Complement Deficiency Flashcards
1
Q
What clinical features will you see with deficiencies affecting C1-C4?
A
Recurrent sinopulmonary infections due to ENCAPSULATED bacteria
2
Q
What clinical features will you see with deficiencies affecting C5-C9?
A
Recurrent Neisseria infections
Increased risk of meningitis
3
Q
How are most complement deficiencies inherited?
A
Autosomal Recessive
4
Q
How do you screen for complement deficiencies?
A
CH50 assay.
5
Q
How do you treat complement deficiencies inherited?
A
NO therapy!
But kids can receive ALL vaccines
6
Q
What are the encapsulated organisms?
A
Step pneumoniae
Hemophilus influenza (type B)
Niesseria meningitis
E. Coli
Salmonella typhii
Klebsiella pneumoniae
Steptococcus (GBS)
