Cushings Syndrome

Question 1

Cushing’s syndrome is associated with which condition?

Answer 1

MEN1 syndrome

Question 2

What is the most common cause of Cushing syndrome?

Answer 2

Exogenous steroid use

Question 3

What is the first-line diagnostic test for Cushing’s?

Answer 3

Overnight Dexomethasone Supression test

Question 4

What does it mean if on a Overnight Dexamethasone Suppression test there is low cortisol when giving 1mg Dexamethasone?

Answer 4

This is NORMAL

Question 5

What would be found on U&Es and on an ABG in patients with Cushing’s syndrome?

Answer 5

Hypokalaemia

Metabolic alkalosis

Question 6

What does it mean if on a Overnight Dexamethasone Suppression test there is high cortisol when giving 1mg Dexamethasone?

Answer 6

Cushing SYNDROME

Question 7

What does it mean if on a Overnight Dexamethasone Suppression test there is low cortisol when giving 8mg Dexamethasone?

Answer 7

Cushing’s Disease i.e. Pituitary adenoma

Question 8

What does it mean if on a Overnight Dexamethasone Suppression test there is high cortisol when giving 8mg Dexamethasone?

Answer 8

Either Adrenal Cushing’s or Ectopic ACTH (need to look at ACTH)

Question 9

What does it mean if on a Overnight Dexamethasone Suppression test there is high cortisol and low ACTH when giving 8mg Dexamethasone?

Answer 9

Adrenal Cushing’s

Question 10

What does it mean if on a Overnight Dexamethasone Suppression test there is high cortisol and high ACTH when giving 8mg Dexamethasone?

Answer 10

Ectopic ACTH i.e. small cell lung cancer