Complications of diabetes Flashcards Preview

Year 2 Endocrine > Complications of diabetes > Flashcards

Flashcards in Complications of diabetes Deck (10):
1

the majority of people with diabetes die of what cause?

(ischemic) heart disease

2

what is a critical step in the pathway to diabetic microvascular complications?

activation of PKC beta

3

non proliferative diabetic retinopathy:

pathology / pathogenesis
visual manifestation
fundoscopic findings

- retinal capillatires leak protein, lipids, RBC
- causes interference with visual acuity
- microaneurysms, blot hemorrhages, cotton wool spots

4

proliferative diabetic retinopathy:

pathology / pathogenesis
fundoscopic findings

- small vessel occlusion and retinal hypoxia
- stimulates growth of new capillaries and fibrous tissue within retina
- vitreous hemorrhage and retinal detachment

5

what are the ADA recommendations for prevention of retinopathy?

- dilated eye exam annually
- starting at 5 years after diagnosis of DM1 or DM2

6

what are the treatments for diabetic retinopathy?

- panretinal xenon / argon laser photocoagulation
- focal laser for macular edema
- surgery for retinal detachment

7

natural history of diabethic NEPHROPATHY

- glomerular hyperperfusion and hypertrophy, increased GFR
- thickening of BM, normalization of GFR
- microalbuminuria
- nephropathy
- ESRD

8

what is the treatment for diabetic nephropathy?

ACE inhibitors
ARBs
dietary

9

definition: autonomic neuropathy

dysfunction of the cholinergic, noradrenergic systems

10

has aggressive glycemic control been shown to reduce coronary heart disease in high risk patients?

no