Connective Tissue and Bullous Disorders Lecture Powerpoint Flashcards Preview

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Flashcards in Connective Tissue and Bullous Disorders Lecture Powerpoint Deck (19)
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1
Q

Connective tissue diseases have ___ symptoms and affect ____ body systems

A

Varying, almost all

2
Q

Lupus erythematosus and what 7 things does it clinically present with?

A

Chronic multisystem autoimmune disease of skin, joints, and internal organs that presents with fatigue, myalgia, low grade fever, mucocutaneous symptoms, raynauds, weight changes, and a malar rash**

3
Q

Malar rash

A

Lesion that occurs when systemic lupus is active, a classic rash in sun exposed areas that spares nasolabial folds and knuckles and is nonpruritic

4
Q

Discoid rash

A

Lesion that indicates systemic lupus, appears like psoriasis with thickened scaly patches on ears, predisposition to future skin cancer, spares the knuckles

5
Q

Musculoskeletal signs of lupus

A

Symmetrical pain and swelling

6
Q

Neurological signs of lupus

A

Migraine headaches that do not respond to treatment, seizures

7
Q

Sicca syndrome/sjogrens

A

Associated autoimmune disease occurs with lupus, indicated by dry eyes, sandy feeling in eye, dry mouth

8
Q

Drug induced lupus syndrome

A

Autoimmune reacion associated with chronic use of specific medications, typically see improvement upon withdrawal of offending drug

9
Q

Labs for lupus (3)

A
  • CBC
  • ESR/CRP
  • ANA
10
Q

Positive ANA

A

A cardinal feature of lupus erythmatosus, indicates 90% likely positive, chances of false positive increases in older patients

11
Q

Dermatomyositis

A

Rare inflammatory muscle and skin disease that typically presents with a violet colored red rash that does not spare the knuckles followed by proximal skeletal muscle weakness and inflammation, gottron’s papules are pathognomonic finding, often autoimmune and co-occurs with malignant tumor (and resolves with their clearance)

12
Q

Gottron’s papules

A

Round 1cm red flat topped papules that occur ofer the knuckles and alongside the sides of fingers pathognomonic for dermatomyositis

13
Q

Labs for dermatomyositis (3)

A
  • CK levels
  • Muscle biopsy
  • ANA
14
Q

Scleroderma

A

Unknown etiology rare chronic disease that causes abnormal tissue fibrosis and hardening of either skin and subQ (crest syndrome) or systemic organs

15
Q

Signs of Crest syndrome (5)

A
  • telangiectasia
  • raynauds
  • esophageal dysfunction
  • sclerodactyly (claw hand)
  • Ca2+ deposit buildup
16
Q

Scleroderma diagnosis and treatment

A
  • clinical

- none, supportive therapy

17
Q

Pemphigus vulgaris

A

Group of rare blistering diseases of skin and mucus membranes, fatal unless treated with immunosuppressive drugs and corticosteroids due to autoimmune origin, occurs almost exclusively in middle aged older people

18
Q

Bullous Pemphigoid

A

Rare skin condition that is common in older adults that causes fluid filled bliters on area of skin but not any on oropharyngeal leasions, low mortality and often self limiting, treated by oral prednisone

19
Q

Dermatitis herpetiformis

A

Pruritic (distinguishing feature) group of erythematous papulovesicles often seen with gluten sensitvity and associated with thyroid disorders, treated with dapsone and gluten free diet

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