Cytochrome P450 system Flashcards
(29 cards)
Which shows most phenotypic variation
2D6
Which involved in clozapine metabolism
1A2
What does tobacco do to 1A2
Induces it
Grapefruit juice - inhibitor to what (2)
1A2
3A4
Enzymes located where in cells
Endoplasmic reticulum
Inducer or inhibitor: Smoking
Inducer
Inducer or inhibitor: Alcohol
Inducer
Inducer or inhibitor: Barbiturates (to what)
Inducer (1A2, phenobarbital to 3A4)
Inducer or inhibitor: Carbemazepine (to what)
Inducer (3A4)
Inducer or inhibitor: St John’s Wort (to what)
Inducer (3A4)
Inducer or inhibitor: Phenytoin (to what)
Inducer (3A4)
Inducer or inhibitor: Chlorpromazine
Inhibitor
Inducer or inhibitor: SSRIs
Inhibitor
Inducer or inhibitor: Grapefruit juice
Inhibitor
Clozapine
Olanzapine
Asenapine
Agomelatine
Melatonin - substrates to what
1A2
Amphetamines
Atomoxetine
Aripiprazole
Clomipramine
Fluoxetine*
Olanzapine
Risperidone
Mianserin
Imipramine
Venlafaxine
Zuclopenthixol - substrates to what
2D6
Aripiprazole
Clonazepam
Donepazil
Fentanyl
Methadone
Mirtazapine
Quetiapine
Zopiclone - substrates to what
3A4
Olanzapine - substrate to which 2
1A2
2D6
Aripiprazole - substrates to which 2
2D6
3A4
Fluvoxamine inhibits what
1A2 (mainly)
(To lesser extent 2D6 and 3A4)
Fluoxetine inhibits what (2)
2D6
3A4
Paroxetine inhibits what (2)
2D6
3A4
It is an autoinhibitor at 2D6
Bupropion inhibits what
2D6
Amitriptyline inhibits what
2D6
