COPD Flashcards

1
Q

COPD definition

A

COPD, a common preventable and treatable disease, is characterized by persistent airflow limitation that is usually progressive and associated with an enhanced chronic inflammatory response in the airways and the lung to noxious particles or gases. Exacerbations and comorbidities contribute to the overall severity in individual patients.

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2
Q

COPD Comorbidities

7

A
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3
Q

COPD risk factors

Particles

Gender

5 other things

A
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4
Q

Mechanisms of Underlying airflow

Small Airway Disease

Parenchymal Destruction

A
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5
Q

Symptoms of COPD

A
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6
Q

COPD diagnosis

A
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7
Q

COPD classifications based on spiro

A
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8
Q

Chronic bronchitis

defined as?

for how long?

increase in?

A
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9
Q

Emphysema

Disease of the?

Characterized by?

A
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10
Q

Emphysema contributing factors

A
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11
Q

COPD vs Asthma

A
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12
Q

COPD vs asthma

End result of both causing?

A
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13
Q

Therapeutic options key points

5

A
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14
Q

Therapeutic options smoking

Nicotine ____ Therapy

Pharmacologic 2 options

A
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15
Q

Therapy options meds

8 types

A
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16
Q

Therapy options bronchodilators

  • _____ medications are _____ to the _____ management of COPD
  • Prescribed in 2 ways
  • Principle bronchodilator txs are?
  • Choice of treatment depends on?
  • ___________ are convienient and more effective for symptom relief than _____ acting and reduce _____ and related hospitalizations
  • ____________ Of different pharmacological class may improve?
A
17
Q

Therapy options inhaled cortico

Regular Tx with inhaled corticosteroids improves?

Withdrawal from tx may lead to?

________ _______ _____ ____ is more effective than an individual components in improving?

Addition of a ____/inhaled corticosteroid combination to an ______ apprears to provide additional benefits

Chronic Tx with _____ should be avoided because of poor?

A
18
Q

Theophylline and Phosphodiesterase-4 inhibitors

Less?

Modest?

Options?

A
19
Q

Other tx

Alpha Trypsin, recommended for?

Antitussive?

Vasodilators? What is contraindicated?

A
20
Q

Therapy at each stage

A
21
Q

Objectives

A
22
Q

Emphysema Contributing Factors

Smoking

A
  • Decreases effects of Alpha1-antitrypsin
  • Increases neutrophil number in alveoli and release elastase
23
Q

Emphysema Contributing Factors

Genetic

A
  • Alpha1-Antitrypsin def (Inhibits action of protease)
  • Elastase breaks down elastic fibers, Destructive process increases in people with low
24
Q

Emphysema Contributing Factors

Changes in lung tissue

two sub

A
  • Breakdown of alveolar wall
    • Decrease SA for gas exchange
    • loss of elastic fibers
    • loss of pulmonary capillaries
    • Altered ventilation/perfusion ratio
    • Decrease support for small bronchi
  • Progressive difficulty with expiration
    • Air trapping, increases residual volume
    • Overinflation of lungs