Cutaneous Disorders Flashcards

(49 cards)

1
Q

Tx for seborrheic dermatitis in peds AKA cradle cap

A

Soap and water
Emollient (petrolatum, mineral oil) or selenium sulfide shampoos
Low-potency topical corticosteroids only for extensive or persistent cases
Ketoconazole shampoo

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2
Q

Distinguishing diaper rashes (seborrheic dermatitis vs. candidal dermatitis vs. contact dermatitis)

A

Seborrheic Dermatitis
- “greasy,” transparent to pink-red patches that are macerated located on scalp, ears, face, chest, groin

Candidal dermatitis
- beefy red plaques with satellite lesions

Contact dermatitis
- Erythematous, indurated, scaly plaques (severe cases with vesiculation and bullae)

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3
Q

Which rare potentially life-threatening disease can present resembling a candidal diaper rash?

A

Langerhans cell histiocytosis

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4
Q

Tx for seborrheic dermatitis when involves body areas other than scalp in infants

A

Ketoconazole 2% cream or a low potency topical corticosteroid (hydrocortisone 1% cream)

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5
Q

Timing of rash in parvovirus B19 infection

A

URI sx for 3-4 days then “slapped cheek” rash

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6
Q

Most common cause of impetigo?

A

Staph aureus followed by group A strep

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7
Q

Tx for impetigo

A

Limited number of lesions: topical mupirocin

Numerous lesions or involvement of more than one area:: oral abx such as cephalexin or dicloxacillin

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8
Q

Symptoms of IgA vasculitis (Henoch-Schonlein Purpura)

A
  • Palpable purpura - lower extremities and buttocks (NORMAL platelets)
  • Colicky abdominal pain - can complicate to intussusception
  • Heme-positive stool
  • Microscopic hematuria, proteinuria, elevated BUN/Cr
  • Arthralgias
    Uncommon: orchitis or testicular torsion
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9
Q

Most commonly implicated medications leading to SJS or TEN

A
  • Allopurinol
  • Antiepileptic meds
  • Lamotrigine
  • Sulfonamide abx
  • Sulfasalazine
  • Oxicam NSAIDs
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10
Q

Classic drug reaction patterns: a series

A

Q117080

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11
Q

Which tinea infections in children always requires systemic antifungal therapy?

A

Tinea capitis, tinea unguium (onychomycosis)

Griseofulvin, terbinafine, fluconazole, itraconazole

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12
Q

What is the most common cause of death from seafood consumption in the United States?

A

Vibrio vulnificus septicemia

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13
Q

What is Dyshidrotic Eczema?

A

Vesicular rash typically found on the palms, soles, and sides of fingers that presents in the third decade of life with lifelong occurrences

Has similar appearance as herpes, lesions are opaque and deep-seated, either flush with the skin or slightly elevated and do not break easily

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14
Q

Description of erythema multiforme

A

Target-like lesions - central dark papule surrounded by a pale area and halo of erythema

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15
Q

Causes of erythema multiforme

A
  • Herpes simplex (most common viral cause)
  • Mycoplasma
  • Sulfonamides
  • Penicillins
  • Barbiturates
  • Phenytoin
  • NSAIDs
  • Oral hypoglycemics
  • Lupus
  • Hepatitis
  • Lymphoma
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16
Q

What is the most common corneal lesion in herpes zoster ophthalmicus?

A

Punctate epithelial keratitis

Pseudodendrites are also associated (no terminal bulb)

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17
Q

Main difference between staphylococcal scalded skin syndrome vs. SJS

A

SSSS - circumoral erythema without mucosal involvement

SSSS toxins target desmoglein 1 which is not predominant in mucosa

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18
Q

What is a fixed drug eruption?

A

Solitary erythematous patch that is round or oval and well-circumscribed

  • Typically pruritic
  • May become dusky and violaceous
  • Swelling, bullae, and erosion of lesion may occur
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19
Q

Common causes of fixed drug eruptions

A
  • Tetracyclines
  • Sulfonamides
  • Fluoroquinolones
  • Penicillins
  • Dapsone
  • NSAIDs
  • Barbiturates
  • Acetaminophen
  • Antimalarials
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20
Q

Why are breastfed infants less likely to get diaper dermatitis?

