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Flashcards in Consolidation Deck (34)
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1

You should check kidney function before which cytotoxic drug?

Methotrexate

2

Which cytotoxic drug is cardiotoxic?

Doxorubicin

3

Which cytotoxic drug is neurotoxic? What does this cause?

Vincristine
• Neuropathic pain
• Foot drop
• Severe constipation

4

Which cytotoxic drug can cause liver and kidney toxicity, alongside a skin rash?

Methotrexate (forms crystals)
-kidney function should be tested

5

Which ADR is characterised by epidermal necrosis causing blisters over 3-30% of the body?

Stevens-Johnson syndrome
• NSAIDS
• Penicillin
• Lamotrigine

6

Which class of antiviral can cross the blood-brain barrier?

Integrase inhibitors

7

Which antiviral drug is excreted though the small intestine as well as metabolised by CYP-P450?

Protease inhibitors:
• Darunavir
• Ritanovir

8

Class I, II and III denote side effect profiles for which classes of drugs? Recall them

Phenothiazines
Thioxanthenes
I)
II) Antimuscarinic
III) Extrapyrimidal side effects

9

Agranulocytosis is a side effect of which antipsychotic?

Clozapine

10

Weight gain and insulin-resistant diabetes are side effects of which antipsychotics?

Olanzapine
Risperidone

11

Which class of drugs have the followings affinities:
H2: Low
H3: High
H4: High
5-HT2A: High

2nd Generation Antipsychotics

12

Which nucleus is stimulated by the suprachiasmatic nucleus and goes on to stimulate the arousal pathways?

Dorsomedial hypothalamic nucleus

13

What is the tuberomammillary nucleus?

Histaminergic nucleus

14

What does the ventrolateral preoptic nucleus do?

Releases GABA and galanine to inhibit the arousal pathways

15

For which cytotoxic drug should you inject intrathecal doses to prevent meningeal leukaemia?

Methotrexate

16

Which drug class is unique to chronic myeloid leukaemia

Protein kinase inhibitors

17

What is the precursor amino acid for 5-HT

Tryptophan

18

Which CPTP drugs are cardiotoxic?

TCAs:
• Amitriptiline
• Trazodone

Anthracyclines:
• Doxorubicin

19

Galactorrhoea and gynecomastia is caused by what?

Inhibition of the tuberoinfundibular pathway D2 transmission (which acts as prolactin release inhibiting factor) (PRIF)

20

Which component of the cephalosporin structure makes it mare resistant to beta-lactamases than the penicillins?

The Dihydrothiazine ring

21

Which type of antibiotic can be used topically for burns victims?

Sulphonamides
• Co-trimoxazole

22

What drug is typically used for UTIs, RTIs and immunocompromised patients?

Sulphonamides including trimethoprim

23

Which bacteriocidal drug should never be used on pregnant women or neonates?

Sulphonamides

(Penicillins for neonates due to poor removal)

24

Which drugs are malabsorbed with PPI use?

Protease inhibitors

25

Which drug is malabsorbed with calcium, magnesium and aluminium salts?

Doxycycline

26

Clarithromycin is particularly effective against?

• H. influenzae
• H. pylori

27

What are the long-acting NSAIDs?

Celecoxib and Naproxen

28

Which NSAID can cross the BBB?

Celecoxib

29

Which NSAID causes CVD?

Celecoxib

30

Which NSAID does not cause GI side effects?

Celecoxib (as it is COX-2 selective)