Cytokines Flashcards
Produced by macrophages and act on the hypothalamus to increase temperature set point?
IL-1
Product of Ag activated CD4 and CD8 T-Cell to increase proliferation of T-cells in periphery
IL-2
Strongly associated with stimulation of myeloid cell precursors in bone marrow (macrophage, B-cell, dendritic cells)
IL-3
Production of acute phase proteins from hepatocytes to induce differentiation in myeloid stem cell in bone marrow?
IL-6
Production of lymphoid cells in bone marrow (B-lymphocytes, NK cells, Plasma cells. T- lymphocytes)
IL-7
Most of the biological response from IL-12 is mediated by?
STAT4
IL-12 signaling causes the translocation of several what across the nucleus?
STAT 4
What cytokine is the most critical for mediating increased eosinophils with allergic disease
IL-5
TH1 expresses
IFN-gamma, IL-2, & TFN-beta
TH2 expresses
IL-4, IL-5, IL-10, & IL-13
Th17 expresses
IL-22, IL-17, & IL-21
IL-4 activates STAT 6 that activates?
GATA3 which generates Th2
IL-6 activates STAT3 that activates?
RORyt which generates Th17
