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Flashcards in Complement Deck (19)
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1
Q

How many major complement factors are there?

A

9

2
Q

What are complement factors?

A

Pro-enzymes present in normal serum hat are not increased by antigenic stimulation

3
Q

What are the three complement pathways?

A

1) Classical
2) Alternate
3) Mannan-binding lectin pathway

4
Q

Which pathway/pathways act independent of antibody?

A

The alternate pathway and the mannan-binding lectin pathway

5
Q

What antibodies are involved in the classical pathway?

A

Either IgM or a doublet of IgG1, IgG2, or IgG3

6
Q

What antibody can be involved in the alternate pathway?

A

IgA

7
Q

Initiating factor in the classical pathway

A

C1qrs/C1q

8
Q

Initiating factor in the alternate pathway

A

C3b

9
Q

Initiating factor for mannan-binding lectin pathway

A

mannose binding lectin (MBL)

10
Q

Which pathway uses all 9 factors?

A

only the classical pathway

11
Q

Which factors are not used by the alternate pathway?

A

C1, C2, C4

12
Q

Which factors are not used by the mannose binding lectin pathway?

A

C1, because MBL acts like C1

13
Q

Which factors combine to form the membrane attack complex (MAC)?

A

C5b, C6-9

14
Q

The C3bBbC3b/C3bBb complexes are associated with which pathway?

A

alternate

15
Q

Factors B and D are associated with which pathway?

A

alternate

16
Q

MAC is associated with which pathways?

A

All three pathways

17
Q

properdin is associated with which pathway?

A

alternate

18
Q

Which complement factors act as chemotactic adjuncts?

A

C3a and C5a

19
Q

Which complement factors promote opsonization by binding to microoganisms?

A

C3b