Connective Tissue Disorder

Question 1

Systemic Lupus Erythematosus Cause

Answer 1

• Autoimmune
• +Ve serum antinuclear antibodies (ANA)

Question 2

Systemic Lupus Erythematosus
Presentation

Answer 2

Joints: arthritis,effusion
Skin:
- Butterfly rash
- localized erythema and edema
- alopecia (loss of hair)
- photosensitive
- mucosal ulcer
- Raynaud’s

Blood: formation of DVT,PE, low blood cell count

Lungs: pleuritis

Kidney: impaired kidney function

CNS: seizure, transverse myelitis, CVA

Hear:inflammation and valve dysfunction

Question 3

Scleroderma

Answer 3

• fibrous degeneration of connective tissue of the skin, lungs and internal organs
• lead to:
  Joint contractures
  pulmonary fibrosis
  GI dysmotility
  tight, drawn skin

Question 4

Ehlers-danlos

Answer 4

Cause:
- Genetic
- defect in collagen synthesis

S&S:
- associated with hypermobility and can affect the cardiac muscle

Question 5

Larsen syndrome

Answer 5

Cause:
- Genetic

S&S
- Prominent forehead
- Widespread eyes
- Multiple joint dislocation
- Foot deformities

Question 6

Marfan’s syndrome

Answer 6

Cause:
- Genetic disease
- lack of fibrillin

S&S:
- long hands
- loose joints, scoliosis
- involves the heart and eyes