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Dermatology > Common Drug Reaction Culprits > Flashcards

Common Drug Reaction Culprits Flashcards

1
Q

Acneiform lesions

A

EGFR inhibitors (eg erlotinib, cetuximab, gefitinib)

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2
Q

Acral erythema (erythrodysesthesia)

A

Doxorubicin, daunorubicin, 5-FU, cytarabine, docetaxel, MTX

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3
Q

Acral sclerosis

A

bleomycin

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4
Q

AGEP

A
  • beta-lactam antibiotics

- macrolides, CCB, chloroquine, terbinafine

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5
Q

Alopecia

A

alkylating agents (cyclophosphamide), antrhacyclines (doxorubicin, daunarubicin), taxanes (paclitaxel, docetaxel), vincristine, vinblastine, actinomycin-D, etoposide

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6
Q

Autoimmune hepatitis

A

Minocycline

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7
Q

Bullous pemphigoid

A
  • Furosemide, PCN, captopril, beta-blockers

- sulfonamides, terbinafine, penicllamine

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8
Q

DM-like eruption

A
  • Hydroxyurea

- penicillamine, statins

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9
Q

Eccrine squamous syringometaplasia

A
  • Cytarabine, paclitaxel, docetaxel

- cyclophosphamide, busulfan, carmustine

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10
Q

Elastosis perforans serpiginosa

A

D-penicillamine

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11
Q

Erythema nodosum

A

OCPs, antiobiotics (SULFA, tetracycline), NSAIDs

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12
Q

Extravasation reaction (ulcer, chemical cellulitis)

A

Anthracyclines (doxorubicin/daunorubicin)

-actinomycin-D, docetaxel, paclitaxel, vinblastine, vincristine, etoposide, 5-FU

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13
Q

Fixed drug eruption

A

NSAIDs, sulfonamides, TCNs, phenolphthalein, pseudoephedrine (non-pigmenting variant)
-acetaminophen, ASA, OCP, barbituates

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14
Q

Flag sign (of chemo)

A

MTX (horizontal hyperpigmented bands of hair alternating with normal color)

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15
Q

Gingival hyperplasia

A

Phenytoin, cyclosporine, CCBs

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16
Q

Hyperpigmentation

A

antimalarials, clofazamine (violet-brown to blue in lesional skin), imipramine, amiodarone (blue-gray), phenothiazines (chlorpromaine, promethaine, prochlorperazine), chemotherapeutics, and minocycline

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17
Q

Minocycline hyperpigmentation

A

Type 1: blue-black color within scars, +iron (hemosiderin) with Perls stain
Type 2: blue-gray color on shins, +melanin (Fontana-Masson stain), +iron (Perls stain)
Type 3: generalized “muddy brown” hyperpigmentation in sun-exposed sites (increased melanin within epidermis, no iron deposition)

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18
Q

Hypersensitivity syndrome

A

aromatic anticonvulsants (phenytoin, phenobarbital, carbamazepine, lamotrigine, oxcarbazepine), sulfonamides, allopurinol, dapsone, gold, olanzapine, saquinavir

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19
Q

Hypertrichosis

A

cyclosporine, phenytoin, minoxidil, danazol, anabolic steroids

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20
Q

Inflamed ADs

A

5-FU

-Capecitabine, pentostatin

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21
Q

Inflamed SCC

A

fludarabine

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22
Q

Inflamed SKs

A

cytarabine, docetaxel

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23
Q

Leg ulcers

A

hydroxyurea

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24
Q

Leukocytoclastic vascultitis

A

Abx (especially beta-lactam)

-NSAIDs, diuretics

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25
Q

Lichenoid eruption

A
  • HCTZ, beta-blockers, antimalarials, quinidine

- penicillamine, gold, furosemide, ACEi

26
Q

Linear IgA bullous dermatosis

A
  • vancomycin, beta-lactam antibiotics, captopril, furosemide

- NSAIDs, phenytoin, sulfonamides, amiodarone, lithium

27
Q

Flagellate hyperpigmentation

A

bleomycin

28
Q

Supravenous serpentine hyperpigmentation

A

5-FU

29
Q

Sun-exposed hyperpigmentation

A

daunorubicin, 5-FU, MTX

30
Q

Mucosal hyperpigmentation

A

busulfan, cyclophosphamide, 5-FU, hydroxyurea, doxorubicin

31
Q

Hyperpigmentation of Occluded areas

A

thiotepa

-ifosfamide, topical carmustine, docetaxel, cisplatin

32
Q

Lupus (SCLE)

