Important Cytokines Flashcards Preview

Immunology > Important Cytokines > Flashcards

Flashcards in Important Cytokines Deck (16):
1

Secreted by Macrophages

1, 2, 3,4, 5, 6, 8, 12, TNF-alpha

2

1, 2, 3, 4, 5, 6

1 - Fever 2 - stimulates T cells 3 - stimulates BONE marrow 4 - stimulates IgE produciton 5 - stimulates IfA production 6 - stimulates aKute-phase protein production "Hot T-bone stEAK"

3

1

Causes: Fever and inflammation Activates endothelium to express adhesion molecules Recruits WBCs Activates Osteoclasts

4

6

Fever and acute phase proteins

5

8

Chemotactic factor for neutrophils "Clean up on aisle 8"-Neutrophils are recruited to clear infections

6

12

Tcells --> Th1 Activates NK cells

7

Tumor necrosis factor Alpha

Activates endothelium Recruits WBCs Vascular leak Maintains granulomas in TB Causes wasting (cachexia) in cancer

8

Secreted by ALL T-Cells

2, 3

9

2

Growth of helper, cytotoxic, Tregs, NK cells

10

3

Support growth and differentiation of bone marrow stem cells (like GM-CSF)

11

From Th1 Cells

Inerferon-gamma

12

Interferon-gamma

Secreted by NK cells and T cells in response to IL-12 from macrophages Stims macrophages to kill phagocytosed pathogens Inhibits differentiation of Th2 cells Activates NK cells to kill virus infected cells Increased MHC expresion on all cells

13

From Th2 cells

4, 5, 10

14

4

Induces differentiation of T cells to Th (helper) 2 cells Promotes growth of B cells Enhances class switching to IgE and IgG Ain't too proud "2 BEG 4 help)

15

5

Promotes growth and differentiation of B cells Enhances class switching to IgA Stimulates growth and differentiation of eosinophils

16

10

Attentuates inflammatory response Decreases expression of MHC class II and Th1 cytokines Inhibits activated macrophages and dendritic cells Also secreted by regulatory T cells TGF-Beta and IL-10 both aTENuate the immune response