in relation to the main aortic branches. Perfusion to the lower half of the body is therefore dependent on collateral circulation while the clamp is applied. Clamp application increases the afterload of the heart and a sudden increase in arterial pressure proximal to the clamp; this can be attenuated with vasodilators [e.g. glyceryl trinitrate (GTN), sodium nitroprusside], opioids, or deepening of anaesthesia. These measures may also allow fluid loading in preparation for clamp release; however, the effect of vasoactive drugs is unpredictable; they may change haemodynamics without improving cardiac output and tissue perfusion due to blood redistribution.10 Increased afterload and left ventricular end-diastolic volume both increase myocardial contractility and oxygen demand. This increase in myocardial oxygen demand is usually met by an increase in coronary blood flow and oxygen supply, but can cause myocardial ischaemia. After aortic cross-clamp release, peripheral vascular resistance decreases by 70–80%, causing a decrease in arterial pressure. Hypotension can also be caused by blood sequestration in the lower half of the body, ischaemia–reperfusion injury, and the washout of anaerobic metabolites causing metabolic (lactic) acidosis. This can cause direct myocardial suppression and profound peripheral vasodilatation. Coronary blood flow and left ventricular end-diastolic volume also decrease (almost 50% from pre-clamp levels) after clamp release. Strategies to manage hypotension after aortic cross-clamp release include gradual release of the clamp, volume loading, vasoconstrictors, or positive inotropic drugs (e.g. ephedrine, meteraminol, phenylephrine, epinephrine, and norepinephrine). It is important to be aware that vasoactive drugs should only be used after adequate volume repletion.10 Management of aortic cross-clamp application and release requires excellent communication with the surgeon in order to anticipate and manage the physiological effects.

Answer 870

c. Hypercarbia Single-lung ventilation leads to a **right-to-left intrapulmonary shunt** as the nondependent lung continues to undergo perfusion with no ventilation, leading to a widened alveolar-to-arterial (A-a) oxygen gradient, which may contribute further to **hypoxemia**. Factors leading to decreased blood flow to the ventilated lung also lead to hypoxemia. Such factors include: Low Fio2 leads to **hypoxic pulmonary vasoconstriction** in the dependent ventilated lung High mean airway pressures in the dependent ventilated lung Vasoconstrictor agents Intrinsic PEEP The lateral decubitus position under anesthesia: Under anesthesia, there is a decrease in functional residual capacity. The upper lobe moves under anesthesia to a more favorable portion of the compliance curve versus the lower lung, which lies now on a less favorable portion of the compliance curve. Neuromuscular blockade contributes to abdominal contents pressing against the dependent hemidiaphragm, thereby restricting ventilation. Open non-dependent lung leads to variation in compliance and thus **worsens ventilation-perfusion (V/Q) mismatch** - thereby leading to hypoxemia. **Carbon dioxide elimination is usually unaffected **in using single-lung ventilation with adequate maintenance of minute ventilation. Both lungs may be affected independently by single-lung ventilation. The ventilated-dependent lung is prone to ventilator-induced lung injury due to higher tidal volumes used. The nondependent nonventilated lung is prone to injury by surgical trauma and ischemia-reperfusion injuries. Considering these physiological changes in single-lung ventilation is vital to safely performing the anesthetic technique and airway management. Reference: StatPearls Single-Lung Ventilation https://www.ncbi.nlm.nih.gov/books/NBK538314/"

Answer 871

Most likely answer will be related to hypophosphataemia Refeeding syndrome is a constellation of biochemical abnormalities which occurs when normal intake is resumed after a period of starvation. Its characteristic features are **low levels of phosphate, potassium, magnesium and sodium**. Its major complications include **cardiac arrhythmias, heart failure (due to hypophosphataemia), muscle weakness, rhabdomyolysis, seizures and an altered sensorium.** The major risk factors are calorie malnutrition of any cause, alcohol or drug use, low BMI (18-16) and starvation for 5-10 days. Pathophysiology With the restoration of glucose as a substrate, insulin levels rise and cause cellular uptake of these ions. **Depletion of adenosine triphosphate (ATP) and 2,3-diphosphoglyceric acid (2,3-DPG)** results in **tissue hypoxia** and **failure of cellular energy metabolism.** This may manifest as **cardiac and respiratory failure**, with **paraesthesiae** and **seizures** also reported. Thiamine deficiency may also play a part. - Exogenous sources of phosphate are inadequate to supplement the daily phosphate requirements - Intracellular phosphate stores are used to synthesise ATP (using protein and fat as fuel) - Homeostatic mechanisms maintain serum concentrations of these ions at the expense of intracellular stores Reference: https://derangedphysiology.com/main/required-reading/endocrinology-metabolism-and-nutrition/Chapter%20315/refeeding-syndrome "