A

HCTZ, griseofulvin, terbinafine, CCBx

33
Q

Lupus (SLE)

A

hydralazine, procainamide, isoniazid, MCN, phenytoin, penicillamine

34
Q

Melanonychia

A

chemo (melphalan, hydroxyurea, bleomycin, capecitabine, doxorubicin), lamuvidine, MCN, idovudine (AZT)

35
Q

Mucositis

A

cyclophosphamide, daunorubicin, doxorubicin, MTX (high dose), 5-FU

36
Q

Neutrophilic eccrine hidradenitis

A

doxorubicin, daunorubicin, cytarabine, 5-FU, MTX, bleomycin, cyclophosphamide, busulfan, taxanes

37
Q

Onycholysis

A

paclitaxel, docetaxel, etoposide, retinoids, doxorubicin, captopril

38
Q

Photo-onycholysis

A

TCN, OCPs, fluoroquinolones, psoralens

39
Q

Orange-red body fluid

A

Rifampin

40
Q

Pemphigus vulgaris

A 
Thiol drugs (penicillamine, captropril, lisinopril)
-piroxicam, gold, sodium thiomalate, penicillins, cephalosporines, quinolones, rifampicin, phenylbutazone, propranolol, carbamazepine
41
Q

Penile ulcers

A

Foscarnet

42
Q

Photosensitivity (includes allergic and toxic reations)

A

griseofulvin, NSAIDs, phenothiazines, sulfonamides, thiazides, dapsone, MTX, hypdroxyurea, 5-FU, fluoroquinolones, TCNs, furosemid, diltiaem, isotretinoin, imipramine, chlorpromazine, phenothiazines

43
Q

Pseudoporphyria

A

NSAIDs (naproxen, piroxicam), nalidixic acid), furosemide, HCTZ, isotretinoin, TCNs, sulfonamides

44
Q

Pseudotumor cerebri

A

TCN, isotretinoin

45
Q

Pseuodxanthoma elasticum

A

Penicillamine

46
Q

Psoriasis (induce/worsen)

A

terbinafine, NSAIDs, antimalarials, ACEI, lithium, beta-blockers

47
Q

pulmonary fibrosis

A

MTX, bleomycin, busulfan, amiodarone, gold, penicillamine

48
Q

Radiation recall

A

doxorubicin, daunorubicin, paclitael, docetaxel, MTX, actinomycin-D, capecitabine, gemcitabine, bleomycin

49
Q

Raynaud’s phenomenon

A

combination of bleomycin and vinblastine

50
Q

Sweet’s syndrome

A

GCSF

-carbamazepine, TMP-SMZ

51
Q

Toxic epidermal necrolysis (TEN)

A

allopurinol, PCNs, anticonvulsants (carbamazepine, lamotrigine, phenytoin), sulfonamides, antiretrovirals, barbituates, NSAIDs

52
Q

Timeline for AGEP

A

hours to 2 days

53
Q

Timeline for phototoxic eruption

A

hours to 7 days

54
Q

Timeline for urticaria

A

hours to 6 days

55
Q

Timeline for lichenoid eruption

A

30-100 days

56
Q

Timeline for fixed drug eruption

A

up to 2 weeks with first exposure (<24h in subsequent exposure)

57
Q

Timeline for DRESS

A

2-6 weeks (mean 3-4 weeks)

58
Q

Timeline for SJS/TEN

A

7-21 days (first 2 months for anticonvulsants)

59
Q

Timeline for morbilliform reaction

A

7-21 days

60
Q

Timeline for LABD (linear IgA bullous dermatosis)

A

24h-2 weeks

61
Q

Timeline for pemphigus vulgaris reaction

A

several weeks or months

Dermatology (17 decks)

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