CONNECTIVE TISSUE DISORDERS

Question 1

What are connective tissues

Answer 1

Any biological tissues with an extensive matrix that

• provide structure, support, and defense
• Transport material
• bind organs together

Question 2

What do connective tissues consist of

Answer 2

• Cell fibres (collagen or elastic)

- Ground substance (water, fluid, protein)

Question 3

What are the 6 types of connective tissue

Answer 3

• loose tissue
• fibrous tissue
• adipose tissue
• blood
• cartilage
• bone

Question 4

What is loose tissue composed of? Example of this type of tissue?

Answer 4

collagen and elastin

Blood vessels, internal organs

Question 5

What is fibrous tissue composed of? Example of this type of tissue?

Answer 5

mostly collagen, few elastin

Tenson, ligs

Question 6

Many connective tissue diseases feature…

Answer 6

abnormal immune system activity

Question 7

Is there a genetic component to autoimmune diseases?

Answer 7

yes

Question 8

Is there an environmental component to autoimmune disease

Answer 8

yes: Pollution/pesticide infections medications can trigger the onset

Question 9

Is there a behavioural component to autoimmune disease

Answer 9

Yes, smoking or stress can trigger the onset

Question 10

Lupus is referred to as…

Answer 10

“A disease of a thousand faces”

Question 11

What is the shape of the rash seen in lupus

Answer 11

Butterfly-shaped malar rash

Question 12

What ethnicities does lupus effect most

Answer 12

• Asian
• African
• Hispanic

Question 13

Lupus means what in latin

Answer 13

wolf

Question 14

What does erythro mean in greek

Answer 14

red

Question 15

What does systemic lupus effect

Answer 15

• Skin
• Lungs
• Kidney
• CNS
• Circulatory system
• Heart
• GI system
• muscle and joint
• Oral and nasal ulcers

Question 16

What is needed for a systemic lupus classification

Answer 16

• Malar rash
• Discoid rash
• Photosensitivity
• Oral ulcers
• non-erosive arthritis
• Pleuritis or pericarditis
• Renal disorder
• Neurological disorder
• Hematologic disorder
• Immunologic disorder
• Positive antinuclear antibody test

Question 17

What are the characteristics of non-erosive arthritis

Answer 17

• Transient
• Symmetrical
• Affecting small joints
• ## Less sever than RA

Question 18

What are the neurologic clinical features of lupus

Answer 18

- Seizures 
= Psychosis 
- Behaviour/personality changes, depression 
- Cognitive dysfunction 
- Stroke 
- Peripheral neuropathy 
- Chorea (abnormal involuntary movement disorder) 
- Transverse myelitis

Question 19

Up to ___% of patients with SLE develop lupus nephritis

Answer 19

50%

Question 20

__% of SLE patients require a kidney dyalysis or transplant

Answer 20

10%

Question 21

is the renal involvement of lupus normally symptomatic or asymptomatic

Answer 21

asymptomatic

Question 22

What is the hallmark clinical feature of renal involvement in SLE

Answer 22

proteinuria

Question 23

What is the most frequent cause of disease related death from lupus

Answer 23

Renal failure

Question 24

What are some other symptoms of SLE

Answer 24

• Pain
• Severe fatigue
• memory loss
• Depression

Question 25

What is the PT management of Lupus

Answer 25

- Pain management - Therapeutic exercise and PA - Patient education: energy conservation principles, joint protection principles, sun protection

Question 26

What were the results of PA on those with lupus vs. control groups

Answer 26

- Positive effect on depression - positive effect on CR capacity - less fatigue - no adverse effect on the SLE disease activity

Question 27

What are the two energy conservation principles

Answer 27

- Prioritize - what activities are important to you, what activities can your friends and family help with - Plan - Self monitory, balance exercise with rest, eat a well-balanced diet and avoid heavy metals - Pace - Balance rest and activity, take breaks, have a routine, get a good nights sleep - Posture - Maintain good posture, take standing breaks

Question 28

What are the joint protection principles

Answer 28

1. Respect for pain 2. Balance activity and rest 3. Avoid repetitive activities 4. use larger, stronger joints for activities 5. Avoid staying in one position for a prolonged period 6. Maintain good joint alignment 7. Maintain healthy body weight 8. maintain good posture

Question 29

What are the main non-pharmacologic intervention in the management of connective tissue disease such as SLE

Answer 29

- Pain control - Physical activity - Patient education