Flashcards in Consolidation Deck (34)
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1
You should check kidney function before which cytotoxic drug?
Methotrexate
2
Which cytotoxic drug is cardiotoxic?
Doxorubicin
3
Which cytotoxic drug is neurotoxic? What does this cause?
Vincristine
• Neuropathic pain
• Foot drop
• Severe constipation
4
Which cytotoxic drug can cause liver and kidney toxicity, alongside a skin rash?
Methotrexate (forms crystals)
-kidney function should be tested
5
Which ADR is characterised by epidermal necrosis causing blisters over 3-30% of the body?
Stevens-Johnson syndrome
• NSAIDS
• Penicillin
• Lamotrigine
6
Which class of antiviral can cross the blood-brain barrier?
Integrase inhibitors
7
Which antiviral drug is excreted though the small intestine as well as metabolised by CYP-P450?
Protease inhibitors:
• Darunavir
• Ritanovir
8
Class I, II and III denote side effect profiles for which classes of drugs? Recall them
Phenothiazines
Thioxanthenes
I)
II) Antimuscarinic
III) Extrapyrimidal side effects
9
Agranulocytosis is a side effect of which antipsychotic?
Clozapine
10
Weight gain and insulin-resistant diabetes are side effects of which antipsychotics?
Olanzapine
Risperidone
11
Which class of drugs have the followings affinities:
H2: Low
H3: High
H4: High
5-HT2A: High
2nd Generation Antipsychotics
12
Which nucleus is stimulated by the suprachiasmatic nucleus and goes on to stimulate the arousal pathways?
Dorsomedial hypothalamic nucleus
13
What is the tuberomammillary nucleus?
Histaminergic nucleus
14
What does the ventrolateral preoptic nucleus do?
Releases GABA and galanine to inhibit the arousal pathways
15
For which cytotoxic drug should you inject intrathecal doses to prevent meningeal leukaemia?
Methotrexate
16
Which drug class is unique to chronic myeloid leukaemia
Protein kinase inhibitors
17
What is the precursor amino acid for 5-HT
Tryptophan
18
Which CPTP drugs are cardiotoxic?
TCAs:
• Amitriptiline
• Trazodone
Anthracyclines:
• Doxorubicin
19
Galactorrhoea and gynecomastia is caused by what?
Inhibition of the tuberoinfundibular pathway D2 transmission (which acts as prolactin release inhibiting factor) (PRIF)
20
Which component of the cephalosporin structure makes it mare resistant to beta-lactamases than the penicillins?
The Dihydrothiazine ring
21
Which type of antibiotic can be used topically for burns victims?
Sulphonamides
• Co-trimoxazole
22
What drug is typically used for UTIs, RTIs and immunocompromised patients?
Sulphonamides including trimethoprim
23
Which bacteriocidal drug should never be used on pregnant women or neonates?
Sulphonamides
(Penicillins for neonates due to poor removal)
24
Which drugs are malabsorbed with PPI use?
Protease inhibitors
25
Which drug is malabsorbed with calcium, magnesium and aluminium salts?
Doxycycline
26
Clarithromycin is particularly effective against?
• H. influenzae
• H. pylori
27
What are the long-acting NSAIDs?
Celecoxib and Naproxen
28
Which NSAID can cross the BBB?
Celecoxib
29
Which NSAID causes CVD?
Celecoxib
30
