Common Drug Side Effects

Question 1

ACEIs

Answer 1

Cough, angioedema, teratogen

Rash, proteinuria, taste changes

Question 2

Amantadine

Answer 2

Ataxia

Livedo reticularis

Question 3

Aminoglycosides

Answer 3

Ototoxicity

Nephrotoxicity 2/2 ATN

Question 4

Amiodarone

Answer 4

Acute: AV block, hypotension, bradycardia
Chronic: pulmonary fibrosis, peripheral deposition leading to bluish discoloration, arrhythmias, hypo/hyperthyroidism, corneal deposition

Question 5

Amphotericin

Answer 5

Fevers/rigors (shake and bake)
Nephrotoxicity
BM suppression and anemia

Question 6

Antipsychotics

Answer 6

Sedation, acute dystonic reaction, akithesia, tardive dyskinesia, parkinsonism, NMS

Question 7

Azoles ie fluconazole

Answer 7

inhibition of P-450

Question 8

AZT (zidovudine)

Answer 8

thrombocytopenia

Megaoblastic anemia

Question 9

B-blockers

Answer 9

asthma exacerbation, masking of hypoglycemia, impotence

Bradycardia, AV block, CHF

Question 10

Benzodiazepines

Answer 10

Sedation, dependence, respiratory depression

Question 11

Bile acid resins

Answer 11

GI upset, malabsorption of vitamins and meds

Question 12

Carbamazepine

Answer 12

Agranulocytosis

Induction of P450, aplastic anemia, liver tox

Question 13

CCBs

Answer 13

peripheral edema, constipation, cardiac depression

Question 14

Chloramphenicol

Answer 14

Gray baby syndrome

Aplastic anemia

Question 15

Cisplatin

Answer 15

Nephrotoxicity

Acoustic nerve damage

Question 16

Clonidine

Answer 16

Severe rebound HTN and headache

Dry mouth

Question 17

Clozapine

Answer 17

Agranulocytosis

Question 18

Corticosteroids

Answer 18

Mania, hyperglycemia, immunosuppression, bone mineral loss, thinning of skin, easy bruising, myopathy, cataracts with chronic use

Question 19

Cyclophosphamide

Answer 19

Hemorrhagic cystitis

Myelosuppression

Question 20

Digoxin

Answer 20

Yellow visual changes, arrhythmias (junctional tachycardia or SVT)
GI disturbances

Question 21

Doxorubicin

Answer 21

cardiotoxicity (cardiomyopathy)

Question 22

Ethyl alcohol

Answer 22

Anion gap metabolic acidosis
Renal dysfunction
CNS depression

Question 23

Fluoroquinolones

Answer 23

Cartilage damage in children

Achilles tendon rupture in adults

Question 24

Furosemide

Answer 24

Ototoxicity, hypokalemia, nephritis, gout

Question 25

Gemfibrozil

Answer 25

Myositis | Reversible transaminitis

Question 26

Halothane

Answer 26

Malignant hyperthermia | Hepatotoxicity

Question 27

HCTZ

Answer 27

``` Hypokalemia Hyponatremia Hyperuricemia Hyperglycemia Hypercalcemia ```

Question 28

HMG-CoA reductase inhibitors

Answer 28

Myositis | Transaminitis (reversible)

Question 29

Hydralazine

Answer 29

Drug induced SLE

Question 30

Hydroxychloroquine

Answer 30

Retinopathy

Question 31

INH

Answer 31

``` Peripheral neuropathy (use pyridoxine/B6 to prevent this) Hepatotoxicity, P-450 inhibition, seizures with overdose, hemolysis in G6PD deficiency ```

Question 32

MAOIs

Answer 32

``` Hypertensive tyramine reaction Serotonin syndrome (with meperidine) ```

Question 33

Methanol

Answer 33

Blindness | Ion-gap metabolic acidosis

Question 34

Methotrexate

Answer 34

Hepatic fibrosis, pneumonitis, anemia

Question 35

Methyldopa

Answer 35

+ Coombs tests | drug induced SLE

Question 36

Metronidazole

Answer 36

Disulfiram reaction Vestibular dysfunction Metallic taste

Question 37

Niacin

Answer 37

Cutaneous flushin

Question 38

Nitroglycerin

Answer 38

Hypotension, tachycardia, headache, tolerance

Question 39

Penicillamine

Answer 39

Drug-induced SLE

Question 40

PCN/B-lactam

Answer 40

Hypersensitivity reaction

Question 41

Phenytoin

Answer 41

Nystagmus Gingival hyperplasia Diplopia, ataxia, arrhythmia, hirsutism, teratogen

Question 42

Prazosin

Answer 42

First-dose hypotension

Question 43

Procainamide

Answer 43

Drug-induced SLE

Question 44

Propylthiouracil

Answer 44

Agranulocytosis | Aplastic anemia

Question 45

Quinidine

Answer 45

Cinchonism (headache + tinnitus) | Thrombocytopenia, arrhythmias (TdP)

Question 46

Reserpine

Answer 46

Depression

Question 47

Rifampin

Answer 47

P450 induction | Orange-red body secretions

Question 48

Salicylates

Answer 48

Hyperventilation with respiratory alkalosis and metabolic acidosis Fever, dehydration, diaphoresis, hemorrhagic gastritis Tinnitus + fever + tachypnea

Question 49

SSRIs

Answer 49

Sexual dysfunction, anxiety, serotonin syndrome

Question 50

Succinylcholine

Answer 50

Malignant hyperthermia, hyperkalemia

Question 51

TCAs

Answer 51

QRS prolongation, sedation and coma, anticholinergic effects, seizures, arrhythmias

Question 52

Tetracyclines

Answer 52

Tooth discoloration, prhotosensitivity, Fanconi's syndrome, GI distress

Question 53

Trimethoprim

Answer 53

Megaloblastic anemia, leukopenia, granulocytopenia

Question 54

Valproic acid

Answer 54

Teratogenicity leads to neural tube defects | Rare fatal hepatotoxicity

Question 55

Vancomycin

Answer 55

Nephrotoxicity Ototoxicity Red man syndrome 2/2 histamine release (not an allergy)

Question 56

Vinblastine

Answer 56

Severe myelosuppression

Question 57

Vincristine

Answer 57

Peripheral neuropathy | Paralytic ileus