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Dermatology > Common Drug Reaction Culprits > Flashcards

Common Drug Reaction Culprits Flashcards

(61 cards)

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1
Q

Acneiform lesions

A

EGFR inhibitors (eg erlotinib, cetuximab, gefitinib)

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2
Q

Acral erythema (erythrodysesthesia)

A

Doxorubicin, daunorubicin, 5-FU, cytarabine, docetaxel, MTX

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3
Q

Acral sclerosis

A

bleomycin

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4
Q

AGEP

A
  • beta-lactam antibiotics

- macrolides, CCB, chloroquine, terbinafine

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5
Q

Alopecia

A

alkylating agents (cyclophosphamide), antrhacyclines (doxorubicin, daunarubicin), taxanes (paclitaxel, docetaxel), vincristine, vinblastine, actinomycin-D, etoposide

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6
Q

Autoimmune hepatitis

A

Minocycline

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7
Q

Bullous pemphigoid

A
  • Furosemide, PCN, captopril, beta-blockers

- sulfonamides, terbinafine, penicllamine

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8
Q

DM-like eruption

A
  • Hydroxyurea

- penicillamine, statins

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9
Q

Eccrine squamous syringometaplasia

A
  • Cytarabine, paclitaxel, docetaxel

- cyclophosphamide, busulfan, carmustine

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10
Q

Elastosis perforans serpiginosa

A

D-penicillamine

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11
Q

Erythema nodosum

A

OCPs, antiobiotics (SULFA, tetracycline), NSAIDs

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12
Q

Extravasation reaction (ulcer, chemical cellulitis)

A

Anthracyclines (doxorubicin/daunorubicin)

-actinomycin-D, docetaxel, paclitaxel, vinblastine, vincristine, etoposide, 5-FU

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13
Q

Fixed drug eruption

A

NSAIDs, sulfonamides, TCNs, phenolphthalein, pseudoephedrine (non-pigmenting variant)
-acetaminophen, ASA, OCP, barbituates

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14
Q

Flag sign (of chemo)

A

MTX (horizontal hyperpigmented bands of hair alternating with normal color)

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15
Q

Gingival hyperplasia

A

Phenytoin, cyclosporine, CCBs

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16
Q

Hyperpigmentation

A

antimalarials, clofazamine (violet-brown to blue in lesional skin), imipramine, amiodarone (blue-gray), phenothiazines (chlorpromaine, promethaine, prochlorperazine), chemotherapeutics, and minocycline

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17
Q

Minocycline hyperpigmentation

A

Type 1: blue-black color within scars, +iron (hemosiderin) with Perls stain
Type 2: blue-gray color on shins, +melanin (Fontana-Masson stain), +iron (Perls stain)
Type 3: generalized “muddy brown” hyperpigmentation in sun-exposed sites (increased melanin within epidermis, no iron deposition)

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18
Q

Hypersensitivity syndrome

A

aromatic anticonvulsants (phenytoin, phenobarbital, carbamazepine, lamotrigine, oxcarbazepine), sulfonamides, allopurinol, dapsone, gold, olanzapine, saquinavir

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19
Q

Hypertrichosis

A

cyclosporine, phenytoin, minoxidil, danazol, anabolic steroids

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20
Q

Inflamed ADs

A

5-FU

-Capecitabine, pentostatin

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21
Q

Inflamed SCC

A

fludarabine

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22
Q

Inflamed SKs

A

cytarabine, docetaxel

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23
Q

Leg ulcers

A

hydroxyurea

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24
Q

Leukocytoclastic vascultitis

A

Abx (especially beta-lactam)

