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//Gpe21// > CVS > Flashcards

CVS Flashcards

1
Q

MOA aspirin

A

Blocks prostaglandin synthesis
Non-selective for COX1 and COX2
COX1 - irreversible inhibition of platelet aggregation for 7-10/7
Prevents arachidonic acid —> thromboxane A2 (inducer of platelet aggregation)

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2
Q

Class aspirin

A

NSAID/ anti-platelet

Salicylate

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3
Q

MOA clopidogrel

A

metabolised to active form by carboxylesterase-1
Irreversibly binds p2y12 receptor on platelets
Prevents ADP mediated activation of glycoprotein IIb/IIIa
Inhibits platelet aggregation

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4
Q

P2y12 inhibitors

A

Clopidogrel, prasugrel, ticodipine, ticagrelor, cangrelor

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5
Q

which p2y12 inhibitors are pro-drugs

A

Clopidogrel
Prasugrel
Ticlopidine

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6
Q

Which p2y12 inhibitors are not pro drugs, and already exist in their active forms

A

Cangrelor

Ticagrelor

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7
Q

Clopidogrel class

A

P2y12 inhibitor

Antiplatelet

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8
Q

How many days before surgery should clopidogrel be discontinued

A

7/7

BNF

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9
Q

How many days before surgery should ticagrelor be stopped?

A

5/7

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10
Q

How many days before surgery should prasugrel be stopped?

A

7/7

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11
Q

MOA dipyridamole

A

Inhibits both ADENOSINE DEAMINASE and PHOSPHODIESTERASE
⬇️ release of arachidonic acid
Which ⬇️thromboxane A2 activity (inducer of platelet aggeregation)

Also directly stimulates release of prostacyclin

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12
Q

Normal dose of dipyridamole

A

200mg bd

M/r

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13
Q

How long after opening the original container should dipyridamole m/r capsules be discarded

A

6/52

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14
Q

Clopidogrel dosing/ and duration of tx

A

PCI - 300mg (or 600mg) plus aspirin
TIA or acute stroke in pts with aspirin hypersens - 75mg od
NSTEMI - 300mg, then 75mg up to 12/12 plus aspirin
STEMI - 75mg for at least 4/52 plus aspirin (give loading dose 300mg if ≤75)
Pts with AFib who can’t take warfarin - 75mg od

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15
Q

MOA warfarin

A

Inhibits vitamin K epoxide reductase
Diminishes vit K
Coagulation factors cannot be carboxylated - II, VII, IX, X - vitamin K dependent

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16
Q

Antiarrhythmic Class Amiodarone

A

III - K+ channel blocker

17
Q

Antiarrhythmic Class - Dronedarone

A

III - K+ channel blocker

18
Q

Antiarrhythmic Class - Propranolol

A

Class II - beta blocker

19
Q

Antiarrhythmic Class - Sotalol

A

Class II - beta blocker
AND
Class III - K+ channel blocker

20
Q

Antiarrhythmic Class - Flecainide

A

Class I - Na+ blocker/ membrane stabilising

//Gpe21// (8 decks)

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