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Committee papers Flashcards

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1
Q

Rare SE of lspar reported in a dog?

A

pancreatitis

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2
Q

RR and PFS for rescue MOMP

A

50%; 56 d

no diff T vs B cells

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3
Q

What do all melanoma in dogs and cats express?

A

tyrosinase - no correlation w/ pigment, MHC1, or histo claasification

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4
Q

Which cells does IL12 cytokine activate?

A

Th1 and Tc

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5
Q

What is NHS-IL12?

A

immuncytokine of ab targeting necrotic tumor regions, linked ot IL12

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6
Q

What AE are noted with NHS-IL12 in dogs with melanoma?

A

thrombo, elevated LE, fever, vasculitis

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7
Q

IL10 and intratumoral CD8 cell decreased or increased with NHS-IL12 in melanoma?

A

increased

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8
Q

what is the tolerable dose of NHS-IL12?

A

0.8mg/mg2 SQ q 28 d (if response)

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9
Q

If untx how many melanomas in horses become malignant?

A

2/3rd

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10
Q

what is MC skin tumor in horses?

A

melanoma (gray horses)

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11
Q

Scottish deerhounds have possible linkage between phenotype and markers on what chromosome associated with OSA?

A

Chr. 34

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12
Q

what is incidence of OSA in scottish deerhounds?

A

> 15%

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13
Q

What were prog factors for scottish deerhounds and OSA?

A

gender and genotype

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14
Q

in solid tumors, to what depth can hyperthermia reach therapeutic levels?

A

> 4cm

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15
Q

What is MR appearance of canine MCT?

A

most hyperintense on T2 and isointense T1 and all CE

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16
Q

Is there a sig diff in MRI features of metastatic MCT LN?

A

mets larger and generally more heterogenous (but not stat sig)

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17
Q

What type of LSA is reported in yellow naped Amazon parrot?

A

GI T cell LSA

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18
Q

What is MTD for palladia and dox combination?

A

25mg/m2 dox q 21 d

DLT neutropenia

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19
Q

what was CR, PFS and MST of 12 week vs 19 weeks CHOP?

A

90% CR in both (95% ORR)

  • 12 wk PFS 141 d and 19 wk 208 d
  • 12 wk MST 234 d vs 348d
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20
Q

what is diff in DI in 12 week vs 19 week CHOP?

A

58% increased DI for dox and cytoxan vs 21% reduced for vinc

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21
Q

what is MC small cell GI LSA In cats?

A

CD3+ w/ epitheliotropism

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22
Q

what is ORR and duration in cats w/ small cell GI LSA?

A

96% with MST 786d

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23
Q

what % of dogs with cut OSA mets have mets to lung and bone?

A

86% lung

5% bone

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24
Q

what was time to develop and MST of cut OSA mets in dgos?

