Components of Blood and Bone Marrow Flashcards
Hematopoiesis location: embryo fetus 2nd trimester fetus 3rd trimester adult
embryo: yolk
fetus 2nd trimester: liver/spleen
fetus 3rd trimester: medulla of all bones
adult: BM, sternum, pelvis, femur
components of hemoglobin
Heme + globin
Heme = protoporphryin + iron
During digestion, what does the body absorb and use for erythrocyte production?
amino acids, monosaccharides, lipids, vitamin b12, folic acid, iron
What is an MCH?
measures amount of Hg in individual cells
Mean Cell Hg
What is MCHC?
Mean Corpuscular Hg Concentration
- relative intracellular Hg concentration
- detects hereditary spherocytosis
Neutrophil maturation
Myeloblast Promyelocyte Myelocyte Metamyelocyte Band Neutrophil
Erythrocyte Maturation
Proerythroblast Basophillic Erythroblast Polychromatophilic Erythroblast Otochromatophilic Erythroblast Nucleus Ejects Reticulocyte Erythrocyte
Maturation time: reticulocyte to erythroblast
24-48 hours
Dead RBCs
- taken up by macrophage in spleen/liver/bone
- Hg spilts into heme and globin
- globin turns into AA, goes into blood, back to BM
- heme breaks down into bilirubin and iron
- iron goes back to BM
- bilirubin is excreted in GI tract
Indications for Bone Marrow biopsy
- unexplained low/high counts
- to dx heme malignancy
- staging lymphoma or solid tumors (IV)
- dx infectious disease
- dx granulomatous disease
What is MCV?
Mean Cell Volume
- size distribution curve indicates RBC size
- diagnose micro/macrocytosis
What is RDW?
Red Cell Distribution Width
-shows distribution of red cell volumes
shows anisocytosis
Large? mixed RBC population
anisocytosis
variable RBC sizes
High affinity Hg, decreased P50
low temp
low PCO2
low 2,3-DPG
high pH
Low affinity Hg, increased P50
high temp
high PCO2
high 2,3-DPG
low pH