Answer 872

****D. 20 mins **The time taken to reduce K+ with insulin/dextrose ranges from ~15-30 mins depending on source ** https://www.uptodate.com/contents/treatment-and-prevention-of-hyperkalemia-in-adults Treatment approach to hyperkalemic emergencies — Patients with a hyperkalemic emergency should receive (table 1): Intravenous calcium and insulin are rapidly acting treatments that provide time for the initiation of therapies that remove the excess potassium from the body. ●Intravenous calcium to antagonize the membrane actions of hyperkalemia ●Intravenous insulin (typically given with intravenous glucose) to drive extracellular potassium into cells ●Therapy to rapidly remove excess potassium from the body (ie, loop or thiazide diuretics if renal function is not severely impaired, a gastrointestinal cation exchanger, and/or dialysis [preferably hemodialysis] if renal function is severely impaired) ●Treatment of reversible causes of hyperkalemia, such as correcting hypovolemia and discontinuing drugs that increase the serum potassium (eg, nonsteroidal anti-inflammatory drugs, inhibitors of the renin-angiotensin-aldosterone system) RCH: http://www.rch.org.au/clinicalguide/guideline_index/Hyperkalaemia/ Insulin/glucose to be given at the same time If severe hyperkalaemia: - Dextrose 10% : 5ml/kg IV bolus (if no hyponatremia) - Insulin short action: 0.1 U/kg IV bolus (Max 10 units) Then followed by infusion insulin/glucose (see below) -If moderate hyperkalaemia: - Dextrose 10% IV at maintenance with 0.9% sodium chloride (normal saline) - Insulin short action infusion : 0.1 U/kg/h IV Note: Close monitoring of glucose every 30-60 minutes Onset of Action: 15 minutes, should reduce intravascular K+, reduction of 0.5-1.5mmol/L Duration: peak 60 minutes, 2-3hours American College of Emergency Physicians: Nebulized albuterol by face mask begins to take measurable effect after 15 to 20 minutes and lowers the serum potassium level by up to 1 mEq/L, depending on the dose. β-Agonists are safe despite the side effect of tachycardia. **Insulin, given intravenously in combination with glucose, also results in a similar fall in the potassium level after 20 to 30 minutes **and also lowers levels by up to 1 mEq/L. The combination of nebulized albuterol and intravenous insulin with glucose appears to be additive, lowering serum potassium by a mean of 1.21 mEq/L or more.11 Adult hyperkalemic patients who have ECG changes should receive continuous nebulized albuterol and 50 grams of intravenous dextrose plus 10 units of intravenous regular insulin. Emergency Medicine Journal J Accid Emerg Med. 2000 May; 17(3): 188–191. The management of hyperkalaemia in the emergency department INSULIN WITH GLUCOSE Insulin binds to specific membrane receptors and via an unknown second messenger, stimulates the sodium-potassium (Na-K) adenosine triphosphatase (ATP) pump resulting in intracellular uptake of K.5 This effect is independent of its hypoglycaemic action. Uraemia attenuates the hypoglycaemic response to insulin but does not affect its hypokalaemic action. Insulin has been the traditional temporising treatment against which newer treatments are compared. It is indicated in every case of hyperkalaemia that needs emergency treatment. Ten units (in adults) soluble insulin is given with 40–60 g glucose intravenously as a bolus. In children, a glucose load of 0.5 g/kg/h (2.5 ml/kg/h) should be given. This is because many of these patients increase their endogenous insulin production with the administration of a glucose load. If the blood glucose rises above 10 mml/l, insulin should be added at 0.05 u/kg/h.24 These studies show that the onset of hypokalaemic action is within 15 minutes and lasts for at least 60 minutes. The reduction in K observed is 0.65–1.0 mmol/l.5, 10 Delayed (30–60 minutes post insulin) hypoglycaemia is common (up to 75% of patients10) if less than 30 g glucose is given. LITFL: Treatment of hyperkalaemia involves stabilizing the myocardium to prevent arrhythmias, shifting potassium back into the intracellular space and removing excess potassium from the body. Drive Potassium into the Cell: Insulin & Glucose - Dose: IV fast acting insulin (actrapid) 10-20 units and glucose/dextrose 50g 25-50ml - Insulin drives potassium into cells and administering glucose prevents hypoglycaemia. - Begins to work in 20-30mins reduces potassium by 1mmol/L and ECG changes within the first hour Ca gluconate - should be part of initial treatment but it does not lower either total body or serum potassium, it acts as a membrane stabiliser LITFL: Correct Serious Conduction Abnormalities (Calcium) - Calcium is a very useful agent. It does not lower the serum potassium level, but instead is used to stabilise the myocardium, as a temporising measure. Calcium is indicated if there is widening of QRS, sine wave pattern (when S and T waves merge together), or in hyperkalaemic cardiac arrest. - The ‘cardiac membrane stabilising effects’ take about 15-30mins. Calcium Chloride - Dose: Calcium Chloride 10% 5-10mL = 6.8 mmol - 3 x more potent than Calcium Gluconate - Complication: severe thrombophlebitis - Calcium Gluconate: - Dose: Calcium Gluconate 10% 5-10mL = 2.2 mmol - Less potent, less irritating to veins - Potential Complications of Calcium administration - Bradycardia, hypotension and peripheral vasodilation - Generally these occur if administered too quickly - Avoid in digoxin toxicity (use magnesium as alternative) - salbutamol Drive Potassium into the Cell: Salbutamol - Dose: 10-20mg via nebulizer - Beta 2 agonist therapy lower K via either IV or nebulizer route. - Salbutamol can lower potassium level 1mmol/L in about 30 minutes, and maintain it for up to 2 hours. - Very effective in renal patients that are fluid overloaded - Drive Potassium into the Cell: Sodium Bicarbonate - Dose: 50- 200mmol of 8.4% Sodium Bicarbonate - Bicarbonate is only effective at driving Potassium intracellullarly if the patient is acidotic - Begins working in 30-60 minutes and continues to work for several hours. Eliminate Potassium From the Body: Calcium Resonium - Dose: 15-45g orally or rectally, mixed with sorbitol or lactulose - Calcium polystyrene sulfonate is a large insoluble molecule that binds potassium in the large intestine, where it is excreted in faeces - Effects take 2-3 hours M&M 2016: An intravenous infusion of glucose and insulin (30–50 g of glucose with 10 units of insulin) is also effective in promoting cellular uptake of potassium and lowering plasma [K+], but may take up to 1 h for peak effect

