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Flashcards in Basics Deck (36)
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1

where are b cells found in lymph nodes

follicle
germinal centres

2

where are t cells found in lymph nodes

paracortex

3

where are MO found in lymph nodes

medullary sinuses - commincate with efferent lymphatics

4

where are plasma cells found in lymph nodes

medullary cords

5

what part of a lymph node is underdeveloped in digeorge syndrome (not velocardiofacial syndrome)É

paracortex

6

splenic dysfunction makes susceptibility to what moos increase?

encapsulated
* strep pneumonia
* h influenza
* n meningities
* e coli
* salmonella
* klebsiella
* GBS

7

where are T cells found in the spllen?

periarteriolar lymphatic sheath in the white pulp of the spleen

8

where are B cells found in the spleen

follicles in the white matter

9

where are apcs found in the spleen?

marginal zone between the white and red matter

10

describe what you see post-splenectomy?

howell-joly bodies - nuclear remnants
target cells
thrombocytosis - no sequestration no destruction
lymphocytosis - no sequestration

11

where is the thymus derived from

third pharyngeal pouch

12

what is a Hassall corpuscle

containes epithelial reticular cells
found in medulla
**Remember Dr G first term, first small group room**

13

loci of MHC I

HLA-A
HLA-B
HLA-C

14

loci of MHC II

HLA-DR
HLA-DQ
HLA-DP

15

what type fo antigen does MHC I expresse

endogenous (viral and self)

16

what type of antigen does MHC II express?

exogenous (bacterial)

17

hotdog MHC - Dr Young imm second term KBT

MHC II - alpha and beta, two transmembrane, invariant chain. ag in RER

18

gyro MHC - Dr Young imm second term KBT

MHC II - alpha, b2 macroglobulin, one transmembrane, ag in acidified endosome (degrades invariant chain)

19

crosses epithelium by transcytosis

IgA

20

C reactive protein

positive/upregulated acute phase protein
opsonin; fixes complement and favilitates phagocytosis

21

Ferritin

positive/upregulated acute phase protein
binds and sequesters iron to inhibit microbial iron scavenging

22

Fibrinogen

positive/upregulated acute phase protein
coagulation factor; promotes endothelial repair; correlates with ESR

23

Hepcidin

positive/upregulated acute phase protein
prevents release of iron bound by ferritin - anaemia of chronic disease

24

what is elevated in anaemia of chronic disease

ferritin and hepcidin

25

serum amyloid A

positive/upregulated acute phase protein
prolonged elevation can lead to amyloidosis

26

albumin

negative/downregulated acute phase protein
reduction conserves amino acids for positive reactants

27

transferrin

negative/downregulated acute phase protein
internalized by macrophages to sequester iron

28

alternative pathway C3 convertase

C3bBb

29

alternative pathway c5 convertase

C3bBb3b

30

classic pathway c3 convertase

C4b2b