CV Meds: Antilipidemic Meds Flashcards
(20 cards)
Antilipidemic meds lower ____ and increase ____
Lower Low-Density Lipoproteins (LDL)
LDL = BAD
Increases High-Density Lipoproteins (HDL)
HDL = GOOD
Along with Antilipidemic meds, what other therapies can you support?
Diet, exercise, and weight control
What are the therapeutic uses of antilipidemics? (3)
- Primary hypercholesterolemia
- Prevention of coronary events
- Protection against MI and stroke in clients who have diabetes
Those who are ____ should discontinue antilipidemics
Pregnant
Those with ___ dysfunction, should take caution when taking antilipidemics
Renal dysfunction
What is the main type of antilipidemics?
Statins
What are some examples of statins?
- atorvostatin
- simvastatin
- lovastatin
- pravastatin sodium
- rosuvastatin
- fluvastatin
What are side effects of antilipidemics?
- muscle aches
- hepatotoxicity
- rhabdomyolysis
- peripheral neuropathy
Why should you notify provider if taking antilipidemics and you are feeling muscle aches?
Bc muscle aches are a sign of rhabdomyolysis
What do statins do?
Interferes with hepatic enzyme HMG-CoA to decrease formation of cholesterol precursors
When should you take statins?
In the evening to promote cholesterol synthesis
What should you monitor when taking statins?
- liver profile
- renal profile if rhabdomyolysis is present
What diet should you assume when taking statins?
Low-fat/High-protein diet
When statins are coupled with warfarin, what can occur?
Prolonged bleeding
What medications interact with statins? (LOTS)
Digoxin, warfarin, thyroid hormones, thiazide diuretics, phenoarbitals, NSAIDs, tetracyclines, beta-blocking agents, gemfibrozil, glipizide, glyburide, oral contraceptives, and phenytoin
What food should avoid when taking statins?
Grapefruit juice
What do cholesterol absorption inhibitors do? (They are NOT the same as statins)
Inhibits absorption of cholesterol secreted in bile and from food
Can you take cholesterol absorption inhibitors and antilipidemics together?
Yes, they are often used in combination with one another
Example of cholesterol absorption inhibitor:
Ezetimibe
When should you take ezetimibe?
2 hours before or 4 hours after other antilipidemics
bc statins and this med used together has an increased risk of liver damage