-NSAIDs, diuretics

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25
Lichenoid eruption
- HCTZ, beta-blockers, antimalarials, quinidine | - penicillamine, gold, furosemide, ACEi
26
Linear IgA bullous dermatosis
- vancomycin, beta-lactam antibiotics, captopril, furosemide | - NSAIDs, phenytoin, sulfonamides, amiodarone, lithium
27
Flagellate hyperpigmentation
bleomycin
28
Supravenous serpentine hyperpigmentation
5-FU
29
Sun-exposed hyperpigmentation
daunorubicin, 5-FU, MTX
30
Mucosal hyperpigmentation
busulfan, cyclophosphamide, 5-FU, hydroxyurea, doxorubicin
31
Hyperpigmentation of Occluded areas
thiotepa | -ifosfamide, topical carmustine, docetaxel, cisplatin
32
Lupus (SCLE)
HCTZ, griseofulvin, terbinafine, CCBx
33
Lupus (SLE)
hydralazine, procainamide, isoniazid, MCN, phenytoin, penicillamine
34
Melanonychia
chemo (melphalan, hydroxyurea, bleomycin, capecitabine, doxorubicin), lamuvidine, MCN, idovudine (AZT)
35
Mucositis
cyclophosphamide, daunorubicin, doxorubicin, MTX (high dose), 5-FU
36
Neutrophilic eccrine hidradenitis
doxorubicin, daunorubicin, cytarabine, 5-FU, MTX, bleomycin, cyclophosphamide, busulfan, taxanes
37
Onycholysis
paclitaxel, docetaxel, etoposide, retinoids, doxorubicin, captopril
38
Photo-onycholysis
TCN, OCPs, fluoroquinolones, psoralens
39
Orange-red body fluid
Rifampin
40
Pemphigus vulgaris
``` Thiol drugs (penicillamine, captropril, lisinopril) -piroxicam, gold, sodium thiomalate, penicillins, cephalosporines, quinolones, rifampicin, phenylbutazone, propranolol, carbamazepine ```
41
Penile ulcers
Foscarnet
42
Photosensitivity (includes allergic and toxic reations)
griseofulvin, NSAIDs, phenothiazines, sulfonamides, thiazides, dapsone, MTX, hypdroxyurea, 5-FU, fluoroquinolones, TCNs, furosemid, diltiaem, isotretinoin, imipramine, chlorpromazine, phenothiazines
43
Pseudoporphyria
NSAIDs (naproxen, piroxicam), nalidixic acid), furosemide, HCTZ, isotretinoin, TCNs, sulfonamides
44
Pseudotumor cerebri
TCN, isotretinoin
45
Pseuodxanthoma elasticum
Penicillamine
46
Psoriasis (induce/worsen)
terbinafine, NSAIDs, antimalarials, ACEI, lithium, beta-blockers
47
pulmonary fibrosis
MTX, bleomycin, busulfan, amiodarone, gold, penicillamine
48
Radiation recall
doxorubicin, daunorubicin, paclitael, docetaxel, MTX, actinomycin-D, capecitabine, gemcitabine, bleomycin
49
Raynaud's phenomenon
combination of bleomycin and vinblastine
50
Sweet's syndrome
GCSF | -carbamazepine, TMP-SMZ
51
Toxic epidermal necrolysis (TEN)
allopurinol, PCNs, anticonvulsants (carbamazepine, lamotrigine, phenytoin), sulfonamides, antiretrovirals, barbituates, NSAIDs
52
Timeline for AGEP
hours to 2 days
53
Timeline for phototoxic eruption
hours to 7 days
54
Timeline for urticaria
hours to 6 days
55
Timeline for lichenoid eruption
30-100 days
56
Timeline for fixed drug eruption
up to 2 weeks with first exposure (<24h in subsequent exposure)
57
Timeline for DRESS
2-6 weeks (mean 3-4 weeks)
58
Timeline for SJS/TEN
7-21 days (first 2 months for anticonvulsants)
59
Timeline for morbilliform reaction
7-21 days
60
Timeline for LABD (linear IgA bullous dermatosis)
24h-2 weeks
61
Timeline for pemphigus vulgaris reaction
several weeks or months

Dermatology (17 decks)

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