Drug MOAs

Question 1

Mirtazapine

Answer 1

Noradrenaline and serotonin specific antidepressant (NaSSa)
Antagonist to: 5HT2, 5HT3, H1, alpha 1, alpha 2, moderate muscarinic ACh

Question 2

Venlaxafaxine and duloxetine

Answer 2

SNRI

Question 3

Reboxetine

Answer 3

Noradrenaline re-uptake inhibitor (NRI)

Question 4

St John’s Wort

Answer 4

Weak MAO inhibitor, weak SNRI, ? weak SSRI

Question 5

Trazodone

Answer 5

SARI (Serotonin antagonist and reuptake inhibitor).
Blocks SERT (the serotonin reuptake pump)
Antagonist to: 5HT2A, 5HT2C

Question 6

Moclobemide

Answer 6

Reversible MAO-A inhibitor

Question 7

Agomelatine

Answer 7

Melatonergic agonist (MT1 and MT2 receptors)
Antagonist to 5HT2C

Question 8

Bupropion

Answer 8

NDRI (noradrenaline dopamine re-uptake inhibitor)
Antagonist to nicotinic ACh (Acetylcholine) receptor

Question 9

Donepezil

Answer 9

Reversible acetylcholinesterase inhibitor

Question 10

Rivastigmine

Answer 10

Reversible acetylcholinesterase inhibitor, and butyrylcholinesterase inhibitor

Question 11

Galantomine

Answer 11

Reversible acetylcholinesterase inhibitor
Also binds allosterically to nicotinic ACh receptor

Question 12

Memantine

Answer 12

NMDA receptor antagonist (non-competitive)

Question 13

Valproate

Answer 13

GABA agonist
Inhibits GABA aminotransferase

Question 14

Gabapentin

Answer 14

High affinity for binding sites in brain near voltage-gated calcium channels, especially alpha-2-delta-1, which seems to inhibit the release of excitatory neurotransmitters in the presynaptic area

Question 15

Topiramate

Answer 15

GABA agonist
NMDA antagonist
Na (sodium) channel stabiliser
Carbonic anhydrase inhibitor

Question 16

Carbemazepine and phenytoin

Answer 16

Na (sodium) channel stabiliser

Question 17

Lamotrigine

Answer 17

NMDA antagonist
Na (sodium) channel stabiliser

Question 18

Pregabalin

Answer 18

Potent ligand for the alpha-2-delta subunit of voltage-gated calcium channels

Question 19

Benzodiazepines and Z-drugs

Answer 19

GABA-A agonist

Question 20

Buspirone

Answer 20

5HT1A partial agonist

Question 21

Flumezanil

Answer 21

GABA-A antagonist

Question 22

Amisulpride

Answer 22

D2/D3 selective antagonist

Question 23

Olanzapine

Answer 23

Dopamine and 5HT2 antagonist

Question 24

Aripiprazole

Answer 24

Partial agonist of 5HT1A and D2
Antagonist of 5HT2

Question 25

Clozapine

Answer 25

DA antagonist - D4 strongest Agonist of 5HT1A Antagonist of 5HT2

Question 26

Lurasidone

Answer 26

Antagonist at: D2, 5-HT2A, 5-HT7, alpha 2A and alpha 2C adrenoceptors Partial agonist of 5HT1A

Question 27

Ketamine and phencyclidine

Answer 27

NMDA antagonist

Question 28

Lofexidine and clonidine

Answer 28

Alpha 2 agonist

Question 29

Buprenorphine

Answer 29

Partial mu agonist

Question 30

Naloxone

Answer 30

Opioid antagonist (mu, kappa, delta)

Question 31

Naltrexone

Answer 31

Long-acting opioid antagonist, all receptors but mainly mu

Question 32

Atomoxetine

Answer 32

Noradrenaline re-uptake inhibitor

Question 33

Varenicline

Answer 33

Partial agonist of nicotinic ACh receptor

Question 34

Disulfiram

Answer 34

Binds irreversibly to enzyme acetaldehyde dehydrogenase and causes acetaldehyde to accumulate following ingestion of alcohol

Question 35

Acamprosate

Answer 35

NMDA antagonist GABA-A positive allosteric modulators

Question 36

Selegiline

Answer 36

Irreversible MAO-B inhibitor, plus MAO-A inhibitor at higher doses

Question 37

Sildenafil

Answer 37

Inhibitor of cGMP-specific phosphodiesterase type 5 (PDE5)

Question 38

Lithium

Answer 38

Effects intracellular second messenger systems

Question 39

Vigabatrin

Answer 39

Decrease GABA metabolism by GABA transaminase inhibition

Question 40

Vortioxetine

Answer 40

SERT inhibition 5HT3 & 5HT7 antagonism

Question 41

D2, D3, 5HT7 antagonist

Answer 41

Amisulpride