Coxiella Burnetti (Q fever) zoonotic organism

Question 1

Origin

Answer 1

worldwide; typically common in livestock

Question 2

transmission

Answer 2

inhalation of spores; zoonotic(sheep, goat, cattle); vets

Question 3

where do spores lie in livestock

Answer 3

animal placenta and fetal membrane

Question 4

Two forms

Answer 4

small cell variant that is resistant to environmental stress
and
large cell variant that is metabolically active

Question 5

which cells do spores infect

Answer 5

macrophages

Question 6

presentation

Answer 6

a self-limiting acute febrile illness lasting 1 to 3 weeks and an incubation period of approximately 20 days (range 14 to 39). The onset is usually abrupt, with high-grade fevers (104 F or 40 C), headache, fatigue, and myalgias being the most commonly recognized symptoms; occurs about 3 weeks after coming into contact with spores

Question 7

complications

Answer 7

chronic endocarditis, acute pneumonia (!!), granulomatous hepatitis

Question 8

Lab Diagnosis

Answer 8

Serology. The reference standard test for the serologic diagnosis of acute Q fever is the indirect immunofluorescence antibody (IFA) using C
Elisa- for antibodies
PCR

Question 9

Treatment for acute infection

Answer 9

Doxycycline

Question 10

Treatment for chronic infection

Answer 10

Hydroxycholorquine + Doxycycline