Answer 873

c) Staphyloma https://eyewiki.aao.org/Ocular_Anesthesia#cite_note-:2-3 **Contraindications** **Absolute** Confirmed allergy to a necessary anesthetic, and nystagmus. Other contraindications are just those of the particular surgery that is to be performed. **Relative** Long eye (in the anterior to posterior axis, evidenced by high myopia), staphyloma (abnormal protrusion at a weak spot in the wall of the eye), enophthalmos (posteriorly or deep set eyes), and extended surgery duration are relative contraindications to retrobulbar and peribulbar anesthesia. In an uncooperative patient, patients deemed to be unable to follow commands during surgery, children and those with uncontrollable neurological movements, general anesthesia may be considered.

Answer 874

700ml 50% of blood volume in 3 hours S Blaine. BLAE Paediatric massive transfusion

Answer 875

https://associationofanaesthetists-publications.onlinelibrary.wiley.com/doi/10.1111/anae.15291 The 2011 guidelines list seven ‘acceptable’ reasons for delaying surgery: 1 Haemoglobin < 80 g.l−1 2 Plasma sodium concentration < 120 or > 150 mmol.l−1 and potassium concentration < 2.8 or > 6.0 mmol−1 3 Uncontrolled diabetes 4 Uncontrolled or acute onset left ventricular failure. 5 Correctable cardiac arrhythmia with a ventricular rate > 120.min−1 6 Chest infection with sepsis 7 Reversible coagulopathy

Answer 876

All muscles in the anterior compartment of the arm are innervated by the musculocutaneous nerve. - biceps brachii: forearm flexion and supination. Accessory shoulder flexor - coracobrachialis: shoulder flexion, arm adduction. - Brachialis: forearm flexion The musculocutaneous nerve innervates skin on the anterolateral side of the forearm.

