Cytokines Flashcards
(21 cards)
which cytokines are secreted by macrophages?
IL-1, IL-6, IL-8, IL-12, TNF-alpha
which cytokines are secreted by T cells?
IL-2 and IL-3
which cytokines are secreted by Th1 cells?
IFN-gamma and IL-2
which cytokine inhibits differentiation of Th2?
IFN-gamma
which cytokines does Th2 secrete?
IL-4, IL-5, IL-10 and IL-13
what does IL-1 do?
causes fever and acute inflammation
activates endothelium to express adhesion molecules
chemokine secretion to recruit WBCs
what are the acute cytokines?
IL-1, IL-6 and TNF-alpha
what does IL-6 do?
causes fever and stimulates production of acute-phase proteins
what does TNF-alpha do?
activates endothelium
causes WBC recruitment and vascular leak
which cytokine maintains granulomas in TB?
TNF-alpha
what does IL-8 do?
chemotactic factor for neutrophils
“clean up on aisle 8!”
what does IL-12 do?
induces differentiation of T cells into Th1 cells
and activates NK cells
which cytokine facilitates granuloma formation in TB?
IL-12
what does IL-3 do?
stimulates bone marrow
what cytokines activate NK cells?
IL-2 and IL-12
what does IL-4 do?
stimulates IgE production
“2 BEG 4 help”
differentiation of T cells into TH2 helper cells
growth of B cells
class switching to IgE and IgG
what does IL-5 do?
stimulates IgA production
“I have 5 BAEs”
growth of B cells
class switching to IgA
stimulates growth of eosinophils
what does IL-10 do?
attenuates inflammatory response
decreases expression of MHC class II and Th1 cytokines
inhibits activated macrophages and dendritic cells
which cytokines attenuate immune response?
IL-10 and TGF-beta
what does IL-13 do?
promotes IgE production by B cells and induces alternative macrophage activation
“thirtEEn”
what does IL-2 do?
stimulates T cells
and NK cells
