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Andrews > Neural, Muscle, and Fat Tumors > Flashcards

Neural, Muscle, and Fat Tumors Flashcards

1
Q

3 types of true neuromas

A
  1. traumatic
  2. multiple mucosal
  3. solitary palisaded encapsulated (PEN)
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2
Q

what is a neurothekoma

what are the two types

A

nerve sheath myxoma on head and neck

2 types: classic myxoid and cellular

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3
Q

genoderm with myxomas, myxoid neurofibromas

A

Carney Complex (PRKARA1)

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4
Q

genoderm with psammomatous melanotic schwannoma

A

Carney Complex (PRKARA1)

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5
Q

aggregates of coarse granules surrounded by a clear zone of cytoplasm in granular cell tumors

A

pustulo-ovoid body of Milan

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6
Q

virus implicated in merkel cell tumor

A

polyomavirus

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7
Q

stain to differentiate merkel cell tumor from small cell lung cancer

A

TTF-1 (neg in MCC), CK20 (pos in MCC)

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8
Q

3 midline nasal lesions

A
  1. dermoid cysts
  2. nasal gliomas (heterotopic brain)
  3. encephalocele (yes transillumination)
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9
Q

infant w/ firm blue dermal nodules
periorbital ecchymosis (raccoon eyes)
heterochromia of irises
increased catecholamines

A

infantile neuroblastoma

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10
Q

Ddx small blue cell tumor/blue balls in dermis

A 
LEMONS
lymphoma
ewing's sarcoma
merkel cell & melanoma
oat cell carcinoma of lung
neuroblastoma
small cell endocrine carcinoma
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11
Q

Ddx blueberry muffin baby

A
  1. ToRCH infections
  2. Heme (hemolytic anemia, spherocytosis, ABO incompatibility, twin-twin transfusion, intracranial bleed)
  3. Malignancy (congenital leukemia cutis, rhabdomyosarcoma, Langerhans cell histiocytosis, neuroblastoma)
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12
Q

genoderms ganglioneuromas

A

GI = MEN 2B
NF1
start in autonomic nerve cells, can occur anywhere

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13
Q

genoderm with congenital lipomatosis

A

Proteus syndrome (AKT1)

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14
Q

genoderms with multiple lipomas

A
  1. Bannayan-Riley-Ruvalcaba (PTEN)
  2. Cowden (PTEN)
  3. Gardner (APC)
  4. MEN 1 (Menin)
  5. Frohlich syndrome (lipomas, obesity, sexual infantalism)
  6. Encephalocraniocutaneous lipomatosis
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15
Q

3 types of leiomyoma

A

piloleiomyoma, genital leiomyoma, angioleiomyoma

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16
Q

genoderm with multiple leiomyomas

A 
Reed syndrome (fumarate hydratase)
uterine leiomyomas, renal cell ca
17
Q

genoderm with genital leiomyomas

A

Alport syndrome
X-linked dominant defect in type IV collagen
hematuric nephropathy, deafness, maculopathy

18
Q

DDx painful tumor

A 
BLEND AN EGG
blue rubber bleb
leiomyoma
eccrine spiradenoma
neuroma
dermatofibroma
angiolipoma
neurilemmoma (schwannoma)
endometrioma
glomus tumor
granular cell tumor
19
Q

Ddx deep tumor

A 
rheumatoid nodule
sclerosing lipogranuloma (parrafinoma)
giant cell tumor of tendon sheath
schwannoma
angiolipoma
myxoid liposarcoma
hibernoma
chondroid sarcoma
angioleiomyoma
nodular fasciitis
angioleiomyoma
20
Q

DDx spindle cells in superficial dermis

A 
SLAM'd against epi
Spindle cell SCC (cytokeratin 5 &6)
Leiomyosarcoma (actin, desmin)
AFX (CD10, CD68, CD99)
Melanoma, desmoid (S100)
21
Q

lymphangiosarcoma in site of chronic lymphedema

A

Stewart-Treves syndrome

22
Q

Bazex syndrome

A 
acrokeratosis paraneoplastica
violaceous scaling fingers, toes, nose, helices
nail dystrophy
PPK
aerodigestive malignancy
23
Q

necrolytic migratory erythema

A

glucagonoma
DM, wt loss, anemia, glossitis
erythema with bulla and light brown papules and scale of face, groin, abdomen

24
Q

erythema gyratum repens

A

breast, stomach, bladder, prostate, cervical ca

25
Q

hypertrichosis lanuginosa acquisita

A

malignant down

lung, colon, breast

26
Q

leser-trelat sign

A

sudden eruptive SKs

stomach ca

27
Q

paraneoplastic pemphigus

A

NHL, CLL, Castleman’s

bronchiolitis obliterans complication

28
Q

exfoliative erythroderma malignancy

A

lymphoproliferative dz

29
Q

sweet syndrome malignancy

A

AML

30
Q

pityriasis rotunda

A

hepatocellular ca

31
Q

tripe palms

A

w/ AN = GI, w/o AN = lung

32
Q

cicatricial pemphigoid malignancy

A

anti-epilegrin (laminin 5)

adenocarcinoma

33
Q

neurofibromas are composed of what cell types?

A

schwann cells, perineural cells, mast cells

34
Q

stain for neurothekoma

A

NK1C3

35
Q

soft yellow papules or cerebriform plaques with a wrinkled surface, follow lines of blaschko, buttocks or thigh

A

nevus lipomatosus superficialis

Andrews (15 decks)

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