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Flashcards in Cytokines/Chemokines Deck (26)
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1

enhance activity of NK cells

IL-2-12 and IFNa-b

2

Il-2, Il-12, IFNa and IFNb

enhance activity of NK cells

3

cytokines secreted by TH1 cells

IFNy

4

cytokines secreted by TH2 cells

Il-4-5-10-13

5

inhibition of TH1 lineage

IL-4 and IL-10 from TH2 lineage

6

inhibition of TH2 lineage

IFNy from TH1 lineage

7

activation of TH1 lineage

IFNg and IL-12

8

activation of TH2 lineage

IL-4

9

stimulation of macrophages

IFNg from TH1

10

macrophages --> ? --> To --> TN1 --> ? --> macrophages

macrophages secreted IL-12 that stimulate To cells to differentiate into TH1 cells that secreted IFN to activated MO

11

cytokines produced by regulatory T cells

anti inflammatory
TGF beta
IL-10

12

Cytokines secreted by macrophages

IL-1-6-8-12 and TNFa

13

Describe IL-1

aka osteoclast-activating factor
causes fever, acute inflammation
activates endothelium to express adhesion molecules
induces chemokine secretion to recruite wbcs

from macrophages

14

Describe TNFa

mediates septic shock
activates endothelium
causes wbc recruitement and vascular leak

from macrophages

15

Describe IL-6

causes fever
stimulates production of acute-phase proteins

from macrophages

16

Describe IL-8

major chemotactic factor for PMNs

from macrophages

17

Describe IL-12

induces To --> TH1
activates NK cells (also IL-2, IFna and IFNb)

from macrophatges

18

Cytokines secreted by ALL T cells

IL-2, IL-3

19

Describe IL-2

from all T cells

stimulates forwth of helper, cytotoxic and regulatory t cells as well as NK cells

20

Describe IL-3

supports growth and differentiation of bone marrow stem cells
functions like GM-CSf

21

Cytokiens from TH1 cells

IFNy

22

Describe IFNy

secreted by NK cells in response to IL-12 from macrophages and TH1 cells

stimulates macrophages to kill phagocytosed pathogens
activates NK cells to kill virus-infected cells
increases MHC expression
increases antigen presentation by all cells

23

list cytokines from TH2 cells

IL-4-5-10-13

24

Describe IL-4

induces differentiation of TH2 cells
promotes growth of B cells
enhances clas switching to IgE and IgG

25

Describe IL-5

promotes differentiation of B cells
enhances class switching to IgA
stimulates growth and differentiaton of eosionophils

26

DEscribe IL-10

modulates inflammatory response
decreases expression of MHC I and TH1 cytokines
inhibits activated macropahges and dendritic cells

secreted by regulatory T cells (with TGFb) and TH2 cells