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Question 1

What is the order of potency of Estrone, estradiol, and estraiol from most potent to least potent?

Answer 1

Potency
Estradiol> Estrone > Estriol

Question 2

What is the order of potency of others, DHT, and testosterone from most potent to least potent?

Answer 2

Potency
DHT > Testosterone > others

Question 3

Where is 5a-reductase found and what is its function?

Answer 3

Found in: peripheral tissues adipose, prostate and skin

Function: Converts Testosterone into 5a-Dihydrotestosterone

Question 4

What intiates male growth in an embryo?

Answer 4

by sex-determining region of the Y chromosome (SRY gene).

Question 5

What is the first thing that begins the development of the testis and from where does it develop?

Answer 5

The SRY transcription factor begin development of the testis - from medulla of primordial gonad.

Question 6

What does testosterone stimulate the development of?

Answer 6

Testosterone stimulate development of epididymis, vas deferens, and seminal vesicle from Wolffian ducts.

Question 7

What does DHT stimulate the development of?

Answer 7

DHT stimulate development of male external structures – prostate, penis, penile urethra and scrotum.

Question 8

What would happen if there was an absence in the SRY gene?

Answer 8

Absence SRY gene, gonads develop into ovaries

Question 9

What happens when there is a deficeny in 5a-reductase in an embryo?

Answer 9

Clinical Box
5α-reductase deficiency—inability to convert testosterone into DHT → normal male internal genitalia, ambiguous external genitalia until puberty (when ↑ testosterone levels cause masculinization)

Question 10

What would be the consequence of fever on spermatogenesis and steroidogenesis?

Answer 10

Spermatogenesis: failure

Steroidogenesis: uneffected