A

The pH of their feces is lower

21
Q

Risk factors for melanoma

A
  • Ultraviolet irradiation (particularly light-skinned individuals)
  • BRAF gene
  • Family hx
  • Dysplastic nevi
22
Q

What is the most important factor in melanoma?

23
Q

Characteristics of epidermal cysts (sebaceous cysts)

A
  • skin-colored lesion
  • present for long period of time
  • often with central punctate area
  • white or yellowish waxy material drainage
24
Q

What genetic condition is associated with numerous epidermoid cysts on face, ears, trunk?

A

Gardner syndrome

25
What is a pilar cyst?
Firm, slow-growing nodule similar to epidermoid cyst, but grow from root of hair follicle, so more often located on the scalp
26
What key clinical findings differentiates erysipelas from cellulitis?
Sharp demarcation from uninvolved skin Can also spread to pinna of ear, whereas cellulitis cannot Tends to have acute onset with systemic manifestations whereas cellulitis is more indolent Erysipelas involves upper dermis and superficial lymphatics Cellulitis involves deeper dermis and subcutaneous fat
27
Common cause of erysipelas
Beta-hemolytic streptococci
28
Classic manifestation of erysipelas
Butterfly pattern over face
29
Tx for erysipelas
Mild-moderate: Amoxicillin, cephalexin | Systemic: Ceftriaxone or cefazolin
30
Description of erythema multiforme
Sudden appearance of erythematous violaceous macules and papules Commonly found on soles of feet and palms of hands Lesions are target-like with a central dark papule surrounded by a pale area and a “halo” of erythema
31
Causes of Erythema Multiforme
- HSV (most common viral cause) - Mycoplasma - Drugs: SOAPS - sulfa, oral hypoglycemics, anticonvulsants, penicillin, nSAIDs - Lupus - Hepatitis - Lymphoma
32
Tx of Erythema Multiforme
Mild: supportive - oral antihistamines and topical steroids | Severe (significant mucous membrane involvement): systemic corticosteroids
33
Pathophysiology of Kerion
Starts as tinea capitis (painless) that then undergoes delayed-type hypersensitivity reaction to causative fungus which causes initial erythematous, scaly plaque to become boggy with inflamed purulent nodules and plaques and the hair follicle is destroyed by the inflammatory process leading to scarring alopecia
34
Clinical presentation of Kerion
Q586281 image - Painful - Hair loss - Fever - Lymphadenopathy
35
Tx for kerion
Oral griseofulvin Abx to treat any secondary bacterial infection Oral corticosteroids to treat severe inflammation
36
What is black dot Tinea capitis?
Refers to an infection that causes the individual hairs to fracture, leaving the infected dark stubs visible in the infected regions
37
Locations commonly involved in stasis dermatitis
Medial distal and pretibial area of the legs; bilateral malleoli
38
What are the EFG prediction criteria added to the ABCD prediction rule for diagnosing unpigmented nodular melanomas?
Elevation Firm on palpation Continuous growth for 1 month
39
Characteristics of basal cell carcinoma
- Pearly nodule - Telangiectatic vessels - “Rolled” raised edge
40
Characteristics of squamous cell carcinoma
- Indurated and ulcerated papule - May bleed - Arise from actinic keratosis
41
What are five treatments for genital warts caused by HPV?
- Podofilox - Imiquimod - Cryotherapy - Trichloroacetic acid - Surgical removal
42
What is the most common STD?
HPV
43
Risk factors for MRSA
- Recent hospitalization/surgery - Hemodialysis - HIV infection - IVDU - Purulence - Residence in long-term healthcare facility
44
Abx regimens to cover cellulitis with MRSA coverage
- Amoxicillin and minocycline - Amoxicillin and doxycycline - Bactrim - Clindamycin
45
What risk factor has the strongest association for cellulitis
Lymphedema
46
Pahtophysiology of pemphigus vulgaris
IgG autoantibodies against keratinocytes and their desmosomes
47
Tx for pemphigus vulgaris
Steroids and immunomodulators such as azathioprine, cyclosporine, or methotrexate
48
Dispo for pemphigus vulgaris
Admission - high mortality
49
Mechanism of pemphigus vulgaris
Bullae and blister formation from deposition of immunoglobulin G autoantibodies in the epithelial cell surface IgG against keratinocytes in desmosomes causing acantholysis