Flashcards in Consolidation Deck (34)
You should check kidney function before which cytotoxic drug?
Which cytotoxic drug is cardiotoxic?
Which cytotoxic drug is neurotoxic? What does this cause?
• Neuropathic pain
• Foot drop
• Severe constipation
Which cytotoxic drug can cause liver and kidney toxicity, alongside a skin rash?
Methotrexate (forms crystals)
-kidney function should be tested
Which ADR is characterised by epidermal necrosis causing blisters over 3-30% of the body?
Which class of antiviral can cross the blood-brain barrier?
Which antiviral drug is excreted though the small intestine as well as metabolised by CYP-P450?
Class I, II and III denote side effect profiles for which classes of drugs? Recall them
III) Extrapyrimidal side effects
Agranulocytosis is a side effect of which antipsychotic?
Weight gain and insulin-resistant diabetes are side effects of which antipsychotics?
Which class of drugs have the followings affinities:
2nd Generation Antipsychotics
Which nucleus is stimulated by the suprachiasmatic nucleus and goes on to stimulate the arousal pathways?
Dorsomedial hypothalamic nucleus
What is the tuberomammillary nucleus?
What does the ventrolateral preoptic nucleus do?
Releases GABA and galanine to inhibit the arousal pathways
For which cytotoxic drug should you inject intrathecal doses to prevent meningeal leukaemia?
Which drug class is unique to chronic myeloid leukaemia
Protein kinase inhibitors
What is the precursor amino acid for 5-HT
Which CPTP drugs are cardiotoxic?
Galactorrhoea and gynecomastia is caused by what?
Inhibition of the tuberoinfundibular pathway D2 transmission (which acts as prolactin release inhibiting factor) (PRIF)
Which component of the cephalosporin structure makes it mare resistant to beta-lactamases than the penicillins?
The Dihydrothiazine ring
Which type of antibiotic can be used topically for burns victims?
What drug is typically used for UTIs, RTIs and immunocompromised patients?
Sulphonamides including trimethoprim
Which bacteriocidal drug should never be used on pregnant women or neonates?
(Penicillins for neonates due to poor removal)
Which drugs are malabsorbed with PPI use?
Which drug is malabsorbed with calcium, magnesium and aluminium salts?
Clarithromycin is particularly effective against?
• H. influenzae
• H. pylori
What are the long-acting NSAIDs?
Celecoxib and Naproxen
Which NSAID can cross the BBB?
Which NSAID causes CVD?