A

160 days with MST 55 days

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25
what was MST for cut OSA mets tx w/ sx + chemo vs chemo vs supportive?
3mn vs 2mn vs 11d
26
What is MTD carbo + palladia
200mg/m2
27
What enzymes are directly inhibited by Zinc oxide?
ERK and AKT
28
What unique features does Zinc oxide have?
unique surface ROS induction lipid peroxidation pH/ionic gradient changes in cancer cells and microenvironment
29
What was successful tx of a oral FSA in an alpaca?
sx followed by RT after recurrence resulted in >2 yr ST (110 weeks)
30
What drug and where was contamination found at VTH?
carboplatin on biological safety cabinet
31
What features were used to develop risk score for dogs w/ hemoabd?
weight, plasma protein, platelet count and CXR
32
Using HeLP score, what % of HSA in low, medium and high risk groups?
36% 76% 96%
33
Of malignant splenic tumors, how common are they HSA in small (<27.8kg) and large dogs?
46% small | 65% large
34
What findings were more common in all dogs dx with splenic HSA?
preop anemia hemoab thrombo blood transfusion
35
In canine nasal tumors, what RTK is phosphorylated?
EGFR1 most common | NOT VEGFR2, PDGFR alpha/beta, cKIT
36
What is mechanism of palladia efficacy in canine nasal tumors?
unknown -not likely VEGFR, PDGFR or kit as not phosphorylated
37
What is ORR and MST for intermittent single agent dox in BCL?
78% RR | MST 170d
38
Does gadoxetate disodium contrast enhanced MRI find more or less lesions than usual MRI for HCC?
yes ID new lesions in 3/7 patients
39
With gadoxetate disodium contrast MRI of livers, a signal intensity ratio of <1 indicates what?
retained but impaired liver fnx
40
what small breed dog is predisposed to HS?
mini schnauzers
41
What may predispose mini schnauzers to HS?
inherited risk factor likely based on pedigree analysis
42
what is OR of prior joint dz in a limb affected by periarticular HS vs control dogs?
13.42
43
How commonly did stifle joints with PAHS have dz and what was most common?
88% - CrCL rupture
44
what is RR for combination CCNU/dox for HS and MST?
58% | 185d
45
Substitution of mito for dox in first line tx of canine LSA had was ORR, PFI and MST?
CHOP 97%, PFI 208; MST 348d | CMOP 100%, PFI 165; MST 234
46
What is RV1001?
PI3K inhibitor
47
What tumor type and RR has been noted with RV1001?
LSA in dogs with 62% and 77% RR
48
what was main toxicity of RV1001?
hepatobiliary (DLT) and GI
49
what is most common initial diagnosis for lingual TZL?
plasma cell tumor
50
what clinical findings and outcome were noted with lingual TZL?
11/12 lymphocytosis +/- LN involvement | 7/12 CR and 4/12 SD
51
What is RR and MST for canine small cell GI LSA?
70% | 424d
52
What is most common phenotype of small GI LSA in dogs?
T cell (95%) with 60% epitheliotropic
53
Protein kinase CK2 is increased or decreased in cancer?
increased
54
what is tenfibgen and what is it's use?
ligand to target Tenascin-C receptors - used to deliver siRNA targeting protein kinase CK2 to tumor tissue
55
What is ORR for cats with MM to chemotherapy?
71-83% (melphalan vs cytoxan)
56
What is MST for cats with MM tx with cytoxan and melphalan and were they different?
cytoxan 13mn melphalan 8mn Not diff
57
What is the role of protein kinase CK2?
activate NFkB, WNT-B catenin, PI3K-AKT pathway, inactivate tumor suppressors (PTEN) and suppress apoptosis
58
what feline tumor type expresses protein kinase CK2 and what occurs with inhibition in vitro?
SCC | siRNA targeting resulted in decrease viability and apoptosis
59
What the important targets on protein kinase CK2?
CK2alpha (most important) and CK2alpha'
60
Was tenfibgen coated tumor specific nanoparticles with CK2 miRNA targets effective?
2 samples reduced IHC score
61
what were SE of tenfibgen coated tumor specific nanoparticles with CK2 miRNA targets
MC grade 1-2 weight loss/anorexia; gr 3 necrosis in 1 cat and asymp gr 4 ALT and CK
62
Does tenfibgen coated tumor specific nanoparticles with CK2 miRNA targets induce tumor response?
1 PR and 3 SD in feline OSCC
63
T/F Aurora kinase inhibitors are effective in OSA cell lines
false
64
Vinblastine as 2nd rescue for canine LSA has what RR and PFS?
25% | PFS 30d
65
MRI signal intensity of what organs may diff btw hematopoiectic neoplasia?
visual and ROI evaluated liver < skeletal muscle in affected (healthy > than skeletal muscle)
66
what is the DFS and MST for OSA dogs tx w/ amputation, carbo, MC +/- palladia?
w/o palladia: DFI 215d nad MST 242d | w/ palladia DFI 233 and 318 (no diff)
67
What was 1 yr survival for OSA dogs tx w/ amputation, carbo, MC +/- palladia?
38% and 35%
68
contoured BSA differed from routine formula by how much?
-9 to +19%
69
what is eBAT?
bispecific angiotoxin of pseudomonas exotoxin fused with EGF and uPAR
70
what was 6mn ST in eBAT vs SOC dogs?
70% vs 38%
71
what human cancer expresses uPAR and EGFR?
pediatric sarcoma
72
what is MOA of iniparib?
PARP inhibitor
73
what is KPT-335?
SINE inhibitor
74
what is MTD of KPT-335?
1.75mg/kg twice weekly (later study used 1.5mg/kg)
75
what is DLT of KPT-335?
hepatotox, anorexia, weight loss
76
what is impact of repeated cycles of eBAT in HSA?
increased AE and no benefit vs SOC
77
What is utility of FDG PET CT for HSA in dogs?
2/9 dogs had lesions not noted on CXR/AUS
78
what is ORR of KPT-335 and response in T cells?
ORR 37% | T cell ORR 71%
79
what is valspodar?
selective inhibitor of ATP binding cassette B1 transporter (ABCB1)
80
what was impact of valspodar on lymphoid progenitor cells (CD34+, CD117+, CD133+)?
no difference, although safe
81
What was efficacy of salmonella encoding IL2 combination w/ amputation and dox for OSA?
Longer DFI vs dox alone but not vs carbo/dox
82
What is RR in gross dz setting to 5-FU/carboplatin in dogs?
43%
83
what is most common AE with 5-FU/carbo in dogs?
myelosuppression (plt > neut) and one episode ataxia
84
what MOA do 6-TG and Zebularine share?
DMNT 1 inhibitors
85
Does SQ administration of excipient free nanoparticle paclitaxel have systemic absorption?
no - so may be good intratumoral drug
86
what is MTD of excipient free nanoparticle paclitaxel?
unknown - doses used 80-136mg/m2 SQ and IV
87
what PK model fits hyaluronan-cisplatin nanoconjugate?
3 compartment
88
what cancer type had CR to hyaluronan-cisplatin nanoconjugate?
nasal and oral SCC
89
what is MC AE with hyaluronan-cisplatin nanoconjugate?
40% myelosuppression, 12% cardiotox
90
T/F Papillomavirus is a causative agent of canine orbital adenomas
false

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