CREATININE/CREATINE part 2

Question 1

converts creatine to creatinine and the difference between the two sample measurements is the creatine concentration

Answer 1

Heating

Question 2

may result in the formation of additional chromogens and the precision of this method is poor

Answer 2

High temperatures

Question 3

Several enzymatic methods have been developed; one is the creatininase assay. The initial enzyme is

Answer 3

omitted

Question 4

coupled to produce a measurable colored product

Answer 4

creatine kinase (EC 2.7.3.2), pyruvate kinase (EC 2.1.7.40), and lactate dehydrogenase (EC 1.1.1.27)

Question 5

Creatine can be measured by

Answer 5

HPLC

Question 6

Reference intervals vary with

Answer 6

assay type, age, and gender

Question 7

Creatinine concentration decreases with age beginning in the __th decade of life

Answer 7

5

Question 8

associated with abnormal renal function, especially as it relates to glomerular function

Answer 8

Elevated creatinine concentration

Question 9

Plasma concentration of creatinine is inversely proportional to the clearance of creatinine. Therefore, when plasma creatinine concentration is elevated, GFR is decreased, indicating

Answer 9

renal damage

Question 10

relatively insensitive marker and may not be measurably increased until renal function has deteriorated more than 50%

Answer 10

Plasma creatinine

Question 11

-In muscle disease such as
-both plasma creatine and urinary creatinine are often elevated. Plasma creatinine concentrations are usually normal in these patients

Answer 11

muscular dystrophy, poliomyelitis, hyperthyroidism, and trauma

Question 12

used typically for the diagnosis of muscle disease because analytic methods for creatine are not readily available in most clinical laboratories

Answer 12

Measurement of creatine kinase

Question 13

Plasma creatine concentration is not elevated in

Answer 13

renal disease