Corticosteroids

Question 1

what are corticosteroids

Answer 1

–steroids
–are a group of chemicals secreted by the adrenal cortex and are referred to as adrenal cortical hormones
–they are controller… not a rescue agent

Question 2

Mode of Action of Corticosteroids

Answer 2

–steroids work by reducing inflammation, swelling, and mucus production in the airways. As a result, the airways are less inflamed and less likely to react to triggers

Question 3

Indications for Use of Inhaled Corticosteroids

Answer 3

–maintenance, control therapy of chronic persistent asthma
-helps prevent the symptoms of asthma
-COPD
-Intranasal aerosol agent: seasonal and perennial allergic and nonallergic rhinitis

Question 4

Aerosol Steroids: Asthma

Answer 4

–Early use in asthma:
reduces morbidity and airway hyperresponsiveness
spacer is recommended
–Acute Severe Asthma:
not beneficial, for controlling rather than relieving can help improve lung function
–Inhaled Corticosteroids
low dose preferred for decreased side effects

Question 5

Aerosol Steroids: COPD

Answer 5

–relieves symptoms and exacerbations
–little or no effect on FEV1

Question 6

Inhaled Corticosteroids: Beclomethasone Dipropionate

Answer 6

–Trade Name: Qvar
–Method of Admin: is a breath-actuated MDI, primeless canister, does not need to be shaken due to having a primeless canister

Question 7

Inhaled Corticosteroids: Flunisolide

Answer 7

–Trade Name: AeroSpan
–Method of Admin: MDi manufactured with a spacer attached

Question 8

Inhaled Corticosteroids: Fluticasone Propionate

Answer 8

–Trade Name and Admin: Flovent HFA MDI
Flovent Diskus DPI
ArmonAir Respiclick DPI: spacer should not be used

Question 9

Inhaled Corticosteroids: Fluticasone Furoate

Answer 9

–Trade Name: Arnuity Ellipta
–Admin: DPI has better affinity for the glucocorticoid receptor this providing a longer duration action
–Given once daily

Question 10

Inhaled Corticosteroids: Budesonide

Answer 10

–Trade Name and Admin: Pulmicort Flexhaler DPI
Pulmicort respules SVN: is the inhaled corticosteroid available as an SVN. Can be mixed with other liquid medication

Question 11

Inhaled Corticosteroids: Mometasone furoate

Answer 11

–Trade Name and Admin: Asmanex Twisthaler, DPI,given once daily
Asmanex HFA, MDI, Twice daily over age 12

Question 12

Inhaled Corticosteroids: Ciclesonide

Answer 12

–Trade Name: Alvesco MDI
–for ages 12 and older
–decreases the incidence of oral thrush

Question 13

Comination Corticosteroids: Fluticasone Propionate / Salmeterol

Answer 13

–Trade Name and admin: Advair Diskus, DPI
Advair HFA, MDI
AirDuo Respiclick, DPI, is not used with a spacer/holder chamber

Question 14

Combination Corticosteroids: Mometasone Furoate / Formterol

Answer 14

–Trade Name and Admin: Dulera, MDI
–increase lung function as a combination drug
–steroid and bronchodilator

Question 15

Combination Corticosteroids: Budesonide / Formoterol

Answer 15

–Trade Name and Admin: Symbicort, MDI, increase beta-adrenergic receptor transcription

Question 16

Combination Corticosteroids: Fluticasone furoate / vilanterol

Answer 16

–Trade Name and Admin: BreoEllipta, DPI, contains 2 double-foil blisters of powder formulation

Question 17

Triple Therapy Coricosteroid: Fluticasone furoate / umeclidinium / vilanterol

Answer 17

–Trade name and Admin: Trelegy Ellipta, DPI
–Treats: COPD
–not allow to change the dose of each drug in it

Question 18

Steroid hazards and side effects

Answer 18

–systemic administration
–suppression of the Hypothalamic-Pituitary- Adrenal (HPA)
–immunosuppression
–peptic ulcer
–hypertension
–increase WBC
–slowing growth in children

Question 19

Systemic side effects

Answer 19

–aerosol admin
–HPA suppression
–Loss of bone density
–growth restriction in children

Question 20

Inhaled Corticosteroid Assess.

Answer 20

–instruct patient in correct use of delivery
–respiratory assess
–subjective response
–use a peak flow meter
–exacerbations
–missed work/school
–ER vists
–assess for side effects

Question 21

A side effect of corticosteroid use is inhibition of?

Answer 21

–HPA axis

Question 22

the product combining an inhaled steroid and a bronchodilator is?

Answer 22

–dulera