Complement Flashcards Preview

Immunology > Complement > Flashcards

Flashcards in Complement Deck (11):
1

Classic

C1, C2b, C3 convertase, C3b, C5, C5b9 (Membrane Attack Complex MAC)
IgG or IgM mediated ("GM makes classic cars")

2

Alternative

C3, C5, C5b9 (Membrane Attack Complex MAC)
microbe
Microbe surface molecules

3

Lectin (Mannose)

C4, C3b, C5b9 (Membrane Attack Complex MAC)
Mannose or other sugars on microbe surface

4

C3b

Opsonization
"c3B Binds Bacteria"

5

C3a, C4a (only on Mannose pathway), C5a

Analphylaxis (all the "a"=A)

6

C5a

Neutrophil chemotaxis
Given off by all pathways before MAC

7

c5b9

Membrane Attack Complex (MAC)
cytolysis by MAC

8

Early complement deficiences

C1-C4
Increased risk severe, recurrent pyogenic sinus and resp tract infections
Increased risk of SLE

9

Terminal complement deficiencies

C5-C9
Increased risk of Neisseria bacteremia

10

C1 esterase inhibitor deficiency

Causes hereditary angioedema due to increased bradykinin
Decreased C4 levels
ACE are Contraindicated

11

Paroxysmal nocturnal hemoglobinuria

Complement mediated lysis of RBCs
Complement inhibitors can't anchor (PIGA gene defect)