Flashcards in Connective tissues Deck (7)
Macrophages have multiple functions. What are they?
-engulfment of invading microbes
-removal of damaged tissue, remodeling of repaired tissue
-remodeling of normal tissue during development, maintenance, and physiological restructuring.
Fibrous ECM 3 types mentioned in lecture
Fibrillar (Type I)
Network forming (Type IV)
Life cycle of fibrillar collagen:
mRNA made in nucleus --->ER for translation -->Golgi for processing [hydroxylation of proline, lysine] -->secreted into ECT--> cleavage of N and C terminal end to form N-telo peptide ---> allows polymerization of collagen fibers
Used as a marker for bone disease. Indication of excessive bone turnover.
Defects in every step of collagen formation pathway. Has many clinical manifestations. Bruising, bone fracture, joint pain, bleeding, etc.
Wound healing very basics
1) Inflammation: Mast cells secrete histamines and cytokines (interleukins), macrophages and lymphocytes also secrete these. These signals increase permeability of capillaries. Recruit white blood cells.
2) Proliferation: increase in fibroblast number and secretory capacity. Macrophages increase blood vessel formation
3) Remodeling: trying to recapitulate the damaged structure