Connective Tissue And Joint Diseases

Question 1

Which DMARD medication can cause proteinuria, leukopenia, thrombocytopenia and anemia

Answer 1

Gold salts

Question 2

What joint is involved in RF- polyarticular JRA that is not involved in RF+ polyarticular JRA

Answer 2

The hip

Question 3

What is deficient in Hemophilia A, B, C

Answer 3

Hemophilia A = Factor 8
Hemophilia B = Factor 9
Hemophilia C = Factor 11

Question 4

What vascular disease is characterized by strawberry tongue, pharyngeal erythema, red chapped lips and high fever

Answer 4

Kawasaki disease (infantile polyarteritis)

Question 5

Antibiotic treatment of Lyme disease in adults vs children

Answer 5

Children = amoxicillin
Adults = doxycycline

Question 6

Involvement of which joint in JRA indicates poor prognosis

Answer 6

The hip

Question 7

According to ACR criteria, how old do you have to be to be diagnosis with JRA?

Answer 7

<16yo

Question 8

What type of polymyositis/dermatomyositis is seen in children?

Answer 8

Type IV

Question 9

Minor jones criteria

Answer 9

Fever, arthralgia, elevated ESR or CRP, prolonged PR interval

Question 10

First and 2nd line therapy for JRA

Answer 10

1st = NSAIDs
2nd = DMARDs

Question 11

How many joints are involved in polyarticular JRA vs pauciarticular JRA

Answer 11

Polyarticular = 5+ joints
Pauciarticular = < or equal to 4 joints

Question 12

In hemophiliacs, what kind of exercises should be done when child has hemarthrosis?

Answer 12

Passive exercises to prevent joint stiffness and fibrosis

Question 13

How often do patients with pauciarticular JRA need to see the ophthalmologist?

Answer 13

4x in the 1st year, then annually x 4 years

Question 14

MC organism causing septic arthritis in neonates <2mths

Answer 14

Staphylococcus aureus

Question 15

Which type of JRA can you see sacroiliitis?

Answer 15

Type II pauciarticular JRA

Question 16

Etiology of rheumatic fever

Answer 16

Streptococcal infection

Question 17

3 things used to diagnose streptococcal infection

Answer 17

1. Throat culture
2. Rapid streptococcal antigen
3. Elevated streptococcal antibody

Question 18

According to ACR criteria, how long do symptoms have to last to diagnose JRA?

Answer 18

> or = to 6 weeks

Question 19

Difference between type 1 and type 2 pauciarticular JRA

Answer 19

Type 1 = early onset (<4yo) in girls

Type 2 = late onset (9-10 yo) in boys

Question 20

Which type of JRA may be HLA-B27 positive?

Answer 20

Type II pauciarticular JRA

Question 21

Which type of JRA has risk of developing chronic iridocyclitis

Answer 21

Type I pauciarticular JRA

Question 22

Major Jones criteria

Answer 22

Joints
Carditis
Nodules
Erythema marginatum
Sydenham Chorea

Question 23

MC organism causing septic arthritis in anyone >2yo, not sexually active

Answer 23

Staphylococcus aureus

Question 24

MC organism causing septic arthritis in sexually active adults

Answer 24

Neisseria gonorrhea

Question 25

MC type of JRA

Answer 25

Type 1 Pauciarticular JRA

Question 26

MC organism causing septic arthritis in RA patients

Answer 26

Staphylococcus aureus

Question 27

3 main clinical features of Lyme disease

Answer 27

1. Heart disease (AV block) 2. Arthritis/myalgias 3. Neurological disease (bell's palsy)

Question 28

MC organism causing septic arthritis in children between 2mth and 2 yo

Answer 28

Haemophilus influenzae

Question 29

Least common type of JRA

Answer 29

Still's disease (systemic)

Question 30

What is the main side effect of Hydroxychloroquine?

Answer 30

Macular degeneration

Question 31

MC joint involved in pauciarticular JRA

Answer 31

The knee

Question 32

Which type of JRA has worst prognosis

Answer 32

RF+ polyarticular JRA

Question 33

Which type of JRA is HLA-DR4 positive

Answer 33

RF+ Polyarticular JRA

Question 34

Which type of JRA is at most risk of developing acute iridocyclitis

Answer 34

Type II pauciarticular JRA

Question 35

Diagnostic criteria for rheumatic fever

Answer 35

Presence of 2 major Jones criteria OR 1 major and 2 minor with evidence of streptococcal infection

Question 36

What is the hallmark sign of hemophilia

Answer 36

Hemarthrosis