Answer 877

b) crescendo TIA symptoms https://academic.oup.com/bja/article/99/1/119/269458 Ideally, patients presenting with a suspected TIA should have undergone investigation and, if appropriate, surgery within 2 weeks of presentation.

Answer 878

c) Vasopressin https://emcrit.org/ibcc/pressors/ - From UP TO DATE: > At low doses of 1 to 3 mcg/kg per min, dopamine acts primarily on dopamine-1 receptors to dilate the renal and mesenteric artery beds > At 3 to 10 mcg/kg per min (and perhaps also at lower doses), dopamine also stimulates beta-1 adrenergic receptors and increases cardiac output, predominantly by increasing stroke volume with variable effects on heart rate. > At medium-to-high doses, dopamine also stimulates alpha-adrenergic receptors, although a small study suggested that renal arterial vasodilation and improvement in cardiac output may persist as the dopamine dose is titrated up to 10 mcg/kg per min *clinically, the haemodynamic effects of dopamine demonstrate individual variability Dobutamine (inodilator): - selective β1-agonist that increases cardiac contractility and reduces pulmonary vascular and systemic vascular resistances Vasopressin: - vasopressin may have pulmonary vasodilatory effects in addition to a systemic vasoconstrictive effect Milrinone (inodilator): - the phosphodiesterase-3 inhibitors, milrinone and enxoimone, have positive inotropic effects combined with the capacity to reduce RV afterload (‘inodilators’) without significant chronotropic effect, but they can be associated with significant systemic hypotension

Answer 879

All People Kick My Cat Atm> PSI > KPA > mmHg > cmH2O 1ATM = 14.69 PSI = 101.325 kPa = 760mmHg = 1033 cmH20

Answer 880

e) stop 2 weeks before, start moclobemide and omit Moclobemide day of surgery -> probably in discussion with the patients psychiatrist Tranylcypromine, sold under the brand name Parnate among others, is a monoamine oxidase inhibitor. More specifically, tranylcypromine acts as nonselective and irreversible inhibitor of the enzyme monoamine oxidase. In the elective setting, there is some debate regarding the management of patients on MAOI. Although the risks associated with anaesthesia in those taking this group of drugs are significant, abrupt withdrawal may precipitate serious psychiatric relapse. Traditionally, irreversible MAOIs have been stopped 2 weeks before operation; however, omitting the dose of moclobemide on the day of surgery is acceptable. It has been suggested that in the elective situation, patients could be switched from an irreversible MAOI to moclobemide to avoid a prolonged period of discontinuation.

Answer 881

b) 2 ATM https://academic.oup.com/bjaed/article/7/1/2/509371 **A typical parameter-set for HFJV via a subglottic catheter is DP, 2 atm; f, 150 min−1; Fio2, 1.0; I-time, 50%. ** Driving pressure 1-2 atm (250-500ml/s) RR 8-10 Automated jet ventilator – typical starting jet pressure for an adult is 1.5 bar (~1.5 atm). Manual jet ventilators deliver up to 3.5-4 bar.

Answer 882

a) Iron transfusion Iron infusion (ferric carboxymaltose) – can cause renal wasting of phosphate resulting in severe hypophosphataemia Vitamin D deficiency and hyperparathyroidism can also cause hypophosphataemia. Vitamin D deficiency would result in low calcium whereas hyperparathyroidism would result in hypercalcaemia. Fanconi syndrome: rare defect of proximal tubule leading to decreased reabsorption -> results in hypokalaemia, hypophosphataemia, hyperchloraemic metabolic acidosis. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6689119/

Answer 883

No change in Mortality, no change in POD No evidence was found that mortality or serious complication were modified by targeting either a BIS of 50 or 35 A broad range of anaesthetic depth can be delivered safely when using volatile anaesthetic agents and processed electroencephalographic monitoring https://www.thebottomline.org.uk/summaries/pom/balance/

