Cytokines, CDs, and abbreviations Flashcards Preview

MICI 3115 > Cytokines, CDs, and abbreviations > Flashcards

Flashcards in Cytokines, CDs, and abbreviations Deck (74)
Loading flashcards...
1

IL-12

Heterodimer
produced by dendritic cells
activates NK cells and Th1

2

IL-23

heterodimer

3

IL-27

Heterodimer

4

IL-35

Heterodimer

5

p40

common signaling peptide for IL-12 and IL-23

6

IL-2

Th1 cytokine
cell mediated response
DTH (delay-type hypersensitivity)
decreased by cAMP
required for CD8+ development

7

IFN-gamma

Th1 cytokine
cell mediated response
inhibits Th2
CTL (Tc1) generation
NK cells are an important source of IFN-gamma.
increase macrophages

8

IL-4

Th2 cytokine
Humoral/B cell response
Antagonized IFN-gamma
shares a gamma chain with IL-7, IL-9, IL-15
Promotes class switching to IgG1 and IgE (T cells influence the class of the B cell)

9

IL-5

Th2 cytokine
Humoral/B cell response

10

IL-10

Th2 cytokine
Humoral/B cell response
Indirectly inhibits IFN-gamma and IL-2
Also a Treg soluble cytokine

11

IL-17

Th17 cytokine
inflammation
cross-regulates Treg

12

gp130

signal transducing peptide for IL-6, IL-11, CTNF, LIF

13

JAK

Janis Kinase
kinase found on cytokine receptors (hematopoeitic, interferon, and GPCRs)

14

STAT

phosphrylated by JAKs
transcription factor that sends the cytokine message intracellularly

15

T-bet

Th1 Transcription factor

16

GATA-3

Th2 Transcription factor

17

RORgammaT

Th17 Transcription factor

18

FOXP3

Treg Transcription factor
Treg cells take a lot of IL-2, used to decrease T cell activation

19

ERK, p38, JNK

MAP kinase effector molecules
cause inflammation

20

CD3

6 polypeptide complex that associates with TCRs to transduce intracellular signal
Has ITAMs with ZAP-70
activated/phosphrylated by p56lck

21

RSS

recombination specific sequences
flag sites for splicing/recombination in the variable heavy/light chains.
12bp sequence always pairs with a 23bp sequence

22

RAG1 & RAG2

recombination activating genes
only expressed in B or T cells
part of the V(D)J recombinase enzyme used for recombining spliced variable regions.

23

CDR

complementarity determining regions.
segments of the BCR variable region that undergo somatic hypermutation to become more specific to a given antigen.

24

AID

Activation induced adenosine deaminase
cuts S regions of the constant heavy chain for class switching (IgA, IgG, IgE, etc.)
Also involved in somatic hypermutation of CDRs in variable BCR regions.

25

B220

on the surface of lymphoid progenitors that are destined to be B cells

26

Ig alpha/beta

complex associated with the BCR to transduce signals.
Uses ITAMs

27

Syk

Mechanism of B cell intracellular signaling
A src family tyrosine kinase
phospharylated by ITAMs
Syk -> BLK -> PLCgamma2 + Btk -> NFkB

28

CD40

costimulatory molecule on B cells, for B cell activation

29

CD40 Ligand

costimulatory molecule on T cells for B cell activation

30

TLRs

recognize PAMPs, and DAMPs
on macrophages and dendritic cells
part of the innate immune response