Coursecram Flashcards
(198 cards)
what is the endocrine system?
- all the hormone secreting cells of an organism
- composed of endorcrine and neuroendocrine glands
- these glands secrete their hormones and neurohormones into body fluids (blood, hemolymph, etc. )
- think “within the body”
what is histamine?
- local regulator
- regulation of immune response and and inflammation
what are local regulators
signals that act like hormones but never enter any circulatory system
what are pheromones
they are signals that leave the organism and act at a distance on another organism
what are the 3 signalling strategies?
- autocrine (self signal)
- paracrine (signal beside it, histamine)
- endocrine (within)
what are the four groups of hormones?
- amino acid derivatives: dopamine, melatonin, thyroid hormones, adrenaline
- peptide hormones: proteins, prolactin,insulin
- steroid: cholestoral derivatives, sex hormones, cortisol
- fatty acid derivatives: in insects
what type of soluble are steroid hormones?
lipid soluble
what are the unique properties and receptor location of peptide hormones?
- encoded by genes
- soluble in blood
- receptors found on the plasma membrane
what are the unique properties and receptor location of steroid hormones?
- insoluble in blood
- need carrier proteins
- made by enzymes
- receptors are found in the cytoplasm
what are the steps in the endocrine signalling pathways?
- synthesis: translation and enzymatic
- transport: either soluble or insoluble (need carrier proteins)
- reception: only cells with the appropriate receptor expressed can respond
- transduction
- response
what are the 2 types a receptor can be?
- angonists: stimulatory
- antagonist: inhibitory
what are the 2 general kinds a receptor can be?
- angonists: stimulatory
- antagonist: inhibitory
what can hormone concentration affect for receptors?
activity
what are peptide hormones synthesized by?
genes that are expressed
what are steroid hormones synthesized by?
enzymes
which can travel through the blood stream? soluble or insoluble hormones
- soluble: can travel
- insoluble: bind carrier proteins in the blood (Albumin and Globulins)
what are signal transduction pathways?
- extracellular signals that produce one or more effects in structure, function, of the gene expression profile of the target cell
what are the types of receptors? what are the types thar use second messengers?
use 2nd messengers
* GCPR
* Ligand gated ion channels
* receptor enzyme
don’t use it
* intracellular receptor (influences gene expression- steroids)
what do second messengers do?
amplify response and most signalling cascades use them
what are protein kinases?
act on each other and transmit signals by a casecase of phorphorylations that cause conformational change in phosphorylated protein
what does phosphorylation usually change in a protein?
changes it from inactive to active form
what are the antagnostic hormones in the human endocrine system? what is their general roles
- general role: maintain homeostasis
Regulation of Glucose
* insulin: decreases blood sugar levels by stimulating uptake at the tissues
* glucagon: increases blood sugar levels by stimulating glucose released by the liver into the blood
Regulation of Sodium Levels
* ADH: less water in urine
* ANP: more sodium in urine
* alsosterone: more sodium in urine
what happens when you eat, in terms of insulin?
- blood sugar spikes
- insulin released from pancres
- causes glucose to be taken out of the blood (by tissues) and stuffed into the cells
what happens when you fast, in terms of glucagon?
- blood sugar is depelted
- glucagon released
- releases glucose from liver and into the blood