CV and Psychiatry Flashcards Preview

Cardiovascular > CV and Psychiatry > Flashcards

Flashcards in CV and Psychiatry Deck (16):
1

Which CV drug has been linked to depression but not proven

Beta-blockers; espicially the lipophilic ones (carvedilol, metoprolol, propranolol)

2

Thiazide diuretics effect on lithium

Increase lithium levels

3

Loop diuretics and ACEi effect on lithium

varied risk of toxicity

4

Example drug interactions

Beta-blockers and SSRIs:
-SSRIs block 2D6; 2D6 metabolizes beta-blockers

Clonidine and mirtazapine:
-Have opposite effects at central alpha2 receptors

5

Schizophrenia mortality rates

Have been increasing; possibly due to increased CVD risk factors

6

Most common CV risk factor seen in schizophrenia

Smoking, obesity, dyslipidemia, HTN

7

Most common CV risk factor seen in bipolar

Smoking, HTN, Obesity

8

Metabolic syndrome; etiology

Schizophrenia; antipsychotic medications may contribute; most by olanzipine

9

Antipsychotic-induced weight gain risk factors

younger age, lower initial BMI, famHx of obesity, non-white

10

Which antipychotic was shown to be most causing of metabolic syndrome

Olanzapine

11

Which antipyschotic was shown to cause the most weight gain

Clozapine (after 10 weeks) and olanzapine (after 1 year)

12

What CV event can be caused by antipsychotics

Long QT

13

Which antipsychotics prolong QT the most

Thioridazine
Citalopram
Ziprasidone

14

When are U waves seen

Hypokalemia, long QT syndrome

15

Tricyclic antidepressants and clinical indications

Amitriptyline
Nortriptyline
Chlorpromazine
Imipramine
Desipramine
Doxepin

Uses- migraines, neuropathy, chronic pain, anxiety/depression

16

CV effects of tricyclics

Widened QRS (>160 msec) = high risk of arrhythmia

Slurred QRS in leads I and AVL

QT/PR prolongation

Right axis deviation

AV block