Corpus Striatum Flashcards
What are the major structures in the corpus striatum?
Caudate nucleus
Lentiform nucleus
Nucleus accumbens
What are the major structures of the basal ganglia.
Corpus striatum
Substantia nigra
Sub thalamic nucleus
What makes up the lentiform nucleus?
PUTAMEN
GLOBUS pallidus
What are the striatal afferents?
Cortex
Thalamus
Substantia nigra
Are the corticostriate fibres excitatory or inhibitory?
Excitatory
Where do the thalamostriate fibres originate from?
Intralaminar nuclei
Where do the nigrostriate fibres originate from?
Substantia nigra pars compacta - PUTAMEN
Ventral tegmental area - nucleus accumbens
What effects does dopamine have on the nigrostriate fibres?
Both excitatory and inhibitory
What are the striatal efferents?
Globus pallidus
Substantia nigra
Where do the striatopallidal fibres originate from and what neurotransmitter is released?
Internal and external GLOBUS pallidus
GABA inhibitory
How is the upper motor neuron in the cortex affected when the striatum is at rest?
No excitation.
What happens to the upper motor neuron in cortex when the striatum is excitatory?
Excitatory
How does dopamine affect the direct pathway of basal ganglia circuits?
Dopamine released from substantia nigra excites striatum and helps facilitate movement.
How does dopamine affect the indirect pathway of the basal ganglia circuits?
Dopamine released from substantia nigra inhibits striatum to facilitate movement
