T-cells

Question 1

Signal transduction complex in all T lymphocytes

Answer 1

CD3

Question 2

CD4+, CD8-, TCR+

Answer 2

Helper T cell in circulation: NOT in thymus

Question 3

CD4-, CD8+, TCR+

Answer 3

Cytotoxic T cell in circulation: NOT in thymus

Question 4

CD4-, CD8-, TCR+

Answer 4

Not Possible- a coreceptor needs to be present before TCR is expressed

Question 5

CD4-, CD8-, TCR-

Answer 5

Is possible of a T-lymphocyte that leaves the bone marrow for the thymus to not have coreceptor or to have not yet rearrange variable domain for TCR.
**If TCR+ there must be a coreceptor expressed

Question 6

MHC Class I antigens are recognized by

Answer 6

CD8

Question 7

MHC class II antigens are recognized by

Answer 7

CD4

Question 8

Adhesion molecule that mediates attachment of lymphocytes and APC

Answer 8

CD2 aka LFA-2

Question 9

Produced by T-cell to increase proliferation of T-cells in the periphery

Answer 9

IL-2

Question 10

Describe a T-cell receptor

Answer 10

Membrane bound Alpha,Beta or Delta, Gamma heterodimer

Question 11

Refers to the recognition of MCH I or MCH II by double positive CD4+, CD8+ thymocytes

Answer 11

Positive Selection

Question 12

What location would you most likely find gamma/delta

T-cells?

Answer 12

They migrate to respiratory organs, skin, and peritoneal cavity

Question 13

The adaptive immune response has to be turned on and off. This is done by the competing of what?

Answer 13

Competing of CTLA-4 (found exclusively on CD4 and CD8) with CD28 for the binding of B7 on the B-cell

Question 14

What expresses high-affinity trimeric IL-2Ralphabetagamma

Answer 14

Ag-activated CD4+ and Ag-activated CD8+

Question 15

What is the fate of a T-cell that has high affinity for self-MHC?

Answer 15

Deletion in the thymus via induced apoptosis

Question 16

When a resting naive T-cell engages its specific MHC/peptide complex displayed on the surface of a fibroblast what happens to the T-Cell?

Answer 16

It becomes anergic

Question 17

What component of the TCR receptor complex is responsible for signal transduction?

Answer 17

CD3

Question 18

What type of structure is the TCR

Answer 18

A heterodimer consisting of an alpha chain and beta chain…….or a gamma chain and delta chain

Question 19

What segment is not present in the alpha chain gene of TCR?

Answer 19

Diversity (D)
The T cell receptor alpha chain genes do not posses D gene segments, although the delta chain genes do.
Any alpha chain rearrangement leads to the loss of the delta chain gene segments.

Question 20

What is the percentage of human peripheral blood T-cells bearing a gamma/delta T-cell receptor?

Answer 20

1-5%