CTD: Lupus. Lecture review Qs

Question 1

what medication unmasks true SLE

Answer 1

penicillamine

Question 2

medications implicated in drug-induced SLE

Answer 2

MMC is HIP
Minocycline
Methyldopa
Chlorpromazine
Hydralazine
Isoniazid
Procainamide
Phenytoin

Question 3

immunologic markers for renal disease in SLE

Answer 3

anti-dsDNA

anti-C1q

Question 4

what is Sneddon syndrome

Answer 4

livedo reticularis, cerebrovascular infarcts and htn (may have SLE)

Question 5

treatment of bullous SLE

Answer 5

dapsone

Question 6

what does bullous SLE attack? HLA associated?

Answer 6

type 7 collagen

HLA-DR2

Question 7

what does ASAP syndrome stand for and what is it

Answer 7

Acute Syndrome of Apoptotic Pan-Epidermolysis

TEN-like presentation in SLE

Question 8

what is Rowell syndrome

Answer 8

EM-like lesions in lupus

Question 9

11 criteria for SLE

Answer 9

SOAP BRAIN MD
Serositis
Oral ulcerations
Arthritis
Pleuritis
Blood abnormalities
Renal abnormalities
ANA +
Immunologic abnormalities
Neurologic abnromalities
Malar rash
Discoid lesions

Question 10

who does SLE affect

Answer 10

young-middle age women (6:1) and African Americans (4:1)

Question 11

clinical presentation of neonatal lupus

Answer 11

periocular edema and erythema (racoon’s eyes)

appear in first few weeks of life

Question 12

associations in neonatal lupus

Answer 12

congenital heart block, thrombocytopenia, hepatobiliary ds

Question 13

if only __ ab is present in neonatal lupus, then there is no risk of heart block

Answer 13

U1RNP

Question 14

what medication can lower the risk of neonatal lupus to 7% if initiated prior to 10 wks gestation

Answer 14

hydroxychloroquine

Question 15

what is the risk that a second child will have neonatal lupus

Answer 15

25%

Question 16

neonatal lupus is due to transferring __ ab across the placenta

Answer 16

anti-Ro/SSa

Question 17

most important treatment for DLE and SCLE

Answer 17

sunscreen

Question 18

30% of SCLE cases are drug-induced. what drugs?

Answer 18

HANG NAIL
HCTZ
ACE-I and Antihistamines
NSAIDs
Griseofulvin
Nifedipine
Anticonvulsants
Interferon
Lamisil

Question 19

clinical description of SCLE

Answer 19

sun exposed scaly, annular plaques

Question 20

10-15% of SCLE pts develop internal symptoms. what are they?

Answer 20

arthritis, leukopenia, renal, CNS, vascular complications

Question 21

antibody in 70% SCLE pts

Answer 21

anti Ro/SSa

Question 22

percentage of pts with positive ANA in SCLE

Answer 22

80%

Question 23

percentage of pts with SCLE that will get SLE

Answer 23

30%

Question 24

anatomical area spared in lupus panniculitis

Answer 24

distal extremities

Question 25

percentage of pts with tumid lupus that will have overlying DLE

Answer 25

30%

Question 26

percentage of pts with tumid lupus that will develop SLE

Answer 26

50%

Question 27

tumid lupus overlaps with what entities

Answer 27

REM (reticular erythematous mucinosis) | jessner's lymphocytic infiltrate

Question 28

how often does tumid lupus have overlying epidermal involvement

Answer 28

never

Question 29

mutation in familial form of chilblain lupus

Answer 29

TREX1

Question 30

LE-LP overlap syndrome most commonly affects what area

Answer 30

palmoplantar | also oral with scarring alopecia

Question 31

percentage of pts with DLE that have +DIF

Answer 31

75%

Question 32

percentage of SLE pts with DLE

Answer 32

25%

Question 33

percentage of DLE pts that develop SLE

Answer 33

5-15%

Question 34

childhood DLE has higher progression to?

Answer 34

SLE

Question 35

what do you need to worry about in long-standing DLE

Answer 35

SCC

Question 36

most common location DLE

Answer 36

above the neck - scalp and concha

Question 37

langue au chat refers to

Answer 37

cat's tongue - follicular carpet tack like plugging in DLE

Question 38

forms of chronic cutaneous lupus

Answer 38

discoid, hypertrophic, LE-LP overlap, chilblain, tumid, lupus panniculitis

Question 39

other name for Sjogren syndrome

Answer 39

Sicca syndrome, Mikulicz ds