CT: Fibers of CT: Collagen, Elastic, Reticular

Question 1

Collagen fiber composition

Answer 1

Collagen protein

Question 2

T/F: collagen protein the most abundant protein in the body

Answer 2

True

Question 3

Synthesized inside the cell from 3 polypeptide chains which have large amounts of glycine, proline and hydroxyproline

Answer 3

Procollagen

Question 4

Essential for the hydroxylation of proline and lysine

Answer 4

Vitamin C

Question 5

What does vitamin C deficiency lead to?

Answer 5

• ⬇️ collagen formation
• Defective wound healing (scurvy)

Question 6

Procollagen is secreted and cleaved to form what?

Answer 6

Tropocollagen

Question 7

What do tropocollagen molecules assemble into?

Answer 7

Collagen fibrils

Question 8

What do tropocollagen fibrils form?

Answer 8

Collagen fibers

Question 9

Collagen fibers are secreted into the ECM are what?

Answer 9

Polarized

Question 10

What produces loose CT?

Answer 10

Fibroblasts

Question 11

What produces bone?

Answer 11

• Osteoblasts

Question 12

What produces cartilage?

Answer 12

• Chondroblasts
• Chondrocytes

Question 13

Type I collagen structures

Answer 13

• Skin
• Bone
• Tendons
• Ligaments

Question 14

Type I collagen function

Answer 14

Resists tension

Question 15

Type II collagen location

Answer 15

Cartilage

Question 16

Type II collagen function

Answer 16

Resists pressure

Question 17

Type III collagen

Answer 17

Loose CT

Question 18

Loose CT function

Answer 18

Structural support

Question 19

Type IV collagen location

Answer 19

Basement membrane

Question 20

Type IV collagen function

Answer 20

• Support
• Filtration

Question 21

A heterogenous group of disorders that result from a defect in synthesis or structure of collagen

Answer 21

Ehlers-Danlos syndrome

Question 22

Deficient production of collagen due to a vitamin C deficiency

Answer 22

Scurvy

Question 23

Excessive collagen production

Answer 23

Keloids

Question 24

Fibers that allow the tissue to stretch and recoil

Answer 24

Elastic fibers

Question 25

Elastic fibers composition

Answer 25

- Elastin - Microfibrils

Question 26

Where are elastic fibers found?

Answer 26

- Arterial walls - Elastic ligaments - Elastic cartilage - Skin - Lungs

Question 27

What are reticular fibers mostly made up of?

Answer 27

Type III collagen

Question 28

Where are reticular fibers found?

Answer 28

Basement membran

Question 29

Where does a majority of reticular fiber production occur?

Answer 29

Fibroblasts

Question 30

Fills spaces not occupied by cells and fibers

Answer 30

Ground substance

Question 31

Ground substance function

Answer 31

Medium for diffusion

Question 32

GAGs commonly located in cartilage and bone

Answer 32

Chondroitin sulfate

Question 33

GAGs commonly found in skin, lungs, and tendons

Answer 33

Dermatin sulfate

Question 34

GAGs most commonly found in cartilage and nucleus pulposus

Answer 34

Keratin sulfate

Question 35

GAGs commonly found in arteries and surfaces of the cells

Answer 35

Heparin sulfate

Question 36

Consists of a core protein to which the GAGs are bound

Answer 36

Proteoglycans

Question 37

Proteoglycan configuration

Answer 37

Bottle brush

Question 38

Glycosylated proteins

Answer 38

Glycoprotein

Question 39

Glycoproteins that **mediates attachment of the cells to ECM**

Answer 39

Fibronectin

Question 40

Glycoproteins that **mediates attachment of epithelial cells to basement membrane**

Answer 40

Lamanin

Question 41

Glycoproteins most commonly associated with bone

Answer 41

Osteonectin

Question 42

Glycoproteins most commonly associated with cartilage

Answer 42

Chondronectin

Question 43

Forces that cause fluid to leave the capillaries and enter the CT space

Answer 43

Starling forces (hemodynamics)

Question 44

Increase in tissue fluid beyond normal

Answer 44

Edema