Answer 884

a) Tamponade Cardiac tamponade occurs ~1%. Can usually be managed with reversal of anticoagulation and percutaneous drainage. Vascular complications most common followed by tamponade. https://www.ahajournals.org/doi/10.1161/circep.113.000768 https://academic.oup.com/bjaed/article/12/5/230/289246#3659733

Answer 885

serum free metanephrines and nor-metanephrines https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3230088/ ## Footnote https://www1.racgp.org.au/ajgp/2021/january-february/adrenal-disease-an-update

Answer 886

c) Larger bolus lower infusion rate https://associationofanaesthetists-publications.onlinelibrary.wiley.com/doi/10.1111/anae.13345 https://journals.lww.com/anesthesia-analgesia/fulltext/2014/06000/a_general_purpose_pharmacokinetic_model_for.12.aspx

Answer 887

D. Withdraw PAC 2 cm and insert DLT LITFL: Pulmonary haemorrhage after PAOP measurement a life threatening time-critical emergency pulmonary artery rupture caused by inflation of the pulmonary artery catheter (PAC) balloon during ‘wedging’ (measurement of the pulmonary artery occlusion pressure) some experts advise against measuring PAWP because of the risk of pulmonary artery rupture 0.2% risk, 30% mortality RISK FACTORS pulmonary hypertension mitral valve disease anticoagulants age >60 years MANAGEMENT Goals prevent further pulmonary haemorrhage stop bleeding resuscitate Call for help ICU consultant anaesthetist/ OT cardiothoracic surgeon interventional radiology Resuscitation A may have to be emergently intubated if not already B FiO2 1.0 controlled ventilation if able to recognize which lung is haemorrhaging may be able to perform lung isolation (insert single lumen tube into unaffected side, exchange for a double lumen tube or use bronchial blocker with bronchoscopic assistance) apply PEEP to tamponade wound C large bore IV cannulae, fluids, blood products, inotropes Specific therapy Lay the patient ruptured side down withdraw pulmonary catheter 2-3 cm with balloon down then refloat PAC with balloon inflated to occlude pulmonary artery (to try to tamponade bleeding) stop antiplatelet agents and anticoagulants give reversal agents: — protamine for heparin — platelets for anti-platelet agents give blood products as indicated by FBC, coags and clinical state interventions — angiogram or bronchoscopy to isolate pulmonary vessel involved — if bleeding doesn’t settle will require lobectomy

Answer 888

b) 3rd nerve palsy https://derangedphysiology.com/main/required-reading/neurology-and-neurosurgery/Chapter%204631/lesions-oculomotor-nerve-cn-iii This is the "down and out" eye syndrome. It is characterised by ptosis, a down-and-out pupil, mydriasis, absent light reflex with intact consensual constriction of the opposite eye, and failure of accommodation. Classically, this is the lesion which develops during uncal herneation, due to an ipsilateral cerebral injury. Causes of unilateral CN III lesions: - Uncal herneation: Pressure from herniating uncus on nerve - Fracture involving ipsilateral cavernous sinus - Cavernous sinus thrombosis (ipsilateral) - Aneurysm (ipsilateral) - Midbrain lesion (see Question 26.2 from the second paper of 2011) Causes of bilateral CN III lesions: - Cavernous sinus thrombosis - Aneurysm - Contralateral brainstem lesion (midbrain) Exclusion of a 4th nerve lesion - Tilt the head to the same side as the lesion - The affected eye will intort if the fourth nerve is intact.

Answer 889

d) Dexamethasone The ECG shows LONG QT https://litfl.com/qt-interval-ecg-library/

Answer 890

c) T6 LITFL: https://litfl.com/trauma-spinal-injury/ **Neurogenic shock** is classically characterised by hypotension, bradycardia and peripheral vasodilatation. Neurogenic shock is due to loss of sympathetic vascular tone and happens only after a significant proportion of the sympathetic nervous system has been damaged – as may occur with lesions at the T6 level or higher. **Spinal shock** is not a true form of shock. It refers to the flaccid areflexia that may occur after spinal cord injury, and may last hours to weeks. It may be thought of as ‘concussion’ of the spinal cord and resolves as soft tissue swelling improves. Priapism may be present.

Combined Deck: 24.1, 23.2, 23.1, 22.2, 22.1, 21.1, 21.2, 20.1, 20.2 Flashcards

MCQs with remembered answeres from the last 5yrs of released stems for the ANZCA part 2 exam (983 cards)