Crohns and ulcerative colitis

Question 1

What is the difference between the 2

Answer 1

Ulc Col:
-Disease continuous
-Rectum always involved
-Anal fissures 25%
-Ileum involved 10%
-Mucosa gran. & ulcers
-Vascular
-Serosa normal

Crohns:
-Discontinuous
-Rectum involved 50%
-Anal fissures 75%
-Ileum involved 30%
-Mucosa cobbled & fissures
-Non-vascular
-Serosa inflamed

Question 2

What treatment is there for inflammatory bowel disease

Answer 2

Systemic steroids- Prednisolone

Anti inflam drugs- 5 ASA based drugs, Pentasa, mesalazine,sulphasalazine

Non steroid immunosuppressants- Azathioprine, Methotrexate

Anti TNF (alpha) therapy- Infliximab, adalimumab